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| 1 | 肾功能和贫血是冠心病及其死亡率的危险因素:社区动脉粥样硬化风险(ARIC)研究显示文摘Background: Kidney failure causes anemia and is associated with a very high risk of coronary heart disease(CHD). Mildly to moderately decreased kidney function is far more common and also is associated with an elevated prevalence of anemia and CHD risk. Recent data suggest an even higher risk of CHD when both conditions are present. Methods: We investigated the association of kidney dysfunction and anemia with CHD events(fatal or nonfatal CHD or coronary revascularization procedures) and CHD and all- cause mortality over 12 years of follow- up in 14 971 adults aged 45 to 64 years in the ARIC Study. Glomerular filtration rate(GFR) was estimated from calibrated serum creatinine using the MDRD Study equation(< 30 mL/min per 1.73 m2 excluded, n=32). Anemia was defined as hemoglobin level<13.5 g/dL in men(648/6746, 9.6% ) and< 12 g/dL in women(1049/8225, 12.8% ). Results: The prevalence of anemia was progressively higher at lower estimated GFR< 75 mL/min per 1.73 m2(both P< .001) for both men and women. A total of 1635(10.9% ) participants had a CHD event, 360(2.4% ) died of CHD, and 1722(11.5% ) died of any cause during follow- up. After adjustment for known risk factors, including diabetes, lipid levels, blood pressure, and use of antihypertensive medication, decreased kidney function was associated with a higher risk of recurrent CHD events and mortality from CHD and all causes. These associations were significantly stronger among participants with anemia. The adjusted relative hazards of all- cause mortality associated with moderately decreased versus normal kidney function(GFR 30- 59 vs ≥ 90 mL/min per 1.73 m2) were 1.7(95% CI 1.3- 2.2) in the absence of anemia and 3.5(95% CI 2.4- 5.1) in the presence of anemia(P interaction=.001) . Conclusions: The combination of moderately decreased kidney function and anemia is associated with an increased risk of CHD events and mortality, emphasizing the need to identify individuals with these conditions and evaluate interventions to treat anemia and slow the progression of chronic kidney disease. | Astor B.C. Coresh J. Heiss G. 赵君 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，6： | 2 |
| 2 | Comparison of Measured GFR, Serum Creatinine, Cystatin C, and Beta-Trace Protein to Predict ESRD in African Americans With Hypertensive CKD显示文摘 | Nrupen A. Bhavsar Lawrence J. Appel John W. Kusek Gabriel Contreras George Bakris Josef Coresh Brad C. Astor | 2011 | American Journal of Kidney Diseases2011，，6： | 1 |
| 3 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Circulation: Journal of the American Heart Association2003，，17： | 1 |
| 4 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Circulation: Journal of the American Heart Association2003，，17： | 1 |
| 5 | Kidney function and anemia as risk factors for coronary heart disease and mortality: The Atherosclerosis Risk in Communities (ARIC) Study显示文摘 | Brad C. Astor Josef Coresh Gerardo Heiss Dan Pettitt Mark J. Sarnak | 2006 | American Heart Journal2006，，2： | 1 |
| 6 | Blood Pressure and White-Matter Disease Progression in a Biethnic Cohort: Atherosclerosis Risk in Communities (ARIC) Study显示文摘 | Rebecca F. Gottesman Josef Coresh Diane J. Catellier A Richey Sharrett Kathryn M. Rose Laura H. Coker Dean K. Shibata David S. Knopman Clifford R. Jack Thomas H. Mosley | 2010 | Stroke2010，，1： | 1 |
| 7 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Hypertension: Journal of the American Heart Association2003，，5： | 1 |
| 8 | Comparative Performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study Equations for Estimating GFR Levels Above 60 mL/min/1.73 m 2显示文摘 | Lesley A. Stevens Christopher H. Schmid Tom Greene Yaping (Lucy) Zhang Gerald J. Beck Marc Froissart Lee L. Hamm Julia B. Lewis Michael Mauer Gerjan J. Navis Michael W. Steffes Paul W. Eggers Josef Coresh Andrew S. Levey | 2010 | American Journal of Kidney Diseases2010，，3： | 1 |
| 9 | Associations Between Lipoprotein(a) Levels and Cardiovascular Outcomes in Black and White Subjects: The Atherosclerosis Risk in Communities (ARIC) Study显示文摘 | Salim S. Virani Ariel Brautbar Brian C. Davis Vijay Nambi Ron C. Hoogeveen A. Richey Sharrett Josef Coresh Thomas H. Mosley Joel D. Morrisett Diane J. Catellier Aaron R. Folsom Eric Boerwinkle Christie M. Ballantyne | 2012 | Circulation2012，，2： | 1 |
| 10 | Comparative Performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study Equations for Estimating GFR Levels Above 60 mL/min/1.73 m 2显示文摘 | Lesley A. Stevens Christopher H. Schmid Tom Greene Yaping (Lucy) Zhang Gerald J. Beck Marc Froissart Lee L. Hamm Julia B. Lewis Michael Mauer Gerjan J. Navis Michael W. Steffes Paul W. Eggers Josef Coresh Andrew S. Levey | 2010 | American Journal of Kidney Diseases2010，，3： | 1 |
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