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| 1 | 热处理对激光熔融沉积镍基超合金Rene41的显微组织和力学性能的影响显示文摘镍基超合金Rene 41是用激光熔融沉积工艺(LMD)生产的。这种LMD材料在1065℃,4 h固溶,接着空淬,然后760℃时效16 h,接着空冷。沉积固溶处理和固溶-时效的合金用扫描电镜和透射电镜观测它的特征,并检测拉伸性能和硬度。这种固溶-时效的超合金合金Rene 41呈现高硬度,低强度和低延伸率。γ'的大量沉积造成高硬度和延伸率,以及γ'沉积连续排列和集聚引起低强度。在三种不同热处理条件下研究了合金的组织与性能的关系,结果表明为这种精炼的Rene 41推荐的标准热处理不适合LMD合金,必须改变获得最佳力学性能。 | J.Li,H.M.Wang,H.B.Tang | 2012 | 热处理技术与装备2012，33，3： | 6 |
| 2 | Statistical moment-based structural damage detection method in time domain显示文摘A novel structural damage detection method with a new damage index,i.e.,the statistical moment-based damage detection(SMBDD) method in the frequency domain,has been recently proposed.The aim of this study is to extend the SMBDD method in the frequency domain to the time domain for building structures subjected to non-Gaussian and non-stationary excitations.The applicability and effectiveness of the SMBDD method in the time domainis verified both numerically and experimentally.Shear buildings with various damage scenarios are first numerically investigated in the time domain taking into account the effect of measurement noise.The applicability of the proposed method in the time domain to building structures subjected to non-Gaussian and non-stationary excitations is then experimentally investigated through a series of shaking table tests,in which two three-story shear building models with four damage scenarios aretested.The identified damage locations and severities are then compared with the preset values.The comparative results are found to be satisfactory,and the SMBDD method is shown to be feasible and effective for building structures subjected to non-Gaussian and non-stationary excitations. | J.Zhang Y.L.Xu J.Li Y.Xia J.C.Li | 2013 | Earthquake Engineering and Engineering Vibration2013，12，1： | 6 |
| 3 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 4 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 5 | MHD Instabilities and Their Effects on Plasma Confinement in Large Helical Device Plasmas with Intense Neutral Beam Injection显示文摘MHD stability of the Large Helical Device (LHD) plasmas produced with intense neutral beam injection is experimentally studied. When the steep pressure gradient near the edge is produced through L-H transition or linear density ramp experiment, interchange-like MHD modes whose rational surface is located very close to the last closed flux surface are strongly excited in a certain discharge condition and affect the plasma transport appreciably. In NBI-heated plasmas produced at low toroidal field, various Alfvén eigenmodes are often excited. Bursting toroidal Alfvén egenmodes excited by the presence of energetic ions induce appreciable amount of energetic ion loss, but also trigger the formation of internal and edge transport barriers. | K.Toi S.Ohdachi S.Yamamoto S.Sakakibara K.Y.Watanabe N.Nakajima X.Ding J.Li S.Morita K.Narihara K.Tanaka T.Tokuzawa H.Yamada Q.Yang | 2004 | Plasma Science and Technology2004，6，3： | 3 |
| 6 | Cutting Characteristics of Zr-Based Bulk Metallic Glass显示文摘Cutting behavior exerts a considerable influence on the fabrication of bulk metallic glass(BMG) components. In this study,the influences of machining parameters(i.e.,depth of cutting,feed rate,and spindle rate) on the turned surface of a Zr-based BMG after observing the 3D morphologies of this surface were characterized.The results showed that the influence of the spindle rate on the surface morphologies is more substantial as compared to the depth of cutting and the feed rate. Nanoscratch tests were conducted to further characterize the separation mechanism of the chips,which revealed that the chips are torn off the surface of a BMG because of inhomogeneous localized maximum shear stress. | D.X.Han G.Wang J.Li K.C.Chan S.To F.F.Wu Y.L.Gao Q.J.Zhai | 2015 | Journal of Materials Science & Technology2015，31，2： | 2 |
| 7 | Analysis of delivery and recalculation of dose using DICOM treatment records显示文摘Objective:A procedure has been proposed for patient-specific QA that,instead of comparing a measurement to the planned dose,compares the dose calculated by an independent system to the dose calculated by the planning system.It is still prudent,however,to check the accuracy of the beam delivery.For this purpose,the DICOM records from the first treatment fraction can be compared to the planned treatment using an in-house developed planning system.Methods:Totally 1,398 patient portals were subjected to the new QA procedure.The dose distribution for each portal was first recalculated on a water phantom by two treatment planning systems and the dose distributions were compared.When agreement was observed,the patient was allowed to start treatment without a measure-ment.The record from the first day was imported into an in-house planning system which was used to evaluate the delivery for errors and calculate the delivered dose distribution and compare it to the planned dose distribution.Results:A total of 266 portals passed a strict comparison between the clinical and QA dose calculations and directly used for treatment without measurements.For those portals,the comparison of the delivery records to the plan showed that 99%of spot positions deviated less than 0.2 mm and 99.7%of spot metersets deviated by less than 0.3%.On the other hand,64 portals showed spot size deviations greater than the tolerance of15%with some as large as25%.For 32 portals in which the record was used to calculate the delivered dose distribution,the Gamma passing rates between the planned and delivered distributions were always above 95%using a 2%dose difference and 2 mm distance-to-agreement criteria.Conclusions:The new QA process has been implemented slowly with strict constraints.The amount of beam time required has been reduced while maintaining safety. | Z.Chen M.F.Moyers Y.Deng H.L.Chen J.Li Z.M.Shen J.Lin Q.Wang P.Yepes | 2022 | Radiation Medicine and Protection2022，3，3： | 2 |
| 8 | 中庭烟气管理系统的设计导则回顾(英文)显示文摘本文回顾在中庭中常用的烟气管理设计导则。概括了在这些导则中采用的不同方法,并解释了这些方法背后的烟气物理。这些设计导则中的烟气动力学的工程原理是相似的。基本上,方法包括强加逆向流来阻止烟气蔓延,采用压差来对付物理障碍物,烟气稀释和抽取。烟气通风看来是中庭中烟气管理的常用方法,可以将烟气层界面的高度保持在可接受值,或者至少降低烟气层的下降速率。这些导则给出了设计的一般原则,但并未覆盖所有中庭,特别是在远东地区新建建设性项目中的中庭。 | 周允基 J.Li | 2005 | 火灾科学2005，14，3： | 2 |
| 9 | (−)- and (+)-Securidanes A and B, Natural Triarylmethane Enantiomers: Structure and Bioinspired Total Synthesis显示文摘Two pairs of enantiomers,(−)and(+)-securidanes A(1 and 2)and B(3 and 4)featuring unprecedented triarylmethane(TAM)skeletons,were isolated from Securidaca inappendiculata.Teir structures were established by spectroscopic data,X-ray crystallography,and CD analysis.A plausible biosynthetic pathway for 1−4 based on the co-isolated precursors was proposed.Bioinspired total synthesis of 1−4was completed in high yield,which in turn corroborated the biosynthetic hypothesis.Compounds 1−4 showed good inhibition against protein tyrosine phosphatase 1B(PTP1B).Te molecular docking demonstrated that the strongest inhibitor 3(IC50=7.52�M)reaches deeper into the binding pocket and has an additional H-bond. | B.Zhou D.X.Liu X.J.Yuan J.Y.Li Y.C.Xu J.Li YLi J.M.Yue | 2018 | Research2018，，1： | 2 |
| 10 | Studies of laser-plasma interaction physics with low-density targets for direct-drive inertial confinement fusion on the Shenguang III prototype显示文摘The physics of laser-plasma interaction is studied on the Shenguang III prototype laser facility under conditions relevant to inertial confinement fusion designs.A sub-millimeter-size underdense hot plasma is created by ionization of a low-density plastic foam by four high-energy(3.2 kJ)laser beams.An interaction beam is fired with a delay permitting evaluation of the excitation of parametric instabilities at different stages of plasma evolution.Multiple diagnostics are used for plasma characterization,scattered radiation,and accelerated electrons.The experimental results are analyzed with radiation hydrodynamic simulations that take account of foam ionization and homogenization.The measured level of stimulated Raman scattering is almost one order of magnitude larger than that measured in experiments with gasbags and hohlraums on the same installation,possibly because of a greater plasma density.Notable amplification is achieved in high-intensity speckles,indicating the importance of implementing laser temporal smoothing techniques with a large bandwidth for controlling laser propagation and absorption. | V.T.Tikhonchuk T.Gong N.Jourdain O.Renner F.P.Condamine K.Q.Pan W.Nazarov L.Hudec J.Limpouch R.Liska M.Krus F.Wang D.Yang S.W.Li Z.C.Li Z.Y.Guan Y.G.Liu T.Xu X.S.Peng X.M.Liu Y.L.Li J.Li T.M.Song J.M.Yang S.E.Jiang B.H.Zhang W.Y.Huo G.Ren Y.H.Chen W.Zheng Y.K.Ding K.Lan S.Weber | 2021 | Matter and Radiation at Extremes2021，6，2： | 2 |
| 11 | The Treg/Th17 Imbalance in Patients with Idiopathic Dilated Cardiomyopathy显示文摘 | J.Li L.Wang S.Wang H.Zhu P.Ye A.Xie B.Shen C.Liu C.Guo Q.Fu K.Zhang J.Xia | 2010 | Scandinavian Journal of Immunology2010，，4： | 2 |
| 12 | Melanoma:Molecular genetics,metastasis,targeted therapies,immunotherapies,and therapeutic resistance显示文摘Cutaneous melanoma is a common cancer and cases have steadily increased since the mid 70s.For some patients,early diagnosis and surgical removal of melanomas is lifesaving,while other patients typically turn to molecular targeted therapies and immunotherapies as treatment options.Easy sampling of melanomas allows the scientific community to identify the most prevalent mutations that initiate melanoma such as the BRAF,NRAS,and TERT genes,some of which can be therapeutically targeted.Though initially effective,many tumors acquire resistance to the targeted therapies demonstrating the need to investigate compensatory pathways.Immunotherapies represent an alternative to molecular targeted therapies.However,inter-tumoral immune cell populations dictate initial therapeutic response and even tumors that responded to treatment develop resistance in the long term.As the protocol for combination therapies develop,so will our scientific understanding of the many pathways at play in the progression of melanoma.The future direction of the field may be to find a molecule that connects all of the pathways.Meanwhile,noncoding RNAs have been shown to play important roles in melanoma development and progression.Studying noncoding RNAs may help us to understand how resistance e both primary and acquired e develops;ultimately allow us to harness the true potential of current therapies.This review will cover the basic structure of the skin,the mutations and pathways responsible for transforming melanocytes into melanomas,the process by which melanomas metastasize,targeted therapeutics,and the potential that noncoding RNAs have as a prognostic and treatment tool. | William Wagstaff Rimel N.Mwamba Karina Grullon Mikhayla Armstrong Piao Zhao Bryce Hendren-Santiago Kevin H.Qin Alexander J.Li Daniel A.Hu Andrew Youssef Russell R.Reid Hue H.Luu Le Shen Tong-Chuan He Rex C.Haydon | 2022 | Genes & Diseases2022，9，6： | 2 |
| 13 | Fabrication of all-transparent polymer-based and encapsulated nanofluidic devices using nano-indentation lithography显示文摘In this paper,we describe a novel and simple process for the fabrication of all-transparent and encapsulated polymeric nanofluidic devices using nano-indentation lithography.First,a nanomechanical probe is used to‘scratch’nanoscale channels on polymethylmethacrylate(PMMA)substrates with sufficiently high hardness.Next,polydimethylsiloxane(PDMS)is used twice to duplicate the nanochannels onto PDMS substrates from the‘nano-scratched’PMMA substrates.A number of experiments are conducted to explore the relationships between the nano-indentation parameters and the nanochannel dimensions and to control the aspect ratio of the fabricated nanochannels.In addition,traditional photolithography combined with soft lithography is employed to fabricate microchannels on another PDMS‘cap’substrate.After manually aligning the substrates,all uncovered channels on two separate PDMS substrates are bonded to achieve a sealed and transparent nanofluidic device,which makes the dimensional transition from microscale to nanoscale feasible.The smallest dimensions of the achievable nanochannels that we have demonstrated thus far are of~20 nm depth and~800 nm width,with lengths extendable beyond 100μm.Fluid flow experiments are performed to verify the reliability of the device.Two types of colloidal solution are used to visualize the fluid flow through the nanochannels,that is,ethanol is mixed with gold colloid or fluorescent dye(fluorescein isothiocyanate),and the flow rate and filling time of liquid in the nanochannels are estimated based on time-lapsed image data.The simplicity of the fabrication process,bio-compatibility of the polymer substrates,and optical transparency of the nanochannels for flow visualization are key characteristics of this approach that will be very useful for nanofluidic and biomolecular research applications in the future. | Cong Wu Tiffany G.Lin Zhikun Zhan Yi Li Steve C.H.Tung William C.Tang Wen J.Li | 2017 | Microsystems & Nanoengineering2017，3，1： | 2 |
| 14 | Effect of Different Treatment on Anther Callus Formation and Browning in Balsam Pear (Mornordica charantia L.)显示文摘 | Y. Tang J. Liu B. Liu J.Li X. M. Li H. X. Li | 2010 | Journal of Agricultural Science and Technology2010，4，6： | 2 |
| 15 | Observation of the Crab Nebula with LHAASO-KM2A−a performance study显示文摘A sub-array of the Large High Altitude Air Shower Observatory(LHAASO),KM2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 TeV.Even though the detector construction is still underway,half of the KM2A array has been operating stably since the end of 2019.In this paper,we present the KM2A data analysis pipeline and the first observation of the Crab Nebula,a standard candle in very high energy γ-ray astronomy.We detect γ-ray signals from the Crab Nebula in both energy ranges of 10-100 TeV and>100 TeV with high significance,by analyzing the KM2A data of 136 live days between December 2019 and May 2020.With the observations,we test the detector performance,including angular resolution,pointing accuracy and cosmic-ray background rejection power.The energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE=(1.13±0.05stat±0.08sys)×10^(-14).(E/20 TeV)-309±0.06stat±0.02syscm^(-2) s^(-1) TeV^(-1).It is consistent with previous measurements by other experiments.This opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena,such as cosmic PeVatrons,might be discovered. | F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai D.della Volpe B.D'Ettorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li F.Li H.B.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu H.Zhu K.J.Zhu X.Zuo | 2021 | Chinese Physics C2021，45，2： | 2 |
| 16 | On the microstructural origin of premature failure of creep strength enhanced martensitic steels显示文摘The creep strength enhanced martensitic steels are key material for the main power generating units in ultra-supercritical plants.Studies on the evaluation of their creep rupture life show there is an overestimation of rupture life after long-term creep,which is known as premature failure.However,the microstructural origin of the premature failure remains unclear.Here in this study,we have carefully investigated the microstructural transformations and their influences on creep rupture behavior,showing that the evolution of martensite and M_(23)C_(6) carbides as well as Laves phase are responsible for the premature failure.By using multi-step TTP-LMP method,we confirmed a three-stage creep rupture behavior under different stress regions.Further quantitative analysis showed that the coarsening of M_(23)C_(6) carbides and recovery of martensite exert equal and dominant effects on the premature failure in the medium stress region,while precipitation and coarsening of Laves phase are responsible for the premature failure in the low stress region. | J.Li C.Xu G.Zheng W.J.Dai C.C.Bu G.Chen | 2021 | Journal of Materials Science & Technology2021，，28： | 2 |
| 17 | Too little or too much? Untangling the relationship between corporate philanthropy and firm financial performance显示文摘 | Wang H J.Choi J.Li | | 0，，1： | 1 |
| 18 | Theoretical study of carotene as a molecular wire显示文摘 | J.Li J.K.Tomfohr O.F.Sankey | | 0，，1： | 1 |
| 19 | 查看详情显示文摘 | Han H.B Zhou S.S Zhang D.J Feng S.W.Li L.F.Liu K.Feng W.F.Nie J.Li H.Huang X.J.Armand M.Zhou Z.B | | 0，，07： | 1 |
| 20 | Preparation of chitosan functionalized monolithic silica column for hydrophilic interaction liquid chromatography显示文摘 | Z.L.Lü P.F.Zhang J.Li | | 0，，： | 1 |
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