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| 1 | 产前皮质激素及产后肺泡表面活性物质防治新生儿呼吸窘迫综合征的疗效(英文)显示文摘目的探讨产前应用皮质激素(ACS)联合产后应用外源性肺表面活性物质(PS)与单一应用防治新生儿呼吸窘迫综合征(RDS)的疗效。方法选取2003年1月-2007年1月本院NICU收治的143例RDS新生儿。随机分为4组:第1组为产前应用ACS联合产后应用PS (n=36);第2组为单一产前应用ACS (n=33);第3组为单一产后应用PS (n=39);第4组为2种治疗措施均未采用(n=35)。对4组患儿的一般资料如性别、胎龄、出生体质量、分娩方式、Apgar评分、产时复苏情况、围生期并发症进行分析,并对不同组间应用鼻导管吸氧、头罩吸氧、持续呼吸道正压(CPAP)、机械通气(MV)等不同氧疗模式的时间,治愈的平均治疗时间及疗效进行比较。结果 4组患儿的一般资料和临床特征相似(Pa>0.05)。第1、2、3、4组采用鼻导管吸氧时间分别为(75.81±15.63)、(130.09±27.32)、(150.67±28.59)、(174.32±25.92) h (P=0.041);头罩吸氧时间分别为(37.16±5.51)、(55.29±11.71)、(62.69±12.39)、(100.75±28.10) h (P=0.047);CPAP时间分别为(24.33±4.41)、(27.44±4.47)、(26.53±3.13)、(56.50±5.50) h (P=0.005);MV时间分别为(56.12±15.65)、(110.19±21.59)、(127.79±26.36)、(156.61±12.92) h (P=0.009);第1组采用MV的几率最低。4组患儿住院天数分别为(15.89±1.29)、(21.61±2.30)、(28.31±3.40)、(32.73±4.57) d(P=0);治愈率分别为63.89%、51.52%、35.90%、20.0%(P=0.005)。结论产前应用ACS联合产后外源性补充PS是治疗RDS的最佳措施,单一产前应用ACS对RDS的疗效优于单一产后应用PS。 | 徐发林 Shrestha Him Kumar 程秀永 | 2008 | 实用儿科临床杂志2008，23，16： | 14 |
| 2 | Initial experience in children using conventional laparoscopic instruments in single-incision laparoscopic surgery显示文摘 | Yuk Him Tam Kim Hung Lee Jennifer Dart Yin Sihoe Kin Wai Chan Sing Tak Cheung Kristine Kit Yi Pang | 2010 | Journal of Pediatric Surgery2010，，12： | 4 |
| 3 | Cystic meconium peritonitis with jejunoileal atresia:Is it associated with unfavorable outcome?显示文摘AIM To compare the outcome between patients with jejunoileal atresia(JIA) associated with cystic meconium peritonitis(CMP) and patients with isolated JIA(JIA without CMP).METHODS A retrospective study was conducted for all neonates with JIA operated in our institute from January 2005 to January 2016.Demographics including the gestation age,sex,birth weight,age at operation,the presence of associated syndrome was recorded.Clinical outcome including the type of operation performed,operative time,the need for reoperation and mortality were studied.The demographics and the outcome between the 2 groups were compared.RESULTS During the study period,53 neonates had JIA underwent operation in our institute.Seventeen neonates(32%) were associated with CMP.There was no statistical difference on the demographics in the two groups.Patients with CMP had earlier operation than patients with isolated JIA(mean 1.4 d vs 3 d,P = 0.038).Primaryanastomosis was performed in 16 patients(94%) with CMP and 30 patients(83%) with isolated JIA(P = 0.269).Patients with CMP had longer operation(mean 190 min vs 154 min,P = 0.004).There were no statistical difference the need for reoperation(3 vs 6,P = 0.606) and mortality(2 vs 1,P = 0.269) between the two groups.CONCLUSION Primary intestinal anastomosis can be performed in94% of patients with JIA associated with CMP.Although patients with CMP had longer operative time,the mortality and reoperation rates were low and were comparable to patients with isolated JIA. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 3 |
| 4 | Colonoscopy in Hong Kong Chinese children显示文摘AIM:To investigate the safety and diagnostic yield of colonoscopy in Chinese children in whom the procedure is not often done.METHODS:We conducted a retrospective review of all colonoscopies in consecutive children who underwent their fi rst diagnostic colonoscopy from Jan 2003 to 2008.RESULTS:Seventy-nine children (48 boys,31 girls;mean age 9.2 ± 4.2 years) were identified and reviewed with a total of 82 colonoscopies performed.Successful caecal and ileal intubation rates were 97.6% and 75.6% respectively.Forty patients (50.6%) had a positive diagnosis made in colonoscopy and that included colonic polyps (23),Crohn's disease (12),ulcerative colitis (1),and miscellaneous causes (4).80% of polyps were in the rectosigmoid colon.All but one were juvenile hamartomatous polyps.The exceptionwas an adenomatous polyp.The mean ages for children with inflammatory bowel disease (IBD) and polyps were 11.3 and 4.3 years respectively.There was no procedure-related complication.CONCLUSION:Colonoscopy is a safe procedure in our Chinese children.The increasing diagnosis of IBD in recent decades may reflect a rising incidence of the disease in our children. | Yuk Him Tam Kim Hung Lee Kin Wai Chan Jennifer Dart Yin Sihoe Sing Tak Cheung Jennifer Wai Cheung Mou | 2010 | World Journal of Gastroenterology2010，16，9： | 3 |
| 5 | Laparoscopic excision of Meckel's diverticulum in children:What is the current evidence?显示文摘Complications aroused from Meckel's diverticulum tend to developed in children.Children presented with abdominal pain,intestinal obstruction,intussusception or gastrointestinal bleeding may actually suffered from complicated Meckel's diverticulum.With the advancement of minimally invasive surgery(MIS) in children,the use of laparoscopy in the diagnosis and subsequent laparoscopic excision of Meckel's diverticulum has gained popularity.Recently,single incision laparoscopic surgery(SILS) has emerged as a new technique in minimally invasive surgery.This review offers the overview in the development of MIS in the management of children suffered from Meckel's diverticulum.The current evidence in different laparoscopic techniques,including conventional laparoscopy,SILS,the use of special laparoscopic instruments,intracorporeal diverticulectomy and extracorporeal diverticulectomy in the management of Meckel's diverticulum in children were revealed. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 6 | Use of laparoscopy as the initial surgical approach of impalpable testes:10-year experience显示文摘AIM: To review the experience in the management of impalpable testes using laparoscopy as the initial approach and the need for inguinal exploration.METHODS: From January 2004 to June 2014, 339 patients with undescended testes underwent operation in our institute. Fifty patients(15%) had impalpable testes. All children with impalpable testes underwent initial laparoscopy. A retrospective review was conducted on this group of patients and the outcome was analyzed.RESULTS: Forty children had unilateral impalpable testis. Ten children had bilateral impalpable testes. Thirty-one children(78%) in the unilateral group underwent subsequent inguinal exploration while 4 children(40%) in the bilateral group underwent inguinal exploration(P < 0.05). Orchidopexy was performed in 16 children(40%) in the unilateral group and 9 children(90%) in the bilateral group(P < 0.05). Regarding the 24 children with unilateral impalpable testis and underwent orchidectomy for testicular nubbin(n = 19) or atrophic testes(n = 2) or has vanishing testes(n = 3); contralateral testicular hypertrophy was noticed in 10(41%). No intra-operative complication was encountered. Two children after staged Fowler-Stephensprocedure and 1 child after inguinal orchidopexy had atrophic testes.CONCLUSION: The use of laparoscopy in children with impalpable testes is a safe procedure and can guide the need for subsequent inguinal exploration. Children with unilateral impalpable testis were associated with an increased need for inguinal exploration after laparoscopy. Orchidopexies could be performed successfully in 90% of children with bilateral impalpable testes. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 2 |
| 7 | Rescue of a human mRNA splicing defect by the plant cytokinin kinetin显示文摘 | Slaugenhaupt S A Mull J Leyne M Cuajungco M P Gill S P Hims M M Quintero F Axelrod | | 0，，04： | 1 |
| 8 | Bone defects following curettage do not necessarily need augmentation显示文摘 | Him M de Silva U Sidharthan S | 2009 | Acta Orthop2009，80，1： | 1 |
| 9 | Risk for infection after anterior cervical fusion:prevention with iodophor impregnated incision deapes显示文摘 | Him K R London N Gee A O | 2012 | The American journal of orthopedics2012，36，8： | 1 |
| 10 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 11 | Increased sensitivity to gemcitabine of Pglycoprotein and multi-drug ed proteinoverexpressing human cancer cell lines 显示文摘 | Bergman AM Pinedo HiM Talianidis I | 2003 | Br J Cancer2003，88，： | 1 |
| 12 | PCR-based methods for identification of species of the Anopheles minimus group: allele-specific amplifcation and single- strand conformation polymorphism 显示文摘 | Sharpe R G Hims M M Harbach R E | 1999 | Med Vet Ento- tool1999，13，3： | 1 |
| 13 | The long-term im- pact of surgical complications after resection of stage I nonsmaU cell lung cancer: a population-based survival analysis显示文摘 | Rueth NM Parsons HiM Habermann EB | 2011 | Ann Surg2011，254，2： | 1 |
| 14 | Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis显示文摘Tissue (re)vascularization strategies face various challenges, as therapeutic cells do not survive long enough in situ, while the administration of pro-angiogenic factors is hampered by fast clearance and insufficient ability to emulate complex spatiotemporal signaling. Here, we propose to address these limitations by engineering a functional biomaterial capable of capturing and concentrating the pro-angiogenic activities of mesenchymal stem cells (MSCs). In particular, dextran sulfate, a high molecular weight sulfated glucose polymer, supplemented to MSC cul-tures, interacts with MSC-derived extracellular matrix (ECM) components and facilitates their co-assembly and accumulation in the pericellular space. Upon decellularization, the resulting dextran sulfate-ECM hybrid material can be processed into MIcroparticles of SOlidified Secretome (MIPSOS). The insoluble format of MIPSOS protects protein components from degradation, while facilitating their sustained release. Proteomic analysis demonstrates that MIPSOS are highly enriched in pro-angiogenic factors, resulting in an enhanced pro-angiogenic bioactivity when compared to naïve MSC-derived ECM (cECM). Consequently, intravital microscopy of full-thickness skin wounds treated with MIPSOS demonstrates accelerated revascularization and healing, far superior to the ther-apeutic potential of cECM. Hence, the microparticle-based solidified stem cell secretome provides a promising platform to address major limitations of current therapeutic angiogenesis approaches. | Thomas Spater Marisa Assunçao Kwok Keung Lit Guidong Gong Xiaoling Wang Yi-Yun Chen Ying Rao Yucong Li Chi Him Kendrick Yiu Matthias W.Laschke Michael D.Menger Dan Wang Rocky S.Tuan Kay-Hooi Khoo Michael Raghunath Junling Guo Anna Blocki | 2022 | Bioactive Materials2022，7，11： | 1 |
| 15 | The early responses of VEGF and its receptors during acute lung injury:implication of VEGF in alveolar epithelial cell survival显示文摘 | Mura M Him B Andrade C F | 2006 | Critical Care2006，10，5： | 1 |
| 16 | Long-term experience with competitive exclusion and Salmonellas in Finland显示文摘 | HIM J NURMI E JOHANSSON T | 1992 | Int J Food Mi- crobiol1992，15，34： | 1 |
| 17 | Groove effects on thrust washer lubrication显示文摘 | Him Y T Sadeghi F | 2001 | Journal of Tribology2001，123，： | 1 |
| 18 | Mutation in the RP1 gene causing autosomal dominant retinitis pigmentosa显示文摘 | Daiger SP Hims MM Sohocki MM Malone KA McKie AB | 1999 | Hum Mol Genet1999，8，11： | 1 |
| 19 | PA-824 kills nonreplicating mycobacterium tuberculosis by intracellular NO release显示文摘 | Singh R Manjunatha U Boshoff HIM | 2008 | Science2008，322，5906： | 1 |
| 20 | Tonic activity and GABA responsiveness of medial vestibular nucleus neurons in aged rats显示文摘 | Him A Johnston AR Yau JL | 2001 | Neuroreport2001，12，： | 1 |
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