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14篇 您的检索式:作者名="Luedike"
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1Potential of dietary nitrate in angiogenesis显示文摘Endothelial dysfunction with impaired bioavailability of nitric oxide(NO) is the hallmark in the development of cardiovascular disease. Endothelial dysfunction leads to atherosclerosis, characterized by chronic inflammation of the arterial wall and stepwise narrowing of the vessel lumen. Atherosclerosis causes deprivation of adequate tissue blood flow with compromised oxygen supply. To overcome this undersupply, remodeling of the vascular network is necessary to reconstitute and sustain tissue viability. This physiological response is often not sufficient and therapeutic angiogenesis remains an unmet medical need in critical limb ischemia or coronary artery disease. Feasible approaches to promote blood vessel formation are sparse. Administration of pro-angiogenic factors, gene therapy, or targeting of micro RNAs has not yet entered the daily practice. Nitric oxide is an important mediator of angiogenesis that becomes limited under ischemic conditions and the maintenance of NO availability might constitute an attractive therapeutic target. Until recently it was unknown how the organism provides NO under ischemia. In recent years it could be demonstrated that NO can be formed independently of its enzymatic synthesis in the endothelium by reduction of inorganic nitrite under hypoxic conditions. Circulating nitrite derives from oxidation of NO or reduction of inorganic nitrate by commensal bacteria in the oral cavity. Intriguingly, nitrate is a common constituent of our everyday diet and particularly high concentrations are found in leafy green vegetables such as spinach, lettuce, or beetroot. Evidence suggests that dietary nitrate supplementation increases the regenerative capacity of ischemic tissue and that this effect may offer an attractive nutrition-based strategy to improve ischemia-induced revascularization. We here summarize and discuss the regenerative capacity of dietary nitrate on the vascular system.Christos Rammos Peter Luedike Ulrike Hendgen-Cotta Tienush Rassaf 2015World Journal of Cardiology2015,7,10:4
2Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation显示文摘Matthias Totzeck Ulrike B. Hendgen-Cotta Peter Luedike Michael Berenbrink Johann P. Klare Heinz-Juergen Steinhoff Dominik Semmler Sruti Shiva Daryl Williams Anja Kipar Mark T. Gladwin Juergen Schrader Malte Kelm Andrew R. Cossins Tienush Rassaf 2012Circulation2012,,3:2
3Dietary inorganic nitrate mobilizes circulating angiogenic cells显示文摘Christian Heiss Christian Meyer Matthias Totzeck Ulrike B. Hendgen-Cotta Yvonne Heinen Peter Luedike Stefanie Keymel Nassim Ayoub Jon O. Lundberg Eddie Weitzberg Malte Kelm Tienush Rassaf 2012Free Radical Biology and Medicine2012,,9:2
4Cardioprotection through Snitros(yl)ation of macrophage migration inhibitory factor 显示文摘Luedike P Hendgen-Cotta U B Sobierajski J 2012Circulation2012,125,:1
5NADPH oxi- dase plays a central role in blood -brain barrier damage in experimental stroke 显示文摘Kahles T Luedike P Endres M 2007Stroke2007,38,11:1
6NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke显示文摘Kahles T Luedike P Endres M 0,,11:1
7NADPH oxidase plays a central role in blood - brain barrier damage in experimental stroke显示文摘Kahles T Luedike P Endres M 2007Stroke2007,38,11:1
8NADPH oxidase plays acentral role in blood-brain barrier damage in experimental stroke显示文摘Kahles T Luedike P Endres M 2007Stroke:a journal of cerebral circulation2007,38,:1
9NADPH oxidase plays a central role in blood - brain barrier damage in experimental stroke显示文摘KAHLES T LUEDIKE P ENDRES M 2007Stroke2007,38,11:1
10Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly显示文摘Christos Rammos Ulrike B. Hendgen-Cotta Julia Pohl Matthias Totzeck Peter Luedike Volker T. Schulze Malte Kelm Tienush Rassaf Elísio Costa 2014BioMed Research International2014,,:1
11Dietary Nitrate Supplementation Improves Revascularization in Chronic Ischemia显示文摘Ulrike B. Hendgen-Cotta Peter Luedike Matthias Totzeck Martina Kropp Andreas Schicho Pia Stock Christos Rammos Michael Niessen Christian Heiss Jon O. Lundberg Eddie Weitzberg Malte Kelm Tienush Rassaf 2012Circulation2012,,16:1
12NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke显示文摘Kahles T Luedike P Endres M 2007Stroke2007,38,11:1
13Cardioprotection Through S-Nitros(yl)ation of Macrophage Migration Inhibitory Factor显示文摘Peter Luedike Ulrike B. Hendgen-Cotta Julia Sobierajski Matthias Totzeck Marcel Reeh Manfred Dewor Hongqi Lue Christoph Krisp Dirk Wolters Malte Kelm Jürgen Bernhagen Tienush Rassaf 2012Circulation2012,,15:1
14Nadph oxidase plays a cetltral role in blood-brain barrier damage in experimental stroke显示文摘Kahles T Luedike P Endres M 2007Stroke2007,38,11:1
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