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| 1 | 产业创新生态系统的价值创造和获取机制分析——基于中国电动汽车的跨案例分析显示文摘研究聚焦于产业创新生态系统的'价值创造'和'价值获取'的动态过程和作用机制,以产业生态系统中的龙头企业及其协同整合的行为主体为分析对象,分析在'构建-管理'产业生态系统两阶段过程中的'价值创造'和'价值获取'机制。选择杭州、深圳两个电动汽车产业创新生态体系的案例,分析其2000—2013年的动态演化过程,进行跨案例比较。研究发现:在构建电动汽车产业创新生态系统的阶段,主要是形成有利于'价值创造'的产业前提条件,同时厘清各主体'价值获取'基础关系;在管理电动汽车产业创新生态的阶段,一方面是维持'价值创造'的稳定性和产业系统整体竞争力,另一方面则是促进产业行为主体从中实现'价值获取'。 | 陈衍泰 孟媛媛 张露嘉 范海霞 Dimitris Assimakopoulos | 2015 | 科研管理2015，36，S1： | 55 |
| 2 | Leptin, cardiovascular diseases and type 2 diabetes mellitus显示文摘Leptin,经由胃口抑制在食物吸入的控制被含有的 adipokine,可以也刺激氧化应力,发炎,血栓,动脉的僵硬, angiogenesis 和 atherogenesis。这些导致 leptin 的效果可以预先安排到心血管的疾病的发展。在现在的评论,我们讨论与两个的存在,严厉或预后连接 leptin 层次的证据冠的动脉疾病和非心脏的脉管的疾病象中风那样,颈动脉动脉疾病,外部动脉疾病(垫)和象与长期的肾疾病( CKD )和类型一样的腹的大动脉的动脉瘤( AAA ) 2 糖尿病 mellitus ( T2DM )。Leptin 层次断然与存在,严厉,程度和冠的动脉粥样硬化以及与存在,严厉和 ischemic 和出血性的击的差的临床的结果的损害复杂性被联系了。但是冲突结果也存在。而且, leptin 被报导独立地预言普通颈动脉 intima 媒介厚度和颈动脉匾不稳定性。在 hyperleptinemia 和垫之间的一个连接被报导了,而有限数据在在 leptin 和 AAA 之间的潜在的协会上是可得到的。提高的 leptin 集中也象与胰岛素抵抗一样与 CKD 发生和前进有关, T2DM,微 -- 并且 macrovascular 糖尿病患者复杂并发症。Statins 和 antidiabetic 药(包括的 sitagliptin, metformin, pioglitazone, liraglutide 和 empagliflozin ) 可以影响 leptin 层次。进一步的研究被需要建立潜在的使用(如果任何) 是的 leptin 在这些疾病的一个治疗学的目标。 | Niki KATSIKI Dimitri P MIKHAILIDIS Maciej BANACH | 2018 | Acta Pharmacologica Sinica2018，39，7： | 41 |
| 3 | Heterotopic pancreas in the stomach:A case report and literature review显示文摘Ectopic pancreas is defined as pancreatic tissue found outside the usual anatomic location of the pancreas. It is often an incidental finding and can be found at different sites in the gastrointestinal tract. It may become clinically evident when complicated by pathologic changes such as inflammation, bleeding, obstruction, and malignant transformation. In this report, a 40 years old woman with epigastric pain due to ectopic pancreatic tissue in the stomach is described. The difficulty of making an ac- curate diagnosis is highlighted. The patient has remained free of symptoms since she underwent wedge resection of the lesion three years ago. Frozen sections may help in deciding the extent of resection intraoperatively. Al- though ectopic pancreas is rare, it should be considered in the differential diagnosis of a submucosal gastric tumour. | Grigorios Christodoulidis Dimitris Zacharoulis Sotiris Barbanis Emmanuel Katsogridakis Konstantine Hatzitheofilou | 2007 | World Journal of Gastroenterology2007，13，45： | 31 |
| 4 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 5 | 汽油机GPF碳载量模型和再生策略的试验研究显示文摘针对某V型六缸GDI机械增压汽油机,搭建基于Matlab Simulink平台的颗粒捕集器(gasoline particulate filter,GPF)碳载量模型,通过试验数据对模型中的相关脉谱进行仿真标定;并对样机的GPF主动及被动再生策略进行研究,评价分析策略表现。模型试验验证结果表明,累碳模型的偏差值为+5.8%;主动再生模型的偏差值为+9%;被动再生(断油)模型的偏差值为+6%;综合碳载量模型的偏差值为+3%,模型精度良好。 | 范明哲 张宾 Sterzer Alexander Sokolov Dimitri | 2018 | 内燃机与动力装置2018，35，6： | 20 |
| 6 | Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients显示文摘AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P< 0.001) and preoperative serum levels of CEA (P=0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented signif icant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RTPCR assay can provide useful information concerning disease stage and overall survival of CRC patients. | Aikaterini Tsouma Chrysanthi Aggeli Panagiotis Lembessis George N Zografos Dimitris P Korkolis Dimitrios Pectasides Maria Skondra Nikolaos Pissimissis Anastasia Tzonou Michael Koutsilieris | 2010 | World Journal of Gastroenterology2010，16，47： | 19 |
| 7 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 8 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 9 | Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy:A review of the literature and critical reappraisal of the implicated pathomechanism显示文摘Pylorus-preserving pancreaticoduodenectomy (PPPD) is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head, neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE) comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the effi cacy of a recently reported (but not yet tested in large- scale studies) modifi cation, that is, PPPD with antecolic duodenojejunostomy. | Kosmas I Paraskevas Costas Avgerinos Costas Manes Dimitris Lytras Christos Dervenis | 2006 | World Journal of Gastroenterology2006，12，37： | 16 |
| 10 | Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer显示文摘瞄准:在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ,肿瘤坏死因素高山哈( TNFalpha ), peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma ),细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法:学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行,结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ,和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果:ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77, 95% CI:1.34-2.34;或 = 1.83, 95% CI:1.23-2.72;并且或 = 1.35, 95% CI:1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78, 95% CI:1.25-2.49 ) 。结论:在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些, SNP 可以改进在风险的为亚人口的适当屏蔽。 | George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli | 2006 | World Journal of Gastroenterology2006，12，31： | 16 |
| 11 | Role of probiotics,prebiotics and synbiotics in chemoprevention for colorectal cancer显示文摘Colorectal cancer is the third most common form of cancer.Current treatments are all associated with a high risk of complications and a low success rate.Recently,synbiotics have been proposed as a new preventive and therapeutic option.There is no direct experimental evidence for cancer suppression in humans as a result of the consumption of pro-,pre-or synbiotics.However,there is a wealth of evidence emerging from laboratory studies.The mechanisms by which pro-,pre-and synbiotics may inhibit colon cancer are now beginning to be understood and will be addressed in the present review. | Constantine Iosif Fotiadis Christos Nikolaou Stoidis Basileios Georgiou Spyropoulos Eleftherios Dimitriou Zografos | 2008 | World Journal of Gastroenterology2008，14，42： | 16 |
| 12 | 管内稠密气固两相流数值模拟计算:颗粒动力学方法显示文摘基于稠密气固两相流流体动力学模型、颗粒动力学的颗粒湍动能模型 (KTGF)和气体湍动能模型(SGS) ,模拟计算结果得到了实验研究所揭示的环 -核流动结构 .模拟计算与Miller和Gidaspow的实验结果进行了比较 ,颗粒相浓度、速度和颗粒相动力黏性系数分布与实验值基本吻合 . | 陆慧林 刘文铁 赵广播 Dimitri Gidaspow | 2000 | 化工学报2000，51，1： | 14 |
| 13 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 14 | Active gastrointestinal bleeding:Use of hemostatic forceps beyond endoscopic submucosal dissection显示文摘To the best of our knowledge,this is the f irst report of the application of hemostatic forceps in active gastrointestinal(GI) bleeding that is not related to endoscopic submucosal dissection.An 86-year-old woman with chronic intake of low-dose aspirin had a Dieulafoy's lesion of the third duodenal portion.Bleeding control with epinephrine injection was unsuccessful.A 60-year-old man presented with a bleeding ulcer in the duodenal bulb.Ten days after combined endotherapy,he had recurrent bleeding from two minimal lesions in the same location.A 66-year-old woman under combined antithrombotic treatment was referred to us for chronic GI bleeding of unexplained origin.Endoscopy revealed active diverticular bleeding in the second duodenal portion.A 61-year-old woman underwent endoscopic mucosal resection of superficial gastric adenocarcinoma,which was complicated with immediate bleeding.In all cases,the blood was washed out using a water-jet-equipped,single-channel gastroscope with a large working channel.The bleeding points were pinched and retracted with hemostatic forceps.Monopolar electrocoagulation was performed using an electrosurgical current generator.Hemostasis was achieved.No complications occurred.In conclusion,hemostatic forceps may be an effective as well as safe alternative approach for active GI bleeding of various origins. | Dimitri Coumaros Niki Tsesmeli | 2010 | World Journal of Gastroenterology2010，16，16： | 13 |
| 15 | Low rectal cancer:Sphincter preserving techniques-selection of patients,techniques and outcomes显示文摘Low rectal cancer is traditionally treated by abdominoperineal resection. In recent years, several new techniques for the treatment of very low rectal cancer patients aiming to preserve the gastrointestinal continuity and to improve both the oncological as well as the functional outcomes, have been emerged. Literature suggest that when the intersphincteric resection is applied in T1-3 tumors located within 30-35 mm from the anal verge, is technically feasible, safe, with equal oncological outcomes compared to conventional surgery and acceptable quality of life. The Anterior Perineal Plan E for Ultra-low Anterior Resection technique, is not disrupting the sphincters, but carries a high complication rate, while the reports on the oncological and functional outcomes are limited. Transanal Endoscopic Micro Surgery(TEM) and Trans Anal Minimally Invasive Surgery(TAMIS) should represent the treatment of choice for T1 rectal tumors, with specific criteria according to the NCCN guidelines and favorable pathologic features. Alternatively to the standard conventional surgery, neoadjuvant chemo-radiotherapy followed by TEM or TAMIS seems promising for tumors of a local stage T1sm2-3 or T2. Transanal Total Mesorectal Excision should be performed only when a board approved protocol is available by colorectal surgeons with extensive experience in minimally invasive and transanal endoscopic surgery. | Nikoletta Dimitriou Othon Michail Dimitrios Moris John Griniatsos | 2015 | World Journal of Gastrointestinal Oncology2015，7，7： | 13 |
| 16 | Brain stem cells as the cell of origin in glioma显示文摘Glioma incidence rates in the United States are near 20000 new cases per year, with a median survival time of 14.6 mo for high-grade gliomas due to limited therapeutic options. The origins of these tumors and their many subtypes remain a matter of investigation. Evidence from mouse models of glioma and human clinical data have provided clues about the cell types and initiating oncogenic mutations that drive gliomagenesis, a topic we review here. There has been mixed evidence as to whether or not the cells of origin are neural stem cells, progenitor cells or differentiated progeny. Many of the existing murine models target cell populations defined by lineage-specific promoters or employ lineagetracing methods to track the potential cells of origin. Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial cell types. Knowledge of key driver mutations and susceptible cell types will allow us to understand cancer biology from a developmental standpoint and enable early interventional strategies and biomarker discovery. | Aram S Modrek N Sumru Bayin Dimitris G Placantonakis | 2014 | World Journal of Stem Cells2014，6，1： | 12 |
| 17 | Overview of coronary artery variants, aberrations and anomalies显示文摘Coronary artery anomalies and variants are relatively uncommon congenital disorders of the coronary artery anatomy and constitute the second most common cause of sudden cardiac death in young competitive athletes. The rapid advancement of imaging techniques, including computed tomography, magnetic resonance imaging, intravascular ultrasound and optical coherence tomography, have provided us with a wealth of new information on the subject. Anomalous origin of a coronary artery from the contralateral sinus is the anomaly most frequently associated with sudden cardiac death, in particular if the anomalous coronary artery has a course between the aorta and the pulmonary artery. However, other coronary anomalies, like anomalous origin of the left coronary artery from the pulmonary artery, atresia of the left main stem and coronary fistulae, have also been implicated in cases of sudden cardiac death. Patients are usually asymptomatic, and in most of the cases, coronary anomalies are discovered incidentally during coronary angiography or on autopsy following sudden cardiac death. However, in some cases, symptoms like angina, syncope, heart failure and myocardial infarction may occur. The aims of this article are to present a brief overview of the diverse coronary variants and anomalies, focusing especially on anatomical features, clinical manifestations, risk of sudden cardiac death and pathophysiologic mechanism of symptoms, as well as to provide valuable information regarding diagnostic workup, follow-up, therapeutic choices and timing of surgical treatment. | Stylianos Kastellanos Konstantinos Aznaouridis Charalambos Vlachopoulos Eleftherios Tsiamis Evangelos Oikonomou Dimitris Tousoulis | 2018 | World Journal of Cardiology2018，10，10： | 12 |
| 18 | Feature-Based Aggregation and Deep Reinforcement Learning:A Survey and Some New Implementations显示文摘In this paper we discuss policy iteration methods for approximate solution of a finite-state discounted Markov decision problem, with a focus on feature-based aggregation methods and their connection with deep reinforcement learning schemes. We introduce features of the states of the original problem, and we formulate a smaller 'aggregate' Markov decision problem, whose states relate to the features. We discuss properties and possible implementations of this type of aggregation, including a new approach to approximate policy iteration. In this approach the policy improvement operation combines feature-based aggregation with feature construction using deep neural networks or other calculations. We argue that the cost function of a policy may be approximated much more accurately by the nonlinear function of the features provided by aggregation, than by the linear function of the features provided by neural networkbased reinforcement learning, thereby potentially leading to more effective policy improvement. | Dimitri P.Bertsekas | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 12 |
| 19 | Quantifying land degradation in the Zoige Basin,NE Tibetan Plateau using satellite remote sensing data显示文摘Considerable efforts have been dedicated to desertification research in the arid and semi-arid drylands of central Asia. However,there are few quantitative studies in conjunction with proper qualitative evaluation concerning land degradation and aeolian activity in the alpine realm. In this study,spectral information from two Landsat-5 TM scenes(04.08.1994 and 28.07.2009,respectively) was combined with reference information obtained in the field to run supervised classifications of eight landscape types for both time steps. Subsequently,the temporal and spatial patterns of the alpine wetlands/grasslands evolutions in the Zoige Basin were quantified and assessed based on these two classification maps. The most conspicuous change is the sharp increase of ~627 km^2 degraded meadow. Concerning other land-covers,shallow wetland increases ~107 km^2 and aeolian sediments(mobile dunes and sand sheets) have an increase of ~30 km^2. Considering the deterioration,an obvious decrease of ~440 km^2 degraded wetland can be observed. Likewise,decrease of deep wetland(~78 km^2),humid meadow(~80 km^2) and undisturbed meadow(~88 km^2) were determined. These entire evolution matrixes undoubtedly hint a deteriorating tendency of the Zoige Basin ecosystem,which is characterized by significantly declined proportion of intact wetlands,meadow,rangeland and a considerable increase ofdegraded meadow and larger areas of mobile dunes. In particular,not only temporal alteration of the landcover categories,the spatial and topographical characteristics of the land degradation also deserves more attention. In the alpine rangelands,the higher terraces of the river channels along with their slopes are more liable to the degradation and desertification. This tendency has significantly impeded the nomadic and agriculture activities. The set of anthropozoogenic factors encompassing enclosures,overgrazing and trampling,rodent damaging and exceedingly ditching in the wetlands are assumed to be the main controlling mechanisms for the landscape degradation. A suite of strict protection policies is urgent and indispensable for self-regulation and restoration of the alpine meadow ecosystem. Controlling the size of livestock,less ditching in the rangeland,and the launching of a more strict nature reserve management by adjacent Ruoergai,Maqu and Hongyuan Counties would be practical and efficacious in achieving these objectives. | YU Kai-feng Frank LEHMKUHL Dimitri FALK | 2017 | Journal of Mountain Science2017，14，1： | 12 |
| 20 | FAIR Data and Services in Biodiversity Science and Geoscience显示文摘We examine the intersection of the FAIR principles(Findable,Accessible,Interoperable and Reusable),the challenges and opportunities presented by the aggregation of widely distributed and heterogeneous data about biological and geological specimens,and the use of the Digital Object Architecture(DOA)data model and components as an approach to solving those challenges that offers adherence to the FAIR principles as an integral characteristic.This approach will be prototyped in the Distributed System of Scientific Collections(DiSSCo)project,the pan-European Research Infrastructure which aims to unify over 110 natural science collections across 21 countries.We take each of the FAIR principles,discuss them as requirements in the creation of a seamless virtual collection of bio/geo specimen data,and map those requirements to Digital Object components and facilities such as persistent identification,extended data typing,and the use of an additional level of abstraction to normalize existing heterogeneous data structures.The FAIR principles inform and motivate the work and the DO Architecture provides the technical vision to create the seamless virtual collection vitally needed to address scientific questions of societal importance. | Larry Lannom Dimitris Koureas Alex R.Hardisty | 2020 | Data Intelligence2020，2，1： | 12 |
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