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| 1 | 四成分教学设计模型--面向复杂学习环境的多媒体原理显示文摘四成分教学设计模型认为要实现复杂学习需要借助学习任务、支持性信息、程序性信息和子任务练习等因素。本文探讨运用这一模型设计多媒体学习环境及相关的14条多媒体原理。学习者可以在一个模拟的环境下完成学习任务,利用相关的多媒体原理有利于促进归纳学习过程;学习者还可以在超媒体系统中掌握支持性信息,相关的多媒体原理有利于促进信息的提取和精细加工过程;学习者也可以通过电子绩效支持系统来获取程序性信息,相关的多媒体原理有利于知识处理;最后,学习者能通过基于计算机练习程序来进行子任务的练习与训练,相关的多媒体原理有利于促进知识技能的巩固。本文还讨论了四成分模型框架的启示和不足。 | Jeroen J. G. van Merrienboer Liesbeth Kester 盛群力(译) 徐瑞(译) | 2008 | 远程教育杂志2008，26，2： | 13 |
| 2 | 乙型肝炎病毒导致的肝硬化伴肝癌患者血清中N糖组学改变显示文摘肝细胞癌(HCC)是最常见的肿瘤和最主要的死因之一,多发生于HBV和HCV感染导致的肝硬化患者,筛查肝硬化人群,早期诊断HCC可降低肿瘤的病死率。甲胎蛋白(AFP)是目前广泛应用的辅助诊断HCC的血清学指标,是对B超、CT等影像学诊断的有效补充。最近的荟萃分析表明,不同研究论文报道的AFP的灵敏度和特异度有很大的不同,这种现象不能完全用AFP的临界值不同解释。血清中的N糖蛋白主要由肝脏和B淋巴细胞合成,N糖成分的改变可反应肝脏或B淋巴细胞功能的改变,糖链的改变常常反应出机体的异常改变。糖组学在诊断领域的应用曾经因为缺少合适的分析技术而受限制,血清中N糖组学分析技术克服了这一屏障。本研究的目的是评价血清中N糖指纹图谱应用于乙型肝炎后肝硬化伴肝癌辅助诊断的意义。 | 刘学恩 Liesbeth Desmyter 高春芳 Wouter Laroy Sylviane Dewaele Valerie Vanhooren 王玲 庄辉 Nico Callewaert Claude Libert Roland Contreras 陈翠英 | 2008 | 中华肝脏病杂志2008，16，1： | 11 |
| 3 | 单绒毛膜双羊膜囊性双胎妊娠的合并症及处理方式(Ⅱ)显示文摘综述目的与双绒双胎妊娠相比,单绒双胎妊娠有非常高的胎儿丢失率、围产期死亡率和发病率。这是因为双胎间无法预料的血管交通吻合及单个胎盘的不均衡分配。最新发现尽管某些特定的血流动力学因素和激素可能参与双胎输血综合征(TTTS)的病理生理过程,但通常认为TTTS的病理生理过程是以血管构建为基础的。关于减少羊水、胎儿镜下激光凝固术和造口术的大规模随机试验仍无结果。随着胎儿镜激光治疗所需的硬件和仪器进一步完善,单绒双胎在妊娠早期出现严重的生长不协调问题已得到解决。已提出几个TTTS的发病机制,但对于其发生过程仍知之甚少。而且脐动脉多普勒波形对双胎妊娠并无和单胎妊娠同样的预测价值。对双胎间的血管吻合进行预防性激光阻塞可以预防单胎胎死宫内这类不良事件的发生。但这一预防措施至今对改善妊娠结局并无任何益处。最后本文讨论了关于单绒双胎妊娠生长不协调和染色体异常的病理生理学机制及处理。通过针孔导入的激光和单极凝固术可以用来在妊娠早期进行选择性减胎或改善血流动力学情况。妊娠晚期或血流动力学正常时,双极凝固术似乎更有效。总结近几年来,对单绒双胎妊娠合并症的理解已进一步深入。希望这些进步可以指导这类高危妊娠进行更好的检测,最终改善妊娠结局。 | Liesbeth Lewi Dominique Van Schoubroeck Eduard Gratacós Ingrid Witters Dirk Timmerman Jan Deprest 赵德鹏 刘丹 樊佳丽 | 2010 | 中国产前诊断杂志(电子版)2010，，2： | 8 |
| 4 | 单绒毛膜双羊膜囊性双胎妊娠合并症及处理方式(Ⅰ)显示文摘综述目的与双绒双胎妊娠相比,单绒双胎妊娠有非常高的胎儿丢失率、围产期死亡率和发病率。这是因为双胎间无法预料的血管交通吻合及单个胎盘的不均衡分配。最新发现尽管某些特定的血流动力学因素和激素可能参与双胎输血综合征(TTTS)的病理生理过程,但通常认为TTTS的病理生理过程是以血管构建为基础的。关于减少羊水、胎儿镜下激光凝固术和造口术的大规模随机试验仍无结果。随着胎儿镜激光治疗所需的硬件和仪器进一步完善,单绒双胎在妊娠早期出现严重的生长不协调问题已得到解决。已提出几个TTTS的发病机制,但对于其发生过程仍知之甚少。而且脐动脉多普勒波形对双胎妊娠并无和单胎妊娠同样的预测价值。对双胎间的血管吻合进行预防性激光阻塞可以预防单胎胎死宫内这类不良事件的发生。但这一预防措施至今对改善妊娠结局并无任何益处。最后本文讨论了关于单绒双胎妊娠生长不协调和染色体异常的病理生理学机制及处理。通过针孔导入的激光和单极凝固术可以用来在妊娠早期进行选择性减胎或改善血流动力学情况。妊娠晚期或血流动力学正常时,双极凝固术似乎更有效。总结近几年来,对单绒双胎妊娠合并症的理解已进一步深入。希望这些进步可以指导这类高危妊娠进行更好的检测,最终改善妊娠结局。 | Liesbeth Lewi Dominique Van Schoubroeck Eduard Gratacós Ingrid Witters Dirk Timmerman Jan Deprest 赵德鹏 刘丹 樊佳丽 | 2010 | 中国产前诊断杂志(电子版)2010，，1： | 7 |
| 5 | Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks显示文摘AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results. | Geert Robaeys Jozef De Bie Marieke C Wichers Liesbeth Bruckers Frederik Nevens Peter Michielsen Marc Van Ranst Frank Buntinx | 2007 | World Journal of Gastroenterology2007，13，43： | 4 |
| 6 | Regional differences in lung radiosensitivity after radiotherapy for non–small-cell lung cancer显示文摘 | Yvette Seppenwoolde Katrien De Jaeger Liesbeth J. Boersma José S.A. Belderbos Joos V. Lebesque | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 2 |
| 7 | Anti-tumor necrosis factor treatment restores the gut barrier in Crohn’s disease显示文摘 | Peter Suenaert Veerle Bulteel Liesbeth Lemmens Maja Noman Benny Geypens Gert Van Assche Karel Geboes Jan L Ceuppens Paul Rutgeerts | 2002 | The American Journal of Gastroenterology2002，，8： | 2 |
| 8 | Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy显示文摘Post-exposure prophylaxis(PEP)for leprosy is administered as one single dose of rifampicin(SDR)to the contacts of newly diagnosed leprosy patients.SDR reduces the risk of developing leprosy among contacts by around 60%in the first 2–3 years after receiving SDR.In countries where SDR is currently being implemented under routine programme conditions in defined areas,questions were raised by health authorities and professional bodies about the possible risk of inducing rifampicin resistance among the M.tuberculosis strains circulating in these areas.This issue has not been addressed in scientific literature to date.To produce an authoritative consensus statement about the risk that SDR would induce rifampicin-resistant tuberculosis,a meeting was convened with tuberculosis(TB)and leprosy experts.The experts carefully reviewed and discussed the available evidence regarding the mechanisms and risk factors for the development of(multi)drug-resistance in M.tuberculosis with a view to the special situation of the use of SDR as PEP for leprosy.They concluded that SDR given to contacts of leprosy patients,in the absence of symptoms of active TB,poses a negligible risk of generating resistance in M.tuberculosis in individuals and at the population level.Thus,the benefits of SDR prophylaxis in reducing the risk of developing leprosy in contacts of new leprosy patients far outweigh the risks of generating drug resistance in M.tuberculosis. | Liesbeth Mieras Richard Anthony Wim van Brakel Martin W.Bratschi Jacques van den Broek Emmanuelle Cambau Arielle Cavaliero Christa Kasang Geethal Perera Lee Reichman Jan Hendrik Richardus Paul Saunderson Peter Steinmann Wing Wai Yew | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 9 | A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease 显示文摘 | Liesbeth van Emst Anton V M B Schattenberg | 2000 | Blood2000，95，12： | 1 |
| 10 | Imaging electron wave functions of quantized energy levels in carbon nanotubes 显示文摘 | LIESBETH C V JEROEN W G JORG W J | 1999 | Science1999，283，： | 1 |
| 11 | Long-lasting symptoms and diagnostics in a patient with unrecognized right sided heart failure: Why listening to the heart is so important显示文摘M Ebstein is usually diagnosed in early childhood or ad-olescence. The young woman in our case complainted of fatigue and shortness of breath, on physical exami-nation she showed signs of heart failure with raised central venous pressure, palpable liver, an a cardiac murmer. Based on these findings she should have been referred to a cardiologist in an early stage after which transthoracic echocardiography resulted in the correct diagnosis. In this case the anomaly was missed for many years by different specialists and the patient was treated for liver disease, while she was suffering from liver congestion due to right-sided heart failure. | Liesbeth C de Vette Jasper J Brugts Jacky S McGhie Jolien W Roos-Hesselink | 2014 | World Journal of Cardiology2014，6，5： | 1 |
| 12 | Exploring the links between conceptions of the neighbourhood and gerontological research perspectives显示文摘 | Tine Buffel Dominique Verte Liesbeth De Donder Nico De Witte | 2008 | Studies on Social Sciences2008，，1： | 1 |
| 13 | The role of ultrasound examination in the first trimester and at 16 weeks’ gestation to predict fetal complications in monochorionic diamniotic twin pregnancies显示文摘 | Liesbeth Lewi Paul Lewi Anke Diemert Jacques Jani Leonardo Gucciardo Tim Van Mieghem Elisa Doné Eduardo Gratacós Agnes Huber Kurt Hecher Jan Deprest | 2008 | American Journal of Obstetrics and Gynecology2008，，5： | 1 |
| 14 | A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-preducing T cell that cross-react with the mammalian self-hsp 70 homologue 显示文摘 | Uwe Wendling Liesbeth Paul Ruurd van der Zee | 2000 | J Immunol2000，164，5： | 1 |
| 15 | Effect of high oxygen modified atmosphere packaging on microbial growth and sensorial qualities of fresh-cut produce显示文摘 | Liesbeth J Frank D Caroline V | 2001 | Internation Journal of Food Microbiology2001，71，： | 1 |
| 16 | A Post‐Hoc Comparison of the Utility of S anger Sequencing and Exome Sequencing for the Diagnosis of Heterogeneous Diseases显示文摘 | Kornelia Neveling Ilse Feenstra Christian Gilissen Lies H. Hoefsloot Erik‐Jan Kamsteeg Arjen R. Mensenkamp Richard J. T. Rodenburg Helger G. Yntema Liesbeth Spruijt Sascha Vermeer Tuula Rinne Koen L. Gassen Danielle Bodmer Dorien Lugtenberg Rick Reuver We | 2013 | Human Mutation2013，，12： | 1 |
| 17 | Remifentanil for fetal immobilization and maternal sedation during feto- scopic surgery: a randomized, double-blind comparison with diazepam 显示文摘 | Van de Velde Marc Van Schoubroeck Dominique Lewi Liesbeth E | 2005 | Anesth Analg2005，101，1： | 1 |
| 18 | Identification Of Bifidobacterium Specis Using Rep-PCR Finggerprinting显示文摘 | Geert Huys etc | 2003 | System Applild Microbiol2003，26，： | 1 |
| 19 | Clinical outcome and placental characteristics of monochorionic diamniotic twin pairs with early- and late-onset discordant growth显示文摘 | Liesbeth Lewi Leonardo Gucciardo Agnes Huber Jacques Jani Tim Van Mieghem Elisa Doné Mieke Cannie Eduardo Gratacós Anke Diemert Kurt Hecher Paul Lewi Jan Deprest | 2008 | American Journal of Obstetrics and Gynecology2008，，5： | 1 |
| 20 | Evaluation of mammary lymphoscigrph by a single intratumoral injection for sentinel node identification 显示文摘 | Valdes O Liesbeth J | 2000 | J Nucl Med2000，41，： | 1 |
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