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| 1 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 2 | Transvaginal/Transumbilical Hybrid—NOTES—Versus 3-Trocar Needlescopic Cholecystectomy: Short-term Results of a Randomized Clinical Trial显示文摘 | Dirk Rolf Bulian Jürgen Knuth Nicola Cerasani Axel Sauerwald Rolf Lefering Markus Maria Heiss | 2015 | Annals of Surgery2015，，3： | 2 |
| 3 | Polyunsaturated fatty acid supply with human milk 显示文摘 | SAUERWALD T U DEMMELMAIR H KOLETZKO B | 2001 | Lipids2001，36，： | 1 |
| 4 | Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial显示文摘 | Fidler N Sauerwald T Pohl A | 2000 | J Lipid Res2000，41，9： | 1 |
| 5 | Changing the Channel: Develop- ments in US Specialty Pharmaceutical Distribution显示文摘 | Pamela Leigh Sauerwald | 2009 | Pharmaceutical Commerce2009，，： | 1 |
| 6 | Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants显示文摘 | Sauerwald UC Fink MM Demmelmair H | 2012 | Journal of pediatric gastroenterology and nutrition2012，54，3： | 1 |
| 7 | Photodynamic therapy with topical application of 5-aminolevulinic acid in the treatment of actinic keratoses: an initial clinical study显示文摘 | Karrer S Sauerwald A | 1996 | Dermatology1996，192，3： | 1 |
| 8 | A new diffusion-based multilevel algorithm for computing graph partitions显示文摘 | MEYERHENKE H MONIEN B SAUERWALD T | 2009 | Journal of Parallel and Distributed Computing2009，69，9： | 1 |
| 9 | Codon engineering for improved antibody expression in mammalian cells 显示文摘 | Carton JM Sauerwald T Hawley-Nelson P | 2007 | Protein Expr Purification2007，55，2： | 1 |
| 10 | Breastfeeding and obesity: cross-sectional study显示文摘 | Von KR Koletzko B Sauerwald T | 1999 | BMJ1999，319，7203： | 1 |
| 11 | Prophylaxis of Postoperative Nausea and Vomiting Following Gynaecological Laparoscopy显示文摘 | Rusch D Palm S Sauerwald M | 2002 | Anasthesiol Intensivmed Notfallmed Schmerzther2002，37，1： | 1 |
| 12 | Does breast-feeding protect against childhood obesity显示文摘 | Von Kries R Koletzko B Sauerwald T | | 0，，： | 1 |
| 13 | Ordered mesoporous In2O3 : Synthesis by structure replication and application as a methane gas sensor显示文摘 | Thomas Waltz Thorsten Wagner Tilman Sauerwald | 2009 | Adv Funct Mater2009，19，4： | 1 |
| 14 | Codon engi- neering for improved antibody expression in mammalian ceils 显示文摘 | Carton JM Sauerwald T Hawley-Nelson P | 2007 | Protein Expr Purif2007，55，2： | 1 |
| 15 | A comparision ofthe properties of a Bcl-xl variant to the wild-type anti-apoptosisinhibitor in mammalian cell cultures 显示文摘 | Figueroa B Jr Sauerwald TM Oyler GA | 2003 | Metab Eng2003，5，4： | 1 |
| 16 | Regulation of glycerol metabolism in Enterococcus faecalis by phosphoenolpyruvatedependent phosphorylation of glycerol kinase catalyzed by enzyme I and HPr of the phosphotransferase system显示文摘 | Deutscher J Bauer B Sauerwald H | 1993 | J Bacteriol1993，175，12： | 1 |
| 17 | Combined antibacteria and antifungal properties of water soluble fractions of royal jelly显示文摘 | SAUERWALD N POLSTER J BENGSCH | 1998 | Advances in food sciences1998，20，： | 1 |
| 18 | Spectrometric pK determination of daphnctin, chlorogcnic acid and quereetin显示文摘 | SAUERWALD N SCHWENK M POLSTER J | 1998 | Z Naturforsch1998，，： | 1 |
| 19 | Fat content and fatty acid composition of fresh, pasteurized, or steril- ized human milk 显示文摘 | FIDLER N SAUERWALD TU DEMMELMAIR H | 2001 | Adv Exp Med Biol2001，50，1： | 1 |
| 20 | Gas sensor based on ordered mesopornus 1n2O3 显示文摘 | Wagner T Sauerwald T Kohl C D | 2009 | Thin Solid Film2009，517，22： | 1 |
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