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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis显示文摘BACKGROUND To date, the histopathological parameters predicting the risk of lymph node (LN) metastases and local recurrence, associated mortality and appropriateness of endoscopic or surgical resection in patients with gastric neuroendocrine neoplasms type 1 (GNENs1) have not been fully elucidated. AIM To determine the rate of LN metastases and its impact in survival in patients with GNEN1 in relation to certain clinico-pathological parameters. METHODS The PubMed, EMBASE, Cochrane Library, Web of Science and Scopus databases were searched through January 2019. The quality of the included studies and risk of bias were assessed using the Newcastle-Ottawa Scale (NOS) in accordance with the Cochrane guidelines. A random effects model and pooled odds ratios (OR) with 95%CI were applied for the quantitative meta-analysis. RESULTS We screened 2933 articles. Thirteen studies with 769 unique patients with GNEN1 were included. Overall, the rate of metastasis to locoregional LNs was 3.3%(25/769). The rate of LN metastases with a cut-off size of 10 mm was 15.3% for lesions > 10 mm (vs 0.8% for lesions < 10 mm) with a random-effects OR of 10.5 (95%CI: 1.4 -80.8;heterogeneity: P = 0.126;I2 = 47.5%). Invasion of the muscularis propria was identified as a predictor for LN metastases (OR: 17.2;95%CI: 1.8-161.1;heterogeneity: P = 0.165;I2 = 44.5%), whereas grade was not clearly associated with LN metastases (OR: 2;95%CI: 0.3-11.6;heterogeneity: P = 0.304;I2 = 17.4%). With regard to GNEN1 local recurrence, scarce data were available. The 5-year disease-specific survival for patients with and without LN metastases was 100% in most available studies irrespective of the type of intervention. Surgical resection was linked to a lower risk of recurrence (OR: 0.3;95%CI: 0.1-1.1;heterogeneity: P = 0.173;I2 = 31.9%). The reported complication rates of endoscopic and surgical intervention were 0.6 and 3.8%, respectively. CONCLUSION This meta-analysis confirms that tumor size ≥ 10 mm and invasion of the muscularis propria are linked to a higher risk of LN metastases in patients with GNEN1. Overall, the metastatic propensity of GNEN1 is low with favorable 5- year disease-specific survival rates reported;hence, no clear evidence of the prognostic value of LN positivity is available. Additionally, there is a lack of evidence supporting the prediction of local recurrence in GNEN1, even if surgery was more often a definitive treatment. | Apostolos V Tsolakis Athanasia Ragkousi Miroslav Vujasinovic Gregory Kaltsas Kosmas Daskalakis | 2019 | World Journal of Gastroenterology2019，25，35： | 6 |
| 4 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 3 |
| 5 | Markers of bacterial translocation in end-stage liver disease显示文摘Bacterial translocation(BT) refers to the passage of viable bacteria or bacterial products from the intestinal lumen, through the intestinal epithelium, into the systemic circulation and extraintestinal locations. The three principal mechanisms that are thought to be involved in BT include bacterial overgrowth, disruption of the gut mucosal barrier and an impaired host defence.BT is commonly observed in liver cirrhosis and has been shown to play an important role in the pathogenesis of the complications of end stage liver disease, including infections as well as hepatic encephalopathy and hepatorenal syndrome. Due to the importance of BT in the natural history of cirrhosis, there is intense interest for the discovery of biomarkers of BT. To date, several such candidates have been proposed, which include bacterial DNA, soluble CD14, lipopolysaccharides endotoxin, lipopolysaccharide-binding protein, calprotectin and procalcitonin. Studies on the association of these markers with BT have demonstrated not only promising data but, oftentimes, contradictory results. As a consequence, currently, there is no optimal marker that may be used in clinical practice as a surrogate for the presence of BT. | Ioannis Koutsounas Garyfallia Kaltsa Spyros I Siakavellas Giorgos Bamias | 2015 | World Journal of Hepatology2015，7，20： | 2 |
| 6 | Combination of diclofenac plus somatostatin in the prevention of post-ERCP pancreatitis: a randomized, double-blind, placebo-controlled trial显示文摘 | P. Katsinelos K. Fasoulas G. Paroutoglou G. Chatzimavroudis A. Beltsis S. Terzoudis T. Katsinelos E. Dimou C. Zavos A. Kaltsa J. Kountouras | 2012 | Endoscopy2012，，01： | 2 |
| 7 | High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis显示文摘 | Giorgos Bamias Garyfallia Kaltsa Spyros I. Siakavellas Kostis Papaxoinis Evanthia Zampeli Spyros Michopoulos Irene Zouboulis-Vafiadis Spiros D. Ladas | 2010 | Clinical Immunology2010，，2： | 2 |
| 8 | Frontside bulk silicon micromachining using porous-silicon technology 显示文摘 | Kaltsas G Nassiopoulou A G | 1998 | Sens Actuat1998，65，： | 2 |
| 9 | The VEGF pathway in lung cancer显示文摘 | Michalis Alevizakos Serafim Kaltsas Konstantinos N. Syrigos | 2013 | Cancer Chemotherapy and Pharmacology2013，，6： | 2 |
| 10 | Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn’s disease显示文摘 | Giorgos Bamias Garyfallia Kaltsa Spyros I. Siakavellas Michalis Gizis George Margantinis Evanthia Zampeli Irene Vafiadis-Zoumboulis Spyros Michopoulos George L. Daikos Spiros D. Ladas | 2011 | Digestive and Liver Disease2011，，1： | 1 |
| 11 | Is ovarian and adrenal venous catheterization and sampling helpful in the investigating of hyperandrogenic women显示文摘 | Kaltsas GA Mukherjee JJ Kola B | 2003 | Clin Endocrinol2003，59，1： | 1 |
| 12 | Polycystic ovary syndrome:the spectrum of the disorder in 1741 patients显示文摘 | Balen AH Conway GS Kaltsas G | 1995 | Hum Reprod1995，10，8： | 1 |
| 13 | Clinical,radiological and pathological features of patients with Rathke's cleft cysts:tumors that may recur显示文摘 | Mukherjee JJ Islam N Kaltsas G | 1997 | J Clin Endocrinol Metab1997，82，9： | 1 |
| 14 | Menstrual disturbances in thyrotoxicosis显示文摘 | Krassas G E Pontikides N Kaltsas T | 1994 | Clin Endocrinol1994，40，5： | 1 |
| 15 | Menstrualdisturbances in thyrotoxicosis 显示文摘 | Krassas GE Pontikides N Kaltsas T | 1994 | Clin Endocrinol ( Oxf)1994，40，： | 1 |
| 16 | Frontside bulk silicon mi- cromachining using porous-silicon technology显示文摘 | Kaltsas G Nassiopoulou A G | 1998 | Sens Ac- tuators A1998，65，23： | 1 |
| 17 | A silicon thermal accelerometer without solid proof mass usingporous silicon thermal isolation 显示文摘 | GOUSTOURIDIS D KALTSAS G NASSIOPOULOU A G | 2007 | IEEE Sensors Journal2007，7，7： | 1 |
| 18 | Imaging somatostatin receptor activity in patients with active thyroid eye disease using Tc-99m depreotide显示文摘 | Doumas AS Krassas G Kaltsas T | 2003 | Clin Nucl Med2003，28，5： | 1 |
| 19 | Metabolic syn- drome: definitions and controversies 显示文摘 | Kassi E Pervanidou P Kaltsas G | 2011 | BMC Med2011，5，9： | 1 |
| 20 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 1 |
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