|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan显示文摘AIM:To evaluate the efficacy of pegylated interferon α-2b(peg-IFNα-2b) plus ribavirin(RBV) therapy in Japanese patients with chronic hepatitis C(CHC) genotype Ib and a high viral load.METHODS:One hundred and twenty CHC patients(58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were enrolled.Sustained virological response(SVR) and clinical parameters were evaluated.RESULTS:One hundred(83.3%) of 120 patients completed 48 wk of treatment.53 patients(44.3%) achieved SVR.Early virological response(EVR) and end of treatment response(ETR) rates were 50% and 73.3%,respectively.The clinical parameters(SVR vs non-SVR) associated with SVR,ALT(108.4 IU/L vs 74.5 IU/L,P = 0.063),EVR(76.4% vs 16.4%,P < 0.0001),adherence to peg-IFN(≥ 80% of planned dose) at week 12(48.1% vs 13.6%,P = 0.00036),adherence to peg-IFN at week 48(54.7% vs 16.2%,P < 0.0001) and adherence to RBV at week 48(56.1% vs 32.1%,P = 0.0102) were determined using univariate analysis,and EVR and adherence to peg-IFN at week 48 were determined using multivariate analysis.In the older patient group(> 56 years),SVR in females was significantly lower than that in males(17% vs 50%,P = 0.0262).EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with SVR.CONCLUSION:Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%.Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Yasuteru Kondo Jun Inoue Yasunori Matsuda Eiji Kakazu Takeshi Yamamoto Hiroyoshi Onodera Yutaka Miyazaki Hiromasa Okamoto Takehiro Akahane Tomoo Kobayashi Yutaka Mano Takao Iwasaki Motoyasu Ishii Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，47： | 7 |
| 2 | Detection of K‐ras gene mutation by liquid biopsy in patients with pancreatic cancer显示文摘 | Hideaki Kinugasa Kazuhiro Nouso Koji Miyahara Yuki Morimoto Chihiro Dohi Koichiro Tsutsumi Hironari Kato Takehiro Matsubara Hiroyuki Okada Kazuhide Yamamoto | 2015 | Cancer2015，，13： | 4 |
| 3 | Forty-Year Experience With Flow-Diversion Surgery for Patients With Congenital Choledochal Cysts With Pancreaticobiliary Maljunction at a Single Institution显示文摘 | Nobuhiro Takeshita Takehiro Ota Masakazu Yamamoto | 2011 | Annals of Surgery2011，，6： | 2 |
| 4 | Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy显示文摘 | Tameyoshi Yamamoto Hiroaki Nagano Yasuharu Imai Kazuto Fukuda Hitoshi Matsumoto Motoi Kondo Hideo Ota Masato Nakamura Hiroshi Wada Takehiro Noda Bazarragchaa Damdinsuren Keizo Dono Koji Umeshita Shoji Nakamori Masato Sakon Kenichi Wakasa Morito Monden | 2007 | International Journal of Clinical Oncology2007，，2： | 1 |
| 5 | Cystathionine β‐synthase as a carbon monoxide–sensitive regulator of bile excretion显示文摘 | Tsunehiro Shintani Takuya Iwabuchi Tomoyoshi Soga Yuichiro Kato Takehiro Yamamoto Naoharu Takano Takako Hishiki Yuki Ueno Satsuki Ikeda Tadayuki Sakuragawa Kazuo Ishikawa Nobuhito Goda Yuko Kitagawa Mayumi Kajimura Kenji Matsumoto Makoto Suematsu | 2008 | Hepatology2008，，1： | 1 |
| 6 | Development of High Efficiency Swing Compressor for R32 Refrigerant显示文摘 | Yuuichi Yamamoto Takehiro Kanayama Kenichi Yuasa Hideki Matsua | 2015 | Journal of Energy and Power Engineering2015，9，2： | 1 |
| 7 | Evaluation of S-1 as third- or further-line chemotherapy in advanced non-small-cell lung cancer显示文摘 | Akira Ono Tateaki Naito Haruyasu Murakami Toshiaki Takahashi Yukiko Nakamura Asuka Tsuya Kyoichi Kaira Satoshi Igawa Takehiro Shukuya Akihiro Tamiya Rieko Kaira Masahiro Endo Nobuyuki Yamamoto | 2010 | International Journal of Clinical Oncology2010，，2： | 1 |
| 8 | Externalization of Saw-Tooth Architecture in Small Serrated Polyps Implies the Presence of Methylation of IGFBP7显示文摘 | Eisuke Kaji Toshio Uraoka Jun Kato Sakiko Hiraoka Hideyuki Suzuki Mitsuhiro Akita Shunsuke Saito Takehiro Tanaka Nobuya Ohara Kazuhide Yamamoto | 2012 | Digestive Diseases and Sciences2012，，5： | 1 |
| 9 | Circulating tumor DNA dynamics analysis in a xenograft mouse model with esophageal squamous cell carcinoma显示文摘BACKGROUND It remains unclear which factors,such as tumor volume and tumor invasion,influence circulating tumor DNA(ctDNA),and the origin of ctDNA in liquid biopsy is always problematic.To use liquid biopsies clinically,it will be very important to address these questions.AIM To assess the origin of ctDNA,clarify the dynamics of ctDNA levels,assess ctDNA levels by using a xenograft mouse after treatment,and to determine whether tumor volume and invasion are related to ctDNA levels.METHODS Tumor xenotransplants were established by inoculating BALB/c-nu/nu mice with the TE11 cell line.Groups of mice were injected with xenografts at two or four sites and sacrificed at the appropriate time point after xenotransplantation for ctDNA analysis.Analysis of ctDNA was performed by droplet digital PCR,using the human telomerase reverse transcriptase(hTERT)gene.RESULTS Mice given two-site xenografts were sacrificed for ctDNA at week 4 and week 8.No hTERT was detected at week 4,but it was detected at week 8.However,in four-site xenograft mice,hTERT was detected both at week 4 and week 6.These experiments revealed that both tumor invasion and tumor volume were asso ciated with the detection of ctDNA.In resection experiments,hTERT was detected at resection,but had decreased by 6 h,and was no longer detected 1 and 3 d after resection.CONCLUSION We clarified the origin and dynamics of ctDNA,showing that tumor volume is an important factor.We also found that when the tumor was completely resected,ctDNA was absent after one or more days. | Hiroyuki Terasawa Hideaki Kinugasa Kazuhiro Nouso Shumpei Yamamoto Mami Hirai Takehiro Tanaka Akinobu Takaki Hiroyuki Okada | 2021 | World Journal of Gastroenterology2021，27，41： | 1 |
| 10 | Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications显示文摘Carbon monoxide(CO) is a gaseous product generated by heme oxygenase(HO), which oxidatively degrades heme. While the stress-inducible HO-1 has well been recognized as an anti-oxidative defense mechanism under stress conditions, recent studies suggest that cancer cells utilize the reaction for their survival. HO-2, the constitutive isozyme, also plays protective roles as a tonic regulator for neurovascular function. Although protective roles of the enzyme reaction and CO have extensively been studied, little information is available on the molecular mechanisms by which the gas exerts its biological actions. Recent studies using metabolomics revealed that CO inhibits cystathionine β-synthase(CBS), which generates H2 S, another gaseous mediator. The CO-dependent CBS inhibition may impact on the remethylation cycle and related metabolic pathways including the methionine salvage pathway and polyamine synthesis. This review focuses on the gas-responsive regulation of metabolic systems, particularly the remethylation and transsulfuration pathways, and their putative implications for cancer and ischemic diseases. | Takako Hishiki Takehiro Yamamoto Takayuki Morikawa Akiko Kubo Mayumi Kajimura Makoto Suematsu | 2015 | 世界最新医学信息文摘2015，15，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员