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| 1 | Predictors of response to anti-tumor necrosis factor therapy in ulcerative colitis显示文摘Ulcerative colitis(UC) is an immune-mediated, chronic inflammatory disease of the large intestine. Its course is characterized by flares of acute inflammation and periods of low-grade chronic inflammatory activity or remission. Monoclonal antibodies against tumor necrosis factor(anti-TNF) are part of the therapeutic armamentarium and are used in cases of moderate to severe UC that is refractory to conventional treatment with corticosteroids and/or immunosuppressants. Therapeutic response to these agents is not uniform and a large percentage of patients either fail to improve(primary non-response) or lose response after a period of improvement(secondary non-response/loss of response). In addition, the use of anti-TNF agents has been related to uncommon but potentially serious adverse effects that preclude their administration or lead to their discontinuation. Finally, use of these medications is associated with a considerable cost for the health system. The identification of parameters thatmay predict response to anti-TNF drugs in UC would help to better select for patients with a high probability to respond and minimize risk and costs for those who will not respond. Analysis of the major clinical trials and the accumulated experience with the use of anti-TNF drugs in UC has resulted to the report of such prognostic factors. Included are clinical and epidemiological characteristics, laboratory markers, endoscopic indicators and molecular(immunological/genetic) signatures. Such predictive parameters of long-term outcomes may either be present at the commencement of treatment or determined during the early period of therapy. Validation of these prognostic markers in large cohorts of patients with variable characteristics will facilitate their introduction into clinical practice and the best selection of UC patients who will benefit from anti-TNF therapy. | Evanthia Zampeli Michalis Gizis Spyros I Siakavellas Giorgos Bamias | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 2 |
| 2 | High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis显示文摘 | Giorgos Bamias Garyfallia Kaltsa Spyros I. Siakavellas Kostis Papaxoinis Evanthia Zampeli Spyros Michopoulos Irene Zouboulis-Vafiadis Spiros D. Ladas | 2010 | Clinical Immunology2010，，2： | 2 |
| 3 | Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn’s disease显示文摘 | Giorgos Bamias Garyfallia Kaltsa Spyros I. Siakavellas Michalis Gizis George Margantinis Evanthia Zampeli Irene Vafiadis-Zoumboulis Spyros Michopoulos George L. Daikos Spiros D. Ladas | 2011 | Digestive and Liver Disease2011，，1： | 1 |
| 4 | The role of histamine H4 receptor in im-mune and inflammatory disorders 显示文摘 | Zampeli E Tiligada E | 2009 | Br J Pharmacol2009，157，1： | 1 |
| 5 | Tilting of splinted im- plants for improved prosthodontic support: A two-dimension- al finite element analysis 显示文摘 | Zampelis A Rangert B Heijl L | 2007 | J Prosthet Dent2007，97，6： | 1 |
| 6 | Histamine H3 and H4 re-ceptors as novel drug targets 显示文摘 | Tiligada E Zampeli E Sander K | 2009 | Expert Opinion on InvestigatingDrugs2009，18，10： | 1 |
| 7 | treatment of rheumatoid arthritis:Unraveling the conundrum显示文摘 | Evangelia Zampeli | 2015 | Journal of Autoimmunity2015，65，： | 1 |
| 8 | The role of histamine H4 receptor in immune and inflammatory disorders显示文摘 | Zampeli E E.Tiligada | | 0，，01： | 1 |
| 9 | A simple visual analog scale for pain is as responsive as the WOMAC,the SF-36,and the EQ-5Din measuring outcomes of revision hip arthroplasty显示文摘 | ZAMPELIS V ORNSTEIN E FRANZN H | 2014 | Acta Orthop2014，85，： | 1 |
| 10 | Tilting of splinted implants for improved prosthodontic support: a two-dimensional finite element analysis 显示文摘 | Zampelis A Rangert B Heijl L | 2007 | J Prosthet Dent2007，97，6： | 1 |
| 11 | Electromechanical Delay of the Knee Flexor Muscles After Harvesting the Hamstrings for Anterior Cruciate Ligament Reconstruction显示文摘 | Stavros Ristanis Elias Tsepis Dimitrios Giotis Franceska Zampeli Nicholas Stergiou Anastasios D Georgoulis | 2011 | Clinical Journal of Sport Medicine2011，，： | 1 |
| 12 | A simple visual analog scale for pain is as responsive as the womae ,the sf-36, and the eq-5d in measuring outcomes of revision hip arthroplasty显示文摘 | Zampelis V Ornstein E Franzen H | 2014 | Acta Orthop2014，85，2： | 1 |
| 13 | A-symmetries in Functional HopTests,Lower Extremity Ki-nematics ,and Isokinetic Strength Persist 6 to 9 MonthsFollowing Anterior Cruciate Ligament Reconstruction显示文摘 | Sofia Axergia Evangelos Pappas Francersk Zampeli | 2013 | Journal of orthopaedic & sports physical therapy2013，3，43： | 1 |
| 14 | Histamine H3 and H4 receptors as novel drug targets 显示文摘 | Tiligada E Zampeli E Sander K | 2009 | Expert Opin Investig Drugs2009，18，10： | 1 |
| 15 | Tilting of splinted implants for improved prosthodontic support:a two-dimensional finite element analysis显示文摘 | Zampelis A Rangert B Heijl L | | 0，，6： | 1 |
| 16 | The role of histamine H4 receptor in immune and inflammatory disorders显示文摘 | Zampeli E Tiligada E | 2009 | Br J Pharmacol2009，157，1： | 1 |
| 17 | Electromechanical Delay of the Knee Flexor Muscles After Harvesting the Hamstrings for Anterior Cruciate Ligament Reconstruction显示文摘 | Stavros Ristanis Elias Tsepis Dimitrios Giotis Franceska Zampeli Nicholas Stergiou Anastasios D Georgoulis | 2011 | Clinical Journal of Sport Medicine2011，，4： | 1 |
| 18 | Treatment of rheuma-toid arthritis: Unraveling the conundrum显示文摘 | Zampeli E Vlachoyiannopoulos PG Tzioufas AG | 2015 | J Autoimmun2015，65，： | 1 |
| 19 | The role of histamine H4 receptor in immune and inflammatory disorders显示文摘 | ZAMPELI E TILIGADA E | 2009 | Br J Pharmacol2009，157，： | 1 |
| 20 | A simple visual analog scale for pain is as responsive as the WOMAC, the SF- 36, and the EQ -5D in measuring outcomes of revi- sion hip arthroplasty显示文摘 | Zampelis V Ornstein E Franzen H | 2014 | Acta Orthop2014，85，2： | 1 |
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