|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adjuvant chemotherapy for resected colorectal cancermetastases:literature review and meta-analysis显示文摘Surgical resection is the only option of cure for patients with metastatic colorectal cancer(CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy after surgical resection of CRC metastases despite the lower level of evidence(based on the quality of studies in this setting). However, there is still no standard treatment and the effective role of an adjuvant therapy remains controversial. The aim of this review is to report the state-of-art of systemic chemotherapy and regional chemotherapy with hepatic arterial infusion in the management of patients after resection of metastases from CRC, with a literature review and meta-analysis of the relevant randomized controlled trials. | Giovanni Brandi Stefania De Lorenzo Margherita Nannini Stefania Curti Marta Ottone Filippo Gustavo Dall’Olio Maria Aurelia Barbera Maria Abbondanza Pantaleo Guido Biasco | 2016 | World Journal of Gastroenterology2016，22，2： | 13 |
| 2 | Free-breathing radial volumetric interpolated breathhold examination vs breath-hold cartesian volumetric interpolated breath-hold examination magnetic resonance imaging of the liver at 1.5T显示文摘AIM: To compare breath-hold cartesian volumetric interpolated breath-hold examination(cVIBE) and freebreathing radial VIBE(rVIBE) and determine whether rVIBE could replace cVIBE in routine liver magnetic resonance imaging(MRI).METHODS: In this prospective study, 15 consecutive patients scheduled for routine MRI of the abdomen underwent pre- and post-contrast breath-hold cVIBE imaging(19 s acquisition time) and free-breathing rVIBE imaging(111 s acquisition time) on a 1.5T Siemens scanner. Three radiologists with 2, 4, and 8 years post-fellowship experience in abdominal imaging evaluated all images. The radiologists were blinded to the sequence types, which were presented in a random order for each patient. For each sequence, the radiologists scored the cVIBE and rVIBE images for liver edge sharpness, hepatic vessel clarity, presence of artifacts, lesion conspicuity, fat saturation, and overall image quality using a five-point scale. RESULTS: Compared to rVIBE, cVIBE yielded significantly(P < 0.001) higher scores for liver edge sharpness(mean score, 3.87 vs 3.37), hepatic-vessel clarity(3.71 vs 3.18), artifacts(3.74 vs 3.06), lesion conspicuity(3.81 vs 3.2), and overall image quality(3.91 vs 3.24). cVIBE and rVIBE did not significantly differ in quality of fat saturation(4.12 vs 4.03, P = 0.17). The inter-observer variability with respect to differences between rVIBE and cVIBE scores was close to zero compared to random error and inter-patient variation. Quality of rVIBE images was rated as acceptable for all parameters. CONCLUSION: rVIBE cannot replace cVIBE in routine liver MRI. At 1.5T, free-breathing rVIBE yields acceptable, although slightly inferior image quality compared to breath-hold cVIBE. | Sireesha Yedururi HyunSeon C Kang Wei Wei Nicolaus A Wagner-Bartak Leonardo P Marcal R Jason Stafford Brandy J Willis Janio Szklaruk | 2016 | World Journal of Radiology2016，8，7： | 9 |
| 3 | 随机定位模拟微重力促进人前破骨细胞增殖和分化显示文摘目的观察随机定位模拟微重力对人前破骨细胞FLG29.1增殖和分化的影响。方法 FLG29.1细胞分为正常对照组与随机定位处理组,分别培养72 h后收集细胞。采用细胞计数法检测细胞总数和活细胞数;流式细胞术检测细胞周期;Griess法检测培养基中NO(nitric oxide,NO)浓度;抗酒石酸盐酸性磷酸酶(TRAP)染色计算TRAP阳性细胞比例;对硝基苯磷酸(pNPP)法检测胞内TRAP活性。结果随机定位处理后,FLG29.1细胞增殖能力与活细胞比例均较对照组明显增加;细胞周期分布发生变化,处于G1期的细胞比例增加;培养基中NO浓度有增加趋势;在回转处理的同时添加诱导剂12-氧-十四烷酰佛波醋酸酯-13乙酸酯(TPA),发现TRAP阳性细胞数量增多;胞内TRAP活性较对照组明显增加。结论随机定位模拟微重力提高了FLG29.1细胞活力并促进其向破骨细胞分化。 | 狄升蒙 田宗成 高翔 骞爱荣 Maria Luisa Brandi 商澎 | 2012 | 航天医学与医学工程2012，25，1： | 6 |
| 4 | Pancreatic cancer stem cells:Perspectives on potential therapeutic approaches of pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma is one of the most aggressive solid tumours of the pancreas, characterised by a five-year survival rate less than 8%. Recent reports that pancreatic cancer stem cells(PCSCs) contribute to the tumorigenesis, progression, and chemoresistance of pancreatic cancer have prompted the investigation of new therapeutic approaches able to directly target PCSCs. In the present paper the non-cancer related drugs that have been proposed to target CSCs that could potentially combat pancreatic cancer are reviewed and evaluated. The role of some pathways and deregulated proteins in PCSCs as new therapeutic targets are also discussed with a focus on selected specific inhibitors. Finally, advances in the development of nanoparticles for targeting PCSCs and site-specific drug delivery are highlighted, and their limitations considered. | Claudia Di Carlo Jessica Brandi Daniela Cecconi | 2018 | World Journal of Stem Cells2018，10，11： | 3 |
| 5 | Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome显示文摘AIM:To describe our patients affected with ectopic biliary tree gastrinoma and review the literature on this topic.METHODS:Between January 1992 and June 2012,28 patients affected by duodenopancreatic endocrine tumors in multiple endocrine neoplasia type 1(MEN1)syndrome underwent surgery at our institution.This retrospective review article analyzes our experience regarding seventeen of these patients subjected to duodenopancreatic surgery for Zollinger-Ellison syndrome(ZES).Surgical treatment consisted of duodenopancreatectomy(DP)or total pancreatectomy(TP).Regional lymphadenectomy was always performed.Any hepatic tumoral lesions found were removed during surgery.In MEN1 patients,removal of duodenal lesions can sometimes lead to persistence or recurrence of hypergastrinemia.One possible explanation for this unfavorable outcome could be unrecognized ectopic localization of gastrin-secreting tumors.This study described three cases among the seventeen patients who were found to have an ectopic gastrinoma located in the biliary tree.RESULTS:Seventeen MEN1 patients affected with ZES were analyzed.The mean age was 40 years.Fifteen patients underwent DP and two TP.On histopathological examination,duodeno pancreatic endocrine tumors were found in all 17 patients.Eighty-one gastrinomas were detected in the first three portions of the duodenum.Only one gastrinoma was found in the pancreas.The mean number of gastrinomas per patient was 5(range 1-16).Malignancy was established in 12 patients(70.5%)after lymph node,liver and omental metastases were found.Three patients exhibited biliary tree gastrinomas as well as duodenal gastrinoma(s).In two cases,the ectopic gastrinoma was removed at the same time as pancreatic surgery,while in the third case,the biliary tree gastrinoma was resected one year after DP because of recurrence of ZES.CONCLUSION:These findings suggest the importance of checking for the presence of ectopic gastrinomas in the biliary tree in MEN1 patients undergoing ZES surgery. | Francesco Tonelli Francesco Giudici Gabriella Nesi Giacomo Batignani Maria Luisa Brandi | 2013 | World Journal of Gastroenterology2013，19，45： | 3 |
| 6 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cellsAdipose mesenchymal stem cells in the field of bone tissue engineering显示文摘Bone tissue engineering represents one of the most challenging emergent fields for scientists and clinicians.Current failures of autografts and allografts in many pathological conditions have prompted researchers to find new biomaterials able to promote bone repair or regeneration with specific characteristics of biocompatibility,biodegradability and osteoinductivity.Recent advancements for tissue regeneration in bone defects have occurred by following the diamond concept and combining the use of growth factors and mesenchymal stem cells(MSCs).In particular,a more abundant and easily accessible source of MSCs was recently discovered in adipose tissue.These adipose stem cells(ASCs)can be obtained in large quantities with little donor site morbidity or patient discomfort,in contrast to the invasive and painful isolation of bone marrow MSCs.The osteogenic potential of ASCs on scaffolds has been examined in cell cultures and animal models,with only a few cases reporting the use of ASCs for successful reconstruction or accelerated healing of defects of the skull and jaw in patients.Although these reports extend our limited knowledge concerning the use of ASCs for osseous tissue repair and regeneration,the lack of standardization in applied techniques makes the comparison between studies difficult.Additional clinical trials are needed to assess ASC therapy and address potential ethical and safety concerns,which must be resolved to permit application in regenerative medicine. | Cecilia Romagnoli Maria Luisa Brandi | 2014 | World Journal of Stem Cells2014，6，2： | 3 |
| 7 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 3 |
| 8 | Ten years of hip fractures in Italy: For the first time a decreasing trend in elderly women显示文摘AIM:To evaluate the hospitalization rate of femoralneck fractures in the elderly Italian population over ten years.METHODS:We analyzed national hospitalizations records collected at central level by the Ministry of Health from 2000 to 2009.Age-and sex-specific rates of fractures occurred at femoral neck in people≥65 years old.We performed a sub-analysis over a three-year period(2007-2009),presenting data per five-year age groups,in order to evaluate the incidence of the hip fracture in the oldest population.RESULTS:We estimated a total of 839008 hospitalizations due to femoral neck fractures between 2000 and2009 in people≥65,with an overall increase of 29.8%over 10 years.The incidence per 10000 inhabitants remarkably increased in people≥75,passing from158.5 to 166.8(+5.2%)and from 72.6 to 77.5(+6.8%)over the ten-year period in women and men,respectively.The oldest age group(people>85 years old)accounted for more than 42%of total hospital admissions in 2009(n=39000),despite representing only 2.5%of the Italian population.Particularly,women aged>85accounted for 30.8%of total fractures,although they represented just 1.8%of the general population.The results of this analysis indicate that the incidence of hip fractures progressively increased from 2000 to 2009,but a reduction can be observed for the first time in women≤75(-7.9%between 2004 and 2009).CONCLUSION:Incidence of hip fractures in Italy are continuously increasing,although women aged 65-74years old started showing a decreasing trend. | Prisco Piscitelli Maurizio Feola Cecilia Rao Monica Celi Elena Gasbarra Cosimo Neglia Giuseppe Quarta Federico Maria Liuni Simone Parri Giovanni Iolascon Maria Luisa Brandi Alessandro Distante Umberto Tarantino | 2014 | World Journal of Orthopedics2014，5，3： | 2 |
| 9 | A new platform for Real-Time PCR detection of Salmonella spp., Listeria monocytogenes and Escherichia coli O157 in milk显示文摘 | Enrica Omiccioli Giulia Amagliani Giorgio Brandi Mauro Magnani | 2009 | Food Microbiology2009，，6： | 2 |
| 10 | Frequent Gastrointestinal Polyps and Colorectal Adenocarcinomas in a Prospective Series of PTEN Mutation Carriers显示文摘 | Brandie Heald Jessica Mester Lisa Rybicki Mohammed S. Orloff Carol A. Burke Charis Eng | 2010 | Gastroenterology2010，，6： | 2 |
| 11 | A data analytics-based tool for the detection and diagnosis of anomalous daily energy patterns in buildings显示文摘In this paper,a tool for the detection and diagnosis of anomalous electrical daily energy patterns relative to a transformer substation of a university campus was developed and tested.Through an innovative pattern recognition analysis consisting in a multi-step clustering process,six clusters of anomalous daily load profiles were identified and isolated in two-year historical data of total electrical energy consumption.The infrequent electrical load profiles were found to be strongly affected,in terms of both shape and magnitude,by the energy consumption behaviour related to the heating/cooling mechanical room.Then,a fault-free predictive model,which uses artificial neural network(ANN)in combination with a Regression Tree,was developed to detect anomalous trends of the electrical energy consumption.The model was able to detect the 93.7%of the anomalous profiles and only the 5%of fault-free days were wrongly predicted as anomalous.Eventually,a diagnosis phase was conceived and validated with a testing data set.A number of daily abnormal load profiles were detected and compared with the centroids of the anomalous clusters identified in the pattern-recognition stage.The work led to the development of a flexible intelligent tool useful for operating a continuous commissioning of the campus facilities. | Marco Savino Piscitelli Silvio Brandi Alfonso Capozzoli Fu Xiao | 2021 | Building Simulation2021，14，1： | 2 |
| 12 | Genetic test in multiple endocrine neoplasia type 1 syndrome: An evolving story显示文摘Multiple endocrine neoplasia type 1(MEN1) is an autosomal dominant inherited tumour syndrome expressing various endocrine and non-endocrine lesions and tumours. Since the identification of the causative gene, the oncosuppressor gene MEN1, in 1997, genetic testing has revealed an important approach for the early and differential diagnosis of the disease. The finding of a MEN1 mutation in a patient has important clinical implications for relatives since it allows very early disease diagnosis and identification of carriers, even before biochemical and/or clinical manifestation, permitting their inclusion in a specific program of surveillance and subsequent praecox therapy. Currently, genetic testing for MEN1 consists principally of the sequencing of coding regions and intron-exon junctions of the MEN1 gene. However, the recent acquisition of novel high throughput technologies will allow the design of innovative, accurate, complete and rapid genetic diagnosis. These new tools are able to increase the strength of the analysis and almost completely eliminate the possibility of false negative results. This review aims to give an overview on genetic testing of MEN1 syndrome, reporting the positive aspects of performing the analysis and the future perspectives for improving the performance of the test, as well as its application in clinical practice. | Francesca Marini Francesca Giusti Maria Luisa Brandi | 2015 | World Journal of Experimental Medicine2015，5，2： | 2 |
| 13 | Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most frequent causes of cancer-related death.Sorafenib,a multitarget angiogenesis inhibitor,is an approved frontline treatment for advanced HCC in Western countries,although a complete response(CR)to treatment is infrequently reported.Capecitabine,an oral fluoropyrimidine,has been shown to be effect in both treatment-naïve patients and those previously treated with sorafenib.To date,how-ever,only one case of sustained CR to metronomic capecitabine has been reported.Case presentation:We describe three cases of advanced HCC treated with metronomic capecitabine where a CR was obtained.In the first case,capecitabine was administered as first line therapy;in the second case,capecitabine was used after intolerance to sorafenib;while in the third case,capecitabine was administered after sorafenib failure.Conclusion:Capecitabine is a potentially important treatment option for patients with advanced HCC and may even represent a cure in certain cases. | Giovanni Brandi Michela Venturi Stefania De Lorenzo Francesca Garuti Giorgio Frega Andrea Palloni Ingrid Garajovà Francesca Abbati Gioconda Saccoccio Rita Golfieri Maria Abbondanza Pantaleo Maria Aurelia Barbera | 2018 | Cancer Communications2018，38，1： | 2 |
| 14 | Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death显示文摘 | Apoor S. Gami Brandi J. Witt Daniel E. Howard Patricia J. Erwin Lisa A. Gami Virend K. Somers Victor M. Montori | 2007 | Journal of the American College of Cardiology2007，，4： | 2 |
| 15 | Heterotaxy Patients With Total Anomalous Pulmonary Venous Return: Improving Surgical Results显示文摘 | David L.S. Morales Brandi E. Braud Justin H. Booth Daniel E. Graves Jeffrey S. Heinle E. Dean McKenzie Charles D. Fraser | 2006 | The Annals of Thoracic Surgery2006，，5： | 2 |
| 16 | The Science of Team Science显示文摘 | Daniel Stokols Kara L. Hall Brandie K. Taylor Richard P. Moser | 2008 | American Journal of Preventive Medicine2008，，2： | 2 |
| 17 | Distinct Clinicohistologic Features of Inflammatory Bowel Disease-associated Colorectal Adenocarcinoma: In Comparison With Sporadic Microsatellite-stable and Lynch Syndrome-related Colorectal Adenocarcinoma显示文摘 | Xiuli Liu John R. Goldblum Zijin Zhao Michael Landau Brandie Heald Rish Pai Jingmei Lin | 2012 | The American Journal of Surgical Pathology2012，，8： | 2 |
| 18 | Phsiopathological basis of bone turnover显示文摘 | Masi L Brandi ML | 2001 | Q J Nucl Med2001，45，1： | 1 |
| 19 | Insulin resistance of stress:sites and mechanism显示文摘 | Brandi LS Santoro D Natali A | 1993 | Clin Sci1993，85，5： | 1 |
| 20 | Energy metabolism of thoracic surgical patients in the early postoperative period 显示文摘 | Brandi LS Bertolini R Janni A | 1996 | Chest1996，109，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员