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1484篇 您的检索式:作者名="Scheffer"
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1深度神经肌肉阻滞改善腹腔镜手术中术野显露:系统性综述-meta分析显示文摘神经肌肉阻滞常用于腹腔镜手术,可通过松弛腹壁肌肉,防止突发性肌肉收缩,改善手术条件。而常规采用深度肌松目前仍存在争议,故此就有关评价深度肌松对腹腔镜手术中术野显露和转归影响的临床研究,进行系统性综述-meta分析。文献检索情况:自建库至2016年12月间,收录在Medline、Embase以及Central databases数据库中的临床研究,类型包括随机试验、病例交叉研究和队列研究;共纳入12项评价深度肌松对术野显露影响的临床研究。系统评价的结果表明,与中度肌松比较,深度肌松可优化腹腔镜手术中术野显露[术野显露评分(1-5分)均数差0.65分,95%可信区间0.47~0.83分],且有利于低压气腹的实施。深度肌松还可降低麻醉恢复后疼痛程度[疼痛评分均数差-0.52分,95%可信区间-0.71~-0.32分]。由此认为,深度肌松可改善腹腔镜手术条件,并降低术后疼痛程度,而可否降低术中并发症发生,改善术后转归,有待进一步研究。本系统性综述的方法学于2016年7月27日在PROSPERO "国际前瞻性系统综述登记平台"预先详述并注册(注册号:CRD42016042144)。M.H.Bruintjes E. V. van Helden A. E. Braat A. Dahan G. J. Scheffer C. J. van Laarhoven M.C.Warle 2017中华麻醉学杂志2017,37,9:12
2大堡礁和大峡谷世界遗产区的适应性管理显示文摘关于人类和环境相互关系的传统观念正在迅速改变。那种认为人类与自然是相互隔离的,自然资源是取之不尽用之不竭的,而且认为世界是稳定的、可以预测的并且是平衡的旧观点已经过时了。在动态的社会-生态景观中强调学习和灵活性管理为基础的适应性方法的新的理念框架已经迅速初现端倪。我们以两个典型的世界遗产地区(大堡礁和大峡谷)为案例来研究如何在自然资源管理中通过改善科学和社会两个方面的结合来指导多尺度管理系统的变革从而应对和处理人类越来越占据主导的世界中出现的不确定性、风险和变化。Terence P.Hughes Lance H.Gunderson Carl Folke Andrew H.Baird David Bellwood Fikret Berkes Beatrice Crona Ariella Helfgott Heather Leslie Jon Norberg Magnus Nystrm Per Olsson Henrik sterblom Marten Scheffer Heidi Schuttenberg Robert S.Steneck Maria Teng Max Troell Brian Walker James Wilson Boris Worm 丁莉 2007AMBIO-人类环境杂志2007,36,B11:4
3Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery.Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen 2008World Journal of Gastroenterology2008,14,45:4
4癫痫的ILAE分类:ILAE委员会关于分类和术语的意见书显示文摘自从1989年国际抗癫痫联盟(ILAE)最后批准的分类以来,ILAE已经更新了癫痫的分类,以反映我们在获得巨大科学进步后对癫痫及其基本机制理解方面的收获。作为执业医师的重要工具,在我们的思想中癫痫分类必须有恰当和动态的变化,并且应全面的翻译到全球所有地区。癫痫分类最初的目的是对患者进行诊断,但是对于癫痫研究、抗癫痫治疗的发展和全世界的交流也非常重要。这次新分类起源于2013年提交以供公开评论的一份草拟文件,该草拟文件在经过国际癫痫界几轮讨论广泛反馈后得以修订。此分类呈现了3个层次,首先是发作类型,假设患者已经有最新的2017年ILAE癫痫发作分类所确定的发作类型;诊断了发作类型后,下一步就是诊断癫痫类型,包括局灶性癫痫、全面性癫痫、全面性及局灶性癫痫两者兼有,以及分类不明的癫痫;第三层次是癫痫综合征,此处可以做出特定综合征的诊断。这一新分类在每一层次均包含了病因,强调在每一步诊断时都要考虑病因,因为病因将会对治疗产生重要影响。选择将病因分为6个亚组是基于其潜在的治疗因果关系。该分类引入了新的术语如'发育性和癫痫性脑病'等。'自限性'和'药物有效性'取代'良性'一词。希望这一新的框架将有助于提高21世纪癫痫的关爱和研究。Ingrid E Scheffer Samuel Berkovic Giuseppe Capovilla 张静 张月华 刘晓燕 吴逊 2018癫痫杂志2018,4,6:4
5Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs显示文摘Izquierdo MA Scheffer GL Flens MJ 1996Cytotechnology1996,19,3:2
6临界转换的早期预警信号显示文摘从生态系统到金融市场和气候在内的很多复杂动力系统,都会有临界点,在这样的点上系统可能会发生突变,从而演变到一个对立的动力模式上。在这样的临界点到达之前对其进行预测极为困难,但是现在,不同科学领域的研究工作表明,普遍性的早期预警信号有迹可循。对一系列不同类型的系统来说,这些信号会指示是否正在趋近一个临界阈值。Marten Scheffer Jordi Bascompte William A. Brock Victor Brovkin Stephen R. Carpenter Vasilis Dakos Hermann Held Egbert H. van Nes Max Rietkerk George Sugihara 李迎春 闫伟 蒋长胜(译) 左玉玲(校) 2009国际地震动态2009,,9:2
7El Ni?o as a Window of Opportunity for the Restoration of Degraded Arid Ecosystems显示文摘Milena Holmgren Marten Scheffer 2001Ecosystems2001,,2:2
8Antimicrobial Activity of Essential Oils: A 1976-1986 Literature Review. Aspects of the Test Methods显示文摘A. Janssen J. Scheffer A. Svendsen 1987Planta Med1987,,05:2
9The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood显示文摘Emmanuel Jacquemin J. Marleen L. De Vree Danièle Cresteil Etienne M. Sokal Ekkehard Sturm Micheline Dumont George L. Scheffer Marianne Paul Martin Burdelski Piter J. Bosma Olivier Bernard Michelle Hadchouel Ronald P.J. Oude Elferink 2001Gastroenterology2001,,6:2
10Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity显示文摘Cheng Q Aleksunes LM Manautou JE Cherrington NJ Scheffer GL Yamasaki H 2008Mol Pharm2008,5,1:1
11Important concepts for treating ocular surface and tear disorders显示文摘Scheffer CG Tseng Kazuo T 1997Am J Ophthalmol1997,124,:1
12Febrile seizures:genetics and relationship to other epilepsy syndromes显示文摘Berkovic S F Scheffer I E 1998Curr Opin Neurol1998,11,:1
13Generalized epilepsy with febrile seizures plus: a common childhood-onset genetic epilepsy syndrome显示文摘Singh R Scheffer IE Crossland K 1999Ann Neurol1999,45,4:1
14Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus显示文摘Wallace R H Scheffer I E Barnett S 2001Am J Hum Genet2001,68,4:1
15Temperature-pro- grammed reduction of NiO-WOs/AI203 hydrosulphurization catalyst显示文摘Scheffer B Molhoek P Moulijin J A 1989Appl Catal1989,46,:1
16Analysis in chronic fatigue syndrome patients: an event-related potential short-termmemory显示文摘Scheffers M 1992Neurology1992,42,9:1
17Reliability and validity of the visual analogue scale for fear of falling in older persons显示文摘Scheffer AC Schurmans MJ van Dijk N 0,,11:1
18Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissue 显示文摘Maliepaard M Scheffer GL Faneyte IF 2001Cancer Res2001,61,:1
19Negative thermal expansion of dia-mond and some zinc-blendesemiconductors显示文摘BIERNACKI S SCHEFFER M 1989Phys Rev Lett1989,63,:1
20Early seizures : causal events or predisposition to adult epilepsy? 显示文摘Dulac O Nabbout R Plouin P Chiron C Scheffer I 2007Lancet Neurol2007,6,7:1
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