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| 1 | 2500年来艾比湖的环境演变信息显示文摘通过对艾比湖缘 1.8m浅孔的沉积相和孢粉组合 ,结合14 C测年资料分析 ,指出近 2 5 0 0年来艾比湖的沉积环境总体是比较稳定的 ,但由于气候波动引起艾比湖水位曾发生较明显的变化。约在公元前 30 0~ 4 0 0年 ,是艾比湖面积缩小时期 ;约公元前 30 0~公元 30 0年 ,即东周末至西晋 ,是艾比湖水位较高时期 ;约公元 30 0~ 14 0 0年 ,即东晋至 15世纪初 ,是艾比湖的高水位时期 ;约 15世纪初至 17世纪中是艾比湖的水位下降期 ,但水位比现代仍然高 ;约 17世纪中至 19世纪初的小冰期是艾比湖的水位上升期。 | 阎顺 穆桂金 远藤邦彦 Nobuhiko Handa Masao Uchida Naomi Harada | 2003 | 干旱区地理2003，26，3： | 55 |
| 2 | 车辆起-停巡航控制系统的加速度跟踪控制显示文摘针对低速行驶工况下的车辆StopandGo(起停)巡航控制系统,在研究其加速度动态响应非线性特性的基础上,设计了一种基于滑模变结构控制(SMC)的模型匹配控制器,该控制器综合了SMC的鲁棒性及模型匹配控制(MMC)快速响应的优点。通过仿真计算,结果表明该控制器不但能有效提高车辆在低速工况下加速度的快速跟踪性,而且还改善了系统对外界干扰的鲁棒性能。 | 宾洋 李克强 连小珉 UKAWA Hiroshi HANDA Masatoshi IDONUMA Hideyuki | 2005 | 清华大学学报(自然科学版)2005，45，2： | 7 |
| 3 | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis显示文摘BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease pathogenesis.Prebiotics such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut microbiota.Partially hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic syndromes.However,its effects on NAFLD remain to be fully elucidated.To determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver axis.METHODS Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%PHGG.Increased intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate sodium.Body weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were investigated.RESULTS Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG treatment.Furthermore,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluating the lumen-to-blood clearance of fluorescein isothiocyanate-conjugated dextran.PHGG treatment did not affect fatty acid metabolism in the liver.However,it decreased lipopolysaccharide signaling through the gut-liver axis.In addition,it significantly increased the abundance of cecal Bacteroides and Clostridium subcluster XIVa.Treatment with PHGG markedly increased the levels of SCFAs,particularly,butyric acid,acetic acid,propionic acid,and formic acid,in the cecal samples.CONCLUSION PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles. | Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 4 | High Th1/Th2 ratio in patients with multiple myeloma显示文摘 | Hatsue Ogawara Hiroshi Handa Tohru Yamazaki Takuma Toda Kensuke Yoshida Natsumi Nishimoto Wedad Hamdi Saleh Al-ma’Quol Yoriaki Kaneko Takafumi Matsushima Norifumi Tsukamoto Yoshihisa Nojima Morio Matsumoto Morio Sawamura Hirokazu Murakami | 2004 | Leukemia Research2004，，2： | 3 |
| 5 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 6 | Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis(NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH. An immune response is triggered by countless signals called damage-associated molecular patterns(DAMPs) elicited by lipid-laden and damaged hepatocytes, which are recognized by pattern recognition receptors(PRRs) on hepatic immune cells to initiate inflammatory signaling. In this editorial, in addition to summarizing innate immune signaling in NAFLD and discussing potential therapies that target innate immune pathways, we have described a recent study that demonstrated that mitochondrial DNA serves as a DAMP activating a hepatic PRR, TLR9, in mice and in the plasma of NASH patients. In addition to identifying a new ligand for TLR9 during NASH progression, the study shows that blocking TLR9 reverses NASH, paving the way for the development of future NASH therapy. | Priya Handa Akhila Vemulakonda Kris V Kowdley Misael Uribe Nahum Méndez-Sánchez | 2016 | World Journal of Gastroenterology2016，22，31： | 3 |
| 7 | “起-停”巡航控制系统的纵向车距控制方法显示文摘针对单一设计距离控制中出现的速度滞后问题,综合考虑速度和距离的控制,提出了一种基于'起停'巡航控制系统的纵向车间距控制器设计方法。该控制器的设计中引入了控制因子,建立了兼顾速度和距离控制的目标性能函数,并对控制因子的取值作了讨论。通过理论分析和仿真实验表明,所提出的控制方法使速度滞后的问题得到改善,同时控制器对质量具有鲁棒性。 | 周亮 李克强 连小珉 UKAWA Hiroshi HANDA Masatoshi IDONUMA Hideyuki | 2004 | 清华大学学报(自然科学版)2004，44，8： | 3 |
| 8 | Synthesis of hollow ferrite nanospheres for biomedical applications显示文摘 | Masaru Tada Takashi Kanemaru Takeshi Hara Takashi Nakagawa Hiroshi Handa Masanori Abe | 2009 | Journal of Magnetism and Magnetic Materials2009，，10： | 2 |
| 9 | Stiffness and elastic behavior of human intracranial and extracranial arteries显示文摘 | Hayashi K Handa H Nagasawa S | 1980 | Journal of Biomechanics1980，13，： | 2 |
| 10 | Proteins associate with adaptation of cultured tobacco cells to NaCl显示文摘 | Sing N K Handa A K Hasegawa P M | 1985 | Plant Physiol1985，79，： | 2 |
| 11 | Primary rhegmatogenous retinal detachment:evaluation of a minimally restricted face-down positioning after pars plana vitrectomy and gas tamponade显示文摘AIM:To evaluate the safety and efficacy of a minimally restricted face-down postoperative positioning following pars plana vitrectomy(PPV)with gas tamponade for primary rhegmatogenous retinal detachment(RRD).METHODS:Patients with primary RRD treated with PPV and gas tamponade and followed up for at least 6 mo were selected for the study.All phakic eyes underwent simultaneous cataract surgery.The patients were required to be in a postoperative position that prevented downward flow of retinal tears.Patients with macular detachment were positioned face-down for only a couple of hours.The patients were assessed for preoperative and postoperative best-corrected visual acuity(BCVA),anatomical retinal reattachment rate,and postoperative complications.RESULTS:In total,40 eyes of 39 patients with primary RRD were included in the study.A single tear was present in 30 eyes(75.0%),multiple retinal tears were present in nine eyes(22.5%),and oral dialysis was present in one eye(2.5%).The anatomical success rate was 90.0%(36 cases)after the primary surgery,and the final anatomical success rate was 100%.The BCVA improved significantly(P<0.001)from 0.75 logarithm angle of resolution(log MAR)preoperatively to 0.12 log MAR at the final visit.Postoperative complications included intraocular pressure elevation(≥25 mm Hg)in 11 patients(27.5%),fibrin formation in two patients(5.0%),pupillary capture of the intraocular lens in two patients(5.0%),and posterior synechia in one patient(2.5%).CONCLUSION:A minimally restricted face-down and flexible postoperative positioning after PPV and gas tamponade for primary RRD is effective and safe. | Kiichiro Kusaba Kotaro Tsuboi Tsuneaki Handa Yukihiko Shiraki Takuya Kataoka Motohiro Kmaei | 2021 | International Journal of Ophthalmology(English edition)2021，14，6： | 2 |
| 12 | Rebamipide, a Gastroprotective Drug, Inhibits Indomethacin-Induced Apoptosis in Cultured Rat Gastric Mucosal Cells: Association with the Inhibition of Growth Arrest and DNA Damage-Induced 45α Expression显示文摘 | Yuji Naito Hirokazu Kajikawa Katsura Mizushima Makoto Shimozawa Masaaki Kuroda Kazuhiro Katada Tomohisa Takagi Osamu Handa Satoshi Kokura Hiroshi Ichikawa Norimasa Yoshida Hirofumi Matsui Toshikazu Yoshikawa | 2005 | Digestive Diseases and Sciences2005，，1： | 2 |
| 13 | Prevalence of Plateau Iris in Primary Angle Closure Suspects显示文摘 | Rajesh S. Kumar Mani Baskaran Paul T.K. Chew David S. Friedman Swati Handa Raghavan Lavanya Lisandro M. Sakata Hon-Tym Wong Tin Aung | 2008 | Ophthalmology2008，，3： | 2 |
| 14 | Therapy of Helicobacter pylori : Present Medley and Future Prospective显示文摘 | Amin Talebi Bezmin Abadi Osamu Handa | 2014 | BioMed Research International2014，，： | 2 |
| 15 | Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein显示文摘瞄准:为了在 ischemia-reperfusion (红外) 上调查 rosuvastatin 的保护的效果,并且在内皮的氮的氧化物 synthase (eNOS ) 的表示上决定这个代理人的效果,在老鼠导致了小肠的损害和发炎蛋白质。方法:肠的损坏被为 30 min 夹钳优异 mes 伤寒动脉和腹的箱子在男 Sprague-Dawley 老鼠导致,为 60 min 由灌注列在后面。在生理盐水溶解的 Rosuvastatin intraperitoneally 被管理在局部缺血前的 60 min。肠的粘膜损害和发炎的严厉被几个生物化学的标记,以及由组织检查所见评估。eNOS 的蛋白质层次被西方的污点决定。结果:当粘膜的索引损坏,管腔内血红素和蛋白质的层次显著地在假冒操作组与那些相比在红外组被增加。然而,这些增加被处理显著地以一种剂量依赖者方式与 rosuvastatin 禁止。rosuvastatin 的保护的效果被组织检查所见也证实。到红外的小肠的暴露导致了 thiobarbituric 的重要增加描绘的粘膜发炎酸反应的物质,联系织物的 myeloperoxidase 活动,和老鼠的粘膜内容导致 cytokine 的嗜中性的 chemoattractant-1 (CINC-1 ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 。在红外以后的煽动性的参数的这些增加被预告的处理显著地在 10 mg/kg 的剂量与 rosuvastatin 禁止。而且, CINC-1 和 TNF-alpha 的 mRNA 表示在红外以后被增加,并且这增加被 rosuvastatin 也禁止。eNOS 的粘膜蛋白质层次在红外期间减少了,但是在与 rosuvastatin 对待的老鼠被保存。结论:Rosuvastatin 禁止老鼠红外导致的肠的损害和发炎,和它的保护与 eNOS 的保藏被联系蛋白质。 | Yuji Naito Kazuhiro Katada Tomohisa Takagi Hisato Tsuboi Masaaki Kuroda Osamu Handa Satoshi Kokura Norimasa Yoshida Hiroshi Ichikawa Toshikazu Yoshikawa | 2006 | World Journal of Gastroenterology2006，12，13： | 2 |
| 16 | Senescence marker protein-30 knockout mouse liver is highly susceptibl to tumor necrosis factor-alpha- and fas-mediated apoptosis 显示文摘 | Ishigami A Fujita T Handa S | 2002 | Am J Pathol2002，161，4： | 2 |
| 17 | 在印度北方一所医院中一项比较HanifinRajka诊断标准与英国工作组诊断标准诊断特应性皮炎的效率的研究 | Kanwar A.J. Handa S. 党倩丽 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，11： | 2 |
| 18 | Effect of hydrostatic pressure and salinity on the stability of gas hydrates显示文摘 | Handa Y P | 1990 | J Phys Chem1990，94，26： | 1 |
| 19 | Functional improvements in dried egg white through the Maillard reaction显示文摘 | HANDA A KURODA N | 1999 | Journal of Agricultural and Food Chemistry1999，47，： | 1 |
| 20 | Involvement of glycoprotein Vl in platelet thrombus formation on both collagen and von Willebrand factor surfaces under flow conditions 显示文摘 | Goto S Tamura N Handa S | 2002 | Circulation2002，106，2： | 1 |
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