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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis. | Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert | 2007 | World Journal of Gastroenterology2007，13，36： | 3 |
| 3 | Storage stability of freeze-dried starter cultures(Streptococcus thermophilus)as related to physical state of freezing matrix显示文摘 | Astrid B A Mette S F Heidi L et a1 | 1999 | Lebensmittel-Wissenschaft und-Technologie1999，32，： | 1 |
| 4 | Comparison of pond production efficiency, fatty acid profiles, and Contaminants in Litopenaeus vannamei Fed Organic plant-based and fish- meat-based diets 显示文摘 | CRAIG B GLORIA S HEIDI A | 2006 | Journal of the World Aquaculture Society2006，37，4： | 1 |
| 5 | The Scholarship of Teaching and Learning: A Special Niche for Faculty at Comprehensive Universities 显示文摘 | Bruce B Henderson Heidi E | 2007 | Research in Higher Educa- tion2007，，5： | 1 |
| 6 | Preparation of polyurethane nano- capsules by miniemulsion polyaddition 显示文摘 | Heidi Johnsen Ruth B Schmid | 2007 | Journal of Microencap- sulation2007，24，8： | 1 |
| 7 | Annexin A5 downregulates surface expression of tissue factor显示文摘 | Susana R Abdelkader B Heidi K | 2005 | J Biol Chem2005，280，7： | 1 |
| 8 | PPAR-α agonist actions in the liver of obese insulin-resistant monkeys: reduction in hepatic lipoprotein lipase activity, triglyceride content and TNF-αexpression显示文摘 | HEIDI K O RUBY I B CAMILLE H | 2006 | The Journal of the Federation of American Sociaties for Experimental Biology2006，20，3： | 1 |
| 9 | The face of the patent is not the ' WholeStory” : determining effective life of a pharmaceutical patent in theUnited States 显示文摘 | CLARK AM HEIDI B | 2004 | World Pat Information2004，，26： | 1 |
| 10 | Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites显示文摘 | Neela Guha Dana Loomis Yann Grosse Béatrice Lauby-Secretan Fatiha El Ghissassi Véronique Bouvard Lamia Benbrahim-Tallaa Robert Baan Heidi Mattock Kurt Straif | 2012 | Lancet Oncology2012，，12： | 1 |
| 11 | Facile synthesis of aliphatic isothioeyanates and thioureas on solid phase using peptide coupling reagents 显示文摘 | ULRIK BOAS HEIDI GERTZ JORN B CHRISTENSENB | 2004 | Tetrahedron Lett2004，45，： | 1 |
| 12 | HIVinhibitory gallotannins form Lepidobotrys staudtii显示文摘 | Heidi R B Tawnya C M Michael J C | 1996 | Nuturul Prod Lett1996，8，2： | 1 |
| 13 | Accumulating Mutations in Series of Haplotypes at the KITand MITF Loci Are Major Determinants of White Markings in Franches-Montagnes Horses 显示文摘 | Haase B Heidi S H Matthew M B | 2013 | Plos One2013，8，75： | 1 |
| 14 | Identification of A-colored Stars and Structure in the Halo of theMilky Way from Sloan Digital Sky Survey Commissioning Data显示文摘 | YANNY B NEWBERG HEIDI JO KENT STEVE | 2000 | Astrophysical Journal2000，540，： | 1 |
| 15 | Inhibition of angiogenesis by IL-32: Possible role in asthma显示文摘 | Norbert Meyer Janine Christoph Heidi Makrinioti Philippe Indermitte Claudio Rhyner Michael Soyka Thomas Eiwegger Maciej Chalubinski Kerstin Wanke Hiroyuki Fujita Paulina Wawrzyniak Simone Bürgler Sherrie Zhang Mübeccel Akdis Günter Menz Cezmi Akdis | 2012 | The Journal of Allergy and Clinical Immunology2012，，4： | 1 |
| 16 | Fabrication and characterization of contact lenses bearing surfaceimmobilized layers of intact liposomes显示文摘 | Anne D Heidi B Yves M | 2007 | J Biomed-Mater Res A2007，80，： | 1 |
| 17 | Magnetic imaging of craniovertebral structures : clinical significance in cervicogenic headache 显示文摘 | Heidi K Jostein K Dalius B | 2012 | J Headache Pain2012，，13： | 1 |
| 18 | Characterization of class 1 integron resistance gene cassettes and the identification of a novel IS-like element in Acinetobacter baumannii显示文摘 | Heidi S Robin T B Gay Elisha | 2003 | Plasmid2003，49，： | 1 |
| 19 | Health related quality of life, mood dis orders and coping abilities in an unselected sample of patients显示文摘 | Heidi B Rolke P Frode G | 2008 | Repirat Med2008，102，： | 1 |
| 20 | MRI Study: Objective Olfactory Function and CNS Pathologies in Patients with Multiple Sclerosis显示文摘 | Holinski Franca Schmidt Felix Dahlslett Sarah B Harms Lutz Bohner Georg Olze Heidi | 2014 | European Neurology . 2014 (3-4)2014，，3： | 1 |
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