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| 1 | Timing of laparoscopic cholecystectomy for acute cholecystitis: A prospective non randomized study显示文摘AIM: To study the timing of laparoscopic cholecy- stectomy for patients with acute cholecystitis.METHODS: Between January 2002 and December 2005, all American Society of Anesthesiologists classification (ASA)—RESULTS: One hundred and twenty-nine patients underwent laparoscopic cholecystectomy for acute cholecystitis during the index admission. Thirty six were assigned to group 1, 58 to group 2, and 35 to group 3. The conversion rate and morbidity for the whole cohort of patients were 4.6% and 10.8%, respectively. There was no significant difference in the conversion rate, morbidity and postoperative hospital stay between the three groups.CONCLUSION: Laparoscopic cholecystectomy for acute cholecystitis during the index admission is safe, regardless of the time elapsed from the onset of symptoms. This policy can result in an overall shorter hospitalization. | George Tzovaras Dimitris Zacharoulis Paraskevi Liakou Theodoros Theodoropoulos George Paroutoglou Constantine Hatzitheofilou | 2006 | World Journal of Gastroenterology2006，12，34： | 11 |
| 2 | Endoscopic treatment and follow-up of gastrointestinal Dieulafoy's lesions显示文摘AIM: To investigate retrospectively the clinical and endoscopic features of bleeding Dieulafoy's lesions and to assess the short- and long-term effectiveness of endoscopic treatment.METHODS: Twenty-three patients who had gastrointestinal bleeding from Dieulafoy's lesions underwent endoscopic therapy. Demographic data, mode of presentation, riskfactors for gastrointestinal bleeding, blood transfusion requirements, endoscopic findings, details of endoscopic therapy, recurrence of bleeding, and mortality rates were collected and analyzed retrospectively.RESULTS: Hemostasis was attempted by dextrose 50% plus epinephrine in 10 patients, hemoclipping in 8 patients,heater probe in 2 patients and ethanolamine oleate in 2 patients. Comorbid conditions were present in 17 patients (74%). Overall permanent hemostasis was achieved in 18 patients (78%). Initial hemostasis was successful with no recurrent bleeding in patients treated with hemoclipping, heater probe or ethanolamine injection. In the group of patients who received dextrose 50% plus epinephrine injection treatment, four (40%) had recurrent bleeding and one (10%) had unsuccessful initial hemostasis.Of the four patients who had rebleeding, three had unsuccessful hemostasis with similar treatment. Surgical treatment was required in five patients (22%) owing to uncontrolled bleeding, recurrent bleeding with unsuccessful retreatment and inability to approach the lesion. One patient (4.3%) died of sepsis after operation during hospitalization. There were no side-effects related to endoscopic therapy. None of the patients in whom permanent hemostasis was achieved presented with rebleeding from Dieulafoy's lesion over a mean long-term follow-up of 29.8 mo.CONCLUSION: Bleeding from Dieulafoy's lesions can be managed successfully by endoscopic methods, which should be regarded as the first choice. Endoscopic hemoclipping therapy is recommended for bleeding Dieulafoy's lesions. | Panagiotis Katsinelos George Paroutoglou Kostas Mimidis Athanasios Beltsis Basilios Papaziogas George Gelas Yiannis Kountouras | 2005 | World Journal of Gastroenterology2005，11，38： | 8 |
| 3 | Long-term results of pneumatic dilation for achalasia: A15 years' experience显示文摘AIM: Although most patients with achalasia respond to pneumatic dilation, one-third experienced recurrence, and prolonged follow-up studies on parameters associated with various outcomes are scanty. In this retrospective study, we reported a 15-years' experience with pneumatic dilation treatment in patients with primary achalasia, and determined whether previously described predictors of outcome remain significant after endoscopic dilation.METHODS: Between September 1989 and September 2004, 39 consecutive patients with primary symptomatic achalasia (diagnosed by clinical presentation, esophagoscopy,barium esophagogram, and manometry) who received balloon dilation were followed up at regular intervals in person or by phone interview. Remission was assessed by a structured interview and a previous symptoms score.The median dysphagia-free duration was calculated by Kaplan-Meier analysis.RESULTS: Symptoms were dysphagia (n = 39, 100%),regurgitation (n =23, 58.7%), chest pain (n = 4, 10.2%),and weight loss (n = 26, 66.6%). A total of 74 dilations were performed in 39 patients; 13 patients (28%) underwent a single dilation, 17 patients (48.7%) required a second procedure within a median of 26.7 mo (range 5-97 mo), and 9 patients (23.3%) underwent a third procedure within a median of 47.8 mo (range 37-120 mo). Post-dilation lower esophageal sphincter (LES) pressure, assessed in 35 patients, has decreased from a baseline of 35.8±10.4-10.0±7.1 mmHg after the procedure. The median follow-up period was 9.3 years (range 0.5-15 years). The dysphagiafree duration by Kaplan-Meier analysis was 78%, 61%and 58.3% after 5, 10 and 15 years respectively.CONCLUSION: Balloon dilation is a safe and effective treatment for primary achalasia. Post-dilation LES pressure estimation may be useful in assessing response. | Panagiotis Katsinelos Jannis Kountouras George Paroutoglou Athanasios Beltsis Christos Zavos Basilios Papaziogas Kostas Mimidis | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 4 | Combined endoscopic and ursodeoxycholic acid treatment of biliary cast syndrome in a non-transplant patient显示文摘A 76-year-old diabetic man underwent cholecystectomy for gangrenous calculous cholecystitis. His postoperative course was complicated by the development of Candida albicans esophagitis necessitating antifungal therapy, and total parenteral nutrition (TPN) for 15 d. Seven weeks after cholecystectomy, he presented with cholangitis. Endoscopic retrograde cholangiopancreatography (ERCP) demonstrated extrahepatic filling defects. Despite endoscopic extraction of a biliary cast, cholestasis remained unchanged. Oral administration of ursodeoxycholic acid (UDCA), 750 mg/d, resulted in normalization of liver function tests. We, therefore, propose for the f irst time, combined endoscopic plus UDCA treatment for the management of biliary cast syndrome. | Panagiotis Katsinelos Jannis Kountouras Grigoris Chatzimavroudis Christos Zavos Ioannis Pilpilidis George Paroutoglou | 2008 | World Journal of Gastroenterology2008，14，33： | 7 |
| 5 | Partially covered vs uncovered sphincterotome and postendoscopic sphincterotomy bleeding显示文摘AIM: To prospectively compare partially covered vs uncovered sphincterotome use on post-endoscopic biliary sphincterotomy (ES) hemorrhage and other complications. METHODS: All patients referred for therapeutic endoscopic retrograde cholangiopancreatography (ERCP) were randomly assigned to undergo ES either with a partially covered or an uncovered sphincterotome. Both patient and technical risk factors contributing to the development of post-ES bleeding were recorded and analyzed. The characteristics of bleeding was recorded during and after ES. Other complications were also compared. RESULTS: Three-hundred and eighty-seven patients were recruited in this study; 194 patients underwent ES with a partially covered sphincterotome and 193 with conventional uncovered sphincterotome. No statistical difference was noted in the baseline characteristics and risk factors for post-ES induced hemorrhage between the 2 groups. No significant difference in the incidence and pattern of visible bleeding rates was found between the 2 groups (immediate bleeding in 24 patients with the partially covered sphincterotome vs 19 patients with the uncovered sphincterotome, P = 0.418). Delayed bleeding was observed in 2 patients with a partially covered sphincterotome and in 1 patient with an uncovered sphincterotome (P = 0.62). No statistical difference was noted in the rate of other complications. CONCLUSION: The partially covered sphincterotome was not associated with a lower frequency of bleeding. Also, there was no difference in the incidence of other significant complications between the 2 types of sphincterotome. | Panagiotis Katsinelos George Paroutoglou Jannis Kountouras Grigoris Chatzimavroudis Christos Zavos Sotiris Terzoudis Taxiarchis Katsinelos Kostas Fasoulas George Gelas George Tzovaras Ioannis Pilpilidis | 2010 | World Journal of Gastroenterology2010，16，40： | 5 |
| 6 | Cecal lipoma with pseudomalignant features: A case report and review of the literature显示文摘Colonic lipoma is a well-documented benign neoplasia, endoscopically appearing as a smooth round yellowish polyp with a thick stalk or broad-based attachment. We describe a 63-year old woman with persistent abdominal pain, in whom colonoscopy revealed a cecal mass with malignant features. Based on the colonoscopy findings, right hemicolectomy was laparoscopically performed for a presumptive diagnosis of a cecal adenocarcinoma, but histological examination revealed a colonic lipoma with overlying mucosal ulceration. | Panagiotis Katsinelos Grigoris Chatzimavroudis Christos Zavos Ioannis Pilpilidis Georgia Lazaraki Basilis Papaziogas George Paroutoglou Jannis Kountouras Dimitris Paikos | 2007 | World Journal of Gastroenterology2007，13，17： | 5 |
| 7 | Treatment of a duodenal perforation secondary to an endoscopic sphincterotomy with clips显示文摘Perforation is one of the most serious complications of endoscopic sphincterotomy (ES) necessitating immediate surgical intervention. We present a case of successful management of such a complication with endoclipping. A85-year-old woman developed duodenal perforation after ES. The perforation was identified early and its closure was achieved using three metallic clips in a single session.There was no procedure-related morbidity or complications and our patient was discharged from hospital 10 d later.Endoclipping of duodenal perforation induced by ES is a safe, effective and alternative to surgery treatment. | Panagiotis Katsinelos George Paroutoglou Basilios Papaziogas Athanasios Beltsis Stavros Dimiropoulos Konstantinos Atmatzidis | 2005 | World Journal of Gastroenterology2005，11，39： | 4 |
| 8 | Endoclipping treatment of life-threatening rectal bleeding after prostate biopsy显示文摘Rectal bleeding is frequently seen in patients undergoing transrectal ultrasound(TRUS)-guided multiple biopsy of the prostate,but is usually mild and stops spontaneously.We report what is believed to be the first case of life-threatening rectal bleeding following this procedure,which was successfully treated by endoscopic intervention through placement of three clips on the sites of bleeding.This case emphasizes endoscopic intervention associated with endoclipping as a safe and effective method to achieve hemostasis in massive rectal bleeding after prostate biopsy.Additionally,current data on the complications of the TRUS-guided multiple biopsy of the prostate and the options for treating fulminant rectal bleeding, a consequence of this procedure,are described. | Panagiotis Katsinelos Jannis Kountouras Georgios Dimitriadis Grigoris Chatzimavroudis Christos Zavos Ioannis Pilpilidis George Paroutoglou George Germanidis Kostas Mimidis | 2009 | World Journal of Gastroenterology2009，15，9： | 4 |
| 9 | Wireless capsule endoscopy in detecting small-intestinal polyps in familial adenomatous polyposis显示文摘AIM:To detect the prevalence of small bowel polyps by wireless capsule endoscopy(WCE)in patients with familial adenomatous polyposis(FAP).METHODS:We examined prospectively 14 patients with FAP to assess the location,size and number of small-intestinal polyps.Patients'age,sex,years of observation after surgery,type of surgery,duodenal polyps and colorectal cancer at surgery were analyzed.RESULTS:During WCE,polyps were detected in 9/14(64.3%)patients.Duodenal adenomatous polyps were found in nine(64.3%)patients,and jejunal and ileal polyps in seven(50%)and eight(57.1%),respectively.The Spigelman stage of duodenal polyposis was associated with the presence of jejunal and ileal polyps.Identification of the ampulla of Vater was not achieved with WCE.Importantly,the findings of WCE had no immediate impact on the further clinical management of FAP patients.No procedure-related complications were observed in the patients.CONCLUSION:WCE is a promising noninvasive new method for the detection of small-intestinal polyps.Further investigation is required to determine which phenotype of FAP is needed for surveillance with WCE. | Panagiotis Katsinelos Jannis Kountouras Grigoris Chatzimavroudis Christos Zavos Ioannis Pilpilidis Kostas Fasoulas George Paroutoglou | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 10 | A comparative study of 10-Fr vs. 7-Fr straight plastic stents in the treatment of postcholecystectomy bile leak显示文摘 | Panagiotis Katsinelos Jannis Kountouras George Paroutoglou Grigoris Chatzimavroudis George Germanidis Christos Zavos Ioannis Pilpilidis Dimitris Paikos Basilis Papaziogas | 2008 | Surgical Endoscopy2008，，1： | 3 |
| 11 | Combination of diclofenac plus somatostatin in the prevention of post-ERCP pancreatitis: a randomized, double-blind, placebo-controlled trial显示文摘 | P. Katsinelos K. Fasoulas G. Paroutoglou G. Chatzimavroudis A. Beltsis S. Terzoudis T. Katsinelos E. Dimou C. Zavos A. Kaltsa J. Kountouras | 2012 | Endoscopy2012，，01： | 2 |
| 12 | The effect of indwelling endoprosthesis on stone size or fragmentation after long-term treatment with biliary stenting for large stones显示文摘 | P. Katsinelos I. Galanis I. Pilpilidis G. Paroutoglou P. Tsolkas B. Papaziogas S. Dimiropoulos E. Kamperis D. Katsiba M. Kalomenopoulou A. Papagiannis | 2003 | Surgical Endoscopy2003，，10： | 2 |
| 13 | Combination of endoprostheses and oral ursodeoxycholic acid or placebo in the treatment of difficult to extract common bile duct stones显示文摘 | P. Katsinelos J. Kountouras G. Paroutoglou G. Chatzimavroudis C. Zavos | 2007 | Digestive and Liver Disease2007，，6： | 2 |
| 14 | Endoscopic management of occluded biliary uncovered metal stents:A multicenter experience显示文摘AIM:To compare diverse endoscopic interventions in the management of occluded uncovered self-expanding metal stents(SEMSs) that had been placed for palliative treatment of unresectable malignant biliary obstruction.METHODS:A retrospective review was undertaken in 4 tertiary endoscopic centers to determine optimal management of different types of occluded SEMSs.The technical success of performed treatment in occluded SEMSs,the patency of the stent,the need for re-intervention and the financial costs of each treatment were analyzed.RESULTS:Fifty four patients were included in the analysis;21 received Hanaro,19 Wallstent and 14 Flexus.For the relief of obstruction,a plastic stent was inserted in 24 patients,a second SEMS in 25 and mechanical cleaning was performed in 5 patients.The overall median second patency rates between second SEMSs and plastic stents did not differ(133 d for SEMSs vs 106 d for plastic stents;P = 0.856).Similarly,no difference was found between the overall survival of SEMS and plastic stent groups,and no procedure-related complications occurred.Incremental cost analysis showed that successive plastic stenting was a cost-saving strategy at least in Greece.CONCLUSION:Insertion of uncovered SEMSs or plastic stents is a safe and effective treatment for occluded uncovered SEMSs;insertion of plastic stents appears to be the most cost-effective strategy. | Panagiotis Katsinelos Athanasios Beltsis Grigoris Chatzimavroudis Dimitris Paikos George Paroutoglou Dimitris Kapetanos Sotiris Terzoudis Georgia Lazaraki Ioannis Pilpilidis Kostas Fasoulas Stefanos Atmatzidis Christos Zavos Jannis Kountouras | 2011 | World Journal of Gastroenterology2011，17，1： | 2 |
| 15 | Laparoendoscopic Rendezvous Versus Preoperative ERCP and Laparoscopic Cholecystectomy for the Management of Cholecysto-Choledocholithiasis: Interim Analysis of a Controlled Randomized Trial显示文摘 | George Tzovaras Ioannis Baloyiannis Eleni Zachari Dimitris Symeonidis Dimitris Zacharoulis Andreas Kapsoritakis George Paroutoglou Spyros Potamianos | 2012 | Annals of Surgery2012，，3： | 2 |
| 16 | Endo- scopic hemoclip application in the treatment of nonvarieeal gas- trointestinal bleeding: short-term and long-term benefits 显示文摘 | KATSINELOS P PAROUTOGLOU G BELTSIS A | 2005 | Surg LAPAROSC Endose Pereutan Tech2005，15，： | 1 |
| 17 | Severe acute haemorrhagie gastritis controlled by hydrogen peroxide显示文摘 | KATSINELOS P KOUNTOURAS J PAROUTOGLOU G | 2006 | Eur J Gastroenterol Hepatol2006，18，： | 1 |
| 18 | Endoclipping for Gastric Perforation After Endoscopicolypectomy:An Alternative Treatment to Avoid Surgery 显示文摘 | Panagiotis Katsinelos MD Athanasios Beltsis George Paroutoglou | 2004 | Surg Laparosc Endosc Percutan Tech2004，14，5： | 1 |
| 19 | Re- cent therapeutic approaches to platelet activation in coro- nary artery disease显示文摘 | Tousoulis D Paroutoglou IP Papageorgiou N | 2010 | Pharmacol Ther2010，127，2： | 1 |
| 20 | Endoscopic hemoclip appilication in the treatment of noncariceal gastroinetstinal bleeding: short-term and long-term benefits显示文摘 | KATSINELOS P PAROUTOGLOU G BELTSIS A | 2005 | Surg Laparose Percutan Tech2005，15，： | 1 |
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