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| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Prognostic utility of myocardial viability assessment显示文摘 | ISKANDER S ISKANDRIAN A E | 1999 | Am J Cardiology1999，83，5： | 2 |
| 3 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 4 | Intravenous administrationof human umbilical cord blood-derived AC133+ endothelial progenitorcells in rat stroke model reduces infarct volume: magnetic resonanceimaging and histological findings 显示文摘 | Iskander A Knight RA Zhang ZG | 2013 | Stem Cells Transl Med2013，2，9： | 1 |
| 5 | Orthotopic tracheal allografts undergo reepithelialization with recipient-derived epithelium 显示文摘 | Genden EM Iskander A J Bromberg JS | 2003 | Arch Otolaryngol Head Neck Surg2003，129，： | 1 |
| 6 | Bootstrapping bispectra: an application to testing for departure from Gaussianity of stationary signals显示文摘 | Zoubir A M Iskander D R | 1999 | IEEE Transactions on Signal Processing1999，47，3： | 1 |
| 7 | The kinetics and pattern of tracheal allograft reepithelialization显示文摘 | Genden EM Iskander A Bromberg JS | 2003 | Am J Respir Cell Mol Biol2003，28，6： | 1 |
| 8 | Estimation of parameters of the K-distribution using higher order and fractional moment显示文摘 | Iskander D R and Zoubir A M | 1999 | IEEE Transactions on Aerospace and Electronic Systems1999，35，4： | 1 |
| 9 | A three-dimensional human model for the IBM/CATIA system 显示文摘 | KAYIS B ISKANDER P A | 1994 | Appl Ergon1994，25，6： | 1 |
| 10 | The kinetics and pattern of tracheal allograft re-epithelializatlom显示文摘 | Genden EM Iskander A Bromberg JS | | 0，，： | 1 |
| 11 | Bootstrap modeling of a class of nonstationary signals显示文摘 | Zoubir A M Iskander D R | 2000 | IEEE Transactions on Signal Processing2000，48，2： | 1 |
| 12 | Survey of network on chip (NoC) architectures contributions 显示文摘 | Agarwal A Iskander C Shankar R | 2009 | Engineering Compu- ting and Architecture2009，3，1： | 1 |
| 13 | The burden of influenza in children under 5 years admitted to the Children's Hospital at Westmead in the winter of 2006 显示文摘 | Iskander M Kesson A Dwyer D | 2009 | J Paediatr Child Health2009，45，12： | 1 |
| 14 | Bootstrap modeling of a class of nonstationary signals显示文摘 | ZOUBIR A M ISKANDER D R | 2000 | IEEE Transactions on Signal Processing2000，48，2： | 1 |
| 15 | Helminth infections of sheep in North Sumatra,Indonesia显示文摘 | Dorny P Batubara A Iskander M | 1996 | Vet Parasitol1996，61，： | 1 |
| 16 | The kinetics and pattern of tracheal allograft re-epithelialization显示文摘 | Genden EM Iskander A Bromberg JS | 2003 | Am J Respir Cell Mol Biol2003，28，： | 1 |
| 17 | Queue position in the endoscopic schedule impacts effectiveness of colonoscopy显示文摘 | Lee A Iskander JM Gupta N | 2011 | Am J Gastroenterol2011，106，8： | 1 |
| 18 | Phase I Clinical Trials in 93 Patients with Brain Metastases: The M. D. Anderson Cancer Center Experience显示文摘 | Tsimberidou AM Letourneau K Wen S Wheler JJ Hong DS Naing A Iskander NG Uehara C Kurzrock R | 2011 | 中国神经肿瘤杂志2011，9，1： | 1 |
| 19 | Risk assessment using single-photon emiSvSion computed tomographic technetium-99rn ses-tamibi imaging 显示文摘 | Iskander S Iskaridrian A E | 1998 | J Am Coll Cardiol Jul1998，32，1： | 1 |
| 20 | Estimation of the parame- ters of the K-distribution using higher order and frac- tional moments显示文摘 | Iskander D R Zoubir A M | 1999 | IEEE Transactions on AES1999，35，4： | 1 |
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