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| 1 | Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma显示文摘Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse,steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative potential, but fewer than 20% of patients are suitable candidates. Interventional treatments are offered to the vast majority of patients. Radiofrequency(RFA) and microwave ablation(MWA) are among the therapeutic modalities, with similar indications which include the presence of up to three lesions, smaller than 3 cm in size, and the absence of extrahepatic disease. The therapeutic effect of both methods relies on thermal injury, but MWA uses an electromagnetic field as opposed to electrical current used in RFA. Unlike MWA, the effect of RFA is partially limited by the heat-sink effect and increased impedance of the ablated tissue. Compared with RFA, MWA attains a more predictable ablation zone, permits simultaneous treatment of multiple lesions, and achieves larger coagulation volumes in a shorter procedural time. Major complications of both methods are comparable and infrequent(approximately 2%-3%), and they include haemorrhage, infection/abscess, visceral organ injury, liver failure, and pneumothorax. RFA may incur the additional complication of skin burns. Nevertheless, there is no compelling evidence for differences in clinical outcomes, including local recurrence rates and survival. | Loukia S Poulou Evanthia Botsa Ioanna Thanou Panayiotis D Ziakas Loukas Thanos | 2015 | World Journal of Hepatology2015，7，8： | 37 |
| 2 | Role of NLRP3 inflammasome in inflammatory bowel diseases显示文摘Inflammasomes are multiprotein intracellular complexes which are responsible for the activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 has been a subject of intensive investigation. NLRP3 is considered to be a sensor of microbial and other danger signals and plays a crucial role in mucosal immune responses, promoting the maturation of proinflammatory cytokines interleukin 1β(IL-1β) and IL-18. NLRP3 inflammasome has been associated with a variety of inflammatory and autoimmune conditions, including inflammatory bowel diseases(IBD). The role of NLRP3 in IBD is not yet fully elucidated as it seems to demonstrate both pathogenic and protective effects. Studies have shown a relationship between genetic variants and mutations in NLRP3 gene with IBD pathogenesis. A complex interaction between the NLRP3 inflammasome and the mucosal immune response has been reported. Activation of the inflammasome is a key function mediated by the innate immune response and in parallel the signaling through IL-1β and IL-18 is implicated in adaptive immunity. Further research is needed to delineate the precise mechanisms of NLRP3 function in regulating immune responses. Targeting NLRP3 inflammasome and its downstream signaling will provide new insights into the development of future therapeutic strategies. | Evanthia Tourkochristou Ioanna Aggeletopoulou Christos Konstantakis Christos Triantos | 2019 | World Journal of Gastroenterology2019，25，33： | 24 |
| 3 | Effect of percutaneous endoscopic gastrostomy on gastroesophageal reflux in mechanically-ventilated patients显示文摘瞄准:在机械地通气的病人在胃的食道的倒流(GER ) 上调查经皮的内视镜的胃造口术(木钉) 的效果。方法:在未来的、使随机化的、控制研究有周期性或坚持的联系通风机的肺病(VAP ) 和 GER >
的 36 个病人 6% 被划分成木钉组(n = 16 ) 或非木钉组(n = 20 ) 。11 通气了没有倒流的病人(GER <
3%) 用作控制组。食道的 pH-metry 被执行由在基线“渡过”方法,在木钉以后的 2 和 7 d。病人们严格地被跟随在上面为胃的滋养的残余的半侧卧的位置和控制。结果:median (范围)的重要减少倒流从 7.8 在木钉组被观察( 6.2 - 15.6 )在到 2.7 的基线( 0 - 10.4 )在 d 上 7 post-gastrostomy ( P <
0.01 ),当倒流从 9 增加了时( 6.2 - 22 )到 10.8 ( 6.3 - 36.6 )( P <
0.01 )在非木钉组。在 GER (%) 和 nasogastric 试管的停留之间的重要关联被检测(r = 0.56, P <
0.01 ) 。结论:胃造口术什么时候与滋养的胃的残余的半侧卧的位置和缺席结合了,在通气病人减少胃的食道的倒流。 | Emmanuel E Douzinas Andreas Tsapalos Antonios Dimitrakopoulos Evanthia Diamanti-Kandarakis Alexandros D Rapidis Charis Roussos | 2006 | World Journal of Gastroenterology2006，12，1： | 15 |
| 4 | Charcot osteoarthropathy in diabetes: A brief review with an emphasis on clinical practice显示文摘Charcot osteoarthropathy (COA) is a potentially limbthreatening condition that mainly affects diabetic patients with neuropathy. In everyday practice, it presents as a red, hot, swollen foot, usually painless, and is frequently trig gered by trivial injury. Its etiology is traditionally attributed to impairment of either the autonomic nervous system, leading to increased blood flow and bone resorption, or of the peripheral nervous system, whereby loss of pain and protective sensation render the foot susceptible to repeated injury. More recently, excessive local inflammation is thought to play a decisive role. Diagnosis is based on clinical manifestation and imaging studies (plain X-rays, bone scan, Magnetic Resonance Imaging). The mainstay of management is immediate off-loading, while surgery is usually reserved for chronic cases with irreversible deformities and/or joint instability. The aim of this review is to provide an overview of COA in terms of pathogenesis, classification and clinical presentation, diagnosis and treatment, with an emphasis on the high suspicion required by clinicians for timely recognition to avoid further complications. | Evanthia Gouveri Nikolaos Papanas | 2011 | World Journal of Diabetes2011，2，5： | 8 |
| 5 | Thermal Ablation in the Management of Adrenal Metastasis Originating from Non-small Cell Lung Cancer: A 5-year Single-center Experience显示文摘 | Evanthia I Botsa Ioanna L Thanou Aspasia T Papatheodoropoulou Loukas I Thanos | 2017 | Chinese Medical Journal2017，，17： | 6 |
| 6 | Toward a new era of hepatitis B virus therapeutics:The pursuit of a functional cure显示文摘Hepatitis B virus(HBV)infection,although preventable by vaccination,remains a global health problem and a major cause of chronic liver disease.Although current treatment strategies suppress viral replication very efficiently,the optimal endpoint of hepatitis B surface antigen(HBsAg)clearance is rarely achieved.Moreover,the thorny problems of persistent chromatin-like covalently closed circular DNA and the presence of integrated HBV DNA in the host genome are ignored.Therefore,the scientific community has focused on developing innovative therapeutic approaches to achieve a functional cure of HBV,defined as undetectable HBV DNA and HBsAg loss over a limited treatment period.A deeper understanding of the HBV life cycle has led to the introduction of novel direct-acting antivirals that exert their function through multiple mechanisms,including inhibition of viral entry,transcriptional silencing,epigenetic manipulation,interference with capsid assembly,and disruption of HBsAg release.In parallel,another category of new drugs aims to restore dysregulated immune function in chronic hepatitis B accompanied by lethargic cellular and humoral responses.Stimulation of innate immunity by pattern-recognition receptor agonists leads to upregulation of antiviral cytokine expression and appears to contribute to HBV containment.Immune checkpoint inhibitors and adoptive transfer of genetically engineered T cells are breakthrough technologies currently being explored that may elicit potent HBV-specific T-cell responses.In addition,several clinical trials are attempting to clarify the role of therapeutic vaccination in this setting.Ultimately,it is increasingly recognized that elimination of HBV requires a treatment regimen based on a combination of multiple drugs.This review describes the rationale for progressive therapeutic interventions and discusses the latest findings in the field of HBV therapeutics. | Efthymios P Tsounis Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos | 2021 | World Journal of Gastroenterology2021，27，21： | 5 |
| 7 | Predictors of response to anti-tumor necrosis factor therapy in ulcerative colitis显示文摘Ulcerative colitis(UC) is an immune-mediated, chronic inflammatory disease of the large intestine. Its course is characterized by flares of acute inflammation and periods of low-grade chronic inflammatory activity or remission. Monoclonal antibodies against tumor necrosis factor(anti-TNF) are part of the therapeutic armamentarium and are used in cases of moderate to severe UC that is refractory to conventional treatment with corticosteroids and/or immunosuppressants. Therapeutic response to these agents is not uniform and a large percentage of patients either fail to improve(primary non-response) or lose response after a period of improvement(secondary non-response/loss of response). In addition, the use of anti-TNF agents has been related to uncommon but potentially serious adverse effects that preclude their administration or lead to their discontinuation. Finally, use of these medications is associated with a considerable cost for the health system. The identification of parameters thatmay predict response to anti-TNF drugs in UC would help to better select for patients with a high probability to respond and minimize risk and costs for those who will not respond. Analysis of the major clinical trials and the accumulated experience with the use of anti-TNF drugs in UC has resulted to the report of such prognostic factors. Included are clinical and epidemiological characteristics, laboratory markers, endoscopic indicators and molecular(immunological/genetic) signatures. Such predictive parameters of long-term outcomes may either be present at the commencement of treatment or determined during the early period of therapy. Validation of these prognostic markers in large cohorts of patients with variable characteristics will facilitate their introduction into clinical practice and the best selection of UC patients who will benefit from anti-TNF therapy. | Evanthia Zampeli Michalis Gizis Spyros I Siakavellas Giorgos Bamias | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 2 |
| 8 | Results of surgery for colorectal carcinoma with obstruction显示文摘 | Antonios-Apostolos K. Tentes Charalambos G. Mirelis Stilianos Kakoliris Odisseas S. Korakianitis Ioannis G. Bougioukas Evanthia G. Tsalkidou Athanasios I. Xanthoulis Konstantina A. Bekiaridou Abraham I. Dimoulas | 2009 | Langenbeck’s Archives of Surgery2009，，1： | 2 |
| 9 | High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis显示文摘 | Giorgos Bamias Garyfallia Kaltsa Spyros I. Siakavellas Kostis Papaxoinis Evanthia Zampeli Spyros Michopoulos Irene Zouboulis-Vafiadis Spiros D. Ladas | 2010 | Clinical Immunology2010，，2： | 2 |
| 10 | Clinical decision support systems for brain tumor characterization using advanced magnetic resonance imaging techniques显示文摘In recent years, advanced magnetic resonance imaging(MRI) techniques, such as magnetic resonance spec-troscopy, diffusion weighted imaging, diffusion tensor imaging and perfusion weighted imaging have been used in order to resolve demanding diagnostic prob-lems such as brain tumor characterization and grading, as these techniques offer a more detailed and non-invasive evaluation of the area under study. In the last decade a great effort has been made to import and utilize intelligent systems in the so-called clinical deci-sion support systems(CDSS) for automatic processing, classification, evaluation and representation of MRI data in order for advanced MRI techniques to become a part of the clinical routine, since the amount of data from the aforementioned techniques has gradually inticle is two-fold. The first is to review and evaluate the progress that has been made towards the utilization of CDSS based on data from advanced MRI techniques. The second is to analyze and propose the future work that has to be done, based on the existing problems and challenges, especially taking into account the new imaging techniques and parameters that can be intro-duced into intelligent systems to significantly improve their diagnostic specificity and clinical application. | Evangelia Tsolaki Evanthia Kousi Patricia Svolos Efthychia Kapsalaki Kyriaki Theodorou Constastine Kappas Ioannis Tsougos | 2014 | World Journal of Radiology2014，6，4： | 2 |
| 11 | Weekly Gemcitabine for the Treatment of Biliary Tract and Gallbladder Cancer显示文摘 | Nikolas Tsavaris Christos Kosmas Panagiotis Gouveris Kostadinos Gennatas Aris Polyzos Despina Mouratidou Heracles Tsipras Helias Margaris George Papastratis Evanthia Tzima Nikitas Papadoniou Gavrilos Karatzas Efstathios Papalambros | 2004 | Investigational New Drugs2004，，2： | 2 |
| 12 | Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis显示文摘BACKGROUND Tidal breathing flow-volume(TBFV)analysis provides important information about lung mechanics in infants.AIM To assess the effects of breastfeeding on the TBFV measurements of infants who recover from acute bronchiolitis.METHODS In this cross-sectional study,TBFV analysis was performed in infants with bronchiolitis prior to hospital discharge.The ratio of time to peak expiratory flow to total expiratory time(tPEF/tE)at baseline and after the administration of 400 mcg salbutamol was evaluated.RESULTS A total of 56 infants(35 boys),aged 7.4±2.8 mo,were included.Of them,12.5%were exposed to tobacco smoke and 41.1%were breastfed less than 2 mo.There were no differences in baseline TBFV measurements between the breastfeeding groups;however,those who breastfed longer than 2 mo had a greater change in tPEF/tE after bronchodilation(12%±10.4%vs 0.9%±7.1%;P<0.001).Moreover,there was a clear dose-response relationship between tPEF/tE reversibility and duration of breastfeeding(P<0.001).In multivariate regression analysis,infants who breastfed less(regression coefficient-0.335,P=0.010)or were exposed to cigarette smoke(regression coefficient 0.353,P=0.007)showed a greater change in tPEF/tE after bronchodilation,independent of sex,prematurity,and family history of asthma or atopy.CONCLUSION Infants who recover from bronchiolitis and have a shorter duration of breastfeeding or are exposed to cigarette smoke,have TBFV measurements indicative of obstructive lung disease. | Evanthia Perikleous Sotirios Fouzas Athina Karageorgiou Paschalis Steiropoulos Evangelia Nena Athanasios Chatzimichael Aggelos Tsalkidis Emmanouil Paraskakis | 2021 | World Journal of Clinical Pediatrics2021，10，6： | 2 |
| 13 | Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn’s disease显示文摘 | Giorgos Bamias Garyfallia Kaltsa Spyros I. Siakavellas Michalis Gizis George Margantinis Evanthia Zampeli Irene Vafiadis-Zoumboulis Spyros Michopoulos George L. Daikos Spiros D. Ladas | 2011 | Digestive and Liver Disease2011，，1： | 1 |
| 14 | Endocrine- dcrineisrupting chemicals: an endocrine society scientific statement 显示文摘 | Evanthia DK Jean-Pierre B Linda CG | 2009 | Endocr Rev2009，30，： | 1 |
| 15 | Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement显示文摘 | Evanthia Diamanti-Kandarakis Jean-Pierre Bourguignon Linda C. Giudice Russ Hauser Gail S. Prins Ana M. Soto R Thomas Zoeller Andrea C. Gore | 2009 | Endocrine Reviews2009，，4： | 1 |
| 16 | Distinct peak at 3.8 ppm observed by 3T MR spectroscopy in meningiomas,while nearly absent in high-grade gliomas and cerebral metastases显示文摘 | Evanthia Kousi Ioannis Tsougos Konstantinos Fountas Kiriaki Theodorou Evaggelia Tsolaki Ioannis Fezoulidis Eftichia Kapsalaki | 2012 | Molecular Medicine Reports2012，，4： | 1 |
| 17 | Phase 1 trial of a path- otropic retroviral vector expressing a cytocidal cyclin G1 construct (Rexin-G) in patients with advanced pancreatic cancer 显示文摘 | Evanthia G Stephanie KC Nathan RF | 2008 | Mol Ther2008，16，5： | 1 |
| 18 | Weekly Gemcitabine for the Treatment of Biliary Tract and Gallbladder Cancer显示文摘 | Nikolas Tsavaris Christos Kosmas Panagiotis Gouveris Kostadinos Gennatas Aris Polyzos Despina Mouratidou Heracles Tsipras Helias Margaris George Papastratis Evanthia Tzima Nikitas Papadoniou Gavrilos Karatzas Efstathios Papalambros | 2004 | Investigational New Drugs2004，，2： | 1 |
| 19 | Hyperhomocysteinemia enhances vascular inflammation and accelerates atheroscle- rosis in a murine model 显示文摘 | Marion A Hofmann Evanthia L | 2001 | J Clin Invest2001，107，： | 1 |
| 20 | Evaluation of adhesion capacity, cell surface traits and immunomodulatory activity of presumptive probiotic Lactobacillus strains显示文摘 | Charalambos Kotzamanidis Andreas Kourelis Evanthia Litopoulou-Tzanetaki Nikolaos Tzanetakis Minas Yiangou | 2010 | International Journal of Food Microbiology2010，，2： | 1 |
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