| 1 | (−)- and (+)-Securidanes A and B, Natural Triarylmethane Enantiomers: Structure and Bioinspired Total Synthesis显示文摘Two pairs of enantiomers,(−)and(+)-securidanes A(1 and 2)and B(3 and 4)featuring unprecedented triarylmethane(TAM)skeletons,were isolated from Securidaca inappendiculata.Teir structures were established by spectroscopic data,X-ray crystallography,and CD analysis.A plausible biosynthetic pathway for 1−4 based on the co-isolated precursors was proposed.Bioinspired total synthesis of 1−4was completed in high yield,which in turn corroborated the biosynthetic hypothesis.Compounds 1−4 showed good inhibition against protein tyrosine phosphatase 1B(PTP1B).Te molecular docking demonstrated that the strongest inhibitor 3(IC50=7.52�M)reaches deeper into the binding pocket and has an additional H-bond. | B.Zhou D.X.Liu X.J.Yuan J.Y.Li Y.C.Xu J.Li YLi J.M.Yue | 2018 | Research2018，，1： | 2 |
| 2 | All-optical μ^- acceleration in the laser wakefield显示文摘Muons produced by the Bethe–Heitler process from laser wakefield accelerated electrons interacting with high Z materials have velocities close to the laser wakefield. It is possible to accelerate those muons with laser wakefield directly.Therefore for the first time we propose an all-optical ‘Generator and Booster’ scheme to accelerate the produced muons by another laser wakefield to supply a prompt, compact, low cost and controllable muon source in laser laboratories. The trapping and acceleration of muons are analyzed by one-dimensional analytic model and verified by two-dimensional particle-in-cell(PIC) simulation. It is shown that muons can be trapped in a broad energy range and accelerated to higher energy than that of electrons for longer dephasing length. We further extrapolate the dependence of the maximum acceleration energy of muons with the laser wakefield relativistic factor γ and the relevant initial energy E_0. It is shown that a maximum energy up to 15.2 GeV is promising with γ = 46 and E_0= 1.45 Ge V on the existing short pulse laser facilities. | F.Zhang Z.G.Deng L.Q.Shan Z.M.Zhang B.Bi D.X.Liu W.W.Wang Z.Q.Yuan C.Tian S.Q.Yang B.Zhang Y.Q.Gu | 2018 | High Power Laser Science and Engineering2018，6，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员