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| 1 | Soft electrostatic trapping in nanofluidics显示文摘Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical diagnostics.We report on establishing a nanofluidic system for reliable and contact-free trapping as well as manipulation of charged nano-objects using elastic polydimethylsiloxane(PDMS)-based materials.This trapping principle is based on electrostatic repulsion between charged nanofluidic walls and confined charged objects,called geometry-induced electrostatic(GIE)trapping.With gold nanoparticles as probes,we study the performance of the devices by measuring the stiffness and potential depths of the implemented traps,and compare the results with numerical simulations.When trapping 100 nm particles,we observe potential depths of up to Q≅24 k_(B)T that provide stable trapping for many days.Taking advantage of the soft material properties of PDMS,we actively tune the trapping strength and potential depth by elastically reducing the device channel height,which boosts the potential depth up to Q~200 k_(B)T,providing practically permanent contactfree trapping.Due to a high-throughput and low-cost fabrication process,ease of use,and excellent trapping performance,our method provides a reliable platform for research and applications in study and manipulation of single nano-objects in fluids. | Michael A.Gerspach Nassir Mojarad Deepika Sharma Thomas Pfohl Yasin Ekinci | 2017 | Microsystems & Nanoengineering2017，3，1： | 0 |
| 2 | Rapid nanomolding of nanotopography on flexible substrates to control muscle cell growth with enhanced maturation显示文摘In vivo,multiple biophysical cues provided by highly ordered connective tissues of the extracellular matrix regulate skeletal muscle cells to align in parallel with one another.However,in routine in vitro cell culture environments,these key factors are often missing,which leads to changes in cell behavior.Here,we present a simple strategy for using optical media discs with nanogrooves and other polymer-based substrates nanomolded from the discs to directly culture muscle cells to study their response to the effect of biophysical cues such as nanotopography and substrate stiffness.We extend the range of study of biophysical cues for myoblasts by showing that they can sense ripple sizes as small as a 100 nm width and a 20 nm depth for myotube alignment,which has not been reported previously.The results revealed that nanotopography and substrate stiffness regulated myoblast proliferation and morphology independently,with nanotopographical cues showing a higher effect.These biophysical cues also worked synergistically,and their individual effects on cells were additive;i.e.,by comparing cells grown on different polymerbased substrates(with and without nanogrooves),the cell proliferation rate could be reduced by as much as~29%,and the elongation rate could be increased as much as~116%.Moreover,during myogenesis,muscle cells actively responded to nanotopography and consistently showed increases in fusion and maturation indices of~28%and~21%,respectively.Finally,under electrical stimulation,the contraction amplitude of well-aligned myotubes was found to be almost 3 times greater than that for the cells on a smooth surface,regardless of the substrate stiffness. | Cong Wu Chriss S.M.Chin Qingyun Huang Ho-Yin Chan Xinge Yu Vellaisamy A.L.Roy Wen J.Li | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
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