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| 1 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Flexible and wearable BaTiO_(3)/polyacrylonitrile-based piezoelectric sensor for human posture monitoring显示文摘Tactile sensors are essential components of wearable electronic devices,but there are still various problems in terms of energy supply,flexibility and skin adaptability.In this paper,we report a self-powered flexible tactile sensor(FTS)mainly composed of a BaTiO_(3)/polyacrylonitrile/Ecoflex(BTO/PAN/Ecoflex)composite film,which can be used for dynamically monitoring human plantar pressure,posture and other physiological and motion parameters.Combining the synergistic piezoelectric properties of PAN and BTO,the output voltage/current of the BTO/PAN/Ecoflex composite film is 4.5/5.8 times that of the BTO/Ecoflex composite film,with maximum instantaneous power that can reach up to 3.375μW.Under the action of external pressure stress,the FTS can reach a normalized voltage sensitivity and voltage linearity of 0.54 V/N and 0.98,respectively.Furthermore,a human-machine interaction test system is built,which can display the stress changes of human body monitoring parts in real time according to voltage changes and different color assignments.The developed human-machine interaction test system provides a new idea for the diagnosis of flatfoot and other medical diseases.Hence,this work proposes new FTSs that use a BTO/PAN/Ecoflex composite film with high sensitivity and great output performance,thus exhibiting immense potential application prospects in medical research,personalized recognition and human-machine interaction. | MU JiLiang XIAN Shuai YU JunBin LI ZhengYang ZHAO JuanHong ZHONG JiXin HAN XiaoTao HOU XiaoJuan HE Jian CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，4： | 3 |
| 3 | Monolithic homogeneous integrated miniaturized triboelectric nanogenerator with an inner air cavity for energy harvesting显示文摘To realize the high-efficiency acquisition of environmental mechanical energy,traditional triboelectric nanogenerators(TENGs)based on contact-separation consist of two separate triboelectric layers.Their large contact-separation gap increases the overall volume of the device,making it difficult to realize miniaturization and flexibility.This work,therefore,presents a fully enclosed all-in-one-shaped flexible TENG(FEAST)with an air cavity using rubber mixing and high-temperature vulcanization.The air pressure inside the enclosed air cavity facilitates effective contact-separation of the FEAST.The homogeneous integration between the triboelectric layer and the electrode layer enhances structural firmness without using extra spacer materials.The developed FEAST presents excellent mechanical durability even after 10000 cycles.By increasing the active contact area between the triboelectric materials,a maximum peak-peak output voltage,current,and power density of 130 V,1.1μA,and277 m W/m^(2),respectively,were obtained with an effective stress area of 1 cm2.Moreover,the fully enclosed structure ensures that the output performance is not affected by the external environment.The FEAST was fixed onto the sole of a shoe to demonstrate its applicability in harvesting mechanical energy from human motions.Overall,the developed method provides a simple approach for optimizing the structure of TENGs and is compatible with large-scale manufacturing. | HOU XiaoJuan ZHANG ShengNan YU JunBin YANG ChangJun ZHANG Ning HE Jian CHOU XiuJian | 2021 | Science China(Technological Sciences)2021，64，3： | 3 |
| 4 | A static-dynamic energy harvester for a self-powered ocean environment monitoring application显示文摘Ocean intelligent buoy is important for ocean environment monitoring.With the increase of requisite sensors and transportable data,a long power supply has become a problem to be solved urgently.In this work,a hybrid nanogenerator integrating triboelectric,piezoelectric,electromagnetic,photovoltaic,and thermotropic units is proposed to maximize ocean ambient energy harvesting,which includes static energy(solar and thermal energy)and dynamic energy(wave energy).Compared with a device with a single energy conversion mechanism,this structural design breaks the limit of harvesting time and natural conditions during the energy harvesting process,thereby increasing the harvested energy.Static energy harvesting is realized by the thermoelectric(TG)and photovoltaic(PV)units located inside the device and the PV unit attached to the device surface.Results show that the maximum open-circuit voltage and short-circuit current are 5 V and 41 mA in the external PV and 1.33 V and 49 mA in the internal PV under 30000 Lux illumination,respectively.The open-circuit voltage and short-circuit current of the TG unit are 5 V and 15 m A,respectively.The core component of the dynamic generation unit is the gimbal used to harvest wave energy by the triboelectric nanogenerator(TENG),piezoelectric generator(PENG),and electromagnetic generator.When the frequency is 2.4 Hz,the maximum peak-to-peak power of the TENG,PENG,and EMG are 0.25,1.58,and 13.8 mW,respectively.Finally,an intelligent ocean buoy is fabricated by the integration of an energy harvester,a power management circuit,sensors,a microcontroller,and a wireless communication module.Driven by static and dynamic energy,temperature signal,humidity signal,GPS signal,and sound signal are sent to the receiving terminal wirelessly.The ocean energy harvester proposed in this work is of great significance for ocean energy harvesting and ocean wireless monitoring systems. | XUE Feng CHEN Liang LI ChunCheng REN Jing YU JunBin HOU XiaoJuan GENG WenPing MU JiLiang HE Jian CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，4： | 2 |
| 5 | Influence of synthesis temperatures on the crystalline grain growth and morphology of lanthanum magnesium hexaaluminate显示文摘Lanthanum magnesium hexaaluminate(LaMgAl_(11)O_(19), LMA) was prepared at different temperatures by solid-state reaction. Phase compositions and crystal morphologies of specimens synthesized at different temperatures were investigated using X-ray diffraction(XRD), scanning electron microscopy(SEM). It was observed that the crystalline grain size of LMA was not only dependent on the preparation temperature but also on its powder morphology. In the temperature range of 1300 e1550℃, LMA showed platelet grain and the average crystalline grain size increases with the increase in temperature. At1600℃, if the powder was sintered for two times, the equiaxed grain could be found with the decrease in grain space, resulting in the reduction of the crystalline grain size. Styles of specimens(powder or disk) might have no obvious influence on morphologies and sizes of LMA crystalline grains which were synthesized with the well-dispersed raw material mixtures. The synthesis temperature played a key role in influencing the free space for the formation and growth of crystalline grains. | Junbin Sun Jinshuang Wang Wenzhi Huang Yu Hui Xin Zhou Lifen Li Jianing Jiang Longhui Deng Yunya Niu Shujuan Dong Xueqiang Cao | 2017 | Journal of Rare Earths2017，35，12： | 2 |
| 6 | Synergistic piezoelectricity enhanced BaTiO_(3)/polyacrylonitrile elastomer-based highly sensitive pressure sensor for intelligent sensing and posture recognition applications显示文摘Designing stretchable and skin-conformal self-powered sensors for intelligent sensing and posture recognition is challenging.Here,based on a multi-force mixing and vulcanization process,as well as synergistically piezoelectricity of BaTiO_(3)and polyacrylonitrile,an all-in-one,stretchable,and self-powered elastomer-based piezo-pressure sensor(ASPS)with high sensitivity is reported.The ASPS presents excellent sensitivity(0.93 V/104 Pa of voltage and 4.92 nA/104 Pa of current at a pressure of 10-200 kPa)and high durability(over 10,000 cycles).Moreover,the ASPS exhibits a wide measurement range,good linearity,rapid response time,and stable frequency response.All components were fabricated using silicone,affording satisfactory skinconformality for sensing postures.Through cooperation with a homemade circuit and artificial intelligence algorithm,an information processing strategy was proposed to realize intelligent sensing and recognition.The home-made circuit achieves the acquisition and wireless transmission of ASPS signals(transmission distance up to 50 m),and the algorithm realizes the classification and identification of ASPS signals(accuracy up to 99.5%).This study proposes not only a novel fabrication method for developing self-powered sensors,but also a new information processing strategy for intelligent sensing and recognition,which offers significant application potential in human-machine interaction,physiological analysis,and medical research. | Junbin Yu Shuai Xian Zhenpeng Zhang Xiaojuan Hou Jian He Jiliang Mu Wenping Geng Xiaojun Qiao Le Zhang Xiujian Chou | 2023 | Nano Research2023，16，4： | 2 |
| 7 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 8 | Porous fiber paper and 3D patterned electrodes composed high-sensitivity flexible piezoresistive sensor for physiological signal monitoring显示文摘The research on flexible pressure sensors has drawn widespread attention in recent years,especially in the fields of health care and intelligent robots.In practical applications,the sensitivity of sensors directly affects the precision and integrity of weak pressure signals.Here,a pressure sensor with high sensitivity and a wide measurement range composed of porous fiber paper and 3D patterned electrodes is proposed.Multi-walled carbon nanotubes with excellent conductivity were evenly sprayed on the fiber paper to form the natural spatial conducting networks,while the copper-deposited polydimethylsiloxane films with micropyramids array were used as electrodes and flexible substrates.Increased conducting paths between electrodes and fibers can be obtained when high-density micro-pyramids fall into the porous structures of the fiber paper under external pressure,thereby promoting the pressure sensor to show an ultra-high sensitivity of 17.65 kPa^(-1)in the pressure range of 0–2 kPa,16 times that of the device without patterned electrodes.Besides,the sensor retains a high sensitivity of 2.06 kPa^(-1)in an ultra-wide measurement range of 150 kPa.Moreover,the sensor can detect various physiological signals,including pulse and voice,while attached to the human skin.This work provides a novel strategy to significantly improve the sensitivity and measurement range of flexible pressure sensors,as well as demonstrates attractive applications in physiological signal monitoring. | HOU XiaoJuan ZHONG JiXin HE Jian YANG ChangJun YU JunBin MEI LinYu MU JiLiang GENG WenPing CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，5： | 2 |
| 9 | CdS magic-size clusters exhibiting one sharp ultraviolet absorption singlet peaking at 361 nm显示文摘We report,for the first time,the synthesis of CdS magic-size clusters (MSCs) which exhibit a single sharp absorption peaking at ~ 361 nm,along with sharp band edge photoemission at ~ 377 nm and broad trap emission peaking at ~ 490 nm.These MSCs are produced in a singleensemble form without the contamination of conventional quantum dots (QDs) and/or other-bandgap clusters.They are denoted as MSC-361.We present the details of several controlled syntheses done in oleylamine (OLA),using C,d(NO3)2 or C,d(OAc)2 as a C,d source and thioacetamide (TAA) or elementary sulfur (S) as a S source.A high synthetic reproducibility of the reaction of Cd(NO3)2 and TAA to single-ensemble MSC-361 is achieved,the product of which is not contaminated by other bandgap clusters and/or QDs.In some cases,the reaction product exhibits an additional absorption peak at ~ 322 nm.We demonstrate that the two peaks,at 361 and 322 nm,do not evolve synchronously.Therefore,the 322 nm peak is not a higher order electronic transition of MSC-361,but due to the presence of another ensemble,namely MSC-322.The present study suggests that there is an outstanding need for the development of a physical model to narrow the knowledge gap regarding the electronic structure in these colloidal semiconductor CdS MSCs. | Junbin Tang Juan Hui Meng Zhang Hongsong Fan Nelson Rowell Wen Huang Yingnan Jiang Xiaoqin Chen Kui Yu | 2019 | Nano Research2019，12，6： | 1 |
| 10 | Electromechanical coupling properties of a self-powered vibration sensing device for near-surface observation tower monitoring显示文摘The wind-induced vibration of a remote sensing tower is the key factor affecting the stability of image sensing and structural reliability. Monitoring the vibration of a long-time unattended tower is critical to its proper operation. Currently, most monitoring devices are supplied with wired power or battery, significantly limiting their practical applications in remote areas. In this paper,a self-powered vibration sensing device based on hybrid electromechanical conversion mechanisms is proposed. The device depends on a cylindrical magnetic levitation structure sensitive to ambient vibration for transferring mechanical energy and is taken as a dual-functional heterogeneous integrated system comprising electromagnetic, piezoelectric, and triboelectric generators. When the device vibrates under environmental force driving, the suspension magnet reciprocates vertically and generates induced electromagnetic energy, which is used to power the device. Moreover, the triboelectric and piezoelectric voltages,respectively originating from magnet impact on two separation friction materials and magnetic field repulsion-induced strain deformation of a piezoelectric sheet, are used as the synergistic sensing signals. To improve the output energy, a set of dualsegmented annular coils is designed in an electromagnetic generator, which greatly avoids the obstructive effect of the suspended magnet on the magnetic flux change at its end. Compared with a whole isochoric coil, it increases the output voltage by 78.3%.For the triboelectric sensing module, a silicone film with a large specific surface area is fabricated via 3D modification, which improves the output voltage by 29.4%. Furthermore, a pair of piezoelectric sensing modules is set to improve the accuracy of comparative sensing data. The experimental measurement shows that the device maintains a high sensitivity of 6.711 V(m s;);and excellent linearity of 0.991 in the range of 0–14 m s;. This work provides a practical strategy for the vibration monitoring of remote sensing towers and exhibits attractive potential in early warning and data analysis. | MU JiLiang HE HuiCheng MU JinBiao HE Jian SONG JinSha HAN XiaoTao FENG ChengPeng ZOU Jie YU JunBin CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，7： | 1 |
| 11 | A Unified Time Scale Intelligent Control Algorithm for Microgrid Based on Extreme Dynamic Programming显示文摘Benefiting from the progress of power electronics technology,distributed generation technology is developing rapidly.Since microgrids cannot rely on traditional multi-time scale control strategies to ensure the high-quality frequency stability control and economic dispatch in the same time scale,this paper proposes an extreme dynamic programming algorithm.The proposed algorithm takes an adaptive dynamic programming algorithm as the framework,an extreme learning machine as a kernel of the evaluation module,a model module,an implementation module and a new prediction module.The resulting unified time scale intelligent control algorithm better realizes the combined functions of“droop control+automatic generation control+economic dispatch”in the traditional opermode.Finally,in order to verify the effectiveness of the proposed algorithm,a microgrid model of 8 nodes is simulated.The results confirm the feasibility and validity of the proposed extreme dynamic programming algorithm. | Junbin Chen Tao Yu Linfei Yin Jianlin Tang Hanqi Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 0 |
| 12 | Hybrid electromechanical properties of hetero-doped and homogeneously bonded dual-mode pressure sensor for indoor body area network node显示文摘Pressure sensors are considerably important for continuous monitoring of human movement and the surrounding environment to construct a caregiving system for the elderly living alone.The challenge for pressure sensors that still remains is combining self-driven,comfort,and multifunctionalization.Herein,an all-in-one conformal pressure sensor(ACPS) based on a homogeneous integrated triboelectric-piezoelectric hybrid sensor is proposed.The ACPS has dual-mode sensing properties due to coupling triboelectrification and piezoelectric effect ensuring a stable response to various external stimulations.Silver-coated glass microspheres and polyacrylonitrile were uniformly filleted into the silicone rubber substrate using a hetero-doping method to create a stretchable electrode layer with flexible conformal characteristics and a piezoelectric layer with excellent piezoelectric properties,respectively.Meanwhile,the triboelectric layer was fabricated using the same silicone rubber,allowing ACPS to be homogeneously bonded into an all-in-one structure with reliable durability.This allowed various functional layers to have outstanding interface characteristics and thus improve the electrical transmission effect.The developed ACPS had outstanding sensitivity(1.04 V/10~4Pa),high linearity(about 0.984),a wide measurement range(10–700 k Pa),and can accurately and continuously distinguish multiple movements.Furthermore,using a homemade signal processing circuit,ACPSs can be deployed in the human body and the room as indoor body area network nodes.When successfully applied to the remote tracking of daily dynamic home life and the remote operation of small electrical equipment,these ACPSs can achieve real-time caregiving for the elderly living alone.As an application area desperately needed by society,this study envisions a caregiving system for the elderly living alone without violating personal privacy. | Junbin YU Shuai XIAN Jinbiao MU Min WANG Yin WANG Xiaojuan HOU Le ZHANG Jian HE Jiliang MU Xiujian CHOU | 2024 | Science China(Information Sciences)2024，67，1： | 0 |
| 13 | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys显示文摘Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. | Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang Fangyu Luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 14 | Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern显示文摘Variants are globally emerging very quickly following pandemic prototypic SARS-CoV-2.To evaluate the cross-protection of prototypic SARS-CoV-2 vaccine against its variants,we vaccinated rhesus monkeys with three doses of prototypic SARS-CoV-2 inactivated vaccine,followed by challenging with emerging SARS-CoV-2 variants of concern(VOCs). | Tianhong Xie Shuaiyao Lu Zhanlong He Hongqi Liu Junbin Wang Cong Tang Ting Yang Wenhai Yu Hua Li Yun Yang Hao Yang Lei Yue Yanan Zhou Fengmei Yang Zhiwu Luo Yanyan Li Hong Xiang Yuan Zhao Jie Wang Haixuan Wang Runxiang Long Dexuan Kuang Wenjie Tan Xiaozhong Peng Qihan Li Zhongping Xie | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 15 | Stretchable and skin-conformal piezo-triboelectric pressure sensor for human joint bending motion monitoring显示文摘Stretchable,skin-conformal,and self-powered wearable pressure sensors have garnered significant attention for use in human joint bending motion monitoring.Here,a piezo-triboelectric pressure sensor(P-TPS)based on triboelectric nanogenerator and piezoelectric nanogenerator is demonstrated.The P-TPS can generate an enhanced electrical output by coupling the dual-mode triboelectrification and piezoelectric effect.The P-TPS shows high sensitivity(voltage=0.3 V/kPa;current=4.3 nA/kPa;pres-sure range=0-200 kPa),high linearity,and good stability.Furthermore,it demonstrates a wide mea-surement range(0-800 kPa),table frequency response,and fast response time.Additionally,all components of the P-TPS are fabricated using flexible and stretchable materials,affording satisfactory stretchability and excellent skin conformality.Owing to their ability to self-power,they can be attached to the outside of joints to monitor human joint bending movements in real time.Hence,this study provides a novel method of using a stretchable and skin-conformal piezo-triboelectric nanogenerator with high electrical performance as a self-powered pressure sensor,which offers significant potential in personalized recognition,medical research,and human machine interface. | Junbin Yu Liang Chen Xiaojuan Hou Jiliang Mu Jian He Wenping Geng Xiaojun Qiao Xiujian Chou | 2022 | Journal of Materiomics2022，8，2： | 0 |
| 16 | BCL9 regulates CD226 and CD96 checkpoints in CD8^(+)T cells to improve PD-1 response in cancer显示文摘To date,the overall response rate of PD-1 blockade remains unsatisfactory,partially due to limited understanding of tumor immune microenvironment(TIME).B-cell lymphoma 9(BCL9),a key transcription co-activator of the Wnt pathway,is highly expressed in cancers.By genetic depletion and pharmacological inhibition of BCL9 in tumors,we found that BCL9 suppression reduced tumor growth. | Mei Feng Zhongen Wu Yan Zhou Zhuang Wei Enming Tian Shenglin Mei Yuanyuan Zhu Chenglong Liu Fenglian He Huiyu Li Cao Xie Joy Jin Jibin Dong Dehua Yang Ker Yu Junbin Qian Diether Lambrechts Ming-Wei Wang Di Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 0 |
| 17 | Research Progress in Laboratory of RIB Physics in 2019显示文摘The progress of research going on in Laboratory of Rare Isotope Beam Physics(RIB),Nuclear Physics Research Center,in 2019 is in the following three aspects. | Sun Zhiyu Yang Yanyun Zhang Xueheng Yu Yuhong Wang Shitao Tang Shuwen Hu Jun Hou Suqin Xu Shiwei Yan Duo Fang Fang Zhang Yongjie Bai Zhen Ma Junbin Ma Shaobo | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 18 | Front-end readout electronics system of ProtoDUNE-SP LAr TPC显示文摘Purpose As a prototype of Deep Underground Neutrino Experiment far detector,ProtoDUNE single-phase Liquid Argon(LAr)Time Projection Chamber(TPC)sits in H4 beam line at CERN to characterize detector response.It consists of 6 full-size Anode Plane Assemblies(APAs)plus 18 Cathode Plane Assembly(CPA)modules to form two 3.6-m drift regions with a total of 15,360 readout channels.To achieve a good signal-to-noise ratio with this noble liquid detector(770ton LAr),cold electronics developed at BNL for extremely low temperature(77K–89K)operation is an optimal solution,which decouples the electrode and cryostat design from the readout design.Methods With CMOS front end ASICs integrated with the TPC electrodes,the electronic noise is independent of the fiducial volume and much lower than with readout electronics at room temperature.In addition,signal digitization and multiplexing to high-speed links inside the cryostat result in large reduction in the quantity of cables and the number of cryostat penetrations,giving the designers of both the TPC and the cryostat the freedom to choose the optimum configurations.Results and conclusions By April 2018,we have successfully instrumented 6 APAs with cold electronics,and the results of the integration test before the final installation in the cryostat look very promising. | Hans-Gerd Berns Hucheng Chen Alessio D’Andragora Jack Fried Daniel Gastler S.Gao Eric Hazen Wenbin Hou Shaorui Li Feng Liu Veljko Radeka Maura Spanu Emerson Vernon Elizabeth Worcester Matthew Worcester Krithika Yethiraj Bo Yu Junbin Zhang | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
| 19 | Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs from Infected Rhesus Macaques显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused the persistent coronavirus disease 2019(COVID-19)pandemic,which has resulted in millions of deaths worldwide and brought an enormous public health and global economic burden.The recurring global wave of infections has been exacerbated by growing variants of SARS-CoV-2.In this study,the virological characteristics of the original SARS-CoV-2 strain and its variants of concern(VOCs;including Alpha,Beta,and Delta)in vitro,as well as differential transcriptomic landscapes in multiple organs(lung,right ventricle,blood,cerebral cortex,and cerebellum)from the infected rhesus macaques,were elucidated.The original strain of SARS-CoV-2 caused a stronger innate immune response in host cells,and its VOCs markedly increased the levels of subgenomic RNAs,such as N,Orf9b,Orf6,and Orf7ab,which are known as the innate immune antagonists and the inhibitors of antiviral factors.Intriguingly,the original SARS-CoV-2 strain and Alpha variant induced larger alteration of RNA abundance in tissues of rhesus monkeys than Beta and Delta variants did.Moreover,a hyperinflammatory state and active immune response were shown in the right ventricles of rhesus monkeys by the up-regulation of inflammation-and immune-related RNAs.Furthermore,peripheral blood may mediate signaling transmission among tissues to coordinate the molecular changes in the infected individuals.Collectively,these data provide insights into the pathogenesis of COVID-19 at the early stage of infection by the original SARS-CoV-2 strain and its VOCs. | Tingfu Du Chunchun Gao Shuaiyao Lu Qianlan Liu Yun Yang Wenhai Yu Wenjie Li Yong Qiao Sun Cong Tang Junbin Wang Jiahong Gao Yong Zhang Fangyu Luo Ying Yang Yun-Gui Yang Xiaozhong Peng | 2023 | Genomics, Proteomics & Bioinformatics2023，21，5： | 0 |
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