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| 1 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Adenoviral-mediated Hath1-EGFP gene transfer into guinea pig cochlea through intact round window membrane显示文摘Objective To study expression of adenoviral-mediated Hath1-EGFP gene in the guinea pig cochlea after transfer through intact round window membrane(RWM), and to assess its effects on hearing. Methods Twenty adult guinea pigs were used, of which: 12 were surgically inoculated with Ad-Hath1-EGFP in the bony groove of round window niche, and 8 with artificial perilymph. Auditory brainstem response(ABR) thresholds were determined in all animals before and 5 days after surgery. On post-surgery day 5 and day 14, animals were sacrificed and whole mounts of cochlea and frozen sections were examined. Results ABR tests showed no significant change of hearing after the surgery. Strong fluorescence staining in the cochleae was seen in Ad-Hath1-EGFP groups. The highest levels of gene expression were seen in the post-surgery day 5 group with little decrease on post-surgery day 14.The contralateral cochlea and those in the control groups were free of fluorescence staining. Conclusion The transgenic Hath1-EGFP can be effectively delivered into the inner ear through intact RWM, in an atraumatic manner. | CHEN Wei1☆, HU Yin-yan1☆, YANG Shi-ming1*, GUO Wei1, SUN Jian-he1, HAN Dong-yi1, ZHAI Suo-qiang1, YANG Wei-yan1, David Z.Z.He2 1. Neurologic Biological centre, Institute of Otolaryngology, Department of Otorhinolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing 100853, China 2. Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA | 2008 | Journal of Otology2008，3，1： | 7 |
| 4 | 加氢裂化预处理催化剂的发展(英文)显示文摘讨论了雪佛龙技术转让部的加氢裂化预处理催化剂的发展历史. 用'更多的类型 II 活性位导致更好的 HDN/HDS 催化性能'理论解释了我们最近研发的加氢裂化预处理催化剂 HDN 催化性能好的原因. | 贾继飞 Bruce YU Theo MAESEN Cecelia RADLOWSKI Art DAHLBERG John CREIGHTON Dave KRENZKE Dan TORCHIA Woody SHIFLETT | 2009 | 催化学报2009，30，8： | 3 |
| 5 | Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer显示文摘 | Chad J. Creighton Jenny C. Chang Jeffrey M. Rosen | 2010 | Journal of Mammary Gland Biology and Neoplasia2010，，： | 3 |
| 6 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 7 | Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes显示文摘 | King J Hamil T Creighton J | 2004 | Microvasc Res2004，167，2： | 1 |
| 8 | Long-term outcomes of anorectal malformations显示文摘 | Creighton SM Wilcox DT | 2004 | 20(8):567-5722004，20，8： | 1 |
| 9 | Widespread deregulation of microRNA expression in human prostate cancer显示文摘 | Ozen M Creighton C J Ozdemir M Ittmann M | 2008 | Oncogene2008，27，12： | 1 |
| 10 | Receptor-dependent activation of store-operated calcium entry increases endothelial cell permeability显示文摘 | Moore TM Norwood NR Creighton JR | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，3： | 1 |
| 11 | Vaginoplasty 显示文摘 | Davies MC Creighton SM | 2007 | Curr Opin Urol2007，17，： | 1 |
| 12 | Reversible adduct formation of trimethylgallium and trimethylindium with am monia显示文摘 | Randall Creighton J George T Wang | 2005 | J Phys Chem A2005，109，1： | 1 |
| 13 | Sherlock Homes in Babylon, American Math- ematial Monthly显示文摘 | Creighton Buck | 1988 | (187) :335-3451988，，187： | 1 |
| 14 | Men on fathering in the content of children' s unintentional injury prevention 显示文摘 | BRUSSONI M CREIGHTON G OLSEN LL | 2013 | Am J Mens Health2013，7，1： | 1 |
| 15 | Comments on' Information measure for performance of image fusion' 显示文摘 | Hossny M Nahavandi S Creighton D | 2008 | Electronics letters2008，44，18： | 1 |
| 16 | Plasma Resonance Enhancement of Raman Scattering by Pyridine Adsorbed on Silver or Gold Sol Particles of Size Comparable to the Excitation Wavelength显示文摘 | CREIGHTON J A BLATCHFORD C G ALBRECHT M G | 1979 | J Chem Soc1979，75，： | 1 |
| 17 | Regional variability in the time course of TGF-beta 1 expression,cellular proliferation and extracellular matrix expansion following arterial injury显示文摘 | Creighton WM Taylor AJ Dichek DA | 1997 | Growth Factors1997，14，4： | 1 |
| 18 | Kinetics of metal or- ganic-ammonia adduct decomposition: Implications for group-III nitride MOCVD显示文摘 | Randall Creighton J George T Wang | 2005 | J Phys Chem A2005，109，10： | 1 |
| 19 | High-grade serous ovarian cancer arises from fallopian tube in a mouse mod- el显示文摘 | Kim J Coffey DM Creighton CJ | 2012 | Proc Natl Acad Sci U S A2012，29，10： | 1 |
| 20 | Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis显示文摘 | Creighton CJ Casa A Lazard Z | 2008 | J Clin Oncol2008，26，25： | 1 |
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