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| 1 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 2 | Transvaginal/Transumbilical Hybrid—NOTES—Versus 3-Trocar Needlescopic Cholecystectomy: Short-term Results of a Randomized Clinical Trial显示文摘 | Dirk Rolf Bulian Jürgen Knuth Nicola Cerasani Axel Sauerwald Rolf Lefering Markus Maria Heiss | 2015 | Annals of Surgery2015，，3： | 2 |
| 3 | Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia显示文摘 | Gattei V Bulian P llaria M | 2008 | Blood2008，111，3： | 1 |
| 4 | Mycoplasma contamination of murine embryonic stem cells affects cell parameters, germline trans- mission and chimeric progeny 显示文摘 | Kyriaki Markoullis Diana Bulian | 2009 | Transgenie Res2009，18，1： | 1 |
| 5 | On the nonlinear modeling of parametric rolling in regular and irregular waves显示文摘 | BULIAN G FRANCESCUTTO A LUGNI C | | 0，，2： | 1 |
| 6 | Processing and ignition characteristics of aluminum-bismuth trioxide nanothermic system显示文摘 | Puszinski J A Bulian C J Swiatkiewicz J J | | 0，，4： | 1 |
| 7 | Flow cytometric reticulocyte cou2 ting! Parallel evaluation of five fully automated analyzers; an NCCIS - ICSH app roach显示文摘 | Butarello M Bulian G | 2001 | Am J Clin Pathol2001，115，1： | 1 |
| 8 | On the nonlinear modeling of parametric rolling in regular and irregular waves显示文摘 | BULIAN G FRANCESCUTTO A LUGNI C | 2004 | International Shipbuilding Progress2004，51，23： | 1 |
| 9 | Nano-scale tungsten oxides for metastable intermolecular composites显示文摘 | Perry W L Smith B L Bulian C J | | 0，，2： | 1 |
| 10 | Qual- itative and quantitative characteristics of parametric ship rolling in random waves in the light of physical model ex- periments显示文摘 | BULIAN G FRANCESCUTrO A UMEDA N | 2008 | Ocean Engineering2008，35，1718： | 1 |
| 11 | , Nonlinear parametric rolling in regular wavesa general procedure for the analytical approximation of the GZ curve and its use in time domain simulations显示文摘 | Bulian G | 2005 | Ocean Engineering2005，，： | 1 |
| 12 | Sysmex SE-9000hematology analyzer:Performance evaluation on leukocyte differential countsusing an NCCLS H20-A protocol 显示文摘 | Buttarello M Bulian p Temporin V Rizotti P | 1997 | Am J Clin Pathol1997，108，： | 1 |
| 13 | Circadian melatonin and yong-to-old pineal grafting postpone aging and maintain juvenile conditions of reproductive functions in mice and rat显示文摘 | Pierpaoli W Bulian D Dallrara A | 1997 | Exp Gerontol1997，32，45： | 1 |
| 14 | The zino pool is involved in the innune-reconstituting effect of melatonin in pinealectomized mice 显示文摘 | Mocchegiani E Bulian D Santarelli L | 1996 | J Pharmacol Exp Ther1996，277，3： | 1 |
| 15 | Relevance of CD49d protein expression as overall survival and progressive disease prog-nosticator in chronic lymphocytic leukemia显示文摘 | Gattei V Bulian P Del Principe MI | 2008 | Blood2008，111，2： | 1 |
| 16 | The zinc pool is involved in the immunoreconstituting effect of melatonin in pinealectomized mice显示文摘 | Mocchegiani E Bulian D Santarelli L | 1996 | JPET1996，277，3： | 1 |
| 17 | Restorative restproctectomy as single-port surgery through the ostomy site in a three-stage procedure显示文摘 | Dirk Rolf Bulian Jürgen Knuth Bernd Krakamp Markus Maria Heiss | 2012 | Surgical Endoscopy2012，，： | 1 |
| 18 | Natural Orifice Translu- minal Endoscopic Surgery (NOTES) for colon resections-analy- sis of the first 139 patients of the German NOTES Registry (GNR) 显示文摘 | Bulian DR Runkel N Burghardt J | 2014 | Int J Colorectal Dis2014，29，7： | 1 |
| 19 | Qualitative and quantitative characteristics of parametric ship rolling in random waves in the light of physical model experiments显示文摘 | Bulian G Francescutto A Umeda N Hashimoto H | 2008 | Ocean Engineering2008，35，1778： | 1 |
| 20 | Transvaginal hybrid-NOTES appendectomy in routine clinical use: prospective analysis of 13 cases and description of the procedure显示文摘 | Jurgen Knuth Markus Maria Heiss Dirk Rolf Bulian | 2014 | Surgical Endoscopy2014，，： | 1 |
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