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| 1 | Cell deaths:Involvement in the pathogenesis and intervention therapy of COVID-19显示文摘The current pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)infection has dramatically influenced various aspects of the world.It is urgent to thoroughly study pathology and underlying mechanisms for developing effective strategies to prevent and treat this threatening disease.It is universally acknowledged that cell death and cell autophagy are essential and crucial to maintaining host homeostasis and participating in disease pathogenesis.At present,more than twenty different types of cell death have been discovered,some parts of which have been fully understood,whereas some of which need more investigation.Increasing studies have indicated that cell death and cell autophagy caused by coronavirus might play an important role in virus infection and pathogenicity.However,the knowledge of the interactions and related mechanisms of SARS-CoV-2 between cell death and cell autophagy lacks systematic elucidation.Therefore,in this review,we comprehensively delineate how SARS-CoV-2 manipulates diverse cell death(including apoptosis,necroptosis,pyroptosis,ferroptosis,and NETosis)and cell autophagy for itself benefits,which is simultaneously involved in the occurrence and progression of COVID-19,aiming to provide a reasonable basis for the existing interventions and further development of novel therapies. | Xue Li Ziqi Zhang Zhenling Wang Pedro Gutiérrez-Castrellón Huashan Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 2 | 中性粒细胞外诱捕网在肝细胞癌转移中的作用机制及应用价值研究进展显示文摘肝癌是常见恶性肿瘤之一,肝细胞肝癌(HCC)是原发性肝癌(PLC)中最常见的类型。转移是HCC复发和患者5年生存率持续较低的重要原因。中性粒细胞介导的炎症反应在HCC转移中的作用受到重视。随着研究的深入,证实中性粒细胞外诱捕网(NETs)与肿瘤进展及转移有关。现就NETs在HCC转移中的作用机制及应用价值进行阐述,期望为HCC转移这一治疗难题提供新的干预靶点。 | 吴颖升 梁向娟 彭嘉敏 黄晶晶 | 2024 | 陕西医学杂志2024，53，3： | 0 |
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