|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
| 2 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 3 | Mechanisms of allergen-specific immunotherapy显示文摘 | Cezmi A. Akdis Mübeccel Akdis | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 2 |
| 4 | MicroRNAs: Essential players in the regulation of inflammation显示文摘 | Ana Rebane Cezmi A. Akdis | 2013 | The Journal of Allergy and Clinical Immunology2013，，1： | 2 |
| 5 | Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4显示文摘 | Michael B. Soyka Paulina Wawrzyniak Thomas Eiwegger David Holzmann Angela Treis Kerstin Wanke Jeannette I. Kast Cezmi A. Akdis | 2012 | The Journal of Allergy and Clinical Immunology2012，，5： | 2 |
| 6 | Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases显示文摘 | Mübeccel Akdis Simone Burgler Reto Crameri Thomas Eiwegger Hiroyuki Fujita Enrique Gomez Sven Klunker Norbert Meyer Liam O’Mahony Oscar Palomares Claudio Rhyner Nadia Quaked Anna Schaffartzik Willem Van De Veen Sabine Zeller Maya Zimmermann Cezmi A. Akdis | 2011 | The Journal of Allergy and Clinical Immunology2011，，3： | 1 |
| 7 | Immunological mechanisms of allergen-specific immunotherapy显示文摘 | MARK L CEZMI A RODOLF V | 2006 | Nature2006，6，： | 1 |
| 8 | Mechanisms of allergen-specific immunotherapy 显示文摘 | AKDIS M CEZMI A AKDIS C A | 2007 | J Allergy Clin Immunol2007，119，： | 1 |
| 9 | Mechanisms of interleukin‐10‐mediated immune suppression显示文摘 | Cezmi A.Akdis KurtBlaser | 2001 | Immunology2001，，2： | 1 |
| 10 | Inhibition of angiogenesis by IL-32: Possible role in asthma显示文摘 | Norbert Meyer Janine Christoph Heidi Makrinioti Philippe Indermitte Claudio Rhyner Michael Soyka Thomas Eiwegger Maciej Chalubinski Kerstin Wanke Hiroyuki Fujita Paulina Wawrzyniak Simone Bürgler Sherrie Zhang Mübeccel Akdis Günter Menz Cezmi Akdis | 2012 | The Journal of Allergy and Clinical Immunology2012，，4： | 1 |
| 11 | T-cell subsets in the pathogenesis of human asthma显示文摘 | Flurina Meiler MSc Maya Zimmermann MSc Kurt Blaser PhD Cezmi A. Akdis MD Mübeccel Akdis MD PhD | 2006 | Current Allergy and Asthma Reports2006，，2： | 1 |
| 12 | Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases显示文摘 | Mübeccel Akdis Simone Burgler Reto Crameri Thomas Eiwegger Hiroyuki Fujita Enrique Gomez Sven Klunker Norbert Meyer Liam O’Mahony Oscar Palomares Claudio Rhyner Nadia Quaked Anna Schaffartzik Willem Van De Veen Sabine Zeller Maya Zimmermann Cezmi A. Akdis | 2011 | The Journal of Allergy and Clinical Immunology2011，，3： | 1 |
| 13 | Numerical Calculation of the Three-Dimensional Swirling Flow Inside the Centrifugal Pump Volutes显示文摘 | E Cezmi Nursen and Erkan Ayder | 2003 | International Journal of Rotating Machinery2003，9，： | 1 |
| 14 | T H 17 cells in the big picture of immunology显示文摘 | Carsten B. Schmidt-Weber Mübeccel Akdis Cezmi A. Akdis | 2007 | The Journal of Allergy and Clinical Immunology2007，，2： | 1 |
| 15 | Mechanism of IL-10 induced T cell inactivation in allergic inflammation and normal response to allergens显示文摘 | Cezmi A Akdis AJ Mubeccel A | 2001 | Int Arch Allergy Immunol2001，124，2： | 1 |
| 16 | Intravitreal aflibercept for ruptured retinal arterial macroaneurysm显示文摘Dear Editor,Retinal arterial macroaneurysm(RAM),which usually occurs within the first three orders of arterial bifurcation,is acquired fusiform or saccular dilatations of retinal arterioles^([1-2]).Aging,the female gender,and systemic vascular pa- | Zafer Oztas Serhad Nalcaci Cezmi Akkin | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 1 |
| 17 | Mechanisms of allergen-specific immunotherapy 显示文摘 | Akdis Muheccel Akdis Cezmi A | 2007 | J Allergy Clin Immunol2007，119，4： | 1 |
| 18 | TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis显示文摘 | Maya Zimmermann Andrea Koreck Norbert Meyer Tomasz Basinski Flurina Meiler Burgler Simone Stefan Woehrl Katharina Moritz Thomas Eiwegger Peter Schmid-Grendelmeier Lajos Kemeny Cezmi A. Akdis | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 1 |
| 19 | Regulation of the immune response and inflammation by histamine and histamine receptors显示文摘 | Liam O’Mahony Mübeccel Akdis Cezmi A. Akdis | 2011 | The Journal of Allergy and Clinical Immunology2011，，6： | 1 |
| 20 | Histamine receptors are hot in immunopharmacology显示文摘 | Cezmi A. Akdis F. Estelle R. Simons | 2006 | European Journal of Pharmacology (-)2006，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员