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| 1 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 2 | Measurement of γ detector backgrounds in the energy range of 3-8 MeV at Jinping underground laboratory for nuclear astrophysics显示文摘The astrophysical reaction rate of the charged-particleinduced reaction is dominated by the cross section within the Gamow window.The total cross section σ(E)of a chargedparticle-induced reaction is known to drops steeply with decreasing energy owing to the Coulomb barrier in the entrance channel: | YangPing Shen Jun Su WeiPing Liu Gang Lian Lin Gan LvHua Qiao ShengQuan Yan Yong Zhou Qian Yue Zhi Zeng QingDong Hu YuHao Mi Wei Zhao | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，10： | 5 |
| 3 | A possible family of Ni-based high temperature superconductors显示文摘We suggest that a family of Ni-based compounds, which contain [Ni_2M_2O]~2à(M = chalcogen) layers with an antiperovskite structure constructed by mixed-anion Ni complexes, Ni M_4O_2, can be potential high temperature superconductors(high-Tc) upon doping or applying pressure. The layer structures have been formed in many other transitional metal compounds such as La_2B_2Se_2O_3(B = Mn, Fe, Co). For the Ni-based compounds, we predict that the parental compounds host collinear antiferromagnetic states similar to those in iron-based high temperature superconductors. The electronic physics near Fermi energy is controlled by two egd-orbitals with completely independent in-plane kinematics. We predict that the superconductivity in this family is characterized by strong competition between extended s-wave and d-wave pairing symmetries. | Congcong Le Jinfeng zeng Yuhao Gu Guang-Han Cao Jiangping Hu | 2018 | Science Bulletin2018，63，15： | 2 |
| 4 | Superconducting nanowire single-photon detectors:recent progress显示文摘Research of superconducting nanowire singlephoton detectors(SNSPDs) has been progressing rapidly in recent years. The combined properties of high efficiency,low noise, and fast speed of SNSPDs permit its applications ranging from long-distance quantum teleportation to moonto-earth optical communications. Here we briefly discussed recent progress of SNSPDs, in particular(1) tungstensilicide SNSPDs,(2) waveguide-integrated SNSPDs, and(3) a few applied demonstrations. | Xiaolong Hu Yuhao Cheng Chao Gu Xiaotian Zhu Haiyi Liu | 2015 | Science Bulletin2015，60，23： | 2 |
| 5 | Robust, healable and hydrophobically recoverable polydimethylsiloxane based supramolecular material with dual-activate hard segment显示文摘In this paper, a novel dual-activate hard segment strategy is proposed for the fabrication of polydimethylsiloxane(PDMS) based supramolecular polymer(PDMS-PDITC-IPDI). The unique design endows the PDMS-PDITC-IPDI with high toughness(43.1–24.5 MJ/m^(3)), tensile strength(11.3–6.6 MPa) and elongation at break(730%–615%), and the mechanical properties and dynamic property can be regulated by varying degrees of hard segment activation. Moreover, the PDMS-PDITC-IPDI polymers exhibit excellent self-recovery property during successive loading-unloading processes. Additionally, both wettability damage caused by O2 plasma treatment and mechanical damage can be healed by simple heating, showing good hydrophobic recovery and selfhealability. Taking advantages of merits of the PDMS-PDITC-IPDI, the applications of the material as recyclable adhesive and 3D printing material are also investigated. | LV Chi QI YuHao HU RuoFei ZHENG JunPing | 2021 | Science China(Technological Sciences)2021，64，2： | 2 |
| 6 | Specific Targeting MRI of Chitosan Oligosaccharide Modified Fe_(3)O_(4) Nanoprobe on Macrophage and the Inhibition of Macrophage Foaming Induced by ox-LDL显示文摘Atherosclerosis(AS)is a primary cause of morbidity and mortality all over the world.Molecular imaging techniques can enable early localization and diagnosis of atherosclerosis plaques.Recent newly developed chitooligosaccharides(CSO)is considered to be capable of target mannose receptors on the surface of macrophages and to inhibit foam cell formation.Here we present a targeting magnetic resonance imaging(MRI)nanoprobe,which was successfully constructed with polyacrylic acid(PAA)modified nanometer iron oxide(Fe_(3)O_(4))as the core,and coating with CSO molecules,possessing the abilities of targeted MRI and specifically inhibition of the formation of foamy macrophages in the atherosclerotic process.The experimental results showed that the distributions of PAA-Fe_(3)O_(4) and CSO-PAA-Fe_(3)O_(4) were uniform and the corresponding sizes were about 5.93 nm and 8.15 nm,respectively.The Fourier transform infrared spectra(FTIR)testified the CSO was coupled with PAA-Fe_(3)O_(4) successfully.After coupled with CSO,the r1 of PAA-Fe_(3)O_(4) was increased from 5.317 mM s-1 to 6.147 mM s-1,indicating their potential as MRI contrast agent.Oil Red O staining and total cholesterols(TC)determination showed that CSO-PAA-Fe_(3)O_(4) could significantly inhibit the foaming process of RAW264.7 cells induced by oxidatively modified low density lipoprotein(ox-LDL).In vitro cellular MRI displayed that,compared with PAA-Fe_(3)O_(4),CSO-PAA-Fe_(3)O_(4) could lower the T1 relaxation time of RAW264.7 cells better.In summary,construction of CSO-PAA-Fe_(3)O_(4) nanoprobe in this study could realize the targeted MRI of macrophages and inhibition of ox-LDL induced macrophage foaming process.This will provide a new avenue in the diagnosis and treatment of AS. | Xu Cao Ke Ma Yuhao Tao Deyang Xi Fangyu Hu Jingjing Li | 2021 | Journal of Advances in Medicine Science2021，4，2： | 1 |
| 7 | Light-Induced Heat Driving Active Ion Transport Based on 2D MXene Nanofluids for Enhancing Osmotic Energy Conversion显示文摘Osmotic energy from the ocean,also called blue energy,serves as a clean,renewable,and vast energy source for the energy demands of the world.Reverse electrodialysis-based blue energy harvesting via ion-selective membranes,by the regulation and manipulation of directional ion transport,has been greatly developed recently.In particular,light has been employed to enhance directional ion transport for energy conversion through an increase in photo-induced surface charge.Here,the authors demonstrate a novel nanofluidic regulation strategy based on the phenomenon of light-induced heat-driven active ion transport through the lamellar MXene membrane.Due to the great light-induced heat effect,a temperature gradient appears as soon as illumination is applied to an off-center position,inducing an actively temperature gradient-driven ionic species transport.By employing this phenomenon,the authors conducted light-induced heat-enhanced osmotic energy conversion and doubled the osmotic energy conversion power density.This study has extended the scope of light-enhanced osmotic energy conversion and could further bring other photothermal materials into this field.Furthermore,the proposed system provides a new avenue of light-controlled ionic transport for ion gathering,desalination,and energy conversion applications. | Pei Liu Teng Zhou Yunfei Teng Lin Fu Yuhao Hu Xiangbin Lin Xiang-Yu Kong Lei Jiang Liping Wen | 2021 | CCS Chemistry2021，3，4： | 1 |
| 8 | Novel mechanical behavior of periodic structure with the pattern transformation显示文摘In periodic cellular structures,novel pattern transformations are triggered by a reversible elastic instability under the axial compression.Based on the deformation-triggered new pattern,periodic cellular structures can achieve special mechanical properties.In this paper,the designed architecture materials which include elastomer matrixes containing empty holes or filled holes with hydrogel material are modeled and simulated to investigate the mechanical property of the periodic materials.By analyzing the relationship between nominal stress and nominal strain of periodic material,and the corresponding deformed patterns,the influence of geometry and shapes of the holes on the mechanical property of architecture material is studied in more details.We hope this study can provide future perspectives for the deformation-triggered periodic structures. | Jianying Hu Yuhao He Jincheng Lei Zishun Liu | 2013 | Theoretical & Applied Mechanics Letters2013，3，5： | 1 |
| 9 | Unconventional high temperature superconductivity in cubic zinc-blende transition metal compounds显示文摘We consider possible high temperature superconductivity(high-Tc)in transition metal compounds with a cubic zinc-blende lattice structure.When the electron filling configuration in the d-shell is close to d7,all three t2g orbitals are near half filling with strong nearest neighbor antiferromagnetic(AFM)superexchange interactions.We argue that upon doping,this electronic environment can be one of'genes'to host unconventional high Tcwith a time reversal symmetry broken d2x2-x2-y2±idx2-y2pairing symmetry.With gapless nodal points along the diagonal directions,this state is a direct three-dimensional analogue to the two-dimensional B1gd-wave state in cuprates.We suggest that such a case may be realized in electron doped CoN,such as CoN1-xOx and(H,Li)1-xCoN. | Qiang Zhang Kun Jiang YuHao Gu JiangPing Hu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 1 |
| 10 | Rh-Catalyzed Formal[3+2]Cyclization for the Synthesis of 5-Aryl-2-(quinolin-2-yl)oxazoles and Its Applications in Metal lons Probes显示文摘Main observation and conclusion A facile and efficient strategy for the synthesis of 5-aryl-2-(quinolin-2-yl)oxazoles via rhodium-catalyzed formal[3+2]cyclization of 4-aryl-1-tosyl-1H-1,2,3-triazoles with quinoline-2-carbaldehydes has been described.The protocol employs mild conditions and offers good yields of diverse 2,5-aryloxazole derivatives with a broad reaction scope.It is amenable to gram-scale synthesis and easily transformation.Moreover,this 5-aryl-2-(quinolin-2-yl)oxazole skeleton is indeed a new fluorophore and its applications in metal ions probes are also investigated and showed fluorescent responses to mercury ion. | Tongtong Zhou Xinwei He Youpeng Zuo Yuhao Wu Wangcheng Hu Shiwen Zhang Jiahui Duan Yongjia Shang | 2021 | Chinese Journal of Chemistry2021，39，3： | 1 |
| 11 | Engineering Multi‑field‑coupled Synergistic Ion Transport System Based on the Heterogeneous Nanofluidic Membrane for High‑Efficient Lithium Extraction显示文摘The global carbon neutrality strategy brings a wave of rechargeable lithium‐ion batteries technique development and induces an ever-growing consumption and demand for lithium(Li).Among all the Li exploitation,extracting Li from spent LIBs would be a strategic and perspective approach,especially with the low energy consumption and eco-friendly membrane separation method.However,current membrane separation systems mainly focus on monotonous membrane design and structure optimization,and rarely further consider the coordination of inherent structure and applied external field,resulting in limited ion transport.Here,we propose a heterogeneous nanofluidic membrane as a platform for coupling multi-external fields(i.e.,lightinduced heat,electrical,and concentration gradient fields)to construct the multi-field-coupled synergistic ion transport system(MSITS)for Li-ion extraction from spent LIBs.The Li flux of the MSITS reaches 367.4 mmol m^(−2)h^(−1),even higher than the sum flux of those applied individual fields,reflecting synergistic enhancement for ion transport of the multi-field-coupled effect.Benefiting from the adaptation of membrane structure and multi-external fields,the proposed system exhibits ultrahigh selectivity with a Li^(+)/Co^(2+)factor of 216,412,outperforming previous reports.MSITS based on nanofluidic membrane proves to be a promising ion transport strategy,as it could accelerate ion transmembrane transport and alleviate the ion concentration polarization effect.This work demonstrated a collaborative system equipped with an optimized membrane for high-efficient Li extraction,providing an expanded strategy to investigate the other membrane-based applications of their common similarities in core concepts. | Lin Fu Yuhao Hu Xiangbin Lin Qingchen Wang Linsen Yang Weiwen Xin Shengyang Zhou Yongchao Qian Xiang‑Yu Kong Lei Jiang Liping Wen | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 12 | Bipolar Blue Light-emitting Polyfluorenes Containing Dibenzothiophene-S,S-dioxide/Carbazole Units显示文摘 | LIANG Li LIU Jie ZHANG Yuhao HU Liwen GUO Ting YANG Wei CAO Yong | 2018 | Chemical Research in Chinese Universities2018，34，3： | 1 |
| 13 | Delay-dependent stability of linear multistep methods for differential systems with distributed delays显示文摘This paper deals with the stability of linear multistep methods for multidimensional differential systems with distributed delays. The delay-dependent stability of linear multistep methods with compound quadrature rules is studied. Several new sufficient criteria of delay-dependent stability are obtained by means of the argument principle. An algorithm is provided to check delay-dependent stability. An example that illustrates the effectiveness of the derived theoretical results is given. | Yanpei WANG Yuhao CONG Guangda HU | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，12： | 1 |
| 14 | MR-seq:measuring a single cell's transcriptome repeatedly by RNA-seq显示文摘We described a novel single-cell RNA-seq technique called MR-seq(measure a single-cell transcriptome repeatedly),which permits statistically assessing the technical variation and identifying the differentially expressed genes between just two single cells by measuring each single cell twice. We demonstrated that MR-seq gave sensitivity and reproducibility similar to the standard single-cell RNA-seq and increased the positive predicate value. Application of MR-seq to early mouse embryos identified hundreds of candidate intra-embryonic heterogeneous genes among mouse 2-,4-and 8-cell stage embryos. MR-seq should be useful for detecting differentially expressed genes among a small number of cells. | Lu Yang Zhaochun Ma Chen Cao Yuhao Zhang Xinglong Wu Raymond Lee Boqiang Hu Lu Wen Hao Ge Yanyi Huang Kaiqin Lao Fuchou Tang | 2017 | Science Bulletin2017，62，6： | 1 |
| 15 | Three-step learning strategy for designing 15Cr ferritic steels with enhanced strength and plasticity at elevated temperature显示文摘15Cr ferrite steels are urgently required in advanced Ultra-supercritical power plants but meet design challenges in balancing excellent strength and plasticity at high temperatures.We developed a three-step learning strategy based on mutually driven machine learning and purposeful experiments to complete this multi-objective task.Compared with traditional adaptive learning and local-interpolation learning,this step-by-step modular manner provides good transparency and interpretability of the information flow,which is ensured by identifying essential factors from an exquisitely prepared composition-microstructure dataset,and learning valuable knowledge about the composition-property relationship.The requirement of only two groups of experiments indicates the low cost and high efficiency of the strategy.Performing the strategy,we found that Ti is another key element affecting the Laves phase besides Mo and W,and their effects on ultimate tensile strength(UTS)and elongation were also uncovered.Importantly,several low-cost steels free of Co were successfully designed,and the best steel exhibited 156%,31%,and 62%higher UTS and elongation at 650°C than the typical 9Cr,15Cr,and 20Cr steels,respectively.Based on the advantages and success of the strategy in terms of alloy improvement,we believe the strategy suits other multi-objective design tasks in more materials systems. | Xiaobing Hu Yiming Chen Jianlin Lu Chen Xing Jiajun Zhao Qingfeng Wu Yuhao Jia Junjie Li Zhijun Wang Jincheng Wang | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
| 16 | Brainmask:an ultrasoft and moist microelectrocorticography electrode for accurate positioning and long-lasting recordings显示文摘Bacterial cellulose(BC),a natural biomaterial synthesized by bacteria,has a unique structure of a cellulose nanofiberweaved three-dimensional reticulated network.BC films can be ultrasoft with sufficient mechanical strength,strong water absorption and moisture retention and have been widely used in facial masks.These films have the potential to be applied to implantable neural interfaces due to their conformality and moisture,which are two critical issues for traditional polymer or silicone electrodes.In this work,we propose a micro-electrocorticography(micro-ECoG)electrode named“Brainmask”,which comprises a BC film as the substrate and separated multichannel parylene-C microelectrodes bonded on the top surface.Brainmask can not only guarantee the precise position of microelectrode sites attached to any nonplanar epidural surface but also improve the long-lasting signal quality during acute implantation with an exposed cranial window for at least one hour,as well as the in vivo recording validated for one week.This novel ultrasoft and moist device stands as a next-generation neural interface regardless of complex surface or time of duration. | Bowen Ji Fanqi Sun Jiecheng Guo Yuhao Zhou Xiaoli You Ye Fan Longchun Wang Mengfei Xu Wen Zeng Jingquan Liu Minghao Wang Huijing Hu Honglong Chang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 17 | Predicting diamond-like Co-based chalcogenides as unconventional high temperature superconductors显示文摘We predict Co-based chalcogenides with a diamond-like structure can host unconventional high temperature superconductivity(high-Tc). The essential electronic physics in these materials stems from the Co layers with each layer being formed by vertex-shared CoA_4(A=S, Se, Te) tetrahedra complexes, a material genome proposed recently by us to host potential unconventional high-Tcclose to a d7 filling configuration in 3 d transition metal compounds. We calculate the magnetic ground states of different transition metal compounds with this structure. It is found that(Mn, Fe, Co)-based compounds all have a G-type antiferromagnetic(AFM) insulating ground state while Ni-based compounds are paramagnetic metal.The AFM interaction is the largest in the Co-based compounds as the three t2 gorbitals all strongly participate in AFM superexchange interactions. The abrupt quenching of the magnetism from the Co to Ni-based compounds is very similar to those from Fe to Co-based pnictides in which a C-type AFM state appears in the Fe-based ones but vanishes in the Co-based ones. This behavior can be considered as an electronic signature of the high-Tcgene. Upon doping, as we predicted before, this family of Co-based compounds favor a strong d-wave pairing superconducting state. | Jiangping Hu Yuhao Gu Congcong Le | 2018 | Science Bulletin2018，63，20： | 0 |
| 18 | The co-transport of Cd(Ⅱ) and nZnO in saturated soil packed column:effects of ionic strength and pH显示文摘The rapid development and widespread use of ZnO nanoparticles(nZnO) in various industries have raised concerns about their potential environmental impact.Therefore,understanding the fate and role of nZnO in the natural environment is crucial for mitigating their hazardous effects on the environment and human safety.The purpose of the present study was to provide scientific support for understanding and eliminating the joint risk of nanoparticle and heavy metal pollution in the soil environment by revealing the co-transport characteristics of Cd(Ⅱ) and ZnO nanoparticles(nZnO) in soil under different ionic strength(IS) and pH.The impacts of different IS and pH on the co-transport of Cd(Ⅱ) and nZnO in a20 cm long with an inner diameter of 2.5 cm acrylic column packed with 10 cm high soil samples were investigated in the present study.In the above system,a500 μg L^(-1) Cd(Ⅱ) loaded nZnO suspension pulse with varying IS or pH was introduced into the soil column for leaching over 5 PVs,followed up by 5 PVs background solutions without nZnO.The IS was 1,10,or 50 mM NaCl,with pH6,or the pH was 6,7 or 8 with 1 mM NaCl.Meanwhile,Sedimentation experiments for nZnO,adsorption of Cd(Ⅱ) on soil,and nZnO,DLVO theory calculation for the same background condition were conducted.The presence of nZnO significantly increased the mobility of Cd(Ⅱ) as a result of its strong adsorption capacity for nZnO-associated Cd(Ⅱ).However,with the increase of IS,the co-transport of nZnO and Cd(Ⅱ) was decreased and the retention of nZnO in the soil column due to more nZnO attended to aggregate and sediment during the transport and the decrease in the adsorption capacity of nZnO for Cd(Ⅱ) by competition of Na^(+).When pH was 6,7,and 8,the co-transport of nZnO and Cd(Ⅱ) increased with higher pH due to the lower electrostatic attraction between nZnO and soil under higher pH.Meanwhile,the DLVO theory was fitted to describe the above co-transport process of nZnO and Cd(Ⅱ).More attention should be paid to the presence of nZnO on the migration of Cd(Ⅱ) in the natural soil to control the potential risk of nanoparticles and heavy metals to the environment.The risk of co-transport of nZnO and Cd(Ⅱ) might be controlled by adjusting IS and pH in the soil solution. | Min Liao Guo Bin Yixin Luo Yuhao Zhang Kangyou Hu Xiongxiong Lu Xiaomei Xie | 2024 | Acta Geochimica2024，43，1： | 0 |
| 19 | Osmotic-Enhanced-Photoelectrochemical Hydrogen Production Based on Nanofluidics显示文摘Harvesting clean energy such as solar energy and salinity gradient energy directly from the surrounding environment has attracted great attention.A promising proof-of-concept combination of cation-selective membrane-based osmotic energy with photoelectrochemical-based solar energy has been developed,highlighting the great potential for the direct conversion of osmotic energy to hydrogen energy.With the help of a 50-fold concentration gradient,the MXene-CdSe quantum dots system exhibits the highest photocurrent enhancement ratio(Δ/_(L-H)/Δ/_(L-L)),and the hydrogen production is increased by about 33%at a bias of 0 V versus reversible hydrogen electrode.Directly converting osmotic energy and solar energy into hydrogen energy suggests the possibility of coupling osmotic energy with other renewable energy sources. | Pei Liu Xiao-Ya Gao Li-Jun Zhang Weipeng Chen Yuhao Hu Xiang-Yu Kong Xu-Bing Li Liping Wen Chen-Ho Tung Li-Zhu Wu Lei Jiang | 2023 | CCS Chemistry2023，5，9： | 0 |
| 20 | Highly Reversible Zn Metal Anodes Enabled by Increased Nucleation Overpotential显示文摘Dendrite formation severely compromises further development of zinc ion batteries. Increasing the nucleation overpotential plays a crucial role in achieving uniform deposition of metal ions. However, this strategy has not yet attracted enough attention from researchers to our knowledge. Here, we propose that thermodynamic nucleation overpotential of Zn deposition can be boosted through complexing agent and select sodium L-tartrate(Na-L) as example. Theoretical and experimental characterization reveals L-tartrate anion can partially replace H_(2)O in the solvation sheath of Zn^(2+), increasing de-solvation energy. Concurrently, the Na^(+) could absorb on the surface of Zn anode preferentially to inhibit the deposition of Zn^(2+) aggregation. In consequence, the overpotential of Zn deposition could increase from 32.2 to 45.1 mV with the help of Na-L. The Zn-Zn cell could achieve a Zn utilization rate of 80% at areal capacity of 20 mAh cm^(-2). Zn-LiMn_(2)O_(4) full cell with Na-L additive delivers improved stability than that with blank electrolyte. This study also provides insight into the regulation of nucleation overpotential to achieve homogeneous Zn deposition. | Zhengqiang Hu Fengling Zhang Anbin Zhou Xin Hu Qiaoyi Yan Yuhao Liu Faiza Arshad Zhujie Li Renjie Chen Feng Wu Li Li | 2023 | Nano-Micro Letters2023，15，10： | 0 |
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