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| 1 | Complementation of sugary-1 phenotype in rice endosperm with the wheat isoamylase1 gene supports a direct role for isoamylase1 in amylopectin biosynthesis显示文摘 | Akiko Kubo Sadequr Rahman Yoshinori Utsumi | 2005 | Plant Physiology2005，137，： | 1 |
| 2 | The effect of oral contrast on large bowel activity in FDG-PET/CT显示文摘 | Hideki Otsuka Michael M. Graham Akiko Kubo Hiromu Nishitani | 2005 | Annals of Nuclear Medicine2005，，2： | 1 |
| 3 | Nationwide Epidemiologic Survey of Idiopathic Osteonecrosis of the Femoral Head显示文摘 | Wakaba Fukushima MD PhD Mikihiro Fujioka MD PhD Toshikazu Kubo MD PhD Akiko Tamakoshi MD PhD Masaki Nagai MD PhD MSc Yoshio Hirota MD PhD | 2010 | Clinical Orthopaedics and Related Research?2010，，10： | 1 |
| 4 | Purification, characterization, and cDNA structure of isoamylase from developing endosperm of rice显示文摘 | Naoko Fujita Akiko Kubo Perigio B. Francisco Makiko Nakakita Kyuya Harada Nobuhiro Minaka Yasunori Nakamura | 1999 | Planta1999，，2： | 1 |
| 5 | The Dynamic Nature of Coronary Artery Lesion Morphology Assessed by Serial Virtual Histology Intravascular Ultrasound Tissue Characterization显示文摘 | Takashi Kubo Akiko Maehara Gary S. Mintz Hiroshi Doi Kenichi Tsujita So-Yeon Choi Osamu Katoh Kenya Nasu Andreas Koenig Michael Pieper Jason H. Rogers William Wijns Dirk B?se M. Pauliina Margolis Jeffrey W. Moses Gregg W. Stone Martin B. Leon | 2010 | Journal of the American College of Cardiology2010，，15： | 1 |
| 6 | Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism显示文摘 | Akiko Kikuchi Mutsuo Yamaya Satoshi Suzuki Hiroyasu Yasuda Hiroshi Kubo Katsutoshi Nakayama Masashi Handa Takahiko Sasaki Shigeki Shibahara Kiyohisa Sekizawa Hidetada Sasaki | 2005 | Human Genetics2005，，5： | 1 |
| 7 | Antisense inhibition of isoamylase alters the structure of amylopectin and the physicochemical properties of starch in rice显示文摘 | Naoko Fujita Akiko Kubo Dong-Soon Suh | 2003 | Plant and Cell Physiology2003，44，6： | 1 |
| 8 | Biomarkers of skin toxicity induced by anti-epidermal growthfactor receptor antibody treatment in colorectal cancer显示文摘Skin toxicity is a common symptom of anti-epidermal rowth factor receptor(EGFR) antibody treatment and is also a predictive marker of its efficacy in colorectal cancer patients. However, severe skin disorders induced by such antibodies negatively impact on the quality of life of patients and decreases drug compliance during treatment. If we can predict the high-risk group susceptible to severe skin toxicity before treatment, we can undertake the early management of any arising skin disorders and formulate a more accurate prognosis for anti-EGFR antibody treatment. Previous studies have identified molecular markers of skin toxicity induced by anti-EGFR antibody, such as EGFR polymorphisms, the expression of inflammatory chemokines and serum levels of EGFR ligands. A clinical trial was undertaken involving the escalation of cetuximab doses, guided by the grade of skin toxicity observed, such as no or low-grade, in metastatic colorectal cancer(the EVEREST study). The dose escalation of cetuximab was confirmed by a safety profile and had the tendency to achieve a higher response rate in KRAS wild-type patients. A large, prospective randomized trial is now ongoing(EVEREST 2) and the results of this trial may contribute to personalized medicine in KRAS wild-type colorectal cancer patients. | Akiko Kubo Hironobu Hashimoto Naoki Takahashi Yasuhide Yamada | 2016 | World Journal of Gastroenterology2016，22，2： | 1 |
| 9 | Changes in cognitive function during the 1-year period following endarterectomy and stenting of patients with high-grade carotid artery stenosis显示文摘 | Akiko Takaiwa Nakamasa Hayashi Naoya Kuwayama Naoki Akioka Michiya Kubo Shunro Endo | 2009 | Acta Neurochirurgica2009，，12： | 1 |
| 10 | Purification, characterization, and cDNA structure of isoamylase from developing endosperm of rice显示文摘 | Naoko Fujita Akiko Kubo Perigio B. Francisco Makiko Nakakita Kyuya Harada Nobuhiro Minaka Yasunori Nakamura | 1999 | Planta1999，，2： | 1 |
| 11 | The use of micro-beam X-ray diffraction for thecharacterization of starch crystal structure in rice mutant kernels of waxy, amylose extender, and sugary显示文摘 | AKIKO KUBO YOSHIAKI YUGUCHI MAKOTO TAKEMASA | 2008 | Journal of Cereal Science2008，，48： | 1 |
| 12 | A multichemical defense mechanism of bitter oliveOlea europaea (oleaceae)显示文摘 | Isao Kubo Akiko Matsumoto Ichiro Takase | 1985 | Journal of Chemical Ecology1985，，2： | 1 |
| 13 | The starch-debranching enzymes isoamylase pullulanase are both involved in amylopectin biosynthesis in rice endosperm显示文摘 | Kubo Akiko Fujita Naoko Harada Kyuya | 1999 | Plant Physiol1999，121，： | 1 |
| 14 | Complementation of sugary-1 phenotype in rice endosperm with the wheat Isoamylase1 gene supports a direct role for isoamylase1 in amylopectin biosynthesis显示文摘 | Kubo Akiko Rahman Sadequr Yoshinori Utsumi | 2005 | Plant Physiology2005，137，： | 1 |
| 15 | Intravascular Ultrasound Comparison of the Retrograde Versus Antegrade Approach to Percutaneous Intervention for Chronic Total Coronary Occlusions显示文摘 | Kenichi Tsujita Akiko Maehara Gary S. Mintz Takashi Kubo Hiroshi Doi Alexandra J. Lansky Gregg W. Stone Jeffrey W. Moses Martin B. Leon Masahiko Ochiai | 2009 | JACC: Cardiovascular Interventions2009，，9： | 1 |
| 16 | Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications显示文摘Carbon monoxide(CO) is a gaseous product generated by heme oxygenase(HO), which oxidatively degrades heme. While the stress-inducible HO-1 has well been recognized as an anti-oxidative defense mechanism under stress conditions, recent studies suggest that cancer cells utilize the reaction for their survival. HO-2, the constitutive isozyme, also plays protective roles as a tonic regulator for neurovascular function. Although protective roles of the enzyme reaction and CO have extensively been studied, little information is available on the molecular mechanisms by which the gas exerts its biological actions. Recent studies using metabolomics revealed that CO inhibits cystathionine β-synthase(CBS), which generates H2 S, another gaseous mediator. The CO-dependent CBS inhibition may impact on the remethylation cycle and related metabolic pathways including the methionine salvage pathway and polyamine synthesis. This review focuses on the gas-responsive regulation of metabolic systems, particularly the remethylation and transsulfuration pathways, and their putative implications for cancer and ischemic diseases. | Takako Hishiki Takehiro Yamamoto Takayuki Morikawa Akiko Kubo Mayumi Kajimura Makoto Suematsu | 2015 | 世界最新医学信息文摘2015，15，5： | 0 |
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