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1Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV显示文摘Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,ie.jet-quenching.Previous measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au collisions.The modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching ef-fect.This paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle pr.The subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are described.The correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow backgrounds.The away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger particles.The near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately constant.The correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from fluc-tuations.It is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak structure.The dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open ques-tion.Even with aФ_(s)-dependent elliptic flow,the away-side correlation structure is robust.These results,with extens-ive systematic studies of the dihadron correlations as a function ofФ_(s),trigger and associated particle pT,and the pseudo-rapidity range△_(η),should provide stringent inputs to help understand the underlying physics mechanisms of jet-medium interactions in high energy nuclear collisions.H.Agakishiev M.M.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied M.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz L.C.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.Cai H.Caines M.Calderon de la Barca Sanchez D.Cebra R.Cendejas M.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.Y.Chen L.Chen J.Cheng M.Cherney A.Chikanian K.E.Choi W.Christie P.Chung M.J.M.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov M.Elnim J.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.Z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger M.Krus L.Kumar P.Kurnadi M.A.C.Lamont J.M.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight M.J.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.M.Li M.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.Ma Y.G.Mai D.P.Mahapatra R.Majka O.I.Mall L.K.Mangotra R.Manweiler S.Margetis C.Markert H.Masui H.S.Matis Yu.A.Matulenko D.MeDonald T.S.McShane A.Meschanin R.Milner N.G.Minaev S.Mioduszewski A.Mischke M.K.Mitrovski B.Mohanty M.M.Mondal B.Morozov D.A.Morozov M.G.Munhoz M.Naglis B.K.Nandi T.K.Nayak P.K.Netrakanti L.V.Nogach S.B.Nurushev G.Odyniec A.Ogawa Oh Ohlson V.Okorokov E.W.Oldag D.Olsont M.Pachr B.S.Page S.K.Pal Y.Pandit Y.Panebratsev T.Pawlak H.Pei T.Peitzmann C.Perkins W.Peryt S.C.Phatak P.Pile M.Planinic M.A.Ploskon J.Pluta D.Plyku N.Poljak A.M.Poskanzer B.V.K.S.Potukuchi C.B.Powell D.Prindle N.K.Pruthi A.M.Poskanzer B.V.K.S.Potukuchi B.Powell D.Prindle N.K.Pruthi P.R.Pujahar J.Putschke H.Qiu R.Raniwala S.Raniwala R.L.Ray R.Redwine R.Reed H.G.Riter J.B.Roberts O.V.Rogachevskiy J.L.Romero A.Rose L.Ruan J.Rusnak N.R.Sahoo S.Sakai I.Sakrejda T.Sakuma S.Salur J.Sandweiss E.Sangaline A.Sarkar J.Schambach R.P.Scharenberg A.M.Schmah N.Schmitz T.R.Schuster J.Seele J.Seger I.Selyuzhenkov P.Seyboth E.Shahaliev M.Shao M.Sharma S.S.Shi Q.Y.Shou E.P.Sichtermann F.Simon R.N.Singaraju M.J.Skoby N.Smirnov H.M.Spinka B.Srivastava T.D.S.Stanislaus D.Staszak S.G.Steadman J.R.Stevens R.Stock M.Strikhanov B.Stringfellow A.A.P.Suaide M.C.Suarez N.L.Subba M.Sumbera X.M.Sun Y.Sun Z.Sun B.Surrow D.N.Svirida T.J.M.Symons A.Szanto de Toledo J.Takahashi A.H.Tang Z.Tang L.H.Tarini T.Tarnowsky D.Thein J.H.Thomas J.Tian A.R.Timmins D.Tlusty M.Tokarev V.N.Tram S.Trentalange R.E.Tribble Tribedy O.D.Tsai T.Ullrich D.G.Underwood G.Van Buren G.van Nieuwenhuizen J.A.Vanfossen R.Varma G.M.S.Vasconcelos A.N.Vasiliev F.Videbaek Y.P.Viyogi S.Vokal M.Wadat M.Walker F.Wang G.Wang H.Wang J.S.Wang Q.Wang X.L.Wang Y.Wang G.Webb J.C.Webb G.D.Westfall C.Whitten H.Wieman S.W.Wissink R.Witt W.Witzke Y.F.Wu Xiao W.Xie H.Xu N.Xu Q.H.Xu W.Xu Y.Xu Z.Xu L.Xue Y.Yang P.Yepes K.Yip I-K.Yoo M.Zawisza H.Zbroszczyk W.Zhan J.B.Zhang S.Zhang W.M.Zhang X.P.Zhang Y.Zhang Z.P.Zhang J.Zhao C.Zhong W.Zhou X.Zhu Y.H.Zhu R.Zoulkarneev Y.Zoulkarneeva 2021Chinese Physics C2021,45,4:351
2DETERMINATION AND APPLICATION OF LARSON-MILLER PARAMETER FOR HEAT RESISTANT STEEL 12CrlMoV AND 15CrMo显示文摘Based on the analysis and processing on relative empirical formula and data, C-values in Larson-Miller (P) expression, P = T(C + lgt), have determined for pearlitic heat resistant steel 12Cr1Mo V and 15 CrMo (20. 62 and 20. 30). The simulation experiments of high temperature aging, heated from 1.5 to 873 hours, have been designed and performed for its verification. And in combination with published information and the present nearly quantitative works, it has further been verified that both the degradations of microstructures and mechanical properties show a good accuracy and practicability using the Larson-Miller parameter with the present determined C-values. Finally, the effects of carbon content on C-value are analyzed by the empirical electron theory of solids and molecules (EET).R.C.Yang K.Chen H.X.Feng H.Wang 2004Acta Metallurgica Sinica(English Letters)2004,17,4:14
3辽宁省农户参与农业保险意愿的实证研究显示文摘辽宁省位于中国的东北地区,主要生产粮食和饲料.对辽宁省农户的保险意愿调查问卷进行了统计分析.结果表明:性别、受教育程度、收入、灾害损失和对保险的了解程度对农户在农业保险意愿上有影响.女性相对于男性,更不愿意参加农业保险;教育程度高和贫穷的农户不愿意参保.以往受灾损失大的农户也不愿意参保,这样,如果政府不能合理的设定保险品种和保险价格可能会出现逆向选择问题.聂荣 Holly H.Wang 2011数学的实践与认识2011,41,4:12
4Molecular Dynamics Simulation of Tensile Deformation and Fracture of γ-TiAl with and without Surface Defects显示文摘Molecular dynamics simulation of uniaxial tension along [001] has been performed to study the influence of various surface defects on the initiation of plastic deformation and fracture of γ-TiAl single crystals.The results indicate that brittle fracture occurs in perfect bulk; surfaces and edges will be detrimental to the strength of materials and provide dislocation nucleation site. The defects on surfaces and edges cause further weakening with various effects depending on defect type, size, position and orientation,while the edge dimples are the most influential. For γ-TiAl rods with surface dimples, dislocations nucleate from an edge of the rod when dimples are small, dimple dislocation nucleation occurs only when the dimples are larger than a strain rate dependent critical size. The dislocations nucleated upon [001]tension are super dislocations with Burger vectors <011] or 1/2 < 112] containing four 1/6 < 112 > partials. The effects of surface scratches are orientation and shape sensitive. Scratches parallel to the loading direction have little influence, while sharp ones perpendicular to the loading direction may cause crack and thus should be avoided. This simulation also shows that, any type of surface defect would lower strength,and cause crack in some cases. But some may facilitate dislocation nucleation and improve ductility of TiAl if well controlled.H.N.Wu D.S.Xu H.Wang R.Yang 2016Journal of Materials Science & Technology2016,32,10:9
5Microstructure and mechanical properties of Al-12Si and Al-3.5Cu-1.5Mg-1Si bimetal fabricated by selective laser melting显示文摘An Al-12 Si/Al-3.5 Cu-1.5 Mg-1 Si bimetal with a good interface was successfully produced by selective laser melting(SLM).The SLM bimetal exhibits four successive zones along the building direction:an Al-12 Si zone,an interfacial zone,a texture-strengthening zone and an Al-Cu-Mg-Si zone.The interfacial zone(<0.2 mm thick)displays an increasing size of the cells composed of eutectic Al-Si and a discontinuous cellular microstructure,resulting in the lowest hardness of the four zones.The texturestrengthening zone(around 0.3 mm thick)shows a remarkable variation of the hardness and<001>fiber texture.Electron backscatter diffraction analysis shows that the grains grow gradually from the interfacial zone to the Al-Cu-Mg-Si zone along the building direction.Additionally,a strong<001>fiber texture develops at the Al-Cu-Mg-Si side of the interfacial zone and disappears gradually along the building direction.The bimetal exhibits a room temperature yield strength of 267±10 MPa and an ultimate tensile strength of 369±15 MPa with elongation of 2.6±0.1%,revealing the potential of selective laser melting in manufacturing dissimilar materials.P.Wang C.S.Lao Z.W.Chen Y.K.Liu H.Wang H.Wendrock J.Eckert S.Scudino 2020Journal of Materials Science & Technology2020,36,1:7
6High throughput synthesis enabled exploration of CoCrFeNi-based high entropy alloys显示文摘To accelerate the exploration,screening,and discovery of structural high-entropy alloys with targeted properties,the newly developed High-Throughput Hot-Isostatic-Pressing based Micro-Synthesis Approach(HT-HIP-MSA)is employed to efficiently synthesize and characterize 85 combinatorial alloys in a 13-principal element alloying space.These Co Cr Fe Ni-based high entropy alloys span 1 quaternary,9 quinary,and 36 senary alloy systems,and their composition-structure-property relationships are characterized and analyzed experimentally and computationally.From the single-phase FCC CoCrFeNi alloy base,with Mn,Cu,Ti,Nb,Ta,Mo,W,Al,and Si as principal element alloying additions,we find(1)the extended Mn solubility in the single-phase FCC CoCrFeNi-Mn_(x) alloys,(2)the destabilizing behavior for most of the quinary and senary alloys,and(3)the distinctive solid-solution-strengthening effects in the alloys.In combining the computational methods,the HT-HIP-MSA can be systematic and economic to explore and refine the compositions,structures,and properties of structural high-entropy alloys.L.Zhao L.Jiang L.X.Yang H.Wang W.Y.Zhang G.Y.Ji X.Zhou W.A.Curtin X.B.Chen P.K.Liaw S.Y.Chen H.Z.Wang 2022Journal of Materials Science & Technology2022,,15:4
7浇注温度对A356合金半固态枝晶衍变规律的影响显示文摘研究了控制浇注法制备A356合金半固态枝晶衍变规律,结果表明:原始显微结构对枝晶半固态衍变具有较大影响,对于原始组织粗大的树枝晶合金,即使经过长时间的保温,初生α相仍为枝晶网状结构;而原始组织细小的等轴晶迅速转变为球状结构.宁志良 H.Wang David H.StJohn 刘殿魁 2005哈尔滨理工大学学报2005,10,4:4
8牛脑Ca^(2+)/CaM依赖性蛋白激酶Ⅱ的纯化和鉴定显示文摘通过一系列层析法,首次从牛脑纯化得到胶凝电泳匀一的Ca^(2+)/CaM PKⅡ。凝胶过滤法测定全酶分子量为550kD,SDS-PAGE法测定亚基分子量为55kD,推测牛脑Ca^(2+)/CaM PK Ⅱ由十个相同的亚基组成。该酶活性绝对依赖于Ca^(2+)和CaM,以63kD PDE同工酶为底物,其AC_(50)分别为0.85μmol/L和0.18μmol/L;以酪蛋白为底物,其AC_(50)分别为0.22μmol/L和0.06μmol/L。牛脑Ca^(2+)/CaM PK Ⅱ旣能催化63kD PDE同工酶等多种蛋白或酶磷酸化,又能进行自身磷酸化。该酶催化63kD PDE同工酶最大磷酸参入量为1mol/mol亚基。磷酸化型63kD PDE同工酶的Ca^(2+)的AC_(50)高于非磷酸化型。张光毅 赵昇皓 Rajendra K.Sharma Jerry H.Wang 1991生物化学杂志1991,7,4:4
9Active Immunization to Prevent De Novo Hepatitis B Virus Infection in Pediatric Live Donor Liver Recipients显示文摘C.‐C.Lin C.‐L.Chen A.Concejero C.‐C.Wang S.‐H.Wang Y.‐W.Liu C.‐H.Yang C.‐C.Yong T.‐S.Lin B.Jawan Y.‐F.Cheng H.‐L.Eng 2006American Journal of Transplantation2006,,1:4
10Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances显示文摘The terms biliary sludge and cholesterol microlithiasis(hereafter referred to as microlithiasis)were originated from different diagnostic techniques and may represent different stages of cholesterol gall-stone disease.Although the pathogenesis of biliary sludge and microlithiasis may be similar,micro-lithiasis could be preceded by biliary sludge,followed by persistent precipitation and aggregation of solid cholesterol crystals,and eventually,gallstone formation.Many clinical conditions are clearly associated with the formation of biliary sludge and microlithiasis,including total parenteral nutrition,rapid weight loss,pregnancy,organ transplantation,administration of certain medications,and a variety of acute and chronic illnesses.Numerous studies have demonstrated complete resolution of biliary sludge in approximately 40%of patients,a cyclic pattern of disappearing and reappearing in about 40%,and progression to gallstones in nearly 20%.Although only a minority of patients with ultrasonographic demonstration of biliary sludge develop gallstones,it is still a matter of controversy whether micro-lithiasis could eventually evolve to cholesterol gallstones.Biliary sludge and microlithiasis are asymp-tomatic in the vast majority of patients;however,they can cause biliary colic,acute cholecystitis,and acute pancreatitis.Biliary sludge and microlithiasis are most often diagnosed ultrasonographically and bile microscopy is considered the gold standard for their diagnosis.Specific measures to prevent the development of biliary sludge are not practical or cost-effective in the general population.Laparoscopic cholecystectomy offers the most definitive therapy on biliary sludge.Endoscopic sphincterotomy or surgical intervention is effective for microlithiasis-induced pancreatitis.Ursodeoxycholic acid can effectively prevent the recurrence of solid cholesterol crystals and significantly reduce the risk of recurrent pancreatitis.Helen H.Wang Piero Portincasa Min Liu Patrick Tso David Q.-H.Wang 2018Liver Research2018,2,4:3
11Estimation of exponential growth rate and basic reproduction number of the coronavirus disease 2019 (COVID-19)in Africa显示文摘Background:Since the first case of coronavirus disease 2019(COVID-19)in Africa was detected on February 14,2020,the cumulative confirmations reached 15207 including 831 deaths by April 13,2020.Africa has been described as one of the most vulnerable region with the COVID-19 infection during the initial phase of the outbreak,due to the fact that Africa is a great commercial partner of China and some other EU and American countries.Which result in large volume of travels by traders to the region more frequently and causing African countries face even bigger health threat during the COVID-19 pandemic.Furthermore,the fact that the control and management of COVID-19 pandemic rely heavily on a country's health care system,and on average Africa has poor health care system which make it more vulnerable indicating a need for timely intervention to curtail the spread.In this paper,we estimate the exponential growth rate and basic reproduction number(R0)of COVID-19 in Africa to show the potential of the virus to spread,and reveal the importance of sustaining stringent health measures to control the disease in Africa.Methods:We analyzed the initial phase of the epidemic of COVID-19 in Africa between 1 March and 13 April 2020,by using the simple exponential growth model.We examined the publicly available materials published by the WHO situation report to show the potential of COVID-19 to spread without sustaining strict health measures.The Poisson likelihood framework is adopted for data fitting and parameter estimation.We modelled the distribution of COVID-19 generation interval(GI)as Gamma distributions with a mean of 4.7 days and standard deviation of 2.9 days estimated from previous work,and compute the basic reproduction number.Results:We estimated the exponential growth rate as 0.22 per day(95%CI:0.20-0.24),and the basic reproduction number,R0,as 2.37(95%CI:2.22-2.51)based on the assumption that the exponential growth starting from 1 March 2020.With an R0 at 2.37,we quantified the instantaneous transmissibility of the outbreak by the time-varying effective reproductive number to show the potential of COVID-19 to spread across African region.Conclusions:The initial growth of COVID-19 cases in Africa was rapid and showed large variations across countries.Our estimates should be useful in preparedness planning against further spread of the COVID-19 epidemic in Africa.Salihu S.Musa Shi Zhao Maggie H.Wang Abdurrazaq G.Habib Umar T.Mustapha Daihai He 2020Infectious Diseases of Poverty2020,9,4:3
12Designing Bulk Metallic Glass Composites with Enhanced Formability and Plasticity显示文摘To address the main stumbling-block of bulk metallic glasses(BMGs), i.e., room temperature brittleness,designing BMG matrix composites has been attracted extensive attention. Up to date, BMG composites in various alloy systems have been successfully developed by forming crystalline phases embedded in the amorphous matrix through either ex-situ or in-situ methods. In this paper, a brief review of our recent work in this topic will be presented and the novel approaches to improving composite formability and mechanical properties will also be highlighted. The main purpose of this manuscript is not to offer a comprehensive review of all the BMG composites, but instead focuses will be placed on illustrating recently developed advanced BMG composites including Fe-based BMG composite with no metalloids, Al-based BMG composite and BMG composites reinforced by the TRIP(transformation-induced plasticity) effects. The basic ideas and related mechanisms underlying the development of these novel BMG composites will be discussed.Y.Wu H.Wang X.J.Liu X.H.Chen X.D.Hui Y.Zhang Z.P.Lu 2014Journal of Materials Science & Technology2014,30,6:3
13MHC class Ⅰ-independent activation of virtual memory CD8 T cells induced by chemotherapeutic agent-treated cancer cells显示文摘Cancer cells can evade immune recognition by losing major histocompatibility complex(MHC)class Ⅰ.Hence,MHC class Ⅰ-negative cancers represent the most challenging cancers to treat.Chemotherapeutic drugs not only directly kill tumors but also modulate the tumor immune microenvironment However,it remains unknown whether chemotherapy-treated cancer cells can activate CD8 T cells independent of tumor-derived MHC class Ⅰ and whether such MHC class Ⅰ-independent CD8 T-cell activation can be exploited for cancer immunotherapy.Here,we showed that chemotherapy-treated cancer cells directly activated CD8 T cells in an MHC class Ⅰ-independent manner and that these activated CD8 T cells exhibit virtual memory(VM)phenotypes.Consistently,in vivo chemotherapeutic treatment preferentially increased tumor-infiltrating VM CD8 T cells.Mechanistically,MHC class Ⅰ-independent activation of CD8 T cells requires cell-cell contact and activation of the PI3K pathway.VM CD8 T cells contribute to a superior therapeutic effect on MHC class Ⅰ-deficient tumors.Using humanized mouse models or primary human CD8 T cells,we also demonstrated that chemotherapy-treated human lymphomas activated VM CD8 T cells independent of tumor-derived MHC class Ⅰ.In conclusion,CD8 T cells can be directly activated in an MHC class Ⅰ-independent manner by chemotherapy-treated cancers,and these activated CD8 T cells may be exploited for developing new strategies to treat MHC class Ⅰ-deficient cancers.Xiaoguang Wang Brittany C.Waschke Rachel A.Woolaver Samantha M.Y.Chen Zhangguo Chen Jing H.Wang 2021Cellular & Molecular Immunology2021,18,3:3
14VARIATION OF SUBSTRUCTURES OF PEARLITIC HEAT RESISTANT STEEL AFTER HIGH TEMPERATURE AGING显示文摘The observations of dislocations, substructures and other microstructural details were conducted mainly by means of transmission electron microscope (TEM) and scanning electron microscope (SEM) for 12Cr1Mo V pearlitic heat-resistant steel. It is shown that during the high temperature long-term aging, the disordered and jumbled phasetransformed dislocations caused by normalized cooling are recovered and rearranged into cell substructures, and then the dislocation density is reduced gradually. Finally a low density linear dislocation configuration and a stabler dislocation network are formed and ferritic grains grow considerably.R.C.Yang K.Chen H.X.Feng H.Wang 2004Acta Metallurgica Sinica(English Letters)2004,17,4:2
15Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti‐tumour immune responses显示文摘H. H.Zhang M. H.Mei R.Fei F.Liu J. H.Wang W. J.Liao L. L.Qin L.Wei H. S.Chen 2010Journal of Viral Hepatitis2010,,:2
16瞬时受体电位香草酸亚型1通道蛋白在心肌梗死后修复和重构中的作用显示文摘目的:研究瞬时受体电位香草酸亚型1通道蛋白(TRPV1)在心肌梗死(心梗)后修复和重构中的保护作用。方法:在TRPV1基因敲除(TRPV1-/-)小鼠和野生型(WT)小鼠左冠状动脉结扎建立心梗模型后分为TRPV1-/-心梗组、野生型心梗组;假手术组分为TRPV1-/-假手术组、野生型假手术组,监测心梗后第7天的死亡率、梗死面积。免疫组化检测成肌纤维细胞渗透和胶原成分沉积,超声心动图检测左心室重构和心功能,用酶联免疫吸附法(ELISA)测定组织转化生长因子(TGF)-β1、血管内皮生长因子和基质金属蛋白酶-2的表达水平,Western blot测定Smad2的表达。结果:心梗后第7天,TRPV1-/-心梗组的死亡率高于野生型心梗组(P<0.05),TRPV1-/-心梗组梗死面积大于野生型心梗组(P<0.001)。TRPV1-/-心梗组与野生型心梗组比较,TRPV1-/-小鼠的成肌纤维细胞渗透明显增多,胶原成分沉积增加,差异有统计学意义(P均<0.05)。TRPV1-/-心梗组比野生型心梗组左心室重构加重,心功能恶化,转化生长因子、血管内皮生长因子和基质金属蛋白酶-2的表达水平增高(P均<0.05),磷酸化Smad2蛋白明显升高,差异均有统计学意义(P<0.05)。结论:TRPV1缺失可能通过增强TGF-β-Smad2蛋白信号通路的表达而损害心梗后修复,加重左心室重构,死亡率增加,表明TRPV1在心梗后的修复和重构中起了保护性的作用。雷寒 柳青 黄玮 马康华 覃数 Donna H.Wang 2008中国循环杂志2008,23,6:2
17Mold-Filling Ability of Aluminum Alloy Melt during the Two-Step Foaming Process显示文摘For the two-step foaming method,one of the most cost-effective ways to fabricate three-dimensional shaped aluminum alloy foams with dense outer surface skin,it is crucial to describe and predict the moldfilling behavior of the shaped aluminum alloy foams with a favorable pore-distribution accurately.In this paper,a mold-filling model for semi-solid aluminum alloy foams was initially established and subsequently employed to predict the filling height,which represents the mold-filling ability of semi-solid aluminum alloy foams in a specially designed tube-like mold.Our results indicate that the proposed model can be applied to characterize the mold-filling property of aluminum alloy melts in a quantitative manner.Theoretically,our findings actually provide a guideline for mass-production of the shaped aluminum alloy foams by using the two-step foaming process.H.Wang Y.M.Zhang B.C.Zhou D.H.Yang Y.Wu X.J.Liu Z.P.Lu 2016Journal of Materials Science & Technology2016,32,6:2
18中国四川盆地页岩气注水压裂导致断层再活化并诱发MW4.7地震显示文摘本文对中国四川盆地最近观察到的注水诱发地震进行了及时和详细的研究,四川盆地页岩气水力压裂已经开始启动,计划在未来几年里被逐渐开采。包括传染型余震序列模型、震中重定位、13个大地震事件(MW>3.5)的震源机制以及库仑破裂应力数值计算的众多证据表明,在地下2.3~3km深度范围内水力压裂短期(每个井位数月)注水过程诱发了一系列最高矩震级达MW4.7的地震。反之,这些诱发地震的出现也支持了注水诱发断层再活化的假设。本文同时讨论了此地区注水压裂为什么会诱发如此大震级地震的地质原因。由于四川盆地中水力压裂作业正如火如荼,这也将有利于地球科学、天然气公司、管理部门和学术界共同探讨显著的注水诱发地震的地区因素,以确保页岩气注水压裂可以有效进行并安全实施。x.l.lei d.j.huang j.r.su g.m.jiang x.l.wang h.wang x.guo h.fu 唐茂云(译) 周红(校) 2018世界地震译丛2018,49,6:2
19Extracellular role of HMGB1 in inflammation and sepsis显示文摘H.Wang H.Yang K. J.Tracey 2004Journal of Internal Medicine2004,,3:2
20Vascular Stents in the Management of Portal Venous Complications in Living Donor Liver Transplantation显示文摘Y.‐F.Cheng H.‐Y.Ou L. L.‐C.Tsang C.‐Y.Yu T.‐L.Huang T.‐Y.Chen A.Concejero C.‐C.Wang S.‐H.Wang T.‐S.Lin Y.‐W.Liu C.‐H.Yang C.‐C.Yong K.‐W.Chiu B.Jawan H.‐L.Eng C.‐L.Chen 2010American Journal of Transplantation2010,,5:2
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