|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Pediatric Nd:YAG laser capsulotomy in the operating room: review of 87 cases显示文摘AIM: To report a large series of children having Nd:YAG laser capsulotomy in the operating room using the lateral decubitus position. METHODS: Medical records of children who underwent Nd:YAG laser capsulotomy in the operating room at Ann & Robert H. Lurie Children's Hospital of Chicago between September 2008 and April 2017 were reviewed. Induction of general anesthesia and intubation was performed in the supine position after which the patient was placed in lateral decubitus position. The Nd:YAG laser capsulotomy was performed using a standard protocol. At the completion of the procedure, the patient was turned back into the supine position and extubated. RESULTS: This study included 87 eyes of 60 patients. Patient's age ranged from 1 to 18 y(mean 6.4±4.1 y). In most cases(84/87, 97%), the procedure was performed under general anesthesia. In all cases, good focus on the membrane was achieved, and the procedure was performed successfully. There were no intraoperative ocular or anesthesia-related complications. CONCLUSION: When performing Nd:YAG laser capsulotomy in the operating room, the lateral decubitus position allowsan easy and safe approach without the risk of potentially devastating complications that have been associated with the previously described sitting and prone positions. | Michael Kinori Narasimhan Jagannathan Anne M Langguth Marjorie A Sasso Marilyn B Mets Bahram Rahmani Hawke Yoon Rebecca Mets-Halgrimson Sudhi P Kurup Janice L Zeid | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 3 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 4 | Trade-off between carbon dioxide emissions and logistics costs based on multiobjective optimization显示文摘 | Kim N S Janic M Wee B | 2009 | Transportation Research Record2009，2139，： | 1 |
| 5 | Modelling the capacity of closely-spaced parallel runways using innovative approach procedures显示文摘 | JANIC M | 2008 | Transportation Research Part C: Emerging Technologies2008，16，6： | 1 |
| 6 | Studies on the microbial populations of the rhizosphere of big sagebrush (Artemisia tridentata)显示文摘 | Antony J B Janice L S Heather M K | 2004 | Journal Indian Microbiology and Biotechnology2004，31，6： | 1 |
| 7 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 8 | Trade-off between carbon dioxide emissions and logistics costs based on multiobjective optimization显示文摘 | Kim N Janic M Wee B | 2009 | Transportation Research Record2009，，2139： | 1 |
| 9 | A taxonomy of DDoS attacks and DDoS defense mechanisms 显示文摘 | JELENA M JANICE M PETER R | 2004 | Computer Communication Re- view2004，34，2： | 1 |
| 10 | A comparison of the business and IT management on success factors for strategic alignmen显示文摘 | Burn Janice M Szeto Colonel | 2000 | Information & Management2000，37，： | 1 |
| 11 | Assessing Some Social and Environmental Effects of Transforming an Airport into a Real Muhimodal Transport Node显示文摘 | Janic M | 2011 | Transport an Environment2011，，6： | 1 |
| 12 | Integrated Transport System in the European Union: An Overview of Some Recent Developments 显示文摘 | Janic M | 2001 | Transport Reviews2001，21，4： | 1 |
| 13 | Catalytic Asymmetric Epoxidation and Kinetic Resolution: Modified Procedures Including in Situ Derivatization 显示文摘 | Yun Gao Robert M Hanson Janice M | 1987 | J Am Chem Soc1987，109，： | 1 |
| 14 | George Cystatin C paradigm of evidence based laboratory medicine 显示文摘 | Janice SC Chew Mohammed Saleem Christopher M | 2008 | Clin Biochem Rev2008，1，： | 1 |
| 15 | A Model of Competition between High Speed Rail and Air Transport显示文摘 | JANIC M | 1993 | Transportation Planning and Technology1993，17，1： | 1 |
| 16 | DUROS technology delivers peptides and proteins at consistent rate continuously for 3 to 12 months 显示文摘 | Catherine M R Thomas R A Bing Y Janice D John P C Scott D L | 2008 | Journal of Diabetes Science and Technology2008，2，3： | 1 |
| 17 | A qualitative and quantitative assessment of Hong Kong's image as tourist destination显示文摘 | W M Choi Andrew Chan Janice Wu | 1999 | Tourism Management1999，，20： | 1 |
| 18 | Prevention and Management of Postpartum Hemorrhage显示文摘 | Anderson Janice M Etches | 2007 | American Family Physician2007，75，6： | 1 |
| 19 | An assessment of risk and safety in civil aviation显示文摘 | JANIC M | 2000 | Journal of Air Transport Management2000，6，1： | 1 |
| 20 | Terminal airspace capacity model显示文摘 | JANIC M TOSIC V | 1982 | Transp Res Part A1982，16，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员