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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Collaborative conflict resolution at devilstower national monument显示文摘 | Daniel D L Ingrid S E | 2001 | Parks & Recreation2001，36，7： | 1 |
| 3 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 4 | RTX toxin genotypes and phenotypes in Actinobacillus pleuropueumoniae field strains显示文摘 | Marianne B Johannes F D B Ingrid M C A J | 1994 | Journal of Clinical Microbiology1994，32，11： | 1 |
| 5 | Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease显示文摘AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODS Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise conditions.Severity of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate co.ncentrations;cardiorespiratory fitness was expressed as VO2 peak.Complete-case analysis was performed(EX:n = 10;ER:n = 6).RESULTS Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in response.to EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P < 0.001) and maximal Fa_(tox) during aerobic exercise(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUSION ER and EX lead to specific benefits on fat metabolism of patients with NAFLD.Increased hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis. | Ilaria Croci Nuala M Byrne Veronique S Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-Sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman | 2016 | World Journal of Hepatology2016，8，27： | 1 |
| 6 | Marginal Cost Criteria for Preventive Replacement of a Group of Components显示文摘 | Rommer D Ingrid F K Roelvink | | 0，，84： | 1 |
| 7 | Direct evidence for ribonucleolytic activity of a PR-10-like protein from white lupin roots显示文摘 | Brigitte Bantignies Jacynthe Séguin Ingrid Muzac Fabienne Dédaldéchamp Patrick Gulick Ragai Ibrahim | | 0，2000，： | 1 |
| 8 | Ancient and medieval labyrinth and contemporary narrative therapy: how do they fit? 显示文摘 | BLOOS INGRID D O'CONNOR | 2002 | Pastoral Psychology2002，50，4： | 1 |
| 9 | Collaborative conflict resolution at devils tower national monument 显示文摘 | Daniel D L Ingrid S E | 2001 | Parks & Recreation2001，36，7： | 1 |
| 10 | Funtional status and quality of life measurement among ophthalmic patients显示文摘 | Ingrid U S Oliver D S Sheila W | 1994 | Arch Ophthalmol1994，112，： | 1 |
| 11 | A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction显示文摘 | Anja M. van der Laan Alexander Hirsch Lourens F.H.J. Robbers Robin Nijveldt Ingrid Lommerse Ronak Delewi Pieter A. van der Vleuten Bart J. Biemond Jaap Jan Zwaginga Wim J. van der Giessen Felix Zijlstra Albert C. van Rossum Carlijn Voermans C. Ellen van d | 2012 | American Heart Journal2012，，1： | 1 |
| 12 | Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice显示文摘 | Stanford Kristin I Bishop Joseph R Foley Erin M Gonzales Jon C Niesman Ingrid R Witztum Joseph L Esko Jeffrey D | 2009 | Journal of Clinical Investigation2009，，11： | 1 |
| 13 | Direct and simultaneous determination of Cr and Fe in crude oil using high-resolution continuum source graphite furnace atomic absorption spectrometry显示文摘 | Ingrid M D Jessee S A S Rennan G O A | 2009 | Spectrochimica Acta Part B2009，64，6： | 1 |
| 14 | Organizational designs for R&D 显示文摘 | Gerardine D Jeffrey T Ingrid M E | 2002 | Academy of management Executive2002，16，3： | 1 |
| 15 | Direct and simultaneous determination of Cr and Fe in crude oil using high- resolution continuum source graphite furnace atomic absorption spectrometry显示文摘 | INGRID M D JESSEE S A S RENNAN G O A | 2009 | Spectrochinaica Acta: Part B2009，64，6： | 1 |
| 16 | Managing the ties between general R&D and businees unit 显示文摘 | Jeffrey T Ingrid M E Gerardine D | 2003 | Research Technology Management2003，，： | 1 |
| 17 | Fenpropimorph and fenhexamid impact phosphorus translocation by arbuscular mycorrhizal fungi显示文摘 | ZOCCO D INGRID M VAN A | 2011 | Mycorrhiza2011，21，5： | 1 |
| 18 | Release of high mobilitygroup box 1 by dendritic cells controls T cell activation via thereceptor for advanced glycation end products 显示文摘 | INGRID E D PARAMITA D BARBARA V | 2005 | J Immunol2005，174，： | 1 |
| 19 | Direct evidence for ribonucleolytic activity of a PR-10-like protein from white lupin roots显示文摘 | Brigitte Bantignies Jacynthe Séguin Ingrid Muzac Fabienne Dédaldéchamp Patrick Gulick Ragai Ibrahim | 2000 | Plant Molecular Biology2000，，6： | 1 |
| 20 | Phosphorelay signal transduction: the emerging family of plant response regulators显示文摘 | Joseph J K | 1999 | TIBS1999，24，： | 1 |
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