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| 1 | Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene显示文摘Primary torsion dystonia (PTD) is a clinically and genetically heterogeneous movement disorder. At least thirteen different types of dystonia can be distinguished on a genetic basis.1 The DYT1 gene was first mapped by Ozelius et al in 1989.2 (Kramer et) al3 linked the same locus to PTD in 12 Ashkenazi Jewish families in 1990. Most patients with early-onset generalized PTD were caused by the same three base pair (GAG) deletion in the DYT1 gene on chromosome 9q34.1,4,5 The product of the gene is a protein called torsinA.5 (Although the) function of this protein is as yet uncertain, it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones. | YEUNG Wai Lan LAM Ching Wan CHENG Wai Tsoi SIN Ngai Chuen WONG Wing Kin WONG Chun Nei TSE Ka Ming FOK Tai Fai | 2005 | Chinese Medical Journal2005，，10： | 2 |
| 2 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 2 |
| 3 | Genome‐wide identification of Epstein‐Barr virus–driven promoter methylation profiles of human genes in gastric cancer cells显示文摘 | Junhong Zhao Qiaoyi Liang Kin‐Fai Cheung Wei Kang Raymond W. M. Lung Joanna H. M. Tong Ka Fai To Joseph J. Y. Sung Jun Yu | 2012 | Cancer2012，，2： | 2 |
| 4 | Zinc finger E‐box binding factor 1 plays a central role in regulating Epstein‐Barr virus (EBV) latent‐lytic switch and acts as a therapeutic target in EBV‐associated gastric cancer显示文摘 | JunhongZhao HongchuanJin Kin FaiCheung Joanna H. M.Tong SuiZhang Minnie Y. Y.Go LinweiTian WeiKang Patrick P. S.Leung ZhirongZeng XiaoxingLi Ka FaiTo Joseph J. Y.Sung JunYu | 2012 | Cancer2012，，4： | 1 |
| 5 | Unusual renal cell carcinomas a pictorial essay 显示文摘 | KIN KA CHOI JW PARK CM | 2006 | Abdominal Imaging2006，31，2： | 1 |
| 6 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 1 |
| 7 | Helicobacter pylori–positive Versus Helicobacter pylori–negative Idiopathic Peptic Ulcers in Children With Their Long-term Outcomes显示文摘 | Yuk Him Tam Kim Hung Lee Ka Fai To Kin Wai Chan Sing Tak Cheung | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，3： | 1 |
| 8 | Blueberry extract prolongs lifespan of Drosophila melanogaster显示文摘 | Cheng Peng Yuanyuan Zuo Kin Ming Kwan Yintong Liang Ka Ying Ma Ho Yin Edwin Chan Yu Huang Hongjian Yu Zhen-Yu Chen | 2011 | Experimental Gerontology2011，，2： | 1 |
| 9 | Effects of interleukin-9 blockadeon chronic airway inflammation in murine asthma models显示文摘 | Kin MS Cho KA Young JC’ | 2013 | AllergyAsthma Immunol Res2013，5，4： | 1 |
| 10 | Tumor necrosis factor-alpha gene promoter polymorphism in coal workers' pneumoconiosis显示文摘 | Kin KA Cho YY Cho JS | 2002 | Mol Cell Biochem2002，，： | 1 |
| 11 | Silica - induced apoptosis in vitro and in vivo 显示文摘 | Lim Y Kin JH Kin KA | 1999 | Toxicol Lett1999，108，23： | 1 |
| 12 | Dietary Calcium Decreases Plasma Cholesterol Level only in Female but not in Male Hamster Fed a High Cholesterol Diet显示文摘Objective To investigate the effect of dietary calcium on plasma lipoprotein profile in castrated and ovariectomized hamsters.Methods Male,castrated,female and ovariectomized hamsters(n=36 each group) were randomly divided into three sub-groups(n=12) and fed one of the three diets containing 0,2,and 8 g calcium per kg diet for a period of six weeks.Changes in plasma lipoprotein profile were monitored at the end of week 0,3 and 6.Results Plasma total cholesterol(TC),non-high density lipoprotein cholesterol(non-HDL-C),triacylglycerols(TG) and TC/HDL-C were decreased only in intact female and ovariectomized hamsters.In contrast,three levels of dietary calcium had no effect on lipoprotein profiles in both intact male and castrated hamsters.Conclusion Beneficial modification of lipoprotein profile by dietary calcium was gender-dependent at least in hamsters. | MA Ka Ying LIANG Yin Tong CHEN Jing Nan JIANG Yue KWAN Kin Ming PENG Cheng JIAO Rui ZUO Yuan Yuan HUANG Yu CHEN Zhen Yu | 2012 | Biomedical and Environmental Sciences2012，25，4： | 1 |
| 13 | Carotidartery angioplasty and after publication of stents-risk patients with contralateral occlusions 显示文摘 | Merice KA Kin SH Lanzino G | 1999 | Jneurosurg1999，90，6： | 1 |
| 14 | Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease: a randomised study显示文摘 | Ka Sing Wong Christopher Chen Ping Wing Ng Tak Hong Tsoi Ho Lun Li Wing Chi Fong Jonas Yeung Chi Keung Wong Kin Keung Yip Hong Gao Hwee Bee Wong | 2007 | Lancet Neurology2007，，5： | 1 |
| 15 | Therapeuticpo- tentials of neural stem cells treated with fluoxetine in Alzheimer' s disease 显示文摘 | Chang KA Kim JA Kin S | 2012 | Neuroehem In2012，61，6： | 1 |
| 16 | An Efficient Bayesian Iterative Method for Solving Linear Systems显示文摘This paper concerns with the statistical methods for solving general linear systems. After a brief review of Bayesian perspective for inverse problems,a new and efficient iterative method for general linear systems from a Bayesian perspective is proposed.The convergence of this iterative method is proved,and the corresponding error analysis is studied.Finally, numerical experiments are given to support the efficiency of this iterative method,and some conclusions are obtained. | Deng DING Kin Sio FONG Ka Hou CHAN | 2012 | Journal of Mathematical Research with Applications2012，32，3： | 0 |
| 17 | COVID-19 outbreaks in residential care homes in Hong Kong and effectiveness of vaccine against severe outcomes显示文摘Background:COVID-19 outbreaks in residential care homes for the elderly(RCHEs)and for persons with disability(RCHDs)have caused significant morbidity and mortality during 5th epidemic in Hong Kong.This article reviewed COVID-19 outbreaks situation and estimated the effectiveness of receiving at least two-dose of COVID-19 vaccine in preventing severe outcomes.Methods:To estimate attack rates and vaccination coverage,documentation on COVID-19 infection and their vaccination records of residential care homes(RCH)residents reported between December 31,2021 and May 31,2022 were reviewed,and infected cases were follow-up for 4 weeks for severe outcomes or death.Correlation between vaccination coverage against attack rate by types of homes was examined.Infected RCH residents with available information were included in the analysis of vaccine effectiveness against severe outcomes and death.Results:COVID-19 vaccination coverage was low in RCHDs(median 0.46,IQR:0.24-0.76)and very low in RCHEs(median 0.08,IQR:0.00-0.19).Higher attack rates were recorded among RCHE residents(median 0.84,IQR:0.64-0.93)and higher case fatality rate(CFR:28.1%)than in RCHDs(median 0.58,IQR:0.31-0.84;CFR:3.9%).The attack rate decreased when vaccination coverage increased for both RCHEs(ρ=−0.131,p<0.001)and RCHDs(ρ=−0.333,p<0.001).Comparing with infected residents who were unvaccinated/vaccinated with one-dose,receiving at least two-dose was estimated to be effective in reducing severe outcomes in 31%and 36%of infected RCHE and RCHD residents respectively;with greater reduction in mortality among RCHD than RCHE residents(54%and 38%,respectively).Vaccine effectiveness of two-dose of BNT162b2 against severe outcomes and death are higher than that of CoronaVac.Conclusions:Increasing COVID-19 vaccination could have significant impact on reducing the risk of COVID-19 outbreaks in RCHs.At least two-dose of COVID-19 vaccine is still effective in reducing severe outcomes and death among infected residents in RCHs during Omicron epidemic. | Mei Hung Joanna Leung Kin Hang Kung Ian Siu-kiu Yau Yan Yee Fung Kirran Nazesh Mohammad Cheong Chi Andrew Lau Ka Wing Albert Au Shuk Kwan Chuang | 2023 | Infectious Medicine2023，2，1： | 0 |
| 18 | Choledochal varices bleeding:A case report显示文摘Choledochal varices are a rare cause of hemobilia associated with chronic portal vein thrombosis.We present a case of chronic portal vein thrombosis comp licated with bleeding from choledochal varices.The presentation,clinical manifestations and management are described. | Chi Ho Ng Lawrence Lai Ka Ho Lok Kin Kong Li Ming Leung Szeto | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，5： | 0 |
| 19 | Resection of T4 hepatocellular carcinomas with adjacent structures, is it justified?显示文摘BACKGROUND: T4 hepatocellular carcinoma(HCC) with invasion to adjacent structure(s) may require resection of not only the tumor but also the invaded structure(s). This study aims to assess whether such combined resection for T4 HCC is justifiable.METHODS: Adult patients with T4 HCC were divided into three groups. Group 1: tumors and invaded adjacent structures were resected together if histopathologically confirmed tumor invasion; group 2: same as group 1 but histopathologically confirmed tumor adhesion; group 3: tumor resection only. Group comparisons were made.RESULTS: Totally 144 patients were included in the study.There were 71, 14 and 59 patients in groups 1, 2 and 3, respectively. The groups were comparable in demographics, complication and survival. Ten hospital deaths occurred(5, 0 and 5 in groups 1, 2 and 3, respectively; P=0.533). The 5-year overall survival(hospital mortality excluded) was 17.8% in group 1,14.3% in group 2, and 28.9% in group 3(P=0.191). The 5-year disease-free survival was 10.4% in group 1 and 14.5% in group 3(no data for group 2 yet)(P=0.565). On multivariate analysis,macrovascular invasion and poor differentiation were risk factors for survival whereas combined resection did not impact patients' survival. CONCLUSIONS: Combined resection achieved survival outcomes similar to tumor resection only. Patients with tumor invasion and those with tumor adhesion had comparable survival after combined resection. At centers with the required expertise, combined resection should be attempted to treat T4 HCCs with clinically suspected invasion of adjacent structures. | Kenneth SH Chok Ka Kin Ng Tan To Cheung Albert CY Chan See Ching Chan Chung Mau Lo | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 0 |
| 20 | The Saturation Characteristics of Glucose Transport in Bovine Retinal Pigment Epithelium显示文摘Purpose: To study the saturation characteristics of the glucose transport across the bovine retinal pigment epithelium(RPE).Methods :The bovine RPE preparations were munted with a modified Ussing chamber. The L-[3H]-glucose and 3-0-methyl-D-[14C]-glucose fluxes across the RPE from the choroid to retina were studied at different glucose concentrations.Results: The glucose transport was found to be stereospecific, with 3-0-methyl-D-glucose (MDG) being transported about three times faster than L-glucose. The glucose transport showed typical saturation characteristics in Michaelis-Menten fashion. The Vmax and the Km of corrected MDG were 2452 nmol cm-2h-1 and 30.8 mM respectively. It was shown that the glucose transport system was saturated at 61.6 mM.Conclusions : The saturation characteristics of the corrected MDG flux suggested that the capacity of glucose transport through the bovine RPE is immense. Eye Science 1998; 14: 726 -729. | Chi Ho To Kin Kwok Cheung Shing Hon Chiu Hon Ming Lai Ka Shun Lung | 1998 | 眼科学报1998，14，3： | 0 |
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