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| 1 | Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma显示文摘Primary liver cancer is the fifth most common malignan- cy in the world and is a leading cause of cancer-related mortality.Available treatment for hepatocellular carcino- ma(HCC),the commonest primary liver cancer,is rarely curative and there is a need to develop therapy that is more effective.Specific and powerful gene silencing that can be achieved by activating RNA interference(RNAi) has generated enthusiasm for exploiting this pathway for HCC therapy.Many studies have been carried out with the aim of silencing HCC-related cellular oncogenes or the hepatocarcinogenic hepatitis B virus(HBV)and hepatitis C virus(HCV).Proof of principle studies have demonstrated promising results,and an early clinical trial assessing RNAi-based HBV therapy is currently in progress.Although the data augur well,there are several significant hurdles that need to be overcome before the goal of RNAi-based therapy for HCC is realized.Particu- larly important are the efficient and safe delivery of RNAi effecters to target malignant tissue and the limitation of unintended harmful non-specific effects. | Patrick Arbuthnot Liam Jed Thompson | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | 监控所有智能电表的重要性显示文摘本文介绍了电表的基本原理,以及精度对电表的重要性。介绍了一种可以避免窃电的解决方法。 | Jed Hurwitz | 2016 | 电子产品世界2016，23，1： | 5 |
| 3 | 中国启东肝癌预防:黄曲霉毒素生物标志物研究的经验(英文)显示文摘原发性肝癌一直是中国启东癌症死亡的首要原因,这一地区的110万居民中大约每年有800人死于原发性肝癌。流行病学研究已经强调了乙肝病毒感染和肝致癌物黄曲霉素的饮食暴露在启东和其他流行地区作为关键相互作用的风险决定因素的重要性。由于生物标志物的发展,使得在病例对照研究和其他群体研究中可以检测这些风险因素的流行程度。20世纪80年代曾经在启东进行了乙肝病毒疫苗接种试点,但直到本世纪初才在新生儿上普遍接种。尽管目前疫苗接种对癌症死亡率的影响微乎其微,但该项目旨在减缓这一地区未来几代人肝脏疾病包括肝癌的发展。减少对黄曲霉毒素暴露的策略也是必需的,尤其是对于那些已经感染乙肝病毒的人群。我们已经进行了一系列原理验证性的临床试验,包括使用药物、膳食补充剂和食物来改变不可避免的暴露后黄曲霉素的代谢及排出。使用黄曲霉素生物标志物作为中间指标,奥替普拉、叶绿素和西兰花豆芽饮料已被证明有效,突出了低成本化学预防途径在预防环境致癌中的作用。值得注意的是,最近对存档的血清样本的回顾性分析表明,启东的黄曲霉素暴露在过去的25年里下降了40倍,这可能是由从玉米到大米的主食变化带来的。因此,一级预防,伴随着20世纪80年代经济和农业政策改变的作用,带来了出乎意料的在短时间内消除这个地区肝癌地方性流行的希望。 | Patricia A.Egner 王金兵 朱源荣 Lisa P.Jacobson Derek Ng Alvaro Munoz Jed W.Fahey 陈建国 陈陶阳 钱耕荪 John D.Groopman Thomas W.Kensler | 2013 | 化学进展2013，25，9： | 5 |
| 4 | Comparison Between Reconstructions of Global Anthropogenic Land Cover Change over Past Two Millennia显示文摘Three global datasets, the History Database of the Global Environment (HYDE), Kaplan and Krumhardt (KK) and Pongratz of reconstructed anthropogenic land cover change (ALCC) were introduced and compared in this paper. The HYDE dataset was reconstructed by Goldewijk and his colleagues at the National Institute of Public Health and the Environment in Netherland, covering the past 12 000 years. The KK dataset was reconstructed by Kaplan and his colleagues, the Soil-Vegetation-Atmosphere Research Group at the Institute of Environmental Engineering in Switzerland, covering the past 8000 years. The Pongratz dataset was reconstructed by Pon-gratz and her colleagues at the Max Planck Institute for Meteorology in Germany, covering AD 800-1992. The results show that the reconstructed datasets are quite different from each other due to the different methods used. The three datasets all allocated the historical ALCC according to human population density. The main reason causing the differences among the three datasets lies on the different relationships between population density and land use used in each reconstructed dataset. The KK dataset is better than the other two datasets for two important reasons. First, it used the nonlinear relationship between population density and land use, while the other two used the linear relationship. Second, Kaplan and his colleagues adopted the technological development and intensification parameters and considered the wood harvesting and the long-term fallow area resulted from shifting cultivation, which were neglected in the reconstructions of the other two datasets. Therefore, the KK dataset is more suitable as one of the anthropogenic forcing fields for climate simulation over the past two millennia that is recently concerned by two projects, the National Basic Research Program and the Strategic and Special Frontier Project of Science and Technology of the Chinese Academy of Sciences. | YAN Mi WANG Zhiyuan Jed Oliver KAPLAN LIU Jian MIN Shen WANG Sumin | 2013 | Chinese Geographical Science2013，23，2： | 2 |
| 5 | Salt Tolerance and Crop Potential of Halophytes显示文摘 | Edward P. Glenn J. Jed Brown Eduardo Blumwald | 1999 | Critical Reviews in Plant Sciences1999，，2： | 2 |
| 6 | Identifying viruses from metagenomic data using deep learning显示文摘Background:The recent development of metagenomic sequencing makes it possible to massively sequence microbial genomes including viral genomes without the need for laboratory culture.Existing reference-based and gene homology-based methods are not efficient in identifying unknown viruses or short viral sequences from metagenomic data.Methods:Here we developed a reference-free and alignment-free machine learning method,DeepVirFinder,for identifying viral sequences in metagenomic data using deep learning.Results'.Trained based on sequences from viral RefSeq discovered before May 2015,and evaluated on those discovered after that date,DeepVirFinder outperformed the state-of-the-art method VirFinder at all contig lengths,achieving AUROC 0.93,0.95,0.97,and 0.98 for 300,500,1000,and 3000 bp sequences respectively.Enlarging the training data with additional millions of purified viral sequences from metavirome samples further improved the accuracy for identifying virus groups that are under-represented.Applying DeepVirFinder to real human gut metagenomic samples,we identified 51,138 viral sequences belonging to 175 bins in patients with colorectal carcinoma(CRC).Ten bins were found associated with the cancer status,suggesting viruses may play important roles in CRC.Conclusions:Powered by deep learning and high throughput sequencing metagenomic data,DeepVirFinder significantly improved the accuracy of viral identification and will assist the study of viruses in the era of metagenomics. | Jie Ren Kai Song Chao Deng Nathan AAhlgren Jed AFuhrman Yi Li Xiaohui Xie Ryan Poplin Fengzhu Sun | 2020 | Quantitative Biology2020，8，1： | 2 |
| 7 | Consumer City 显示文摘 | Glaeser Edward L Jed Kolko and Albert Saiz | 2001 | Journal of Economic Geography2001，1，1： | 1 |
| 8 | Eruption cysts:A clinical report of 24 new cases显示文摘 | Jed G Haim S | 2004 | J Clin Pediatr Dent2004，28，2： | 1 |
| 9 | Nuchtern,Richard Baxter显示文摘 | Jed G | 1995 | Journal of Pediatric Surgery1995，，： | 1 |
| 10 | Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats显示文摘 | Takahiko Mitsui Itzhak Fischer Jed S. Shumsky Marion Murray | 2005 | Experimental Neurology2005，，2： | 1 |
| 11 | PCE oxidation by sodium persulfate in the presence of solids显示文摘 | JED C GRETELL O JOHN C | 2010 | Environmental Science&Technology2010，44，24： | 1 |
| 12 | Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process显示文摘 | Jed J. W. Wiltzius Stuart A. Sievers Michael R. Sawaya David Eisenberg | 2009 | Protein Science2009，，7： | 1 |
| 13 | Microchip-based capillary electrophoresis for immunoassays:analysis of monoclonal antibodiesand theophylline 显示文摘 | Nghia Chiem Jed Harrison D | 1997 | Anal Chem1997，69，： | 1 |
| 14 | How Are Our MPAs Doing? Challenges in Assessing Global Patterns in Marine Protected Area Performance显示文摘 | Helen E. Fox Jed l. Holtzman Kelly M. Haisfield Catherine G. McNally Gonzalo A. Cid Michael B. Mascia John E. Parks Robert S. Pomeroy | 2014 | Coastal Management2014，，3： | 1 |
| 15 | Secondary structural studies of bovine caseins: temperature dependence of 13 casein structure as analyzed by circular dichroism and FTIR spectroscopy and correlation with micellization 显示文摘 | Farrell HM Wickham JED Unruh JJ | 2001 | Food Hydrocolloids2001，15，46： | 1 |
| 16 | The prehistoric and preindustrial deforestation of Europe显示文摘 | Jed O. Kaplan Kristen M. Krumhardt Niklaus Zimmermann | 2009 | Quaternary Science Reviews2009，，27： | 1 |
| 17 | FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis显示文摘 | Ji-hye Paik Zhihu Ding Rujuta Narurkar Shakti Ramkissoon Florian Muller Walid S. Kamoun Sung-Suk Chae Hongwu Zheng Haoqiang Ying Jed Mahoney David Hiller Shan Jiang Alexei Protopopov Wing H. Wong Lynda Chin Keith L. Ligon Ronald A. DePinho | 2009 | Cell Stem Cell2009，，5： | 1 |
| 18 | How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function显示文摘 | Lisandro H. Otero Alzoray Rojas-Altuve Leticia I. Llarrull Cesar Carrasco-López Malika Kumarasiri Elena Lastochkin Jennifer Fishovitz Matthew Dawley Dusan Hesek Mijoon Lee Jarrod W. Johnson Jed F. Fisher Mayland Chang Shahriar Mobashery Juan A. Hermoso | 2013 | Proceedings of the National Academy of Sciences2013，，： | 1 |
| 19 | Microstructure and reten- tion of superplasticity of friction stir welded superplastic 2095 sheet显示文摘 | Hanadi G S Anthony P R Jed S L | 2002 | Seripta Materialia2002，46，： | 1 |
| 20 | Internal Promotion Competitions in Finns 显示文摘 | Jed DeVaro | 2006 | The Rand Journal of Economics2006，2006，3： | 1 |
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