|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity显示文摘AIM To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy(CAN). METHODS A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as corrected QT interval(QTc) and their dispersions(dQT, dQTc) were measured and calculated using a computer-based program. The diagnosis of CAN was based upon the battery of the tests proposed by Ewing and Clarke and the consensus statements of the American Diabetes Association. CAN was diagnosed when two out of the four classical Ewing tests were abnormal. RESULTS QT, QTc and their dispersions were significantly longer(P < 0.01) in patients with cirrhosis than in controls. No significant differences in QT interval were found among the subgroups according to the etiology of cirrhosis. Multivariate regression analysis after controlling for age, gender and duration of cirrhosis demonstrated significant association between QT and presence of diabetes mellitus [standardized regression coefficient(beta) = 0.45, P = 0.02] and treatment with diuretics(beta = 0.55, P = 0.03), but not with the Child-Pugh score(P = 0.54). Prevalence of CAN was common(54.9%) among patients with cirrhosis and its severity was associated with the Child-Pugh score(r = 0.33, P = 0.02). Moreover, patients with decompensated cirrhosis had more severe CAN that those with compensated cirrhosis(P = 0.03). No significant association was found between severity of CAN and QT interval duration.CONCLUSION Patients with cirrhosis have QT prolongation. Treatment with diuretics is associated with longer QT. CAN is common in patients with cirrhosis and its severity is associated with severity of the disease. | Elias Tsiompanidis Spyros I Siakavellas Anastasios Tentolouris Ioanna Eleftheriadou Stamatia Chorepsima Anastasios Manolakis Konstantinos Oikonomou Nikolaos Tentolouris | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，1： | 6 |
| 2 | Markers of bacterial translocation in end-stage liver disease显示文摘Bacterial translocation(BT) refers to the passage of viable bacteria or bacterial products from the intestinal lumen, through the intestinal epithelium, into the systemic circulation and extraintestinal locations. The three principal mechanisms that are thought to be involved in BT include bacterial overgrowth, disruption of the gut mucosal barrier and an impaired host defence.BT is commonly observed in liver cirrhosis and has been shown to play an important role in the pathogenesis of the complications of end stage liver disease, including infections as well as hepatic encephalopathy and hepatorenal syndrome. Due to the importance of BT in the natural history of cirrhosis, there is intense interest for the discovery of biomarkers of BT. To date, several such candidates have been proposed, which include bacterial DNA, soluble CD14, lipopolysaccharides endotoxin, lipopolysaccharide-binding protein, calprotectin and procalcitonin. Studies on the association of these markers with BT have demonstrated not only promising data but, oftentimes, contradictory results. As a consequence, currently, there is no optimal marker that may be used in clinical practice as a surrogate for the presence of BT. | Ioannis Koutsounas Garyfallia Kaltsa Spyros I Siakavellas Giorgos Bamias | 2015 | World Journal of Hepatology2015，7，20： | 2 |
| 3 | Fecal calprotectin measurement is a marker of shortterm clinical outcome and presence of mucosal healing in patients with inflammatory bowel disease显示文摘AIM To evaluate the utility of fecal calprotectin(FC) in predicting relapse and endoscopic activity during follow-up in an inflammatory bowel disease(IBD) cohort.METHODS All FC measurements that were obtained during a 3-year period from patients with inflammatory bowel disease in clinical remission were identified. Data regarding the short-term(6 mo) course of the disease were extracted from the medical files. Exclusion criteria were defined as:(1) An established flare of the disease at the time of FC measurement,(2) Loss to follow up within 6 mo from baseline FC measurement, and,(3) Insufficient data on file. Statistical analysis was performed to evaluate whether baseline FC measurement could predict the short term clinical relapse and/or the presence of mucosal healing.RESULTS We included 149 [Crohn's disease(CD) = 113, Ulcerative colitis(UC) = 36, male = 77] IBD patients in our study. Within the determined 6-month period post-FC measurement, 47(31.5%) had a disease flare. Among 76 patients who underwent endoscopy, 39(51.3%) had mucosal healing. Baseline FC concentrations were significantly higher in those who had clinical relapse compared to those who remained in remission during follow up(481.0 μg/g, 286.0-600.0 vs 89.0, 36.0-180.8, P < 0.001). The significant predictive value of baseline median with IQR FC for clinical relapse was confirmed by multivariate Cox analysis [HR for 100μg/g: 1.75(95%CI: 1.28-2.39), P = 0.001]. Furthermore, lower FC baseline values significantly correlated to the presence of mucosal healing in endoscopy(69.0 μg/g, 30.0-128.0 vs 481.0, 278.0-600.0, in those with mucosal inflammation, median with IQR, P < 0.001). We were able to extract cut-off values for FC concentration with a high sensitivity and specificity for predicting clinical relapse(261 μg/g with AUC = 0.901, sensitivity 87.2%, specificity 85.3%, P < 0.001) or mucosal healing(174 μg/g with AUC = 0.956, sensitivity 91.9%, specificity 87.2%, P < 0.001). FC was better than CRP in predicting either outcome; nevertheless, having a pathological CRP(> 5 mg/L) in addition to the cutoffs for FC, significantly enhanced the specificity for predicting clinical relapse(95.1% from 85.3%) or endoscopic activity(100% from 87.2%). CONCLUSION Serial FC measurements may be useful in monitoring IBD patients in remission, as FC appears to be a reliable predictor of short-term relapse and endoscopic activity. | Athanasios Kostas Spyros I Siakavellas Charalambos Kosmidis Anna Takou Joanna Nikou Georgios Maropoulos John Vlachogiannakos George V Papatheodoridis Ioannis Papaconstantinou Giorgos Bamias | 2017 | World Journal of Gastroenterology2017，23，41： | 2 |
| 4 | Predictors of response to anti-tumor necrosis factor therapy in ulcerative colitis显示文摘Ulcerative colitis(UC) is an immune-mediated, chronic inflammatory disease of the large intestine. Its course is characterized by flares of acute inflammation and periods of low-grade chronic inflammatory activity or remission. Monoclonal antibodies against tumor necrosis factor(anti-TNF) are part of the therapeutic armamentarium and are used in cases of moderate to severe UC that is refractory to conventional treatment with corticosteroids and/or immunosuppressants. Therapeutic response to these agents is not uniform and a large percentage of patients either fail to improve(primary non-response) or lose response after a period of improvement(secondary non-response/loss of response). In addition, the use of anti-TNF agents has been related to uncommon but potentially serious adverse effects that preclude their administration or lead to their discontinuation. Finally, use of these medications is associated with a considerable cost for the health system. The identification of parameters thatmay predict response to anti-TNF drugs in UC would help to better select for patients with a high probability to respond and minimize risk and costs for those who will not respond. Analysis of the major clinical trials and the accumulated experience with the use of anti-TNF drugs in UC has resulted to the report of such prognostic factors. Included are clinical and epidemiological characteristics, laboratory markers, endoscopic indicators and molecular(immunological/genetic) signatures. Such predictive parameters of long-term outcomes may either be present at the commencement of treatment or determined during the early period of therapy. Validation of these prognostic markers in large cohorts of patients with variable characteristics will facilitate their introduction into clinical practice and the best selection of UC patients who will benefit from anti-TNF therapy. | Evanthia Zampeli Michalis Gizis Spyros I Siakavellas Giorgos Bamias | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 2 |
| 5 | High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis显示文摘 | Giorgos Bamias Garyfallia Kaltsa Spyros I. Siakavellas Kostis Papaxoinis Evanthia Zampeli Spyros Michopoulos Irene Zouboulis-Vafiadis Spiros D. Ladas | 2010 | Clinical Immunology2010，，2： | 2 |
| 6 | Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn’s disease显示文摘 | Giorgos Bamias Garyfallia Kaltsa Spyros I. Siakavellas Michalis Gizis George Margantinis Evanthia Zampeli Irene Vafiadis-Zoumboulis Spyros Michopoulos George L. Daikos Spiros D. Ladas | 2011 | Digestive and Liver Disease2011，，1： | 1 |
| 7 | Role of the IL-23/IL-17 axis in Crohn's disease 显示文摘 | Siakavellas SI Bamias G | 2012 | Discov Med2012，14，77： | 1 |
| 8 | Circulating levels of TNF - like cytokine 1A ( TL1A ) and its decoy receptor 3 ( DcR3 ) in rheumatoid arthritis 显示文摘 | Bamias G Siakavellas SI Stamatelopoulos KS | 2008 | Clin Immunol2008，129，2： | 1 |
| 9 | Circulating levels of TNF-like cytokine 1A (TLI A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis显示文摘 | Bamias G Siakavellas SI Stamatelopoulos KS | 2008 | Clin Immunol2008，129，2： | 1 |
| 10 | Experimental evaluation of electromagnetic-Ilaermal non-destructive inspection by eddy current thermography ill square aluminum plates 显示文摘 | TSOPELAS N SIAKAVELLAS N J | 2011 | NDT & E International2011，44，： | 1 |
| 11 | Eddy current thermography in circular aluminum plates for the experimental verification of an electromagnetic- thermal method for NDT显示文摘 | TSOPELAS N SIAKAVELLAS N J | 2010 | Nondestructive Testing and Evaluation2010，25，4： | 1 |
| 12 | Eddy current thermogra- play in circular aluminum plates for the experimental verification of an electromagnetic-thermal method for NDT显示文摘 | Tsopelas N Siakavellas N J | 2010 | Nondestructive Testing and Evaluation2010，25，4： | 1 |
| 13 | Circulating levels of TNF-like cytokine 1 A ( TL1 A) and its decoy receptor 3 ( DcR3 ) in rheumatoid arthritis 显示文摘 | Bamias G Siakavellas SI Stamatelopoulos KS | 2008 | Clin [mmunol2008，129，2： | 1 |
| 14 | Electromagnetic-thermal NDT in thin conducting plates显示文摘 | N Tsopelas N J Siakavellas | | 0，，39： | 1 |
| 15 | Role of the IL-23/IL-17 axis in Crohn's disease显示文摘 | Siakavellas SI Bamias G | 2012 | Discov Med2012，14，77： | 1 |
| 16 | The TL1A/DR3/DcR3 path- way in autoimmune rheumatic diseases 显示文摘 | Siakavellas SI Sfikakis PP Bamias G | 2015 | Semin Arthritis Rheum2015，45，1： | 1 |
| 17 | Improvements in electromagnetic-thermal non-destructive inspection by data processing显示文摘 | Tsopelas N Siakavellas N J | 2009 | NDT&E International2009，42，5： | 1 |
| 18 | Circulating levels of TNF-like cytokine 1A (TL1A)and its decoy receptor 3 (DcR3) in rheumatoid arthritis显示文摘 | Bamias G Siakavellas SI Stamatelopoulos KS | 2008 | Clin Immunol2008，129，2： | 1 |
| 19 | Role of the IL-23/IL-17 axis in Crohn's disease显示文摘 | Siakavellas SI Bamias G | 2012 | Discov Med2012，14，77： | 1 |
| 20 | Experimental evaluation of electromagnetic-thermal non-destructive inspection by eddy current thermography in square aluminum plates显示文摘 | Tsopelas N Siakavellas N J | 2011 | NDT&E International2011，44，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员