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	题名	作者	年代	出处	被引量
1	Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis.	Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié	2008	World Journal of Gastroenterology2008，14，35：	6
2	Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)显示文摘	Fiona McPhee Amy K. Sheaffer Jacques Friborg Dennis Hernandez Paul Falk Guangzhi Zhai Steven Levine Susan Chaniewski Fei Yu Diana Barry Chaoqun Chen Min S. Lee Kathy Mosure Li-Qiang Sun Michael Sinz Nicholas A. Meanwell Richard J. Colonno Jay Knipe Paul S	2012	Antimicrobial Agents and Chemotherapy2012，，10：	2
3	Osteogenic differentiation of human bone marrow mesenchymal stem cells in hydrogel containing nacre powder显示文摘	Alicia Flausse Christel Henrionnet Manuel Dossot Dominique Dumas Sébastien Hupont Astrid Pinzano Didier Mainard Laurent Galois Jacques Magdalou Evelyne Lopez Pierre Gillet Marthe Rousseau	2013	J. Biomed. Mater. Res2013，，11：	2
4	MCML-Monte Carlo modeling of light transport in multi-layered tissues 显示文摘	Wang Lihong Jacques S Zheng Liqiong	1995	Comput Methods Programs Biomed1995，47，：	1
5	Mcml-monte carlo modeling of light transport in multi-layered tissues 显示文摘	Wang L I-I Jacques S L Zheng L	1995	Computer Methods and Programs in Biomedicine1995，47，：	1
6	The three dimensions of species diversity显示文摘	YOU M S LIETTE V JACQUES R	2009	The Open Conservation Biology Journal2009，，3：	1
7	Pulse pressure variation and stroke volume variation during increased intra- abdominal pressure: an experimental study 显示文摘	Jacques D Bendjelid K Duperret S	2011	Crit Care2011，15，1：	1
8	Relatedness of Thermomyces lanuginosus strains producing a thermostable xylanase显示文摘	SUREN S POOVENDHREE R JACQUES H	2000	Journal of Biotechnology2000，81，2：	1
9	Immunocytochemical characterization of pulmonary histiocytosis X cells in lung biopsies显示文摘	Soler P Chollet S Jacque C	1985	Am J Pathol1985，118，3：	1
10	Multiple synchronous serous cystadenomas of the pancreas: uncommon CT and MRI findings显示文摘	Daniel Leonard Jacques Baulieux Agnès Rode Vincent Garbit Eric De La Roche Christian Ducerf Jean-Yves Mabrut	2007	Journal of Hepato - Biliary - Pancreatic Surgery2007，，6：	1
11	Background Subtraction and Shadow Detection in Grayscale Video Se- quences 显示文摘	Jacques J C S Jung C R Raupp Musse S	2005	Computer Graphics and Image Processing2005，1，1：	1
12	Use of the Barthel index and modified rankin scale in acute stroke trials 显示文摘	Geert S Christel S Jacques DK	1999	Stroke1999，30，8：	1
13	The role of ultrasound examination in the first trimester and at 16 weeks’ gestation to predict fetal complications in monochorionic diamniotic twin pregnancies显示文摘	Liesbeth Lewi Paul Lewi Anke Diemert Jacques Jani Leonardo Gucciardo Tim Van Mieghem Elisa Doné Eduardo Gratacós Agnes Huber Kurt Hecher Jan Deprest	2008	American Journal of Obstetrics and Gynecology2008，，5：	1
14	Immunotherapy of malignant melanoma with vaccinia virus显示文摘	Roenigk HH Jr Deodhar S St Jacques R	1974	Arch Dermatol1974，109，5：	1
15	Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure显示文摘	Brealey D Karyampudi S Jacques TS		0，，：	1
16	sur face r ough ness and EDS ch ar acter ization of aY- TZP dentalcer amic tr eated w ith th e Co Jetl TM Sand 显示文摘	Mar ia Catcani Lor ent Susar lne S Sch er r er Jacque S Rich ar d	2010	Dental Mater ials2010，26，11：	1
17	Intravascular volume monitoring and extravascular lung water in septic patients with pulmonary edema显示文摘	Boussat S Jacques T Levy B	2002	Intensive Care Med2002，28，6：	1
18	Viable skin efficiently absorbs and metabolizes bisphenol A 显示文摘	Zalko D Jacques C Duplan H Bruel S Perdu E	2011	Chemosphere2011，82，3：	1
19	Skin optics显示文摘	van Germert M J Jacques S L Sterenborg H J	1989	IEEE Trans Biomed Eng1989，36，12：	1
20	What is Man显示文摘	Jacques Maritain’s Paper	1953	Jacques Maritain Centerof University of Notre Dame1953，，：	1

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