7篇
您的检索式：作者名="Prabhakaran Kumar"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand 2-( 4-( 4-(2-methoxyphenyl) piperazin-1-yl) butyl )-4-methyl-1, 2, 4-triazine-3, 5 ( 2H, 4H)dione in nonhuman primates 显示文摘 | Kumar J S D Prabhakaran J Majo V J | 2007 | Eur J Nucl Med2007，34，7： | 1 |
| 3 | Machine-Cell Grouping in Cellular Manufacturing Systems Using Non-traditional Optimization Techniques-A Comparative Study显示文摘 | Asokan P Prabhakaran G Satheesh G Kumar | | 0，，02： | 1 |
| 4 | Antioxidant and antimicrobial effects of condiments paste used as nitrite replacer in chicken mince 显示文摘 | Meena Goswami P P Prabhakaran Vinay Kumar Tanwar | 2014 | Veterinary World2014，，7： | 1 |
| 5 | Freeform gelcasting of porous tubular alumina substrate 显示文摘 | Prabhakaran K Babu N R Kumar S R | 2002 | Journal of the American Ceramic Society2002，85，12： | 1 |
| 6 | Machine-cell grouping in cellular manufacturing systems using non-traditional optimization techniques-a comparative study显示文摘 | Asokan P Prabhakaran G Satheesh G Kumar | | 0，，18： | 1 |
| 7 | Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis显示文摘 | Kumar A Kumar Dorairaj S Prabhakaran VC | 2007 | Genomics2007，90，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员