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| 1 | Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4显示文摘Objective:To investigate the cytotoxic activity of endophytic fungi isolated from mangrove fungi.Methods:In the present study the DNA was isolated and the ITS region of 5.8s rRNA was amplified using specific primers ITS 1 and ITS4 and sequence was determined using automated sequencers.Blast search sequence similarity was found against the existing non redundant nucleotide sequence database thus,identified as Aspergilus flavus,Hyporcaea lixii,Aspergillus niger,Eutorium amstelodami,Irpex hydnoides and Neurospora crassa.Among the seven isolates, one fungi Irpex hydnoides was selected for further studies.The fungi were grown in sabouraud broth for five days and filtrate were separated and subjected to ethyl acetate for further studies. Results:Nearly half(49.25%) of the extracts showed activity(IC_(50) of 125 μ g/mL).These values were within the cutoff point of the National Cancer Institute criteria for cytotoxicity(IC_(50)<20 μ g/mL) in the screening of crude plant extracts.The GC MS analysis revealed that the active principals might be Tetradecane(6.26%) with the RT 8.606.Conclusions:It is clear from the present study that mangrove fungi with bioactive metabolites can be expected to provide high quality biological material for high throughout biochemical,anti cancer screening programmes.The results help us conclude that me potential of using metabolic engineering and post genomic approaches to isolate more novel bioactive compounds and to make their possible commercial application is not far off. | B Valentin Bhimba DA Agnel Defora Franco Geena Mary Jose Jibi Merin Mathew Elsa Lycias Joel | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 3 |
| 2 | Antibacterial screening of silver nanoparticles synthesized by marine micro algae显示文摘Objective:To explore the biosynthesis of silver nanoparticles synthesized by marine microalgae. Methods:Marine microalgae was collected from Central Marine Fisheries Research Institute (CMFRI,tuticorin) and cultured in the lab.Silver nanoparticles synthesis were observed in normal and microwave irradiated microalgae and screened against human pathogens for the presence of antimicrobials.Results:The presence of silver nanoparticle was confirmed by UV-Visible spectroscopy at 420 nm by the presence of plasmon peak.Further confirmation was done by scanning electron microscope(SEM).Conclusions:These results not only provide a base for further research but are useful for drug development in the present and future. | D Devina Merin S Prakash B Valentine Bhimba | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 2 |
| 3 | Successful use of Landsat Thematic Mapper data for mapping hydrocarbon microseepage-induced mineralogic alteration, Lisbon Valley, Utah显示文摘 | Segal D B Merin I S | 1989 | Photogrammetric Engineering and Remote Sensing1989，55，： | 1 |
| 4 | Diabetic retinopathy: A review for the primary care phy sician显示文摘 | Fonseca V Munshi M Merin LM | 1996 | South Med J1996，89，： | 1 |
| 5 | Atrial fibrillation triggered by postinfarction ventricular premature beats in a patient with Wolff Parkinson White syndrome显示文摘 | Peinade R Merine J L Gnoatte M | 2005 | Europace2005，7，： | 1 |
| 6 | Balloon angioplasty versus bypass grafting in the era of coronary stenting显示文摘 | Ekstein S Elami A Merin G | 2002 | lsr Med Assoc2002，4，8： | 1 |
| 7 | Timing for effective application of anteriorlydirected orthopedic force to the maxilla 显示文摘 | Merin D Nagan P Hagg U | 1997 | Am J Orthod Dentofacial Orthop1997，112，9： | 1 |
| 8 | The systematic development of a nursing intervention aimed at increasing enrollment in cardiac rehabilitation for acute coronary syndrome patients显示文摘 | Cossette S D'Aoust LX Merin M | 2009 | Prog Cardiovasc Nuts2009，24，3： | 1 |
| 9 | Reduction in opioid- and cannabinoid- induced arrdnociception in rhesus monkeys after bilateral lesions of the amygdaloid complex显示文摘 | Manning BH Merin NM Meng ID | 2001 | J Nell2001，21，20： | 1 |
| 10 | Possible basin centered gas accumulation,Roton Basin,Southern Clorado显示文摘 | Rose P R Everett J R Merin J S | 1984 | Oil & gas Journal1984，82，40： | 1 |
| 11 | A Prospective Study of Cutaneous Findings in Newborns in the United States: Correlation with Race, Ethnicity, and Gestational Status Using Updated Classification and Nomenclature显示文摘 | Kimberly Natee Kanada Melissa Reyes Merin Andrea Munden Sheila Fallon Friedlander | 2012 | The Journal of Pediatrics2012，，2： | 1 |
| 12 | Detection of Hepatocellular Carinoma: comparison of CT during arterial portography with CT after intraarterial injection of iodized oil显示文摘 | Merine D Takayasu K Wakao F | 1990 | Radiology1990，175，： | 1 |
| 13 | Recent advances in exploiting goat's milk: Quality, safety and production aspects 显示文摘 | SILANIKOVE N LEITNER G MERIN U | 2010 | SmallRuminRes2010，89，23： | 1 |
| 14 | Recent advances in exploiting goat's milk: Quality, safety and production aspects显示文摘 | Silanikove N Leitner G Merin U | 2010 | Small Ruminant Res2010，89，2： | 1 |
| 15 | Postcardiopulmonary bypass hypoxcmia:a prospective study on incidence,risk factors,and clinical significance显示文摘 | Weiss Y G Merin G Koganov E | | 0，，05： | 1 |
| 16 | AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model 显示文摘 | Hassan WM Merin DA Fonte V | 2009 | Hum Mol Genet2009，18，15： | 1 |
| 17 | Current status quo on COVID-19 including chest imaging显示文摘With each day the number coronavirus disease 2019(COVID-19)cases continue to rise rapidly and our imaging knowledge of this disease is expeditiously evolving.The role of chest computed tomography(CT)in the screening or diagnosis of COVID-19 remains the subject of much debate.Despite several months having passed since identifying the disease,and numerous studies related to it,controversy and concern still exists regarding the widespread use of chest CT in the evaluation and management of COVID-19 suspect patients.Several institutes and organizations around the world have released guidelines,recommendations and statements against the use of CT for diagnosing or screening COVID-19 infection and advocating its use only for those cases with a strong clinical suspicion of complication or an alternate diagnosis.However,these guidelines and recommendations are in disagreement with majority of the widely available literature,which strongly favour CT as a pivotal tool in the early diagnosis,management and even follow-up of COVID-19 infection.This article besides comprehensively reviewing the current status quo on COVID-19 disease in general,also writes upon the current consensus statements/recommendations on the use of diagnostic imaging in COVID-19 as well as highlighting the precautions and various disinfection procedures being employed world-wide at the workplace to prevent the spread of infection. | Rishi Philip Mathew Merin Jose Vinayak Jayaram Paul Joy Danny George Maria Joseph TeenaSleeba Ajith Toms | 2020 | World Journal of Radiology2020，12，12： | 1 |
| 18 | Possible basin centered gas ac-cumulation,Roton Basin,Southern Clorado显示文摘 | Rose P R Everett J R Merin I S | 1984 | Oil&Gas Jour-nal1984，82，40： | 1 |
| 19 | Performance of constructed wetlands for municipal wastewater treatment in rural mountainous area显示文摘 | Merin G Pajean J L Lissolo T | 2002 | Hydrobiologia2002，469，： | 1 |
| 20 | Postcardiopulmonary bypass hypoxemia: a prospective study on incidence, risk factors, and clini- cal significance显示文摘 | Weiss YG Merin G Koganov E | 2000 | J Cardiothorac Vasc Anesth2000，14，5： | 1 |
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