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| 1 | Stool therapy may become a preferred treatment of recurrent Clostridium difficile?显示文摘Fecal enemas were first reported to successfully treat life threatening enterocolitis in 1958, but fecal therapy to treat Clostridium difficile (C. difficile ) infection has remained esoteric and not well investigated until recently. In the past few years, systematic reviews of case series and case reports of fecal microbiota transplant for recurrent C. difficile infection have become available and validate use of fecal transplant for C. difficile enterocolitis. Methods of fecal transplant reported in the literature include: nasogastric tube, gastroscope, duodenal tube, colonoscopy, rectal tube, and fecal enemas administered at home; no method has been shown to be superior. A recent randomized study published in New England Journal of Medicine found fecal transplant to be superior to oral vancomycin alone in treatment of recurrent C. difficile enterocolitis. The significance of this trial cannot be underestimated as it lends credibility to the idea of intentionally using microbes to combat disease, providing an alternative to the older paradigm of disease eradication through use of antimicrobials. | Dinesh Vyas Heidi E L'Esperance Arpita Vyas | 2013 | World Journal of Gastroenterology2013，19，29： | 4 |
| 2 | Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis. | Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert | 2007 | World Journal of Gastroenterology2007，13，36： | 3 |
| 3 | Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial显示文摘 | John Willy Haukeland Zbigniew Konopski Heidi Beate Eggesb? Hilde L?land von Volkmann Gabriele Raschpichler Kristian Bj?ro Terese Haaland Else Marit L?berg K?re Birkeland | 2009 | Scandinavian Journal of Gastroenterology2009，，7： | 3 |
| 4 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 5 | Risk of com- munity-acquired pneumococcal bacteremia in patients with diabetes: a population-based case-control study显示文摘 | Reimar WT Heidi HH Hans-Henrik L | 2004 | Di- abetes Care2004，27，5： | 1 |
| 6 | An Enriching Place显示文摘 | Heidi L Blau AIA | | 0，，11： | 1 |
| 7 | Expression of the cyclin kinase inhibitor p27 in developing and mature human kidney显示文摘 | Combs Heidi L Stuart J | 1998 | Kidney International1998，53，4： | 1 |
| 8 | Identification of the DNA Binding specificity and potential target genes for the farnesold X-activated receptor显示文摘 | Bryan A L Heidi R K Catherine M N | 2000 | J Biol Chem2000，275，10： | 1 |
| 9 | Storage stability of freeze-dried starter cultures(Streptococcus thermophilus)as related to physical state of freezing matrix显示文摘 | Astrid B A Mette S F Heidi L et a1 | 1999 | Lebensmittel-Wissenschaft und-Technologie1999，32，： | 1 |
| 10 | the PPAR /ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in dia- betic mice 显示文摘 | Hwang J Kleinhenz D J Heidi L | 2007 | Vase Pharmacol2007，46，： | 1 |
| 11 | Properties of yttria-aluminoborate glasses显示文摘 | Rutz Heidi L Day Delbert E Spencer Charles F Jr | 1990 | J Am Ceram Soe1990，73，6： | 1 |
| 12 | Roles of salicylicacid,jasmonic acid,and ethylene in cpr-induced resistance inArabidopsis显示文摘 | Joseph D C Sigrid M V Heidi L | 2000 | Plant Cell2000，12，： | 1 |
| 13 | Prognostic impact of immuno histochemieally defined germinal center phenotype in dffuse large B-cell lymphoma patients treated with inununochemotherapy显示文摘 | Heidi N Magdalena A Marja L | 2007 | Blood2007，10，11： | 1 |
| 14 | Using a standardized family to teach clinical skills to medical students显示文摘 | Maria CC Heidi L Stephen EW | | 0，，03： | 1 |
| 15 | TOPLESS mediates auxin-de- pendent transcriptional repression during Arabidopsis embry- ogenesis显示文摘 | HEIDI S MIKE H JEFF A L | 2008 | Science2008，319，5868： | 1 |
| 16 | Risk factor for autism: Perinatal factors, parental psychiatric history, and socioeconomic status显示文摘 | Heidi J L William W E Kreesten M M | 2005 | Am J Epidemiol2005，161，10： | 1 |
| 17 | Information on selected water quality characteristics for the production of black sea bass,Centropristis striata,Juveniles显示文摘 | Heidi L A Shawn P Y Joseph R T | 2004 | Journal of Applied Aquaculture2004，15，34： | 1 |
| 18 | Delay in disclosure of childhood rape: results from a national survey显示文摘 | Daniel W Smith Elizabeth J Letourneau Benjamin E Saunders Dean G Kilpatrick Heidi S Resnick Connie L Best | 2000 | Child Abuse & Neglect2000，，2： | 1 |
| 19 | Subjective Well-Being:Three Decades of Progress 显示文摘 | Diener Ed Eunkook M Suh Richard E Lucas & Heidi L Smith | 1999 | Psychological Bulletin1999，125，2： | 1 |
| 20 | Collaborative testing enhances student learning显示文摘 | SUMANGALA P HEIDI L STEPHEN E | 2002 | Adv Physiol Educ2002，26，14： | 1 |
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