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| 1 | PET imaging in ischemic cerebrovascular disease:current status and future directions显示文摘Cerebrovascular diseases are caused by interruption or significant impairment of the blood supply to the brain,which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphological damage.These pathophysiological changes can be assessed by positron emission tomography(PET),which permits the regional measurement of physiological parameters and imaging of the distribution of molecular markers.PET has broadened our understanding of the flow and metabolic thresholds critical for the maintenance of brain function and morphology:in this application,PET has been essential in the transfer of the concept of the penumbra(tissue with perfusion below the functional threshold but above the threshold for the preservation of morphology)to clinical stroke and thereby has had great impact on developing treatment strategies.Radioligands for receptors can be used as early markers of irreversible neuronal damage and thereby can predict the size of the final infarcts;this is also important for decisions concerning invasive therapy in large('malignant')infarctions.With PET investigations,the reserve capacity of blood supply to the brain can be tested in obstructive arteriosclerosis of the supplying arteries,and this again is essential for planning interventions.The effect of a stroke on the surrounding and contralateral primarily unaffected tissue can be investigated,and these results help to understand the symptoms caused by disturbances in functional networks.Chronic cerebrovascular disease causes vascular cognitive disorders,including vascular dementia.PET permits the detection of the metabolic disturbances responsible for cognitive impairment and dementia,and can differentiate vascular dementia from degenerative diseases.It may also help to understand the importance of neuroinflammation after stroke and its interaction with amyloid deposition in the development of dementia.Although the clinical application of PET investigations is limited,this technology had and still has a great impact on research into cerebrovascular diseases. | Wolf-Dieter Heiss | 2014 | Neuroscience Bulletin2014，30，5： | 10 |
| 2 | Nosocomial Pneumonia After Acute Stroke: Implications for Neurological Intensive Care Medicine显示文摘 | Ruediger Hilker Carsten Poetter Nahide Findeisen Jan Sobesky Andreas Jacobs Michael Neveling Wolf-Dieter Heiss | 2003 | Stroke: Journal of the American Heart Association2003，，4： | 6 |
| 3 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 4 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 5 | Dietary inorganic nitrate mobilizes circulating angiogenic cells显示文摘 | Christian Heiss Christian Meyer Matthias Totzeck Ulrike B. Hendgen-Cotta Yvonne Heinen Peter Luedike Stefanie Keymel Nassim Ayoub Jon O. Lundberg Eddie Weitzberg Malte Kelm Tienush Rassaf | 2012 | Free Radical Biology and Medicine2012，，9： | 2 |
| 6 | MR-arterioportography: A new technical approach for detection of liver lesions显示文摘AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patients with suspected HCC were included before transarterial chemoembolization. In all patients double-enhanced Magnetic resonance imaging (MRI) was performed. A bolus of 10 mL Magnevist was injected through a selectively placed catheter in the superior mesenteric artery and MRI of the liver was performed in arterioportographic phase. Two independent readers evaluated number, size and localization of detected lesions. Diagnostic quality was determined using a 4-point scale. Differences were analyzed for significance using a t -test. Interobserver variability was calculated. RESULTS: In all 20 patients (100%), MR-AP was feasible. Diagnostic quality was, in all cases, between 1 and2 for both modalities and readers. MR-AP detected significantly more lesions than double-enhanced MRI (102.5 vs 61, respectively, P < 0.0024). The inter-observer variability was 0.881 for MRI and 0.903 for MR-AP. CONCLUSION: Our study confirmed that the MR-AP as an additional modality for detection of HCC is beneficial, as significantly more lesions were detected compared to MRI with liver-specific contrast. | Janine Rennert Ernst-Michael Jung Andreas G Schreyer Patrick Hoffstetter Peter Heiss Stefan Feuerbach Niels Zorger | 2011 | World Journal of Gastroenterology2011，17，13： | 2 |
| 7 | Carotid Artery Intimal-Medial Thickness Distribution in General Populations As Evaluated by B-Mode Ultrasound显示文摘 | George Howard A. Richey Sharrett Gerardo Heiss Gregory W. Evans Lloyd E. Chambless Ward A. Riley Gregory L. Burke | 1993 | Stroke1993，，9： | 2 |
| 8 | 肾功能和贫血是冠心病及其死亡率的危险因素:社区动脉粥样硬化风险(ARIC)研究显示文摘Background: Kidney failure causes anemia and is associated with a very high risk of coronary heart disease(CHD). Mildly to moderately decreased kidney function is far more common and also is associated with an elevated prevalence of anemia and CHD risk. Recent data suggest an even higher risk of CHD when both conditions are present. Methods: We investigated the association of kidney dysfunction and anemia with CHD events(fatal or nonfatal CHD or coronary revascularization procedures) and CHD and all- cause mortality over 12 years of follow- up in 14 971 adults aged 45 to 64 years in the ARIC Study. Glomerular filtration rate(GFR) was estimated from calibrated serum creatinine using the MDRD Study equation(< 30 mL/min per 1.73 m2 excluded, n=32). Anemia was defined as hemoglobin level<13.5 g/dL in men(648/6746, 9.6% ) and< 12 g/dL in women(1049/8225, 12.8% ). Results: The prevalence of anemia was progressively higher at lower estimated GFR< 75 mL/min per 1.73 m2(both P< .001) for both men and women. A total of 1635(10.9% ) participants had a CHD event, 360(2.4% ) died of CHD, and 1722(11.5% ) died of any cause during follow- up. After adjustment for known risk factors, including diabetes, lipid levels, blood pressure, and use of antihypertensive medication, decreased kidney function was associated with a higher risk of recurrent CHD events and mortality from CHD and all causes. These associations were significantly stronger among participants with anemia. The adjusted relative hazards of all- cause mortality associated with moderately decreased versus normal kidney function(GFR 30- 59 vs ≥ 90 mL/min per 1.73 m2) were 1.7(95% CI 1.3- 2.2) in the absence of anemia and 3.5(95% CI 2.4- 5.1) in the presence of anemia(P interaction=.001) . Conclusions: The combination of moderately decreased kidney function and anemia is associated with an increased risk of CHD events and mortality, emphasizing the need to identify individuals with these conditions and evaluate interventions to treat anemia and slow the progression of chronic kidney disease. | Astor B.C. Coresh J. Heiss G. 赵君 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，6： | 2 |
| 9 | Cerebral glucose metabolism as a predictor of rehabilitation after ischemic stroke显示文摘 | Heiss WD Emunds HG Herbolz K | 1993 | Stroke1993，24，： | 2 |
| 10 | Effect of piracetam on cerebral blood flow and somatosensory evoked potential during normotension and hypotensive ischemia in cats显示文摘 | Sato M Heiss WD | 1985 | Arznein-Forsch/Drug Res1985，35，： | 2 |
| 11 | Transvaginal/Transumbilical Hybrid—NOTES—Versus 3-Trocar Needlescopic Cholecystectomy: Short-term Results of a Randomized Clinical Trial显示文摘 | Dirk Rolf Bulian Jürgen Knuth Nicola Cerasani Axel Sauerwald Rolf Lefering Markus Maria Heiss | 2015 | Annals of Surgery2015，，3： | 2 |
| 12 | Which Time-to-Peak Threshold Best Identifies Penumbral Flow?: A Comparison of Perfusion-Weighted Magnetic Resonance Imaging and Positron Emission Tomography in Acute Ischemic Stroke显示文摘 | J Sobesky O Zaro Weber F -G. Lehnhardt V Hesselmann A Thiel C Dohmen A Jacobs M Neveling W -D. Heiss | 2004 | Stroke2004，，12： | 2 |
| 13 | Circulating endothelial micropamicle levels predict hemodynamic severity of pulmonary hypertension显示文摘 | Amabile N Heiss C Real WM | 2008 | Am J Respir Crit Care Med2008，177，11： | 1 |
| 14 | The activity patterns of houbara bustards; aspects of a field survey in the Canary Islands显示文摘 | Hinz C Heiss E M | 1989 | Bustard Studies1989，4，： | 1 |
| 15 | Flow thresholds of f unctional and morp hological damage of brain tissue显示文摘 | Heiss WD | 1983 | Stroke1983，14，3： | 1 |
| 16 | Impaired progenitor cell activity in age-related endothelial dysfunction显示文摘 | Heiss C Keymel S Niesler U | 2005 | J Am Coll Cardiol2005，45，9： | 1 |
| 17 | Differential capacity of left and fight hemispheric areas for compensation of poststroke aphasia显示文摘 | Heiss WD Kessler J Thiel A | 1999 | Ann Neurol1999，45，4： | 1 |
| 18 | Shelf life analysis of beer using an automated lag-time EPR system显示文摘 | Barr D Heiss A Kamlowski A | 2001 | Technology Note2001，16，12： | 1 |
| 19 | Nuclear factor κB is a molecular target for sulforaphane-mediated anti-infammatory mechanisms 显示文摘 | Heiss E Herhaus C Klimo K | 2001 | J Biol Chem2001，276，32： | 1 |
| 20 | Early detection of irreversibly damaged ischemic tissue by flumazenil positron emission tomography in cats显示文摘 | Heiss WD Graf W Fujita T | 1997 | Stroke1997，28，： | 1 |
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