|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | 急性阑尾炎显示文摘截止至 2 0 0 2年 6月 ,有关阑尾炎治疗的临床证据如下 :①辅助性抗生素治疗 :1项RCT和 1项回顾性RCT发现 ,经阑尾切除术的复杂性和单纯性阑尾炎的成人和儿童 ,预防性使用抗生素可显著减少伤口感染和腹腔内脓肿。②辅助性抗生素治疗 (儿童复杂性阑尾炎 ) :1项系统评价的亚组分析发现 ,使用抗生素可显著减少伤口感染。③辅助性抗生素治疗 (儿童单纯性阑尾炎 ) :1项系统评价的亚组分析发现 ,使用抗生素不减少伤口感染。 1项儿童单纯性阑尾炎的回顾性RCT发现 ,预防性使用抗生素不能减少伤口感染 ,但该RCT的样本量太小 ,不能排除有临床差别。④抗生素治疗和手术 :1项成人疑诊阑尾炎的RCT发现 ,与手术治疗比较 ,抗生素保守治疗可减少治疗开始后 12h到 10d的疼痛和吗啡的使用。但采取抗生素保守治疗的患者有 35 %在 1年内再次因急性阑尾炎入院 ,并行阑尾切除术。⑤腹腔镜手术和开腹手术 (成人 ) :1项系统评价发现 ,腹腔镜手术可以减少伤口的感染 ,减轻手术后第 1天的疼痛 ,减少住院时间以及恢复工作的时间 ,但增加手术后腹腔内脓肿的发生。⑥腹腔镜手术和开腹手术 (儿童 ) :1项系统评价发现 ,腹腔镜手术可以减少伤口的感染 ,减少住院时间 ,但不能减轻手术后第 1天的疼痛 ,不能减少恢复的时间和腹腔内脓肿的发? | John Simpson William Speake 王慧 周焱 董碧蓉 | 2004 | 中国循证医学杂志2004，4，5： | 10 |
| 3 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 4 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 5 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 6 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 7 | Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease显示文摘 | John J. Kim Nicole Simpson Nancy Klipfel Renee DeBose Nancy Barr Loren Laine | 2010 | Digestive Diseases and Sciences2010，，4： | 2 |
| 8 | Aromatase expression in endometriosis显示文摘 | Simpson ER John A | 1996 | J Clin Endocrinol Metab1996，81，： | 1 |
| 9 | Aromatase expression in endometriosis显示文摘 | Noble LS Simpson ER Johns A | 1996 | Clin Endocrinol Metab1996，81，： | 1 |
| 10 | Long-Term Trends in First Hospitalization for Heart Failure and Subsequent Survival Between 1986 and 2003: A Population Study of 5.1 Million People显示文摘 | Pardeep S. Jhund Kate MacIntyre Colin R. Simpson James D. Lewsey Simon Stewart Adam Redpath James W.T. Chalmers Simon Capewell John J.V. McMurray | 2009 | Circulation2009，，4： | 1 |
| 11 | Did May Company' s Acquisition of Associated Dry Goods Corporation Reduce Competition? --An Event Study Analysis显示文摘 | Simpson John David | 2001 | Review of Industrial Organization2001，，18： | 1 |
| 12 | Electrospinning of poly(ethylene-co-vinyl alcohol) fibers显示文摘 | El-Refaie Kenawy John M. Layman Jessica R. Watkins Gary L. Bowlin Jamil A. Matthews David G. Simpson Gary E. Wnek | 2002 | Biomaterials2002，，6： | 1 |
| 13 | Three-dimensional echocardiography in congenital heart disease显示文摘 | John M. Simpson Owen Miller | 2011 | Archives of Cardiovascular Diseases2011，，1： | 1 |
| 14 | Aromatase expression in endometriosis显示文摘 | Noble LS Simpson ER Johns A | 1996 | J Clin Endocrinol Metab1996，81，： | 1 |
| 15 | Outcomes of systemic to pulmonary artery shunts in patients weighing less than 3 kg: Analysis of shunt type, size, and surgical approach显示文摘 | John W. Myers Nancy S. Ghanayem Yumei Cao Pippa Simpson Katie Trapp Michael E. Mitchell James S. Tweddell Ronald K. Woods | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，： | 1 |
| 16 | Associations Between Inflammation and Cognitive Function in African Americans and European Americans显示文摘 | B. Gwen Windham Brittany N. Simpson Seth Lirette John Bridges Lawrence Bielak Patricia A. Peyser Iftikhar Kullo Stephen Turner Michael E. Griswold Thomas H. Mosley | 2014 | J Am Geriatr Soc2014，，： | 1 |
| 17 | Patterns of recurrence of congenital heart disease显示文摘 | Harinder K Gill Miranda Splitt Gurleen K Sharland John M Simpson | 2003 | Journal of the American College of Cardiology2003，，： | 1 |
| 18 | Effects of Pulp Preconditioning on Total Polyphenols, O-diphenols and Anthocyanin Concentrations during Fermentation and Drying of Cocoa (Theobroma cacao) Beans显示文摘 | Emmanuel Ohene Afoakwa John Edem Kongor Jemmy Felix Takrama Agnes Simpson Budu Henry Mensah-Brown | 2013 | Journal of Food Science and Engineering2013，3，5： | 1 |
| 19 | S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity显示文摘 | Zheng Yang Wei Xing Yan Hong Cai Nicodemus Tedla Chris Armishaw Nick Di Girolamo Hong Wei Wang Taline Hampartzoumian Jodie L. Simpson Peter G. Gibson John Hunt Prue Hart J. Margaret Hughes Michael A. Perry Paul F. Alewood Carolyn L. Geczy | 2007 | The Journal of Allergy and Clinical Immunology2007，，1： | 1 |
| 20 | Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion显示文摘 | Ghassan Mouneimne Scott D. Hansen Laura M. Selfors Lara Petrak Michele M. Hickey Lisa L. Gallegos Kaylene J. Simpson James Lim Frank B. Gertler John H. Hartwig R. Dyche Mullins Joan S. Brugge | 2012 | Cancer Cell2012，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员