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| 1 | Cardiovascular risk factors following renal transplant显示文摘Kidney transplantation is the gold-standard treatment for many patients with end-stage renal disease. Renal transplant recipients(RTRs) remain at an increased risk of fatal and non-fatal cardiovascular(CV) events compared to the general population, although rates are lower than those patients on maintenance haemodialysis. Death with a functioning graft is most commonly due to cardiovascular disease(CVD) and therefore this remains an important therapeutic target to prevent graft failure. Conventional CV risk factors such as diabetes, hypertension and renal dysfunction remain a major influence on CVD in RTRs. However it is now recognised that the morbidity and mortality from CVD are not entirely accounted for by these traditional risk-factors. Immunosuppression medications exert a deleterious effect on many of these well-recognised contributors to CVD and are known to exacerbate the probability of developing diabetes, graft dysfunction and hypertension which can all lead on to CVD. Nontraditional CV risk factors such as inflammation and anaemia have been strongly linked to increased CV events in RTRs and should be considered alongside those which are classified as conventional. This review summarises what is known about risk-factors for CVD in RTRs and how, through identification of those which are modifiable, outcomes can be improved. The overall CV risk in RTRs is likely to be multifactorial and a complex interaction between the multiple traditional and non-traditional factors; further studies are required to determine how these may be modified to enhance survival and quality of life in this unique population. | Jill Neale Alice C Smith | 2015 | World Journal of Transplantation2015，5，4： | 2 |
| 2 | Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS显示文摘 | Simon P Dunlop David Jenkins Keith R Neal Robin C Spiller | 2003 | Gastroenterology2003，，6： | 2 |
| 3 | Changes in efficiency and resource utilization after increasing experience with double balloon enteroscopy显示文摘AIM:To investigate changes in efficiency and resource utilization as a single endoscopist's experience increased with each subsequent 100 double balloon enteroscopy(DBE) procedures.METHODS:We reviewed consecutive DBE procedures performed by a single endoscopist at our center over 4 years.DBE was employed when the clinician deemed the procedure was needed for disease management.The approach(oral,anal or both) was chosen based on suspected location of the target lesion.All DBE was performed in a standard endoscopy room with a portable fluoroscopy unit.Fluoroscopy was used to aid in shortening the small intestine and reducing bowel loops.For oral DBE,measurements were taken from the incisors.For anal DBE,measurements were taken from the anal verge.Enteroscopy continued until the target lesion was reached,until the entire small intestine was examined,or until no further progress was deemed possible.The length of small intestine examined(cm),procedure duration(min),and fluoroscopy time(s) were analyzed for sequential groups of 100 DBE.Sub-groups of diagnostic and therapeutic procedures were analyzed using multivariable linear regression.RESULTS:802 consecutive DBE procedures were analyzed.For oral DBE,median [interquartile range(IQR)] length of small bowel examined was 230.8 cm(range:210-248 cm) and for anal DBE was 143.5 cm(range:100-180 cm).No significant increase in length examined was noted for either the oral or anal approach with advancing position in series.In terms of duration of procedure,the median(IQR) for oral DBE was 86 min(range:71-105 min) and for anal DBE was 81.3 min(range:67-105 min).When comparing by the position in series,there was a significant(P value < 0.001) decrease in procedure duration for both upper and lower procedures with increasing experience.Median(IQR) time of exposure to fluoroscopy for oral DBE was 190 s(114-275) compared to anal DBE which was 196.4 s(312-128).This represented a significant(P value < 0.001) decrease in the amount of fluoroscopy used with increasing position in series.For both oral and anal DBE,fluoroscopy time was reduced by greater than 50% over the course of 802 total procedures performed.Sub-group analysis was conducted on therapeutic and diagnostic groups.Out of 802 procedures,a total of 434 were considered therapeutic.Argon plasma coagulation was by far the most common therapeutic intervention performed.There was no evidence of a difference in length examined or fluoroscopy exposure among oral DBE for diagnostic and therapeutic procedures,P = 0.91 and P = 0.32 respectively.The median(IQR) for length was 235 cm(range:178-280 cm) for diagnostic vs 230 cm(range:180-275 cm) for therapeutic procedures;additionally,fluoroscopy time median(IQR) was 180 s(range:110-295 s) and 162 s(range:102-263 s) for no intervention and intervention.However,there was a significant difference in procedure duration among oral DBE(P < 0.001).The median(IQR) was 80 min(range:60-97 min) and 94 min(range:77-110 min) for diagnostic and therapeutic interventions respectively.CONCLUSION:For a single endoscopist,increased DBE experience with number of performed procedures is associated with increased efficiency and decreased resource utilization. | Neal C Patel William C Palmer Kanwar R Gill David Cangemi Nancy Diehl Mark E Stark | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 4 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 5 | The Moon 35 years after Apollo: What's left to learn? 显示文摘 | Neal C R | 2009 | Chem Erde2009，69，1： | 1 |
| 6 | Improving the oil recovery efficacy of lingo sulfonate solutions 显示文摘 | CHIWETELU C NEALE G HORNOF V | 1980 | Can J Petrol Technol1980，20，3： | 1 |
| 7 | Catchment-scale advection and dispersion as a mechanism for fractal scaling in stream tracer concentrations显示文摘 | Kirchner J W Feng X H Neal C | 2001 | Journal of hydrology2001，254，： | 1 |
| 8 | Near Shannon limit performance of low density parity check codes 显示文摘 | MACKAY D J C NEAL R M | 1997 | Electronics Letters1997，33，6： | 1 |
| 9 | Near Shannon limit performance of low density parity check codes 显示文摘 | Mackay D J C Neal R M | 1996 | Electronics Letters1996，33，6： | 1 |
| 10 | Challenges in the Packaging of MEMS显示文摘 | Malshe A P O'Neal C Singh S B | | 0，，03： | 1 |
| 11 | Near Shannon limit performance of low density parity check codes显示文摘 | MACKAY D J C and NEAL R M | 1996 | Electronics Letters1996，32，18： | 1 |
| 12 | Near Shannon limint performance of low density parity check codes显示文摘 | MACKAY D J C NEAL R M | 1996 | Electronic Letters1996，32，： | 1 |
| 13 | Henoch-Schonlein purpura follow- ing hepatitis B vaccination 显示文摘 | Chave T Neal C Camp R | 2003 | J Dermatol Treat2003，14，3： | 1 |
| 14 | Near Shannon limit performance of low-density parity-check codes 显示文摘 | MacKay D J C Neal R M | 1996 | Electron1996，32，： | 1 |
| 15 | Near Shannon limit performance of low density parity check codes显示文摘 | MACKAY D J C NEAL R M | 1997 | Electronics Letters1997，33，： | 1 |
| 16 | Physical and chemical properties of coal cinders as a container media component 显示文摘 | NEAL J C WAGNER D F | 1983 | Hort Science1983，18，5： | 1 |
| 17 | In vitro displacement by rat serum of adsorbed radiolabeled poloxamer and poloxamine copolymers from model and biodegradable nanospheres显示文摘 | Jonathan C Neal Snow S Etienne S | 1998 | Pharm Sci1998，87，10： | 1 |
| 18 | Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? 显示文摘 | Talge NM Neal C Glover V | 2007 | Child Psychol Psychiatry2007，48，34： | 1 |
| 19 | The moon 35 years after Apollo: What's left to learn?显示文摘 | Neal C R | 2009 | Chemie der Erde - Geochemistry2009，69，1： | 1 |
| 20 | Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus:Results of prospectively designed overviews of randomized trials显示文摘 | Turnbull F Neal B Algert C | 2005 | Arch Intern Med2005，165，12： | 1 |
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