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| 1 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 2 | A static-dynamic energy harvester for a self-powered ocean environment monitoring application显示文摘Ocean intelligent buoy is important for ocean environment monitoring.With the increase of requisite sensors and transportable data,a long power supply has become a problem to be solved urgently.In this work,a hybrid nanogenerator integrating triboelectric,piezoelectric,electromagnetic,photovoltaic,and thermotropic units is proposed to maximize ocean ambient energy harvesting,which includes static energy(solar and thermal energy)and dynamic energy(wave energy).Compared with a device with a single energy conversion mechanism,this structural design breaks the limit of harvesting time and natural conditions during the energy harvesting process,thereby increasing the harvested energy.Static energy harvesting is realized by the thermoelectric(TG)and photovoltaic(PV)units located inside the device and the PV unit attached to the device surface.Results show that the maximum open-circuit voltage and short-circuit current are 5 V and 41 mA in the external PV and 1.33 V and 49 mA in the internal PV under 30000 Lux illumination,respectively.The open-circuit voltage and short-circuit current of the TG unit are 5 V and 15 m A,respectively.The core component of the dynamic generation unit is the gimbal used to harvest wave energy by the triboelectric nanogenerator(TENG),piezoelectric generator(PENG),and electromagnetic generator.When the frequency is 2.4 Hz,the maximum peak-to-peak power of the TENG,PENG,and EMG are 0.25,1.58,and 13.8 mW,respectively.Finally,an intelligent ocean buoy is fabricated by the integration of an energy harvester,a power management circuit,sensors,a microcontroller,and a wireless communication module.Driven by static and dynamic energy,temperature signal,humidity signal,GPS signal,and sound signal are sent to the receiving terminal wirelessly.The ocean energy harvester proposed in this work is of great significance for ocean energy harvesting and ocean wireless monitoring systems. | XUE Feng CHEN Liang LI ChunCheng REN Jing YU JunBin HOU XiaoJuan GENG WenPing MU JiLiang HE Jian CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，4： | 2 |
| 3 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 4 | Comprehensive identification of lysine 2-hydroxyisobutyrylated proteins in Ustilaginoidea virens reveals the involvement of lysine 2-hydroxyisobutyrylation in fungal virulence显示文摘Lysine 2-hydroxyisobutyrylation(Khib) is a newly identified post-translational modification(PTM) that plays important roles in transcription and cell proliferation in eukaryotes. However, its function remains unknown in phytopathogenic fungi. Here,we performed a comprehensive assessment of Khibin the rice false smut fungus Ustilaginoidea virens, using Tandem Mass Tag(TMT)-based quantitative proteomics approach. A total of 3 426 Khibsites were identified in 977 proteins, sugg esting that Khibis a common and complex PTM in U. virens. Our data demonstrated that the2-hydroxyisobutyrylated proteins are involved in diverse biological processes. Network analysis of the modified proteins revealed a highly interconnected protein network that included many well-studied virulence factors. We confirmed that the Zn-binding reduced potassium dependency3-type histone deacetylase(UvRpd3) is a major enzyme that removes 2-hydroxyisobutyrylation and acetylation in U. virens. Notably, mutations of Khib sites in the mitogen-activated protein kinase(MAPK)UvSlt2 significantly reduced fungal virulence and decreased the enzymatic activity of UvSlt2. Molecular dynamics simulations demonstrated that 2-hydroxyisobutyrylation in UvSlt2 increased the hydrophobic solvent-accessible surface area and thereby affected binding between the UvSlt2 enzyme and its substrates. Our findings thus establish Khibas a major post-translational modification in U. virens and point to an important role for Khibin the virulence of this phytopathogenic fungus. | Xiaoyang Chen Xiabing Li Pingping Li Xiaolin Chen Hao Liu Junbin Huang Chaoxi Luo Tom Hsiang Lu Zheng | 2021 | Journal of Integrative Plant Biology2021，63，2： | 2 |
| 5 | The decomposition of permutation module for infinite Chevalley groups显示文摘Let G be a connected reductive group defined over F_q, the finite field with q elements. Let B be a Borel subgroup defined over F_q. In this paper, we completely determine the composition factors of the induced module M(tr) = kG ■tr(where tr is the trivial B-module) for any field k. | Xiaoyu Chen Junbin Dong | 2021 | Science China Mathematics2021，64，5： | 1 |
| 6 | UnionPay Payment Scheme Based on Controlled Quantum Teleportation显示文摘We propose a UnionPay payment scheme based on controlled quantum teleportation in which the whole process is realized through correlation of the three-particle entangled state,controlled quantum teleportation,and the physical property of quantum mechanics.Combined with some typical quantum key distribution protocols,the proposed UnionPay payment scheme with unconditional security(information theory security)overcomes the limitation of computational security generally existing in traditional UnionPay payment systems. | WEN Xiaojun CHEN Yongzhi YI Zhengzhong JIANG LZoe FANG Junbin | 2020 | Chinese Journal of Electronics2020，29，3： | 1 |
| 7 | CdS magic-size clusters exhibiting one sharp ultraviolet absorption singlet peaking at 361 nm显示文摘We report,for the first time,the synthesis of CdS magic-size clusters (MSCs) which exhibit a single sharp absorption peaking at ~ 361 nm,along with sharp band edge photoemission at ~ 377 nm and broad trap emission peaking at ~ 490 nm.These MSCs are produced in a singleensemble form without the contamination of conventional quantum dots (QDs) and/or other-bandgap clusters.They are denoted as MSC-361.We present the details of several controlled syntheses done in oleylamine (OLA),using C,d(NO3)2 or C,d(OAc)2 as a C,d source and thioacetamide (TAA) or elementary sulfur (S) as a S source.A high synthetic reproducibility of the reaction of Cd(NO3)2 and TAA to single-ensemble MSC-361 is achieved,the product of which is not contaminated by other bandgap clusters and/or QDs.In some cases,the reaction product exhibits an additional absorption peak at ~ 322 nm.We demonstrate that the two peaks,at 361 and 322 nm,do not evolve synchronously.Therefore,the 322 nm peak is not a higher order electronic transition of MSC-361,but due to the presence of another ensemble,namely MSC-322.The present study suggests that there is an outstanding need for the development of a physical model to narrow the knowledge gap regarding the electronic structure in these colloidal semiconductor CdS MSCs. | Junbin Tang Juan Hui Meng Zhang Hongsong Fan Nelson Rowell Wen Huang Yingnan Jiang Xiaoqin Chen Kui Yu | 2019 | Nano Research2019，12，6： | 1 |
| 8 | Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats显示文摘Excessive theta(θ)frequency oscillation and synchronization in the basal ganglia(BG)has been reported in elderly parkinsonian patients and animal models of levodopa(L-dopa)-induced dyskinesia(LID),particularly theθoscillation recorded during periods when L-dopa is withdrawn(the off L-dopa state).To gain insight into processes underlying this activity,we explored the relationship between primary motor cortex(M1)oscillatory activity and BG output in LID.We recorded local field potentials in the substantia nigra pars reticulata(SNr)and M1 of awake,inattentive resting rats before and after L-dopa priming in Sham control,Parkinson disease model,and LID model groups.We found that chronic L-dopa increasedθsynchronization and information flow between the SNr and M1 in off L-dopa state LID rats,with a SNr-to-M1 flow directionality.Compared with the on state,θoscillational activity(θsynchronization and informationflow)during the off state were more closely associated with abnormal involuntary movements.Our findings indicate thatθoscillation in M1 may be consequent to abnormal synchronous discharges in the BG and support the notion that M1θoscillation may participate in the induction of dyskinesia. | Jiazhi Chen Qiang Wang Nanxiang Li Shujie Huang Min Li Junbin Cai Yuzheng Wang Huantao Wen Siyuan Lv Ning Wang Jinyan Wang Fei Luo Wangming Zhang | 2021 | Neuroscience Bulletin2021，37，3： | 1 |
| 9 | Ustilaginoidea virens modulates lysine 2-hydroxyisobutyrylation in rice flowers during infection显示文摘The post-translational modification lysine 2-hydroxyisobutyrylation(K_(hib))plays an important role in gene transcription,metabolism,and enzymatic activity.K_(hib)sites have been identified in rice(Oryza sativa).However,the K_(hib)status of proteins in rice flowers during pathogen infection remains unclear.Here,we report a comprehensive identification of K_(hib)-modified proteins in rice flowers,and the changes in these proteins during infection with the fungal pathogen Ustilaginoidea virens.By using a tandem mass tag-based quantitative proteomics approach,we identified 2,891 K_(hib)sites on 964 proteins in rice flowers.Our data demonstrated that 2-hydroxyisobutyrylated proteins are involved in diverse biological processes.K_(hib)levels were substantially reduced upon infection with U.virens.Chromatin immunoprecipitation polymerase chain reaction(PCR)and reverse transcription quantitative PCR analyses revealed that histone K_(hib)is involved in the expression of disease-resistance genes.More importantly,most quantified sites on core histones H3 were downregulated upon U.virens infection.In addition,the histone deacetylases HDA705,HDA716,SRT1,and SRT2 are involved in the removal of K_(hib)marks in rice.HDA705 was further confirmed to negatively regulate rice disease resistance to pathogens U.virens,Magnaporthe oryzae,and Xanthomonas oryzae pv.oryzae(Xoo).Our data suggest that U.virens could modulate K_(hib)in rice flowers during infection. | Xiaoyang Chen Qiutao Xu Yuhang Duan Hao Liu Xiaolin Chen Junbin Huang Chaoxi Luo Dao-Xiu Zhou Lu Zheng | 2021 | Journal of Integrative Plant Biology2021，63，10： | 1 |
| 10 | Rheological Properties of Zwitterionic Wormlike Micelle in Presence of Solvents and Cosurfactant at High Temperature显示文摘 | Jiang Yang Zhen Yang Yongjun Lu Junbin Chen Wenlong Qin | 2013 | Journal of Dispersion Science and Technology2013，，8： | 1 |
| 11 | Pathogenic analysis of coxsackievirus A10 in rhesus macaques显示文摘Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and myocarditis.Different people,particularly young children,may have different immunological responses to infection.Current CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this virus.The characteristics of CV-A10 infection,replication,and shedding in humans remain unknown.In this study,rhesus macaques were infected by CV-A10 via respiratory or digestive route to mimic the HFMD in humans.The clinical symptoms,viral shedding,inflammatory response and pathologic changes were investigated in acute infection(1–11 day post infection)and recovery period(12–180 day post infection).All infected rhesus macaques during acute infection showed obvious viremia and clinical symptoms which were comparable to those observed in humans.Substantial inflammatory pathological damages were observed in multi-organs,including the lung,heart,liver,and kidney.During the acute period,all rhesus macaques displayed clinical signs,viral shedding,normalization of serum cytokines,and increased serum neutralizing antibodies,whereas inflammatory factors caused some animals to develop severe hyperglycemia during the recovery period.In addition,there were no significant differences between respiratory and digestive tract infected animals.Overall,all data presented suggest that the rhesus macaques provide the first non-human primate animal model for investigating CV-A10 pathophysiology and assessing the development of potential human therapies. | Suqin Duan Fengmei Yang Yanyan Li Yuan Zhao Li Shi Meng Qin Quan Liu Weihua Jin Junbin Wang Lixiong Chen Wei Zhang Yongjie Li Ying Zhang Jingjing Zhang Shaohui Ma Zhanlong He Qihan Li | 2022 | Virologica Sinica2022，37，4： | 1 |
| 12 | A Unified Time Scale Intelligent Control Algorithm for Microgrid Based on Extreme Dynamic Programming显示文摘Benefiting from the progress of power electronics technology,distributed generation technology is developing rapidly.Since microgrids cannot rely on traditional multi-time scale control strategies to ensure the high-quality frequency stability control and economic dispatch in the same time scale,this paper proposes an extreme dynamic programming algorithm.The proposed algorithm takes an adaptive dynamic programming algorithm as the framework,an extreme learning machine as a kernel of the evaluation module,a model module,an implementation module and a new prediction module.The resulting unified time scale intelligent control algorithm better realizes the combined functions of“droop control+automatic generation control+economic dispatch”in the traditional opermode.Finally,in order to verify the effectiveness of the proposed algorithm,a microgrid model of 8 nodes is simulated.The results confirm the feasibility and validity of the proposed extreme dynamic programming algorithm. | Junbin Chen Tao Yu Linfei Yin Jianlin Tang Hanqi Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 0 |
| 13 | Comparison of clinical efficacy between LAPS and ALPPS in the treatment of hepatitis B virus-related hepatocellular carcinoma显示文摘Background:Insufficient post-operative future liver remnant(FLR)limits the feasibility of hepatectomy for patients.Staged hepatectomy is an effective surgical approach that can improve the resection rate of hepatocellular carcinoma(HCC).This study aimed to compare the safety and efficacy of laparoscopic microwave ablation and portal vein ligation for staged hepatectomy(LAPS)and classical associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in the treatment of hepatitis B virus(HBV)-related HCC.Methods:Clinical data of patients with HBV-related HCC who underwent LAPS or ALPPS in our institute between January 2017 and May 2022 were retrospectively analysed.Results:A total of 18 patients with HBV-related HCC were retrospectively analysed and divided into the LAPS group(n=9)and ALPPS group(n=9).Eight patients in the LAPS group and eight patients in the ALPPS group proceeded to a similar resection rate(88.9%vs 88.9%,P=1.000).The patients undergoing LAPS had a lower total comprehensive complication index than those undergoing ALPPS but there was not a significant different between the two groups(8.66 vs 35.87,P=0.054).The hypertrophy rate of FLR induced by ALPPS tended to be more rapid than that induced by LAPS(24.29 vs 13.17 mL/d,P=0.095).The 2-year recurrence-free survival(RFS)was 0%for ALPPS and 35.7%for LAPS(P=0.009),whereas the 2-year overall survival for ALPPS and LAPS was 33.3%and 100.0%(P=0.052),respectively.Conclusions:LAPS tended to induce lower morbidity and FLR hypertrophy more slowly than ALPPS,with a comparable resection rate and better long-term RFS in HBV-related HCC patients. | Zebin Chen Shunli Shen Wenxuan Xie Junbin Liao Shiting Feng Shaoqiang Li Jiehui Tan Ming Kuang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 14 | UWB radar target recognition based on time-domain bispectrum显示文摘Complex targets are irradiated by UWB radar, n ot only the mirror scattering echoes but also the multi-scattering interacting ec hoes are included in target echoes. These two echoes can not be distinguished by classical frequency spectrum and power spectrum. Time-domain bispectrum featur es of UWB radar signals that mingled with noise are analyzed, then processing th is kind of signal using the method of time-domain bispectrum is experimented. A t last, some UWB radar returns with different signal noise ratio are simulated u sing the method of time-domain bispectrum. Theoretical analysis and the results of simulation show that the method of extraction partial features of UWB radar targets based on time-domain bispectrum is good, and target classification and recognition can be implemented using those features. | Liu Donghong Zhang Yongshun Chen Zhijie Cheng Junbin | 2006 | Journal of Systems Engineering and Electronics2006，17，2： | 0 |
| 15 | Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment显示文摘Enzyme-driven micro/nanomotors consuming in situ chemical fuels have attracted lots of attention for biomedical applications.However,motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain challenging.Herein,swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy via active motion and ammonia amplification.By decomposing urea into carbon dioxide and ammonia,the designed proteomotors are endowed with self-propulsive capability,which leads to improved internalization and enhanced penetration in vitro.As a glutamine synthetase inhibitor,the loaded L-methionine sulfoximine further prevents the conversion of toxic ammonia into non-toxic glutamine in both tumor and stromal cells,resulting in local ammonia amplification.After intravesical instillation,the proteomotors achieve longer bladder retention and thus significantly inhibit the growth of orthotopic bladder tumor in vivo without adverse effects.We envision that the as-developed swimming proteomotors with amplification of the product toxicity may be a potential platform for active cancer treatment. | Hao Tian Juanfeng Ou Yong Wang Jia Sun Junbin Gao Yicheng Ye Ruotian Zhang Bin Chen Fei Wang Weichang Huang Huaan Li Lu Liu Chuxiao Shao Zhili Xu Fei Peng Yingfeng Tu | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 16 | An Activatable Nanoenzyme Reactor for Coenhanced Chemodynamic and Starving Therapy Against Tumor Hypoxia and Antioxidant Defense System显示文摘It is critical to improve the efficiency of cancer therapy with minimized side effects.Chemodynamic therapy(CDT)is a tumor therapeutic strategy designed to generate abundant reactive oxygen species(ROS)at tumor sites through a Fenton or Fenton-like reaction.Recently,this developing scheme has demonstrated an incredible promise for tumor therapy.The process involved could induce cell death without the input of external energy,and this could only occur via the conversion of hydrogen peroxide(H_(2)O_(2))to hydroxyl radicals(·OH).Although Fenton or Fenton-like reactions are being exploited for CDT,along with an application of oxidation reactions to supplement H_(2)O_(2),it has been proven that in cancer cells,the high levels of the existing antioxidants could suppress CDT via·OH depletion,and,unfortunately,tumor hypoxia also inhibits the oxidation reactions.Herein,the authors aimed to fabricate an activatable nanoenzyme reactor(NER)to solve this challenge.Fluorescent reporters(FRs)and bioenzyme glucose oxidase(GOX)were coassembled on nanozyme MnO_(2) nanosheets,which was enwrapped by the tumor-targeting material,hyaluronic acid(HA).NER was internalized explicitly by cancer cells through ligand/receptor recognitionmediated endocytosis,followed by intracellular hyaluronidase(HAase)-dependent activation.As a result,the oxygen level was improved,and the antioxidants were depleted,leading to the promotion of glucose consumption and an increase in·OH level.Thus,the NER exhibited multiple effects to induce coenhanced,chemodynamic and starving therapy against tumor hypoxia and antioxidant defense system to achieve a favorable targeted tumor therapeutic,via these rigorously highly effective,and targeted biochemical reactions both in an in vitro cultured cancer cells systemor in an in vivo mice tumor model. | Zhihe Qing Ailing Bai Lifang Chen Shuohui Xing Zhen Zou Yanli Lei Junbin Li Juewen Liu Ronghua Yang | 2021 | CCS Chemistry2021，3，5： | 0 |
| 17 | Study of the Compensatory Growth Following Starvation of Juvenile Golden Pompano Trachinotus ovatus显示文摘A starvation trial was conducted to determine compensatory growth of the juvenile golden pompano Trachinotus ovatus which were deprived of food for 1,2,5 and 7 days respectively. The results of tests in outdoor cement pools and net pens showed that,in the first 15 days and 30 days,the growth of 1 day and 2days-deprived groups was probably the same with that of control group,which accorded with fully compensatory description. However,the weight of 5 days and 7days-deprived fingerlings were lower than that of the control group,which accorded with the description of the partial compensatory growth. As the starvation prolonged,feed conversion efficiency of the starved groups increased and was higher than the control group. Meanwhile,feeding rate also increased,but the fish of 1day and 2 days-deprived groups was lower than that of the control group,and feeding quantity reduced and was lower than that of the control group. It suggested that the mechanism of compensatory growth was mainly due to improving feed conversion efficiency. Fish biochemical composition was analyzed: the water content and ash of fish sample increased due to starvation,while the lipid and protein decreased. The loss of lipid was greater than that of the protein,and the biochemical composition of fish in each group was restored to the control level by the end of the experiment. It suggested that Trachinotus ovatus may mainly consume lipid during the period of starvation. | Liu Longlong Luo Ming Chen Fuxiao Tan Wei Zhang Junbin Li Xiangmin | 2015 | Animal Husbandry and Feed Science2015，7，3： | 0 |
| 18 | Stretchable and skin-conformal piezo-triboelectric pressure sensor for human joint bending motion monitoring显示文摘Stretchable,skin-conformal,and self-powered wearable pressure sensors have garnered significant attention for use in human joint bending motion monitoring.Here,a piezo-triboelectric pressure sensor(P-TPS)based on triboelectric nanogenerator and piezoelectric nanogenerator is demonstrated.The P-TPS can generate an enhanced electrical output by coupling the dual-mode triboelectrification and piezoelectric effect.The P-TPS shows high sensitivity(voltage=0.3 V/kPa;current=4.3 nA/kPa;pres-sure range=0-200 kPa),high linearity,and good stability.Furthermore,it demonstrates a wide mea-surement range(0-800 kPa),table frequency response,and fast response time.Additionally,all components of the P-TPS are fabricated using flexible and stretchable materials,affording satisfactory stretchability and excellent skin conformality.Owing to their ability to self-power,they can be attached to the outside of joints to monitor human joint bending movements in real time.Hence,this study provides a novel method of using a stretchable and skin-conformal piezo-triboelectric nanogenerator with high electrical performance as a self-powered pressure sensor,which offers significant potential in personalized recognition,medical research,and human machine interface. | Junbin Yu Liang Chen Xiaojuan Hou Jiliang Mu Jian He Wenping Geng Xiaojun Qiao Xiujian Chou | 2022 | Journal of Materiomics2022，8，2： | 0 |
| 19 | Comparative oxidation proteomics analyses suggest redox regulation of cytosolic translation in rice leaves upon Magnaporthe oryzae infection显示文摘Pathogen attack can increase plant levels of reactive oxygen species(ROS),which act as signaling molecules to activate plant defense mechanisms.Elucidating these processes is crucial for understanding redox signaling pathways in plant defense responses.Using an iodo-tandem mass tag(TMT)-based quantitative proteomics approach,we mapped 3362 oxidized cysteine sites in 2275 proteins in rice leaves.Oxidized proteins were involved in gene expression,peptide biosynthetic processes,stress responses,ROS metabolic processes,and translation pathways.Magnaporthe oryzae infection led to increased oxidative modification levels of 512 cysteine sites in 438 proteins,including many transcriptional regulators and ribosomal proteins.Ribosome profiling(Ribo-seq)analysis revealed that the oxidative modification of ribosomal proteins promoted the translational efficiency of many mRNAs involved in defense response pathways,thereby affecting rice immunity.Our results suggest that increased oxidative modification of ribosomal proteins in rice leaves promotes cytosolic translation,thus revealing a novel function of posttranslational modifications.Furthermore,the oxidation-sensitive proteins identified here provide a valuable resource for research on protein redox regulation and can guide future mechanistic studies. | Xiaoyang Chen Qiutao Xu Yaping Yue Yuhang Duan Hao Liu Xiaolin Chen Junbin Huang Lu Zheng | 2023 | Plant Communications2023，4，3： | 0 |
| 20 | Factors Influencing Fracture Propagation in Collaborative Fracturing ofMultiple HorizontalWells显示文摘Horizontal well-stimulation is the key to unconventional resource exploration and development.The development mode of the well plant helps increase the stimulated reservoir volume.Nevertheless,fracture interference between wells reduces the fracturing effect.Here,a 2D hydro-mechanical coupling model describing hydraulic fracture(HF)propagation is established with the extended finite element method,and the effects of several factors on HF propagation during multiple wells fracturing are analyzed.The results show that with an increase in elastic modulus,horizontal principal stress difference and injection fluid displacement,the total fracture area and the reservoir stimulation efficiency are both improved in all three fracturing technologies.After a comparison of the three technologies,the method of improved zipper fracturing is proposed,which avoids mutual interference between HFs,and the reservoir stimulation effect is improved significantly.The study provides guidance for optimizing the fracturing technology of multiple horizontal wells. | Diguang Gong Junbin Chen Cheng Cheng Yuanyuan Kou | 2024 | Energy Engineering2024，121，2： | 0 |
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