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| 1 | Design and 3D Printing of Scaffolds and Tissues显示文摘A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering(SLS) and fused deposition modeling(FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering. | Jia An Joanne Ee Mei Teoh Ratima Suntornnond Chee Kai Chua | 2015 | Engineering2015，1，2： | 21 |
| 2 | Circular noncoding RNAs as potential therapies and circulating biomarkers for cardiovascular diseases显示文摘在染色体宽的分析和定序 RNA 技术的最近的前进导致了小 noncoding RNA 的发现,例如 microRNAs (米尔) ,以及两线性长 noncoding RNA (lncRNAs ) 和圆形的长 noncoding RNA (circRNAs ) 。在心血管的疾病(CVD ) 的治疗,预后和诊断的米尔和 lncRNAs 的重要性广泛地被报导了。我们以前也为 CVD 在治疗并且作为 biomarkers 考察了他们的含意。更最近, circRNAs 也在 CVD 作为重要管理者出现了。CircRNAs 是被背送信人前 RNA (pre-mRNAs ) 的特定的区域拼接产生的圆形的染色体产品。对 circRNAs 的成长兴趣导致了他们的 pathophysiological 功能的一个宽数组的发现。CircRNAs 被显示了是象心肌的梗塞,动脉粥样硬化,心肌症和心脏的纤维变性那样的 CVD 的关键管理者。因此, circRNAs 最近为 CVD 作为潜在的治疗学的目标和 biomarkers 被建议了。在这评论,我们在 circRNAs 上总结文学的当前的状态,以他们的生物的续生说和行动的全球机制开始。我们然后在各种各样的 CVD 提供他们的参与的一个提要。最后,我们为 CVD 的早察觉作为 biomarkers 强调 circRNAs 的大潜力,并且讨论作为有希望的 biomarkers 加亮 circRNAs 的利用的几项专利和最近的报纸。 | Ahmed S BAYOUMI Tatsuya AONUMA Jian-peng TEOH Yao-liang TANG II-man KIM | 2018 | Acta Pharmacologica Sinica2018，39，7： | 16 |
| 3 | The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men显示文摘我们在中国人调查了前列腺特定的抗原(PSA ) 和 PSA 密度(PSAD ) 的表演特征。经历了 transrectal 的所有中国人到 2013 的从 2000 年的指导超声的前列腺活体检视(TRUS-PB ) 被包括。为 PSA 和 PSAD 操作特征(巨鸟) 曲线的接收装置被分析。敏感,特性,积极预兆的价值(PPV ) 和在不同截止层次的否定预兆的价值(NPV ) 是计算的。2606 个中国人的一个总数被包括。为 ROC,在曲线下面的区域为 PSA 是 0.770 (P <0.001 ) 并且 0.823 为 PSAD (P <0.001 ) 。4.5 ng ml −1 的 PSA 94.4% 的有的敏感, 14.1% 的特性, 29.5% 的 PPV,和 86.9% 的 NPV;0.12 ng ml −1 cc −1 的 PSAD 有 94.5% 的敏感, 26.6% 的特性, 32.8% 的 PPV,和 92.7% 的 NPV。在逻辑回归分析的 multivariate 上,在 4.5 ng ml −1 截止的 PSA (或 1.61, 95% CI 1.05-2.45, P = 0.029 ) 并且在 0.12 ng ml −1 cc 截止的 PSAD −1( 或 6.22, 95% CI 4.20-9.22, P <0.001 ) 是为 TRUS-PB 上的前列腺癌症察觉的重要预言者。在结论,在在中国人的不同截止层次的 PSA 和 PSAD 的表演与在白种人的那些很不同。4.5 ng ml −1 的 PSA 和 0.12 ng ml −1 cc −1 的 PSAD 在 95% 敏感附近有并且是在中国人的前列腺癌症察觉的重要预言者。 | Jeremv YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 13 |
| 4 | Systematic review comparing endoscopic, percutaneous and surgical pancreatic pseudocyst drainage显示文摘AIM: To perform a systematic review comparing the outcomes of endoscopic, percutaneous and surgical pancreatic pseudocyst drainage.METHODS: Comparative studies published between January 1980 and May 2014 were identified on Pub Med, Embase and the Cochrane controlled trials register and assessed for suitability of inclusion. The primary outcome was the treatment success rate. Secondary outcomes included were the recurrence rates, re-interventions, length of hospital stay, adverse events and mortalities.RESULTS: Ten comparative studies were identified and 3 were randomized controlled trials. Four studies reported on the outcomes of percutaneous and surgical drainage. Based on a large-scale national study, surgical drainage appeared to reduce mortality and adverse events rate as compared to the percutaneous approach. Three studies reported on the outcomes of endoscopic ultrasound(EUS) and surgical drainage. Clinical success and adverse events rates appeared to be comparable but the EUS approach reduced hospital stay, cost and improved quality of life. Three other studies comparedEUS and esophagogastroduodenoscopy-guided drainage. Both approaches were feasible for pseudocyst drainage but the success rate of the EUS approach was better for non-bulging cyst and the approach conferred additional safety benefits.CONCLUSION: In patients with unfavorable anatomy, surgical cystojejunostomy or percutaneous drainage could be considered. Large randomized studies with current definitions of pseudocysts and longer-term follow-up are needed to assess the efficacy of the various modalities. | Anthony Yuen Bun Teoh Vinay Dhir Zhen-Dong Jin Mitsuhiro Kida Dong Wan Seo Khek Yu Ho | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，6： | 13 |
| 5 | 国际专家组关于超声内镜引导下胰腺囊性肿瘤消融的立场声明显示文摘背景和目的最近,一些有关胰腺囊性肿瘤(pancreatic cystic neoplasms,PCNs)治疗的指南建议已经发表,但是超声内镜(endoscopic ultrasound,EUS)引导下PCNs消融的作用在这些指南中尚未明确。本文的目的是通过提出一系列临床问题并根据可获得的最佳科学证据提供答案来探讨围绕EUS引导下PCNs消融的问题。方法我们从亚洲EUS学组和一个国际专家组中招募了一个EUS引导下PCNs消融专家小组。创建了一个临床问题列表,并将每个问题分配给一个成员以产生一个陈述。然后在2016年10月至2017年10月的三次互联网会议上讨论了这些陈述。之后相互协商对这些陈述进行修改,直到取得协商一致意见。之后,将完整的陈述总结集体发送给所有小组成员,以对陈述的强度进行投票,对陈述进行分类,对证据进行分级。结果制定了关于EUS引导下PCNs的23个陈述。这些陈述涉及操作步骤、操作技术、操作前和操作后管理,并发症的管理以及手术中所需能力和培训。结论在所有内镜学会中,本共识是关于EUS引导下PCNs消融的首篇共识。有兴趣进行这项技术的临床医生应参考这些共识,未来的研究应设法解决本共识中提出的重要问题。 | Anthony Yuen-Bun Teoh DongWan Seo William Brugge John Dewitt Pradermchai Kongkam 令狐恩强(文/译) Matthew T.Moyer JiKon Ryu Khek Yu Ho 杜晨(翻译) 李惠凯(翻译) | 2019 | 中华胃肠内镜电子杂志2019，6，4： | 8 |
| 6 | Malignant gastric outlet obstruction:Which is the best therapeutic option?显示文摘Malignant gastric outlet obstruction(MGOO)is a clinical condition characterized by the mechanical obstruction of the pylorus or the duodenum due to tumor compression/infiltration,with consequent reduction or impossibility of an adequate oral intake.MGOO is mainly secondary to advanced pancreatic or gastric cancers,and significantly impacts on patients’survival and quality of life.Patients suffering from this condition often present with intractable vomiting and severe malnutrition,which further compromise therapeutic chances.Currently,palliative strategies are based primarily on surgical gastrojejunostomy and endoscopic enteral stenting with self-expanding metal stents.Several studies have shown that surgical approach has the advantage of a more durable relief of symptoms and the need of fewer re-interventions,at the cost of higher procedure-related risks and longer hospital stay.On the other hand,enteral stenting provides rapid clinical improvement,but have the limit of higher stent dysfunction rate due to tumor ingrowth and a subsequent need of frequent reinterventions.Recently,a third way has come from interventional endoscopic ultrasound,through the development of endoscopic ultrasound-guided gastroenterostomy technique with lumen-apposing metal stent.This new technique may ideally encompass the minimal invasiveness of an endoscopic procedure and the long-lasting effect of the surgical gastrojejunostomy,and brought encouraging results so far,even if prospective comparative trial are still lacking.In this Review,we described technical aspects and clinical outcomes of the above-cited therapeutic approaches,and discussed the open questions about the current management of MGOO. | Edoardo Troncone Alessandro Fugazza Annalisa Cappello Giovanna Del Vecchio Blanco Giovanni Monteleone Alessandro Repici Anthony Yuen Bun Teoh Andrea Anderloni | 2020 | World Journal of Gastroenterology2020，26，16： | 7 |
| 7 | Current developments in natural orifices transluminal endoscopic surgery:An evidence-based review显示文摘Tremendous advances have been made in recent years addressing the key obstacles to safe performance and introduction of human natural orifice transluminal endoscopic surgery (NOTES). Animal studies have focused on identifying optimal solutions to these obstacles, in particular methods of creating transluminal access,safe closure of the point of access, and development of a multitasking platform with dedicated instruments. Whether the performance data generated from these animal studies can be reproduced in humans has yet to be determined. Reports of human NOTES procedures are emerging, and the possibility of accomplishing human NOTES based on existing technology has been demonstrated. However, dedicated platforms and devices are still lacking to allow for pure NOTES procedures, and whether NOTES can deliver the postulated benef its of earlier recovery and improved cosmesis remains uncertain. | Anthony Yuen Bun Teoh Philip Wai Yan Chiu Enders Kwok Wai Ng | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 8 | Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy显示文摘我们与优先的主要雄激素剥夺治疗(ADT ) 在变形前列腺癌症在前进木头(PSAVAP ) 以后调查了前列腺特定的抗原天底(TTPN ) 和前列腺特定的抗原速度的对数的时间的协会。从 2000 ~ 2009 与主要 ADT 对待的所有变形前列腺癌症病人被考察。开发了疾病前进的病人在随后的分析被包括。病人们根据他们的 TTPN 被分成三个组:< 的 TTPN; 3 个月, 3-17 月,和 > 17 个月。我们用 Mann-Whitney U-test 和 Kruskal-Wallis 测试比较了在不同 TTPN 组之间的木头(PSAVAP ) 。木头(PSAVAP ) 上的进一步多重的线性回归分析被执行为使因素惊讶的另外的潜力调整。在与主要 ADT 被对待的 419 个病人之中, 306 个病人与 28 个月的中部的后续开发了疾病前进。更长的 TTPN 与更低的木头(PSAVAP ) 被联系(P = 0.008 ) 在所有亚群分析以内(< 的 TTPN; 3 对 3-17 月, P = 0.020;3-17 对 > 的 TTPN; 17 个月, P = 0.009;并且 < 的 TTPN; 3 对 > 17 个月, P = 0.001 ) 。在多重线性回归分析之上,基线 PSA (回归系数 0.001 , P = 0.045 ), PSA 天底(回归系数 0.002 , P = 0.040 ),并且 TTPN (回归系数 − ; 0.030 , P = 0.001 )是显著地与木头( PSAVAP )被联系的三个因素。在结论,更长的 TTPN 在跟随主要 ADT 的变形前列腺癌症病人与更低的木头(PSAVAP ) 被联系。在 3 个月和 17 个月的 TTPN cut-offs 看起来在预言木头(PSAVAP ) 有预示的意义。TTPN 可以在与疾病前进在病人决定治疗策略用作好预示的指示物。 | Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing Wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 6 |
| 9 | 经直肠超声引导下穿刺活检诊断前列腺癌与直肠指检和前列腺特异性抗原水平的关系:在中国人群中的情况如何?显示文摘我们分析了经直肠超声引导下穿刺活检后前列腺癌的检出率与直肠指检和前列腺特异性抗原水平的关系以及中国人群检出前列腺癌的危险因素。我们从数据库中检索了自2000年到2013年所有首次接受经直肠超声引导下前列腺穿刺活检的中国男性的数据。结合直肠指检的发现以及前列腺特异性抗原水平(〈 4, 4-10, 10.1-20,20.1-50 , 〉 50ng/ml)分析了前列腺癌的检出率。使用多因素Logistic回归研究了前列腺癌检出的潜在危险因素。共有2606中国男性人群纳入该研究。在直肠指检正常的患者中,不同前列腺特异性抗原水平(〈 4, 4-10,10.1-20, 20.1-50, 〉 50 ng/ml)患者前列腺癌的检出率分别为8.6%,13.4%,21.8%,41.7%和85.2%。在直肠指检异常的患者中,不同前列腺特异性抗原水平(〈 4, 4-10, 10.1-20, 20.1-50, 〉 50 ng/ml)患者前列腺癌的检出率分别为12.4%, 30.2%, 52.7%, 80.6%和96.4%。多因素Logistic回归分析提示:老龄、较小的前列腺体积、更多针数的穿刺活检、直肠指检异常发现、较高的PSA水平都与增大的前列腺癌检出风险相关(P 〈0.001)。与西方人群相比,中国男性人群的前列腺癌检出率较低。考虑到不同的危险因素,可以采用个体化的方式来决定是否采取经直肠超声引导下穿刺活检。 | Jeremy YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu | 2015 | Asian Journal of Andrology2015，17，5： | 4 |
| 10 | Are Accruals during Initial Public Offerings Opportunistic?显示文摘 | Siew Hong Teoh T. J. Wong Gita R. Rao | 1998 | Review of Accounting Studies (-)1998，，1： | 4 |
| 11 | Difficulties and outcomes in starting endoscopic submucosal dissection显示文摘 | Anthony Yuen Bun Teoh Philip Wai Yan Chiu Simon Kin Hung Wong Joseph Jao Yiu Sung James Yun Wong Lau Enders Kwok Wai Ng | 2010 | Surgical Endoscopy2010，，5： | 3 |
| 12 | Current status and future applications of contrast-enhanced endoscopic ultrasonography显示文摘Endoscopic ultrasonography(EUS) is currently an in-tegral investigation of many gastrointestinal disorders.It has been shown to have a higher efficacy thanconventional computed tomography in detection andcharacterization of small lesions especially in the pan-creas. Much effort has been put to further improvethe sensitivity, specificity and overall accuracy of EUS.One of the major advances is the utilization of contrastagents for better delineation of the vascularity and tis-sue perfusion of the target lesion. This article describesthe basic principles of ultrasound contrast agents andthe different modalities used in contrast-enhanced EUS(CE-EUS) including contrast-enhanced Doppler EUS(CED-EUS) and contrast-enhanced harmonic EUS(CEH-EUS). In addition, the current applications of contrastenhanced EUS in different gastrointestinal conditionswere discussed. Furthermore, the future developmentof hybrid approaches combining CE-EUS with other im-aging modalities and the potential therapeutic aspectof using it as a vector for drug delivery were also dis-cussed. | Hon Chi Yip Anthony Yuen Bun Teoh Charing Ching Ning Chong James Yun Wong Lau | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 3 |
| 13 | Use of the Over-The-Scope Clip for treatment of refractory upper gastrointestinal bleeding: a case series显示文摘 | Shannon Chan Philip Chiu Anthony Teoh James Lau | 2014 | Endoscopy2014，，： | 2 |
| 14 | Limited attention, information disclosure, and financial reporting显示文摘 | David Hirshleifer Siew Hong Teoh | 2003 | Journal of Accounting and Economics2003，，1： | 2 |
| 15 | PalmPhasor算法性能的理论分析显示文摘模板的安全性和隐私性是掌纹系统实际应用的关键问题,然而生物特征保护的多项指标通常相互冲突并且难以同时满足.作为解决上述冲突的一种可撤销掌纹编码算法,Palm Phasor实现了高效、安全的掌纹认证.建立了系统分析Palm Phasor性能的完整框架.为了便于具体分析,将情景分为4种情况,并且提供了支持相应分析的预备知识,包括辅助定理以及Gabor滤波掌纹图像实部和虚部分布特性.在统计学基础上建立的理论分析和实验结果均表明:即使在用户口令被盗的情况下,多方向分数级融合增强的Palm Phasor算法也可以同时有效地满足可撤销生物特征的4项指标. | 冷璐 黎明 Andrew Beng Jin TEOH Cheonshik KIM | 2015 | 软件学报2015，26，5： | 2 |
| 16 | Catalytically active interfaces in titania nanorod-supported copper catalysts for CO oxidation显示文摘One-dimensional titanium dioxide nanorod(TNR)-supported Cu catalysts(2.5 wt.%-12.5 wt.%)were synthesized using deposition-precipitation.X-ray photoelectron spectroscopy,temperature programmed reduction and CO chemisorption measurements showed that Cu doping over TNR offered metal-support interactions and interfacial active sites that had a profound impact on the catalytic performance.The role of the Cu-TNR interface was investigated by comparing the catalytic activity of Cu-TNR catalysts with that of pure CuO nanoparticles in CO oxidation.The presence of highly dispersed copper species,a high number of interfacial active sites,CO adsorption capacity and surface/lattice oxygen were found to be responsible for the excellent activity of 7.5CU-TNR(ie,Cu loading of 7.5 wt.%on TNR).Moreover,the Cu-TNR catalysts followed the Langmuir-Hinshelwood reaction mechanism with 7.5CU-TNR,exhibiting an apparent activation energy of 44.7 kJ/mol.The TNR-supported Cu catalyst gave the highest interfacial catalytic activity in medium-temperature CO oxidation(120-240℃)compared to other commonly used supports,including titanium dioxide nanoparticles(TiO2-P25),silica(SiO2)and alumina(Al20g)in which copper species were nonhomogeneously dispersed.This study confirms that medium-temperature CO oxidation is highly sensitive to the morphology and structure of the supporting material. | Wasim U.Khan Season S.Chen Daniel C.W.Tsang Wey Yang Teoh Xijun Hu Frank L.Y.Lam Alex C.K.Yip | 2020 | Nano Research2020，13，2： | 2 |
| 17 | Coffee and non‐alcoholic fatty liver disease: Brewing evidence for hepatoprotection?显示文摘 | Shaohua Chen Narci C Teoh Shiv Chitturi Geoffrey C Farrell | 2014 | J Gastroenterol Hepatol2014，，3： | 2 |
| 18 | Apolipoproteins and amyloid fibril formation in atherosclerosis显示文摘Amyloid fibrils arise from the aggregation of misfolded proteins into highly-ordered structures.The accumulation of these fibrils along with some non-fibrillar constituents within amyloid plaques is associated with the pathogenesis of several human degenerative diseases.A number of plasma apolipoproteins,including apolipoprotein(apo)A-I,apoA-II,apoC-II and apoE are implicated in amyloid formation or influence amyloid formation by other proteins.We review present knowledge of amyloid formation by apolipoproteins in disease,with particular focus on atherosclerosis.Further insights into the molecular mechanisms underlying their amyloidogenic propensity are obtained from in vitro studies which describe factors affecting apolipoprotein amyloid fibril formation and interactions.Additionally,we outline the evidence that amyloid fibril formation by apolipoproteins might play a role in the development and progression of atherosclerosis,and highlight possible molecular mechanisms that could contribute to the pathogenesis of this disease. | Chai Lean Teoh Michael D.W.Griffin Geoffrey J.Howlett | 2011 | Protein & Cell2011，2，2： | 2 |
| 19 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 2 |
| 20 | Adropin Is a Novel Regulator of Endothelial Function显示文摘 | Fina Lovren Yi Pan Adrian Quan Krishna K. Singh Praphulla C. Shukla Milan Gupta Mohammed Al-Omran Hwee Teoh Subodh Verma | 2010 | Circulation . 2010 (11 S)2010，，： | 2 |
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