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| 1 | Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-specific Entry into Hepatocytes显示文摘 | Yi Ni Florian A. Lempp Stefan Mehrle Shirin Nkongolo Christina Kaufman Maria F?lth Jan Stindt Christian K?niger Michael Nassal Ralf Kubitz Holger Sültmann Stephan Urban | 2013 | Gastroenterology2013，，： | 5 |
| 2 | Non-Hermitian degeneracies of internal–external mode pairs in dielectric microdisks显示文摘Open quantum and wave systems can exhibit non-Hermitian degeneracies called exceptional points, where both the eigenvalues and the corresponding eigenstates coalesce. Previously, such exceptional points have been investigated in dielectric microcavities in terms of optical modes which are well confined inside the cavity. However,beside these so-called 'internal modes' with a relatively high quality factor, there exists another kind of mode called 'external modes,' which have a large decay rate and almost zero intensity inside the cavity. In the present paper, we demonstrate the physical significance of the external modes via the occurrence of exceptional points of internal–external mode pairs for transverse electric polarization. Our numerical studies show that these exceptional points can be achieved by either a boundary deformation of the microdisk or by introducing absorption into a circular cavity. | CHANG-HWAN YI JULIUS KULLIG MARTINA HENTSCHEL JAN WIERSIG | 2019 | Photonics Research2019，7，4： | 3 |
| 3 | Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin显示文摘For subunit vaccines,adjuvants play a key role in shaping the magnitude,persistence and form of targeted antigen-specific immune response.Flagellin is a potent immune activator by bridging innate inflammatory responses and adaptive immunity and an adjuvant candidate for clinical application.Calcium phosphate nanoparticles are efficient carriers for different biomolecules like DNA,RNA,peptides and proteins.Flagellin-functionalized calcium phosphate nanoparticles were prepared and their immunostimuiatory effect on the innate immune system,i.e.the cytokine production,was studied.They induced the production of the proinflammatory cytokines IL-8(Caco-2 cells) and IL-1β(bone marrow-derived macrophages;BMDM) in vitro and IL-6 in vivo after intraperitoneal injection in mice.The immunostimulation was more pronounced than with free flagellin. | Diana Kozlova Viktoriya Sokolova Maohua Zhong Ejuan Zhang Jingyi Yang Wei Li Yi Yang Jan Buer Astrid Maria Westendorf Matthias Epple Huimin Yan | 2014 | Virologica Sinica2014，29，1： | 3 |
| 4 | Global nitrogen input on wetland ecosystem:The driving mechanism of soil labile carbon and nitrogen on greenhouse gas emissions显示文摘Greenhouse gas emissions from wetlands are significantly promoted by global nitrogen input for changing the rate of soil carbon and nitrogen cycling,and are substantially affected by soil labile carbon and nitrogen conversely.However,the driving mechanism by which soil labile carbon and nitrogen affect greenhouse gas emissions from wetland ecosystems under global nitrogen input is not well understood.Working out the driving factor of nitrogen input on greenhouse gas emissions from wetlands is critical to reducing global warming from nitrogen input.Thus,we synthesized 72 published studies(2144 paired observations)of greenhouse gas fluxes and soil labile compounds of carbon and nitrogen(ammonium,nitrate,dissolved organic carbon,soil microbial biomass nitrogen and carbon),to understand the effects of labile carbon and nitrogen on greenhouse gas emissions under global nitrogen input.Across the data set,nitrogen input significantly promoted carbon dioxide,methane and nitrous oxide emissions from wetlands.In particular,at lower nitrogen rates(<100 kg ha^(-1)$·yr^(-1))and with added ammonium compounds,freshwater wetland significantly promoted carbon dioxide and methane emissions.Peatland was the largest nitrous oxide source under these conditions.This meta-analysis also revealed that nitrogen input stimulated dissolved organic carbon,ammonium,nitrate,microbial biomass carbon and microbial biomass nitrogen accumulation in the wetland ecosystem.The variation-partitioning analysis and structural equation model were used to analyze the relationship between the greenhouse gas and labile carbon and nitrogen further.These results revealed that dissolved organic carbon(DOC)is the primary factor driving greenhouse gas emission from wetlands under global nitrogen input,whereas microbial biomass carbon(MBC)more directly affects greenhouse gas emission than other labile carbon and nitrogen. | Mengli Chen Lian Chang Junmao Zhang Fucheng Guo Jan Vymazal Qiang He Yi Chen | 2020 | Environmental Science and Ecotechnology2020，，4： | 2 |
| 5 | Yeast screen for constitutively active mutant G protein-activated potassium channels显示文摘 | Yi BA Lin YF Jan YN | 2001 | Neuron2001，29，3： | 1 |
| 6 | Urbanization in China,ca.1100-1900显示文摘This paper presents new estimates of the development of the urban population and the urbanization ratio for the period spanning the Song and late Qing dynasties.Urbanization is viewed,as in much of the economic historical literature on the topic,as an indirect indicator of economic development and structural change.The development of the urban system can therefore tell us a lot about long-term trends in the Chinese economy between 1100 and 1900.During the Song,the level of urbanization was high,also by international standards--the capital cities of the Song were probably the largest cities in the world.This remained so until the late Ming,but during the Qing there was a downward trend in the level of urbanization from 11%-12% to 7% in the late 18^th century,a level at which it remained until the early 1900s.In our paper we analyse the role that socio-political and economic causes played in this decline,such as the changing character of the Chinese state,the limited impact of overseas trade on the urban system,and the apparent absence of the dynamic economic effects that were characteristic for the European urban system. | Yi Xu Bas van Leeuwen Jan Luiten van Zanden | 2018 | Frontiers of Economics in China-Selected Publications from Chinese Universities2018，13，3： | 1 |
| 7 | Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease显示文摘 | Fabian C. Franzeck Danielle Hof Remo D. Spescha Matthias Hasun Alexander Akhmedov Jan Steffel Yi Shi Francesco Cosentino Felix C. Tanner Arnold von Eckardstein Willibald Maier Thomas F. Lüscher Christophe A. Wyss Giovanni G. Camici | 2011 | Atherosclerosis2011，，1： | 1 |
| 8 | A Systematic Design Methodology for Power-Optimal Design of High-Order Muhi-bit Continuous-Time Delta-Sigma Modulators 显示文摘 | KE Yi RADIOM SOHEIL CRANINCKX JAN | 2009 | Analog Integrated Circuits and Signal Processing2009，58，3： | 1 |
| 9 | 加快大型数据中心服务的可重构结构显示文摘数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个实例都由嵌入48台机器的半机架6×8二维环面高端Stratix V FPGA组成。每台服务器中都放置了一个FPGA,可以通过PCIe来访问,并用成对的10 Gb SAS电缆直接连接到其他FPGA。在本文中,我们描述了这种结构在1,632台服务器组(bed)的中等规模的部署,并测量了其在加快Bing搜索引擎方面的功效。我们描述了系统的要求和架构,详细介绍了关键技术挑战,以及使系统在出现故障情况下保持鲁棒性所需的解决方案,还有根据排名候选文档测量的系统性能、功率和弹性。在高负载时,一定范围内的可重构结构提高了每台服务器固定延迟分布的吞吐量排名95%——或在保持等效吞吐量时,减少29%的尾延迟。 | Andrew Putnam Adrian M.Caulfield Eric S.Chung Derek Chiou Kypros Constantinide John Demme Hadi Esmaeilzadeh Jeremy Fowers Gopi Prashanth Gopal Jan Gray Michael Haselman Scott Hauck Stephen Heil Amir Hormati Joo-Young Kim Sitaram Lanka James Larus Eric Peterson Simon Pope Aaron Smith Jason Thong Phillip Yi Xiao Doug Burger | 2015 | 中国集成电路2015，24，1： | 1 |
| 10 | Molecular profiles of progesterone receptor loss in human breast tumors显示文摘 | Chad J. Creighton C. Kent Osborne Marc J. Vijver John A. Foekens Jan G. Klijn Hugo M. Horlings Dimitry Nuyten Yixin Wang Yi Zhang Gary C. Chamness Susan G. Hilsenbeck Adrian V. Lee Rachel Schiff | 2009 | Breast Cancer Research and Treatment2009，，2： | 1 |
| 11 | Mechanical anisotropy and deep drawing behavior of AZ31 and ZEI0 magnesium alloy sheets 显示文摘 | Yi Sangbong Bohlen Jan Heinemanna Frank Letzig Dietmar | 2010 | Acta Materialia2010，58，2： | 1 |
| 12 | Effect of rare earth elements on the microstructure and texture development in magnesium–manganese alloys during extrusion显示文摘 | Jan Bohlen Sangbong Yi Dietmar Letzig Karl Ulrich Kainer | 2010 | Materials Science & Engineering A2010，，： | 1 |
| 13 | Taking apart the gating of voltage-gated K + channels 显示文摘 | Jan LY | 2000 | Neuron2000，27，： | 1 |
| 14 | Effect of rare earth elements on the microstructure and texture development in magnesium-manganese alloys during extrusion 显示文摘 | Jan Bohlen Yi Sangbong Letzig Dietmar | 2010 | Materi- als Science and Engineering2010，527，26： | 1 |
| 15 | Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer显示文摘 | Yixin Wang Jan GM Klijn Yi Zhang Anieta M Sieuwerts Maxime P Look Fei Yang Dmitri Talantov Mieke Timmermans Marion E Meijer-van Gelder Jack Yu Tim Jatkoe Els MJJ Berns David Atkins John A Foekens | 2005 | The Lancet2005，，9460： | 1 |
| 16 | Hepatitis B virus surface antigen can activate human monocyte‐derived dendritic cells by nuclear factor kappa B and p38 mitogen‐activated protein kinase mediated signaling显示文摘 | Rong‐Hwa Jan Yu‐Li Lin Chia‐Jung Chen Teng‐Yi Lin Ya‐Chun Hsu Li‐Kuang Chen Bor‐Luen Chiang | 2012 | Microbiology and Immunology2012，，10： | 1 |
| 17 | SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9(H3K9)in the zygotic pronuclei improves porcine embryo development显示文摘Background: The histone code is an established epigenetic regulator of early embryonic development in mammals.The lysine residue K9 of histone H3(H3 K9) is a prime target of SIRT1, a member of NAD+-dependent histone deacetylase family of enzymes targeting both histone and non-histone substrates. At present, little is known about SIRT1-modulation of H3 K9 in zygotic pronuclei and its association with the success of preimplantation embryo development. Therefore, we evaluated the effect of SIRT1 activity on H3 K9 methylation and acetylation in porcine zygotes and the significance of H3 K9 modifications for early embryonic development.Results: Our results show that SIRT1 activators resveratrol and BML-278 increased H3 K9 methylation and suppressed H3 K9 acetylation in both the paternal and maternal pronucleus. Inversely, SIRT1 inhibitors nicotinamide and sirtinol suppressed methylation and increased acetylation of pronuclear H3 K9. Evaluation of early embryonic development confirmed positive effect of selective SIRT1 activation on blastocyst formation rate(5.2 ± 2.9% versus 32.9 ± 8.1% in vehicle control and BML-278 group, respectively; P ≤ 0.05). Stimulation of SIRT1 activity coincided with fluorometric signal intensity of ooplasmic ubiquitin ligase MDM2, a known substrate of SIRT1 and known limiting factor of epigenome remodeling.Conclusions: We conclude that SIRT1 modulates zygotic histone code, obviously through direct deacetylation and via non-histone targets resulting in increased H3 K9 me3. These changes in zygotes lead to more successful pre-implantation embryonic development and, indeed, the specific SIRT1 activation due to BML-278 is beneficial for in vitro embryo production and blastocyst achievement. | Katerina Adamkova Young-Joo Yi Jaroslav Petr Tereza Zalmanova Kristyna Hoskova Pavla Jelinkova Jiri Moravec Milena Kralickova Miriam Sutovsky Peter Sutovsky Jan Nevoral | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 1 |
| 18 | A novel deployment of smart cold chain system using 2G-RFID-Sys显示文摘 | Chen Yu yi Wang Yao-jen Jan Jinn-ke | 2014 | Journal of Food Engineering2014，141，5： | 1 |
| 19 | Mechanisms of photoreceptor death and survival in mammalian retina显示文摘 | Jonathan Stone Juliani Maslim Krisztina Valter-Kocsi Kyle Mervin Felicity Bowers Yi Chu Nigel Barnett Jan Provis Geoff Lewis Steven K Fisher Silvia Bisti Claudia Gargini Luigi Cervetto Saul Merin Jacob Pe’er | 1999 | Progress in Retinal and Eye Research1999，，6： | 1 |
| 20 | Pathway analysis of gene signatures predicting metastasis of node - negative primary breast cancer显示文摘 | Jack X Yu Anieta M Sieuwerts Yi Zhang John WM Martens Marcel Staid Jan GM Klijn Yixin Wang John A Foekens | 2007 | BMC Cancer2007，25，7： | 1 |
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