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| 1 | Inequality and the Urban-rural Divide in China:Effects of Regressive Taxation显示文摘Using three comparable national representative household surveys for China in 1988,1995 and 2002, the present paper reveals the regressivity and urban bias of China's directtax and welfare system in this period.It shows that a regressive taxation system and skewedallocation of subsidies increases the urban-rural income gap and enhances overall inequality.Modeling these relationships indicates that the relatively poorer rural population has a nettax liability, whereas those in the richer urban areas receive net subsidies.This pattern iscommon in China, although the extent of the bias varies.This skewed system of tax andwelfare payments is a major cause of the persisting urban-rural income gap and contributesto the overall income inequality in China.The abolishment of the agriculture tax in 2006 hashad a positive impact on rural people's livelihoods. | Jenifer Piesse | 2010 | China & World Economy2010，18，6： | 6 |
| 2 | Isolation and characterization of halophilic Bacillus sp.BS3 able to produce pharmacologically important biosurfactants显示文摘Objective:To characterize the pharmacological importance of biosurfactants isolated from halophilic Bacillus sp BS3.Methods:Halophilic Bacillus sp.BS3 was isolated from solar salt works,identified by 16S rRNA sequencing and was used for screening their biosurfactant production.Characters of the biosurfactant and their anticancer activity were analyzed and performed in mammary epithelial carcinoma cell at different concentrations.Results:The biosurfactant were characterized by TLC,FTIR and GC-MS analysis and identified as lipopeptide type.GC-MS analysis revealed that,the biosurfactant had various compounds including 13Docosenamide.(Z);Mannosamine,9- and N,N,N',N'-tetramethyl.Surprisingly the antiviral activity was found against shrimp white spot syndrome virus(WSSV) by suppressing the viral replication and significantly raised shrimp survival(P<0.01).Anticancer activity performed in the mammary epithelial carcinoma cell at different concentrations of biosurfactants,among the various concentrations of biosurfactants such as 0.000 25,0.002 5,0.025,0.25 and 2.5 μ g,the 0.25 μ g concentration suppressed the cells significantly(P<0.05) to 24.8%.Conclusions:Based on the findings,the present study concluded that,there is a possibility to develop eco-friendly antimicrobial and anticancer drugs from the extremophilic origin. | MBS Donio SFA Ronica V Thanga Viji S Velmurugan J Adlin Jenifer M Michaelbabu T Citarasu | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，11： | 5 |
| 3 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 4 | Three-dimensional structure determination of capsid of Aedes albopicus C6/36 cell densovirus显示文摘The three-dimensional structure of capsid of Aedes albopictus C6/36 densovirus was determined to 14- resolution by electron cryomicroscopy and computer reconstruction. The triangulation number of the capsid is 1. There are 12 holes in each triangular face and a spike on each 5-fold vertex. The validity of the capsid and nucleic acid densities in the reconstructions was discussed. | CHENG Lingpeng1, CHEN Senxiong1, Jenifer M. Brannan2, Joanita Jakana3, ZHANG Qinfen1, Z. H. Zhou2 & ZHANG Jingqiang1 1. State Key Laboratory for Bio-control, Zhongshan University, Guangzhou 510275, China 2. Department of Pathology, Medicine University of Texas-Huston Medical School, Huston, TX77030, USA 3. National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX77, USA | 2004 | Science China(Life Sciences)2004，47，3： | 4 |
| 5 | Combating CHK1 resistance in triple negative breast cancer:EGFR inhibition as potential combinational therapy显示文摘Triple negative breast cancer(TNBC)is marked by a lack of expression of the Estrogen Receptor,Progesterone Receptor,and human epidermal growth factor receptor 2.Therefore,targeted therapies are being investigated based on the expression profiles of tumors.Due to the potential for acquired and intrinsic resistance,there is a need for combination therapy to overcome resistance.In the article by Lee et al.,the authors identify that,while prexasertib(a CHK1 inhibitor)lacks efficacy alone,combination with an EGFR inhibitor provides synergistic anti-tumor effects.Advances in targeted therapy for TNBC will benefit the clinical landscape for this disease,with this study initiating a new avenue of investigation. | Casey D.Stefanski Jenifer R.Prosperi | 2022 | Cancer Drug Resistance2022，5，1： | 3 |
| 6 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 7 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 8 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 9 | Antibiotic Prophylaxis for Gi Endoscopy显示文摘 | Mouen A. Kashab Ruben D. Acosta David H. Bruining Vinay Chandrasekhara Krishnavel V. Chithadi Mohamad A. Eloubeidi Robert D. Fanelli S.A.G.E.S. Representative Ashley L. Faulx Lisa Fonkalsrud Jenifer R. Lightdale V. Raman Muthusamy Shabana F. Pasha John R. | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 10 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 11 | Measuring nursing competence ; development of a self-assessmenttool for general nurses across Europe显示文摘 | Cowan DT Jenifer Wilson-Bamett D Norman U | 2008 | Int J Nurs Stud2008，45，6： | 1 |
| 12 | Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs显示文摘 | Xian Chen Jason S Cordes Jenifer A | 2006 | Pharmacol Toxicol Methods2006，54，3： | 1 |
| 13 | Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis显示文摘 | Jenifer L Mahnke Yusoff D | 2000 | Fertil steril2000，73，： | 1 |
| 14 | Measuring nursing competence:development of a self-assessment tool for general nurses across Europe显示文摘 | Cowan D T Jenifer Wilson-Barnett D Norman I J | 2008 | Int J Nurs Stud2008，45，6： | 1 |
| 15 | Agency Cost And Innovation Some Empiricial Evindence显示文摘 | | 1995 | Journal of Accounting and Economics1995，，： | 1 |
| 16 | The role of endoscopy in Barrett’s esophagus and other premalignant conditions of the esophagus显示文摘 | John A. Evans Dayna S. Early Norio Fukami Tamir Ben-Menachem Vinay Chandrasekhara Krishnavel V. Chathadi G. Anton Decker Robert D. Fanelli Deborah A. Fisher Kimberly Q. Foley Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Jenifer Lightdale Phyllis M | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 17 | Severity of bacterial vaginosis and the risk of sexually transmitted infection显示文摘 | Jenifer E. Allsworth Jeffrey F. Peipert | 2011 | American Journal of Obstetrics and Gynecology2011，，2： | 1 |
| 18 | Class-Based n-gram Models of Natural Language显示文摘 | PETER F B VINCENT J D P PETER V D JENIFER C L ROBERT L M | 1992 | Computational Linguistics1992，，： | 1 |
| 19 | An error correction model of induced innovation in UK agriculture 显示文摘 | Jenifer P David S Colin T | 2011 | Applied Economics2011，43，1： | 1 |
| 20 | A European survey of gen- eral nurses' self assessment of competence 显示文摘 | David T Cowan A Jenifer WB | 2007 | Nurse Educ To day2007，27，： | 1 |
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