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| 1 | 一项中断时间序列研究与集群随机试验:减少耐药细菌在重症监护室中定植和传播的干预措施显示文摘背景 重症监护室(ICU)是耐药细菌传播的高危科室,在设置标准预防措施时缺乏对"全面筛查和隔离携带或感染耐药细菌者"效果评估的对照研究,本研究评估此干预措施对减少ICU中耐药细菌的定植与传播的效果. | 曾翠 吴安华 Derde L P G Cooper B S Goossens H | 2014 | 中国感染控制杂志2014，13，1： | 23 |
| 2 | 同波束VLBI在采样返回式多目标探测器精密测轨测位中的应用显示文摘同波束VLBI即用射电望远镜的主波束同时观测角距很小的两个探测器发出的巧妙配置的多频点信标,据此得到两探测器在两个测站间的误差为皮秒量级的差分相位时延.在月球卫星SELENE的两个小卫星Rstar和Vstar的测定轨中,利用40多分钟的同波束VLBI和测速测距数据数小时的短弧定轨精度已显著提高,而一年多的定轨结果表明弧长数天的长弧定轨精度已达10m左右,充分证明了同波束VLBI在多目标卫星精密测定轨中的作用.本文在介绍SELENE同波束VLBI观测、多普勒数据处理和定轨结果的基础上,以用于月球采样返回探测任务中的多目标探测器如轨道器、着陆器和返回器为例,给出各探测器搭载电波源的信标设计方案及设计原则,并分析S频段多频点同波束VLBI技术在轨道器和着陆器绕月飞行、着陆器月球软着陆、着陆器月球采样、返回器从月面上升、返回器多次变轨、特别是轨道器和返回器交会对接等各个测控段的高精度测定轨或测定位及月球重力场探测中的应用. | 刘庆会 陈明 Sander Goossens 菊池冬彦 松本晃治 平劲松 王广利 郑为民 花田英夫 洪晓瑜 | 2010 | 中国科学:物理学、力学、天文学2010，40，6： | 15 |
| 3 | Applications of same-beam VLBI in the orbit determination of multi-spacecrafts in a lunar sample-return mission显示文摘Same-beam VLBI means that two spacecrafts with small separation angles that transmit multi-frequency signals specially designed are observed simultaneously through the main beam of receiving antennas. In same-beam VLBI,the differential phase delay between the two spacecrafts and the two receiving antennas can be obtained within a small error of several picoseconds. As a successful application,the short-arc orbit determination of several hours for Rstar and Vstar,which are two small sub-spacecrafts of SELENE,has been much improved by using the same-beam VLBI data together with the Doppler and range data. The long-arc orbit determination of several days has also been accomplished within an error of about 10 m with the same-beam VLBI data incorporated. These results show the value of the same-beam VLBI for the orbit determination of multi-spacecrafts. This paper introduces the same-beam VLBI and Doppler observations of SELENE and the orbit determination results. In addition,this paper introduces how to use the same-beam VLBI for a lunar sample-return mission,which usually consists of an orbiter,a lander and a return unit. The paper also offers the design for the onboard radio sources in the lunar sample-return mission,and introduces applications of S-band multi-frequency same-beam VLBI in lunar gravity exploration and applications during all stages in the position/orbit determinations such as orbiting,landing,sampling,ascending,and docking. | GOOSSENS Sander KIKUCHI Fuyuhiko MATSUMOTO Koji HANADA Hideo | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 13 |
| 4 | 嫦娥一号绕月卫星对月球重力场模型的优化显示文摘月球重力场是揭示月球内部结构和物质组成的重要信息,探测月球重力场仍然是绕月探测任务中的重要科学目标之一.在已有月球重力场模型基础上,利用嫦娥一号探测数据,并结合'月女神'一号探测器、月球勘察者(LP)及早期月球探测器轨道跟踪数据,本文解算得到了高精度月球重力场模型CEGM02(100阶次),在CEGM01月球重力场模型基础上对模型进行了优化.对新模型的分析结果表明,嫦娥一号卫星轨道跟踪数据的融入,使得对月球重力场长波长部分的解算精度有显著提高,相比于SGM100h模型在5阶以内精度提高约2倍,在10阶以内有明显贡献,在20阶内都有贡献.初步判断这是由于嫦娥一号卫星轨道动量轮卸载的频度不足'月女神'的1/4,而同时轨道相对较高所导致.文中结合CEGM02和激光测月观测结果解算了月球平均转动惯量0.393446(±0.000006),对月球内部构造研究提供了更强的约束. | 鄢建国 平劲松 KOJI Matsumoto SANDER Goossens 唐歌实 李斐 刘俊泽 李金岭 | 2011 | 中国科学:物理学、力学、天文学2011，41，7： | 12 |
| 5 | 丁酸钠对断奶仔猪生长性能、抗氧化能力、表观消化率和肠道微生物的影响显示文摘试验研究日粮添加不同水平丁酸钠对断奶仔猪生长性能、抗氧化能力、营养物质表观消化率以及肠道微生物组成的影响。试验选取250头胎次、体重相近的21日龄'杜×长×大'断奶仔猪,随机分为4组,每组6个重复,每个重复10~12头仔猪。对照组仔猪饲喂基础日粮,试验组分别在基础日粮中添加500、1000、2000 g/t包被丁酸钠。预试期7 d,试验期42 d。结果显示,与对照组相比,日粮中添加丁酸钠可以显著提高断奶仔猪的平均日增重(P<0.05),显著降低料重比和28~42日龄的腹泻率(P<0.05)。与对照组相比,日粮中添加丁酸钠可以显著提高断奶仔猪血清谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶活性(P<0.05),显著降低仔猪42日龄的血清丙二醛含量(P<0.05)。与对照组相比,日粮中添加丁酸钠可以显著提高拟杆菌门(Bacteroidetes)丰度(P<0.05),显著降低厚壁菌门(Firmicutes)丰度(P<0.05),500 g/t丁酸钠可以显著提高阿克曼氏菌属(Akkermansia muciniphila)丰度(P<0.05),2000 g/t丁酸钠可以显著提高乳杆菌属(Lactobacillus sp.L-YJ)丰度(P<0.05)。研究表明,日粮中添加丁酸钠可显著改善断奶仔猪生长性能,提高抗氧化能力并改善肠道菌群组成。 | 周腊枚 张博 黄强 Tim Goossens 周锡红 | 2021 | 饲料研究2021，44，15： | 12 |
| 6 | 利用LP多普勒数据解算月球重力场模型的分析显示文摘利用GSFC/NASA提供的GEODYNII/SOLVE软件处理月球探测器LP(Lunar Prospector)扩展任务阶段最后3个月的测速和测距跟踪数据,解算月球重力场模型,比较分析全部位系数解算和部分中高阶次位系数解算2种方法,并对2种方法解算得到的模型进行阶方差分析。同时通过轨道残差、重复轨道误差以及模型大地水准面等几个方面对基于部分中高阶次位系数解算的有效性和得到的模型进行精度评估。结果表明基于部分中高阶次位系数解算的方法进行恢复月球重力场是可行的。该方法将用于'嫦娥工程'中月球重力场的解析。 | 鄢建国 李斐 平劲松 GOOSSENS S | 2009 | 测绘学报2009，38，1： | 6 |
| 7 | Nuclear magnetic resonance based metabolomics and liverdiseases:Recent advances and future clinical applications显示文摘Metabolomics is defined as the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification.It is an'omics'technique that is situated downstream of genomics,transcriptomics and proteomics.Metabolomics is recognized as a promising technique in the field of systems biology for the evaluation of global metabolic changes.During the last decade,metabolomics approaches have become widely used in the study of liver diseases for the detection of early biomarkers and altered metabolic pathways.It is a powerful technique to improve our pathophysiological knowledge of various liver diseases.It can be a useful tool to help clinicians in the diagnostic process especially to distinguish malignant and non-malignant liver disease as well as to determine the etiology or severity of the liver disease.It can also assess therapeutic response or predict drug induced liver injury.Nevertheless,the usefulness of metabolomics is often not understood by clinicians,especially the concept of metabolomics profiling or fingerprinting.In the present work,after a concise description of the different techniques and processes used in metabolomics,we will review the main research on this subject by focusing specifically on in vitro proton nuclear magnetic resonance spectroscopy based metabolomics approaches in human studies.We will first consider the clinical point of view enlighten physicians on this new approach and emphasis its future use in clinical'routine'. | Roland Amathieu Mohamed Nawfal Triba Corentine Goossens Nadia Bouchemal Pierre Nahon Philippe Savarin Laurence Le Moyec | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 8 | Stool characteristics of infants receiving short-chain galactooligosaccharides and long-chain fructo-oligosaccharides:A review显示文摘Human milk is considered to be the optimal source of infant nutrition. Some of the benefits of breastfeeding have been ascribed to human milk oligosaccharides(HMO). For instance, HMO can affect faecal characteristics such as stool consistency and stool frequency. Such effects on stool characteristics can be beneficial for young infants as hard stools and even constipation is common in that age group. Prebiotics in infant milk formulas have been introduced to exert similar functionalities. A specific mixture of prebiotics consists of a combination of short chain galacto-oligosaccharides and long-chain fructo-oligosaccharides(scGOS/lcFOS) in a ratio of 9:1. This specific mixture has been developed to closely resemble the molecular size composition of HMO. Many studies have been done with scGOS/lcFOS, and indicators for digestive comfort have often been included as secondary outcomes. This review summarizes the effects of scGOS/lcFOS(9:1) on stool consistency,stool frequency and transit time in healthy term and preterm infants. In several of the studies with scGOS/lcFOS in a ratio of 9:1 in infant milk formulas, positive effects of this mixture on stool characteristics such as stool consistency and stool frequency were observed. As stool consistency was shown to be correlated to whole gut transit time, scGOS/lcFOS can be hypothesised to have a role in reducing the risk of constipation. | Petra AMJ Scholtens Dominique AM Goossens Annamaria Staiano | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 9 | 重症监护病房(ICU)建设中人性化环境要素设计探讨显示文摘重症监护病房(ICU)由于其中病人病情的高风险和不稳定,一直是医疗看护的难点。除了医疗设备和人员培训方面加强ICU管理外,还应该从ICU病房设计、辅助用房设计、采光设计和噪音控制等多方面加强管理,并指定标准。本文以国内外的重症监护病房设计管理标准为基础依据,并对其进行比较,从单元规划和室内环境的角度研究危重病人、病人家属、医务人员对ICU空间的需求,对已建成的国内外ICU病房进行调研并对人性化ICU病房设计进行探讨。从而,满足不同群体对ICU空间的需求,有助于提高愈合效率。 | 李瀛 Richard Goossens 余隋怀 肖东娟 | 2012 | 西北工业大学学报(社会科学版)2012，32，2： | 5 |
| 10 | The Soil-Borne Identity and Microbiome-Assisted Agriculture:Looking Back to the Future显示文摘Looking forward includes looking back every now and then.In 2007,David Weller looked back at 30 years of biocontrol of soil-borne pathogens by Pseudomonas and signified that the progress made over decades of research has provided a firm foundation to formulate current and future research questions.It has been recognized for more than a century that soil-borne microbes play a significant role in plant growth and health.The recent application of high-throughput omics technologies has enabled detailed dissection of the microbial players and molecular mechanisms involved in the complex interactions in plant-associated microbiomes.Here,we highlight old and emerging plant microbiome concepts related to plant disease control,and address perspectives that modern and emerging microbiomics technologies can bring to functionally characterize and exploit plant-associated microbiomes for the benefit of plant health in future microbiome-assisted agriculture. | Peter A.H.M.Bakker Roeland L.Berendsen Johan A.Van Pelt Gilles Vismans Ke Yu Erqin Li Sietske Van Bentum Sanne W.M.Poppeliers Juan J.Sanchez Gil Hao Zhang Pim Goossens Ioannis A.Stringlis Yang Song Ronnie de Jonge CornéM.J.Pieterse | 2020 | Molecular Plant2020，13，10： | 3 |
| 11 | 中国人Bcll/St14 RFLPs研究与甲型血友病基因诊断显示文摘本文报道了St14(DXS52)上的一组BclI限制酶片段长度多态性(RFLPs)。该RFLPs由4.0kb,3.3kb,3.0kb和2.3kb DNA片段组成。在中国人中这组多态性片段出现的频率分别为0.09,0.12,0.44和0.35,提供的多态性信息量为0.66。甲型血友病家系基因连锁分析结果表明,这组RFLPs的DNA杂交图谱较目前国际上广泛使用的TaqI/St14 RFLPs更易于分析,在甲型血友病基因连锁分析中具有较高的应用价值。 | 沈岩 吴冠芸 王申五 刘敬忠 冯继宁 刘毅 姜先华 孙念怙 王凤云 吴玉珍 宁阳 龙桂芳 李琪 梁荣 金琪 唐智宁 苏承武 林伟雄 M. Goossens | 1989 | 中国科学(B辑)1989，，6： | 2 |
| 12 | 基于荷兰老年人社会关系结构特征的用户角色构建显示文摘目的从社会关系的视角分析老年人的差异化特征,定义与老年人的社交需求相关的用户特征,输出典型的用户角色类型、用户角色构建框架,指导老年人社交类产品的设计,促进社会的健康老龄化。方法以荷兰当地的十一名68~72岁的老年人为研究对象,通过结构化访谈了解老年人的日常生活和社会关系结构,通过质性分析定义一组与老年社交产品设计相关的用户角色特征要素。结论得出基于血缘、地缘和业缘(趣缘)关系的三种用户角色类型,包括家人依赖型、朋友陪伴型和事业兴趣型老年人;定义了一组与识别老年人社交需求相关的用户特征要素,形成了用户角色构建框架。典型用户角色类型、用户角色构建框架有助于协助设计研究人员识别老年人的社会关系和社交需求,从而设计出更匹配老年人需求的社交产品。 | 王婷婷 肖东娟 董玉妹 Richard Goossens | 2021 | 包装工程2021，42，4： | 2 |
| 13 | Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity显示文摘 | Goossens V Grooten J De Vos K | 1995 | Proc Natl Acad Sci USA1995，92，18： | 2 |
| 14 | Regulation of jasmonate signaling by reversible acetylation of TOPLESS in Arabidopsis显示文摘The plant hormone jasmonate(JA)regulates plant immunity and adaptive growth by orchestrating a genome-wide transcriptional program.Key regulators of JA-responsive gene expression include the master transcription factor MYc2,which is repressed by the conserved Groucho/Tup1-like corepressor TOPLESS(TPL)in the resting state.However,the mechanisms underlying TPL-mediated transcriptional repression of MYc2 activity and hormone-dependent switching between repression and de-repression remainenigmatic.Here,we report the regulation of TPLactivity and JAsignaling byreversibleacetylation of TPL.We found that the histone acetyltransferase GCN5 could mediate TPL acetylation,which enhances its interaction with the NOVEL-INTERACTOR-OF-JAZ(NINJA)adaptor and promotes its recruitment to MYc2 target promoters,facilitating transcriptional repression.Conversely,TPL deacetylation by the histonedeacetylase HDA6 weakens TPL-NINJA interaction and inhibitsTPL recruitmentto MYC2 target promoters,facilitating transcriptional activation.In the resting state,the opposing activities of GCN5 and HDA6 maintain TPL acetylation homeostasis,promoting transcriptional repression activity of TPL.In response to JA elicitation,HDA6 expression is transiently induced,resulted in decreased TPL acetylation and repressor activity,thereby transcriptional activation of MYC2 target genes.Thus,the GCN5-TPL-HDA6 module main tains the homeostasis of acetylated TPL,thereby determining the transcriptional state of JA-responsive genes.Our findings uncovered a mechanism by which the TPL corepressor activity in JA signaling is activelytuned inarapidandreversiblemanner. | Chunpeng An Lei Deng Huawei Zhai Yanrong You Fangming Wu Qingzhe Zhai Alain Goossens Chuanyou Li | 2022 | Molecular Plant2022，15，8： | 2 |
| 15 | Synthetic aspects and characterization of polypropylene silica nano-composites prepared via solid-state modification and sol gel reactions显示文摘 | Han Goossens Francesco Picchioni | 2005 | Polymer2005，，46： | 1 |
| 16 | The influence of mineral fill- ers on the membrane properties of high flux asymmetric cellu- lose acetate reverse osmosis membranes 显示文摘 | GOOSSEN I VAN HAUTE A | 1976 | Desalnation1976，18，： | 1 |
| 17 | The role of adipose tissue dysfunction in the pathogen esis of obesity - related insulin resistance显示文摘 | Goossens GH | 2008 | Physiology & Beha- cior2008，94，： | 1 |
| 18 | Tourism information and pleasure motivation显示文摘 | Goossens C | 2000 | Annals of Tourism Research2000，27，2： | 1 |
| 19 | Adipose tri- glyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific显示文摘 | Jocken W E Smit E Goossens H G | 2008 | Histo- chemistry and Cell Biology2008，129，4： | 1 |
| 20 | Decreasing antibiotic resistance of Enterobacteriaceae by introducing a new antibiotic combination therapy for neutropenic fever patients显示文摘 | Mebis J Goossens H Bruyneel P | 1998 | Leukemia1998，12，10： | 1 |
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