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| 1 | 多代理人系统在商业街消费者行为模拟中的应用--以上海南京东路为例显示文摘用模型方法研究消费者行为经历了从集合模型到个体模型的过程。随着计算机技术的进步,近十余年来多代理人技术得到了长足的发展。当前,将消费者个体行为模型和多代理人系统相结合来模拟商业街消费者活动,已经成为相关研究和实践领域的前沿方法。其主要优点在于能够使相关人员以单个消费者为基础,整合复杂的相关因素,预测整体或局部商业空间的动态运行效果,作为规划开发的依据。本文介绍由笔者基于NetLogo开发的一个模拟商业街消费者行为的多代理人模拟平台,包括系统的建构和模拟的流程。该模拟系统的核心由四个基于有限理性原理的消费者决策模型构成:回家决策、方向选择决策、休息决策、商店光顾决策。然后应用这个平台于研究上海南京东路消费者行为的实例。该数据收集于2007年,现场记录了消费者在南京东路的活动过程,并被用于拟合行为模型。将模拟的代理人个体行为集合后,于三方面同观察到的消费者实际行为作比较,包括从事不同活动的消费者数量随时间的变化、在各街道段中活动的消费者数量随时间的变化,以及单个商店中的消费者人次和延时;同时分析了模拟中的问题。结果显示该模拟平台总体上能够较好地预测消费者集合行为。 | 朱玮 王德 Harry TIMMERMANS | 2009 | 地理学报2009，64，4： | 19 |
| 2 | Multi-state supernetworks:recent progress and prospects显示文摘Supernetworks have long been adopted to address multi-dimensional choice problems,which are thorny to solve for classic singular networks.Originated from combining transport mode and route choice into a multi-modal network,supernetworks have been extended into multi-state networks to include activity-travel scheduling,centered around activity-based models of travel demand.A key feature of the network extensions is that multiple choice facets pertaining to conducting a full activity program can be modeled in a consistent and integrative fashion.Thus,interdependencies and constraints between related choice facets can be readily captured.Given this advantage of integrity,the modeling of supernetwork has become an emerging topic in transportation research.This paper summarizes the recent progress in modeling multi-state supernetworks and discusses future prospects. | Feixiong Liao Theo Arentze Harry Timmermans | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，1： | 16 |
| 3 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 4 | 单绒毛膜双羊膜囊性双胎妊娠的合并症及处理方式(Ⅱ)显示文摘综述目的与双绒双胎妊娠相比,单绒双胎妊娠有非常高的胎儿丢失率、围产期死亡率和发病率。这是因为双胎间无法预料的血管交通吻合及单个胎盘的不均衡分配。最新发现尽管某些特定的血流动力学因素和激素可能参与双胎输血综合征(TTTS)的病理生理过程,但通常认为TTTS的病理生理过程是以血管构建为基础的。关于减少羊水、胎儿镜下激光凝固术和造口术的大规模随机试验仍无结果。随着胎儿镜激光治疗所需的硬件和仪器进一步完善,单绒双胎在妊娠早期出现严重的生长不协调问题已得到解决。已提出几个TTTS的发病机制,但对于其发生过程仍知之甚少。而且脐动脉多普勒波形对双胎妊娠并无和单胎妊娠同样的预测价值。对双胎间的血管吻合进行预防性激光阻塞可以预防单胎胎死宫内这类不良事件的发生。但这一预防措施至今对改善妊娠结局并无任何益处。最后本文讨论了关于单绒双胎妊娠生长不协调和染色体异常的病理生理学机制及处理。通过针孔导入的激光和单极凝固术可以用来在妊娠早期进行选择性减胎或改善血流动力学情况。妊娠晚期或血流动力学正常时,双极凝固术似乎更有效。总结近几年来,对单绒双胎妊娠合并症的理解已进一步深入。希望这些进步可以指导这类高危妊娠进行更好的检测,最终改善妊娠结局。 | Liesbeth Lewi Dominique Van Schoubroeck Eduard Gratacós Ingrid Witters Dirk Timmerman Jan Deprest 赵德鹏 刘丹 樊佳丽 | 2010 | 中国产前诊断杂志(电子版)2010，，2： | 8 |
| 5 | 单绒毛膜双羊膜囊性双胎妊娠合并症及处理方式(Ⅰ)显示文摘综述目的与双绒双胎妊娠相比,单绒双胎妊娠有非常高的胎儿丢失率、围产期死亡率和发病率。这是因为双胎间无法预料的血管交通吻合及单个胎盘的不均衡分配。最新发现尽管某些特定的血流动力学因素和激素可能参与双胎输血综合征(TTTS)的病理生理过程,但通常认为TTTS的病理生理过程是以血管构建为基础的。关于减少羊水、胎儿镜下激光凝固术和造口术的大规模随机试验仍无结果。随着胎儿镜激光治疗所需的硬件和仪器进一步完善,单绒双胎在妊娠早期出现严重的生长不协调问题已得到解决。已提出几个TTTS的发病机制,但对于其发生过程仍知之甚少。而且脐动脉多普勒波形对双胎妊娠并无和单胎妊娠同样的预测价值。对双胎间的血管吻合进行预防性激光阻塞可以预防单胎胎死宫内这类不良事件的发生。但这一预防措施至今对改善妊娠结局并无任何益处。最后本文讨论了关于单绒双胎妊娠生长不协调和染色体异常的病理生理学机制及处理。通过针孔导入的激光和单极凝固术可以用来在妊娠早期进行选择性减胎或改善血流动力学情况。妊娠晚期或血流动力学正常时,双极凝固术似乎更有效。总结近几年来,对单绒双胎妊娠合并症的理解已进一步深入。希望这些进步可以指导这类高危妊娠进行更好的检测,最终改善妊娠结局。 | Liesbeth Lewi Dominique Van Schoubroeck Eduard Gratacós Ingrid Witters Dirk Timmerman Jan Deprest 赵德鹏 刘丹 樊佳丽 | 2010 | 中国产前诊断杂志(电子版)2010，，1： | 7 |
| 6 | Toll-Like Receptor Expression in the Peripheral Nerve显示文摘Toll样受体(TLRs)是由进化上相对保守的蛋白家族构成的一组识别受体,是固有免疫系统的第一道防线。受到微生物配体刺激后,TLRs通过激活各种信号通路引发机体一系列防御反应。TLRs还能被内源性危险信号激活,因此推断神经退行性变也可能通过TLRs激活免疫反应。近来研究发现中枢神经系统表达各种类型的TLRs,但周围神经系统中TLRs的表达形式尚无定论。本研究结果显示,施万细胞上表达大量TLRs,主要为TLR3和TLR4。感觉神经元和运动神经元上几乎没有TLRs表达。对NF-κB信号通路的检测显示,施万细胞上所有的TLRs都是有功能的,可被细菌脂蛋白(TLR1/TLR2配体)激活,产生强烈反应。静息状态下,坐骨神经上TLRs的表达形式与施万细胞相似,主要为TLR3、TLR4和TLR7,可能在免疫监督中扮演重要角色。通过显微外科方式对坐骨神经造成急性神经退行性变后,诱导TLR1大量表达,其它TLRs的表达水平无变化。综上所述,本研究结果显示,施万细胞可能在周围神经中扮演类似中枢神经系统小胶质细胞的角色。急性神经退行性变诱导TLR表达变化,说明在分布于周围神经的TLRs在静息状态和激活状态下具有不同功能。 | SOFIE GOETHALS ELKE YDENS VINCENT TIMMERMAN SOPHIE JANSSENS | 2010 | 神经损伤与功能重建2010，5，6： | 6 |
| 7 | Analysis of Metro Station Ridership Considering Spatial Heterogeneity显示文摘This study aims to explore the role of spatial heterogeneity in ridership analysis and examine the relationship between built environment, station attributes and urban rapid transit ridership at the station level.Although spatial heterogeneity has been widely acknowledged in spatial data analysis, it has been rarely considered in travel behavior studies.Four models(three global models-ordinary least squares(OLS), spatial lag model(SLM), spatial error model(SEM) and one local model-geographically weighted regression(GWR) model) are estimated separately to explore the relationship between various independent variables and station ridership, and identify the influence of spatial heterogeneity.Using the data of built environment and station characteristics, the results of diagnostic identify evidence the existence of spatial heterogeneity in station ridership for the metro network in Nanjing, China.Results of comparing the various goodness-of-fit indicators show that, the GWR model yields the best fit of the data, performance followed by the SEM, SLM and OLS model.The results also demonstrate that population, number of lines, number of feeder buses, number of exits, road density and proportion residential area have a significant impact on station ridership.Moreover, the study pays special attention to the spatial variation in the coefficients of the independent variables and their statistical significance.It underlines the importance of taking spatial heterogeneity into account in the station ridership analysis and the decision-making in urban planning. | GAN Zuoxian FENG Tao YANG Min Harry TIMMERMANS LUO Jinyu | 2019 | Chinese Geographical Science2019，29，6： | 2 |
| 8 | 超大质量黑洞产生的高能中微子探测及巨型中微子射电探测阵列的选址显示文摘宇宙高能中微子很可能起源于超大质量黑洞与吸积物质的相互作用.这些中微子在传播过程中由于只参与弱相互作用,其轨迹直指起源的特性,使其成为观测宇宙更远的天体的全新窗口.传统的中微子探测方法由于造价高、技术复杂,限制了探测的有效面积和观测时间.巨型中微子射电探测阵列GRAND,由多国共同参与建设,具有造价低、易大面积部署、可全天观测的特点,成为目前最好的选择,通过探测高能中微子寻找超高能宇宙射线的起源.目前在进行GRANDProto300的选址中,我们在内蒙古明安图、新疆巴里坤等地方使用GRANDProto35原型天线进行实地探测.探测结果显示,巴里坤地区具有良好的电磁环境,更加适合该项目的建设.选址探测工作为GRANDProto300的选址及其它射电探测阵列的建设提供了依据. | 朱春花 翟楠楠 沈冬祥 吕国梁 王兆军 李琳 刘荷蕾 Olivier Martineau-Huynh Charles Timmermans | 2019 | 新疆大学学报(自然科学版)2019，36，2： | 2 |
| 9 | Nociceptin effect on intestinal motility depends on opioidreceptor like-1 receptors and nitric oxide synthase colocalization显示文摘AIM: To study the effect of the opioid-receptor like-1(ORL1) agonist nociceptin on gastrointestinal(GI)myenteric neurotransmission and motility. METHODS: Reverse transcriptase- polymerase chain reaction and immunohistochemistry were used to localize nociceptin and ORL1 in mouse tissues. Intracellular electrophysiological recordings of excitatory and inhibitory junction potentials(EJP, IJP) were made in a chambered organ bath. Intestinal motility was measured in vivo. RESULTS: Nociceptin accelerated whole and upper GI transit, but slowed colonic expulsion in vivo in an ORL1-dependent manner, as shown using [Nphe1]NOC and AS ODN pretreatment. ORL1 and nociceptin immunoreactivity were found on enteric neurons. Nociceptin reduced the EJP and the nitric oxide-sensitive slow IJP in an ORL1-dependent manner, whereas the fast IJP was unchanged. Nociceptin further reduced the spatial spreading of the EJP up to 2 cm. CONCLUSION: Compounds acting at ORL1 are good candidates for the future treatment of disorders associated with increased colonic transit, such as diarrhea or diarrhea-predominant irritable bowel syndrome. | Andrei Sibaev Jakub Fichna Dieter Saur Birol Yuece Jean-Pierre Timmermans Martin Storr | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，3： | 2 |
| 10 | The role(s) of somatostatin, structurally related peptides and somatostatin receptors in the gastrointestinal tract: a review显示文摘 | Joeri Van Op den bosch Dirk Adriaensen Luc Van Nassauw Jean-Pierre Timmermans | 2009 | Regulatory Peptides2009，，1： | 2 |
| 11 | 猪食管神经支配的神经化学研究——一氧化氮类及肽类成分在平滑肌中的分布(英文)显示文摘采用免疫荧光组织化学技术及迷走神经切断术,探讨猪食管一氧化氮类及肽类神经支配的神经化学特性。在光学显微镜下可观察到肌间神经丛及粘膜下神经丛中有部分神经元呈nNOS、VIP、GAL、NPY、PACAP、L-ENK、SP、5-HT及CB免疫阳性,但未见CGRP及SOM阳性神经元。nNOS及CB免疫阳性产物主要分布于不同的神经元胞体内。将PGP9.5作为神经元胞体的标记物,并采用免疫荧光免疫组织化学双重染色方法,分别观察了PGP9.5与nNOS、VIP、SP的双标情况。结果如下:(1)nNOS免疫阳性神经元约占PGP9.5标记神经元总数的63%,而VIP免疫阳性神经元约占36%,SP免疫阳性神经元约占28%;(2)神经节内神经元的平均数量呈现吻尾方向的递增趋势,且食管腹段神经丛内神经节数量明显高于食管其他部位;(3)食管肌层内VIP/GAL/NPY免疫阳性纤维分布最广,其中部分阳性纤维同时呈nNOS或PACAP免疫阳性;SP和/或L-ENK免疫阳性纤维在粘膜肌层的分布明显多于平滑肌层。CGRP阳性纤维非常少见,这一点不同于对其他动物的观察结果;(4)经一侧迷走神经切断后,肌间神经丛内PACAP及5-HT免疫阳性纤维明显减少,提示这些纤维可能来源于迷走神经;而平滑肌中VIP/GAL/NPY和/或nNOS免疫阳性纤维数量未发现明显变化,可能为内源性来源。 | 吴梅 李玲 张晨 Timmermans J-P | 2006 | 神经解剖学杂志2006，22，3： | 2 |
| 12 | Improving strategies for diagnosing ovarian cancer: a summary of the International Ovarian Tumor Analysis ( IOTA ) studies显示文摘 | J. Kaijser T. Bourne L. Valentin A. Sayasneh C. Van Holsbeke I. Vergote A. C. Testa D. Franchi B. Van Calster D. Timmerman | 2012 | Ultrasound Obstet Gynecol2012，，： | 2 |
| 13 | Mirtazapine: Efficacy and Tolerability in Comparison With Fluoxetine in Patients With Moderate to Severe Major Depressive Disorder 显示文摘 | Wheatley DP van Moffaert M Timmerman L etal | 1998 | J Clin psychiatry1998，59，16： | 2 |
| 14 | Tissue adhesives in gastrointestinal anastomosis: A systematic review显示文摘 | Konstantinos A. Vakalopoulos Freek Daams Zhouqiao Wu Lucas Timmermans Johannes J. Jeekel Gert-Jan Kleinrensink Arie van der Ham Johan F. Lange | 2012 | Journal of Surgical Research2012，，： | 2 |
| 15 | Tailoring the Diameter of Single-Walled Carbon Nanotubes for Optical Applications显示文摘有特定的直径的围单人赛的碳 nanotubes (SWCNT ) 特别地在电子学和 photonics 为各种各样的应用被要求,自从直径是决定他们的电子、光的性质的一个必要特征。在这个工作,有某个吝啬的直径的 SWCNT 的选择生长被与碳来源(公司) 一起混合进喷雾器(漂浮的催化剂) 的 CO2 的适当数量的增加完成化学蒸汽免职反应堆。在吸收系列的山峰的显著移动表明同样扔的 SWCNT 的吝啬的直径高效地与增加 CO2 集中从 1.2 ~ 1.9 nm 被改变。当一个蚀刻的代理人和罐头有选择地由于他们的高度弄弯的碳表面蚀刻小直径试管, CO2 行动,这被相信当一个蚀刻的代理人和罐头有选择地由于他们的高度弄弯的碳表面蚀刻小直径试管。有需要的直径的没有聚合物的同样扔的 SWCNT 电影在用一种简单干燥转移的技术踩到一面高度思考的 Ag 镜子上以后被用作可饱和的吸收器。在 1.56 m 和 2 m 的亚微微秒锁模式的纤维激光操作被表明,显示出在在 SWCNT 性质的优化以后的表演的改进。 | Ying Tian Marina Y. Timmermans Samuli Kivistoe Albert G. Nasibulin Zhen Zhu Hua Jiang OlegG. Okhotnikov Esko I. Kauppinen | 2011 | Nano Research2011，4，8： | 2 |
| 16 | A disbalance between beta-adrenergic and muscarinic responses caused by hydrogen peroxide in rat airways in vitro显示文摘 | Kramer K Doelman CJ Timmerman H | 1987 | Biochem Biophys Res Commun1987，145，： | 1 |
| 17 | Mirtazapine versus venlafaxine in hospitalized severely depressed patients with melancholic features显示文摘 | GUELFI JD ANSSEAU M TIMMERMAN L | 2001 | J Clin Psychopharmacol2001，21，4： | 1 |
| 18 | Structural breaks,incomplete information,and stock prices显示文摘 | Timmerman A | 2001 | Journal of Business and Economic Statistics2001，19，3： | 1 |
| 19 | Notch and epithelial- mesenchyme transition in development and tumor progression: another turn of the screw显示文摘 | Grego-Bessa J Diez J Timmerman L | 2004 | Cell Cycle2004，3，6： | 1 |
| 20 | Stereotactic body radiation therapy for thoracic cancers: recommendations for patient selection, setup and therapy 显示文摘 | TIMMERMAN R HEINZERLING J ABDULRAHMAN R | 2011 | Front Radiat Ther Oncol2011，43，： | 1 |
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