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| 1 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet . 2009 (9701)2009，，： | 4 |
| 2 | Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa显示文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P< 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women. | Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo Djeneba Ouermi Florencia W Djigma Salvatore Pignatelli Joseph D Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 4 |
| 3 | Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions显示文摘 | Isabelle Soerjomataram Joannie Lortet-Tieulent D Maxwell Parkin Jacques Ferlay Colin Mathers David Forman Freddie Bray | 2012 | The Lancet2012，，9856： | 3 |
| 4 | Antimicrobial resistance of abnormal vaginal discharges microorganisms in Ouagadougou,Burkina Faso显示文摘Objective:To assess the prevalence of bacterial strains and fungal strains infecting the vaginal tract and test their sensitivity to antibiotics in women attending Saint Camille Medical Centre in Ouagadougou.Methods:From January 2008 to December 2009,a total of 2000 vaginal swabs were cultivated for bacterial and fungal identification and isolation.Furthermore,bacterial strains were tested for their susceptibility to several antibiotics used in routine in the centre. Results:The results revealed that microbial isolation and identification was attempted for 1536/2000 sample,a positivity rate of 76.80%.Candida albicans(48.76%),followed by Escherichia coli(16.67%),Streptococcus agalactiae(8-14%) and Staphylococcus aureus(7.55%) were the major agents of genital tract infections in patients.Mycoplasma hominis and Ureaplasma urealyticum combined accounted for less than 7%.Trichomonas vaginalis was identified in 1.04%coses.The antimicrobial tests revealed that the microorganisms developed resistance to several antibiotics including beta lactams.However,antibiotics such as cefamenzol,ciprofloxacin and norfloxacin were still active on these bacteria.Conclusions:The results reveal that many sexually active women are infected by one or more microbial pathogens,probably because of the lock of hygiene or the adoption of some risky behaviors,such as not using condoms or having multiple sexual partners.Efforts should be made to address these points in the country. | Simplice D Karou Florencia Djigma Tani Sagna Christelle Nadembega Moctar Zeba Aboudoulaye Kabre Kokou Anani Djeneba Ouermi Charlemagne Gnoula Virginio Pietra Salvatore Pignatelli Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 2 |
| 5 | Biliary obstruction caused by portal cavernoma: a study of 8 cases显示文摘 | Gabriel Perlemuter Hervé Béjanin Jacques Fritsch Frédéric Prat Marianne Gaudric Stanislas Chaussade Catherine Buffet | 1996 | Journal of Hepatology1996，，1： | 2 |
| 6 | Early Administration of Azathioprine vs Conventional Management of Crohn’s Disease: a Randomized Controlled Trial显示文摘 | Jacques Cosnes Anne Bourrier David Laharie Stéphane Nahon Yoram Bouhnik Franck Carbonnel Matthieu Allez Jean-Louis Dupas Jean-Marie Reimund Guillaume Savoye Pauline Jouet Jacques Moreau Jean-Yves Mary Jean-Frédéric Colombel | 2013 | Gastroenterology2013，，： | 2 |
| 7 | EUS-guided fiducial markers placement with a 22-gauge needle for image-guided radiation therapy in pancreatic cancer显示文摘 | Raquel Dávila Fajardo Selma J. Lekkerkerker Astrid van der Horst Eelco Lens Jacques J. Bergman Paul Fockens Arjan Bel Jeanin E. van Hooft | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 8 | Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia显示文摘AIM: To quantify the intraepithelial lymphocytes (IELs) and to document the membrane expression of CD4, CD8, TCRγδ and adhesion and/or activation-associated molecules (CD103, CD28, CD44, CD69, HLA-DR, CD95/ Fas) in the duodenal mucosa of patients with functional dyspepsia (FD) in order to provide arguments for an immunological process in FD. METHODS: Twenty-six FD patients according to Rome Ⅱ criteria (20 were H pylori negative) were studied and compared to 12 healthy adults. IELs were isolated from five duodenal biopsy samples, then quantified by microscopy and flow cytometry while the membrane phenotypes were determined by cytofluorometry. RESULTS: Duodenal histological examination was normal. In H pylori negative patients, the number of IELs was not different from that in healthy controls. Median percentage expression of CD4, CD8, or TCRγδ and CD103, CD44, CD28, CD69 on CD3+ IELs, among the adhesion/activation associated molecules tested, was not different from that in healthy controls. In contrast, the median percentage expression of CD95/ Fas [22 (9-65) vs 45 (19-88), P = 0.03] and HLA- DR expressing CD3+ IELs [4 (0-30) vs 13 (4-42), P = 0.04] was significantly lower in the H pylori negative FD group than in healthy controls, respectively. The number of IELs was significantly greater in H pylori positive FD patients than in healthy controls [median ratiofor 100 enterocytes 27.5 (6.7-62.5) vs 10.8 (3-33.3), P = 0.02] due to a higher number of CD8+ CD3+ IELs. CONCLUSION: In H pylori negative FD patients, the phenotypic characterization of IELs suggests that we cannot exclude a role of IELs in FD. | Gilles Gargala Stéphane Lecleire Arnaud Franois Serge Jacquot Pierre Déchelotte Jean Jacques Ballet Loic Favennec Philippe Ducrotté | 2007 | World Journal of Gastroenterology2007，13，16： | 2 |
| 9 | Vitamin D Deficiency and Risk of Cardiovascular Disease显示文摘 | Thomas J. Wang Michael J. Pencina Sarah L. Booth Paul F. Jacques Erik Ingelsson Katherine Lanier Emelia J. Benjamin Ralph B. D?Agostino Myles Wolf Ramachandran S. Vasan | 2008 | Circulation2008，，4： | 2 |
| 10 | Continuous production of aligned carbon nanotubes:A step closer to commercial realization显示文摘 | Andrews R Jacques D Rao A M | 1999 | Chemical Physics Letters1999，303，： | 1 |
| 11 | Microelectrode guided posteroventral medial radiofrequency pallidotomy for Parkinson's disease显示文摘 | KOPYOV O JACQUES D DUMA C | 1997 | J Neurosurg1997，87，： | 1 |
| 12 | Localization of laminin,fibronectin,E-caderin,and integrins in endometrium and endometriosis显示文摘 | Aude Beliard M D Jacques Donnez P H D | 1997 | Fertil Steril1997，67，： | 1 |
| 13 | Biofilm formation in bacterial pathogens of veterinary importance 显示文摘 | JACQUES M ARAGON V TREMBLAY Y D | 2010 | Anita Health Res Rev2010，11，2： | 1 |
| 14 | Pulse pressure variation and stroke volume variation during increased intra- abdominal pressure: an experimental study 显示文摘 | Jacques D Bendjelid K Duperret S | 2011 | Crit Care2011，15，1： | 1 |
| 15 | Full laparoscopic total pancreatectomy with and without spleen and pylorus preservation: a feasibility report显示文摘 | Bernard Dallemagne Antonio Talvane Torres Oliveira Croider Franco Lacerda Jacopo D’Agostino Henry Mercoli Jacques Marescaux | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，6： | 1 |
| 16 | Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment显示文摘 | Ariane Vienne Ehlam Hobeika Hervé Gouya Nathanael Lapidus Jacques Fritsch André Daniel Choury Ariane Chryssostalis Marianne Gaudric Gilles Pelletier Catherine Buffet Stanislas Chaussade Frédéric Prat | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
| 17 | Normal Variants and Frequent Marrow Alterations that Simulate Bone Marrow Lesions at MR Imaging显示文摘 | Bruno C. Vande Berg Frédéric E. Lecouvet Christine Galant Baudouin E. Maldague Jacques Malghem | 2005 | Radiologic Clinics of North America2005，，： | 1 |
| 18 | Continues production of aligned carbon nanotubes: A step closer to commercial realization 显示文摘 | Andrews R Jacques D Rao A M | 1999 | Chemical Physics Letters1999，303，56： | 1 |
| 19 | Expression of transforming growth factoralpha, epidermal growth factor, and epidermal growth factor receptor in follicles of human ovarian tissue before and after cryopreservation 显示文摘 | Jianping QU Michelle N Jacques D | 2002 | Fertility and Stertility2002，74，： | 1 |
| 20 | Calibra- tion of Richards' and convection-dispersion equations to field-scale water flow and solute transport under rainfall con- ditions显示文摘 | JACQUES D IMiNEK J TIMMERMAN A | 2002 | Journal of Hydrology2002，259，1： | 1 |
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