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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Adult myelination: wrapping up neuronal plasticity显示文摘In this review, we outline the major neural plasticity mechanisms that have been identified in the adult central nervous system(CNS), and offer a perspective on how they regulate CNS function. In particular we examine how myelin plasticity can operate alongside neurogenesis and synaptic plasticity to influence information processing and transfer in the mature CNS. | Megan O’Rourke Robert Gasperini Kaylene M.Young | 2014 | Neural Regeneration Research2014，9，13： | 6 |
| 3 | Economic feasibihty of producing ethanol from hgnoceUu- losic feedstocks 显示文摘 | KAYLEN M VAN DYNE D L CHOI Y S | 2000 | Bioresource Technology2000，72，1： | 1 |
| 4 | Economic feasibility of producing ethanol from lignocellulosic feedstocks显示文摘 | KAYLEN M VAN DYNE D L CHOI Y S | 2000 | Bioresource Technology2000，72，： | 1 |
| 5 | NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoim mune encephalomyelitis model of demyelinating disease显示文摘 | Richa BT Leanne ER Kaylene M | | 0，，： | 1 |
| 6 | Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion显示文摘 | Ghassan Mouneimne Scott D. Hansen Laura M. Selfors Lara Petrak Michele M. Hickey Lisa L. Gallegos Kaylene J. Simpson James Lim Frank B. Gertler John H. Hartwig R. Dyche Mullins Joan S. Brugge | 2012 | Cancer Cell2012，，5： | 1 |
| 7 | Generation of afunctional mammary gland from a single stem cell显示文摘 | MARK S FRANCOIS V KAYLENE JS | 2006 | Nature2006，439，7072： | 1 |
| 8 | Economic feasibility of producing ethanol from lignocellulosic feedstocks显示文摘 | Donald L Van Dyne Youn-Sang Choi Melvin Blase | 2000 | Bioresource Technology2000，72，： | 1 |
| 9 | Carbon nanostructures: An efficient hydrogen storage medium for fuel cells 显示文摘 | Kaylene A Siegmar R Michael H | 2001 | Fuel Cells Bulletin2001，4，38： | 1 |
| 10 | Vector autoregression forecasting models:recent developments applied to the U S hog market显示文摘 | Kaylen M S | 1988 | American Journal of Agricultural Economics1988，70，3： | 1 |
| 11 | Economic feasibility of producing ethanol from lignocellulosic feedstocks显示文摘 | KAYLEN M DONALD L DYNE V | 2000 | Bioresource Technology2000，72，1： | 1 |
| 12 | Economic feasibility of producing ethanol from lignocellulosic feedstocks显示文摘 | KAYLEN M | 2000 | Bioresource Technology2000，，72： | 1 |
| 13 | Benefits of Liraglutide Treatment in Overweight and Obese Older Individuals With Prediabetes显示文摘 | Sun H. Kim Fahim Abbasi Cindy Lamendola Alice Liu Danit Ariel Patricia Schaaf Kaylene Grove Vanessa Tomasso Hector Ochoa Yeheng V. Liu Yii-Der Ida Chen Gerald Reaven | 2013 | Diabetes Care2013，，10： | 1 |
| 14 | Communication style in the salesperson-customer dyad显示文摘 | WILLIAMS KAYLENE C SPIRO ROSANN L | 1985 | Journal of Marketing Research1985，，22： | 1 |
| 15 | Farm-level Analysis of Agricultural Insurance显示文摘 | Kaylen Loehman & Preckel | 1989 | Agricultural Systems1989，30，3： | 1 |
| 16 | Economic feasibility of producing ethanol from lignocellulosic feedstocks显示文摘 | Kaylen Michael | 2000 | Bioresource Technology2000，72，： | 1 |
| 17 | The Value of PublicInformation for Microeconomic Production Decisions 显示文摘 | Preckel P V Loehman E T Kaylen M S | 1987 | West-ern Joumal of Agricultural Economics1987，，： | 1 |
| 18 | Economic feasibility of producing ethanol from lignocellulosic feedstocks显示文摘 | Kaylen Michael Donald L Dyne Van | 2000 | Bioresource Technology2000，72，： | 1 |
| 19 | Pancreatic beta cell function following liraglutide-augmented weight loss in individuals with prediabetes: analysis of a randomised, placebo-controlled study显示文摘 | Sun H. Kim Alice Liu Danit Ariel Fahim Abbasi Cindy Lamendola Kaylene Grove Vanessa Tomasso Gerald Reaven | 2014 | Diabetologia2014，，3： | 1 |
| 20 | Benefits of Liraglutide Treatment in Overweight and Obese Older Individuals With Prediabetes显示文摘 | Sun H. Kim Fahim Abbasi Cindy Lamendola Alice Liu Danit Ariel Patricia Schaaf Kaylene Grove Vanessa Tomasso Hector Ochoa Yeheng V. Liu Yii-Der Ida Chen Gerald Reaven | 2013 | Diabetes Care2013，，10： | 1 |
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