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| 1 | Saffron (Crocus sativus L.) and major depressive disorder:a meta-analysis of randomized clinical trials显示文摘BACKGROUND:Due to safety concerns and side effects of many antidepressant medications,herbal psychopharmacology research has increased,and herbal remedies are becoming increasingly popular as alternatives to prescribed medications for the treatment of major depressive disorder(MDD).Of these,accumulating trials reveal positive effects of the spice saffron(Crocus sativus L.)for the treatment of depression.A comprehensive and statistical review of the clinical trials examining the effects of saffron for treatment of MDD is warranted.OBJECTIVE:The purpose of this study was to conduct a meta-analysis of published randomized controlled trials examining the effects of saffron supplementation on symptoms of depression among participants with MDD.SEARCH STRATEGY:We conducted electronic and non-electronic searches to identify all relevant randomized,double-blind controlled trials.Reference lists of all retrieved articles were searched for relevant studies.INCLUSION CRITERIA:The criteria for study selection included the following:(1)adults(aged18 and older)with symptoms of depression,(2)randomized controlled trial,(3)effects of saffron supplementation on depressive symptoms examined,and(4)study had either a placebo control or antidepressant comparison group.DATA EXTRACTION AND ANALYSIS:Using random effects modeling procedures,we calculated weighted mean effect sizes separately for the saffron supplementation vs placebo control groups,and for the saffron supplementation vs antidepressant groups.The methodological quality of all studies was assessed using the Jadad score.The computer software Comprehensive Metaanalysis 2 was used to analyze the data.RESULTS:Based on our pre-specified criteria,five randomized controlled trials(n=2 placebo controlled trials,n=3 antidepressant controlled trials)were included in our review.A large effect size was found for saffron supplementation vs placebo control in treating depressive symptoms(M ES=1.62,P<0.001),revealing that saffron supplementation significantly reduced depression symptoms compared to the placebo control.A null effect size was evidenced between saffron supplementation and the antidepressant groups(M ES=-0.15)indicating that both treatments were similarly effective in reducing depression symptoms.The mean Jadad score was 5 indicating high quality of trials.CONCLUSION:Findings from clinical trials conducted to date indicate that saffron supplementation can improve symptoms of depression in adults with MDD.Larger clinical trials,conducted by research teams outside of Iran,with long-term follow-ups are needed before firm conclusions can be made regarding saffron's efficacy and safety for treating depressive symptoms. | Heather Ann Hausenblas Debbie Saha Pamela Jean Dubyak Stephen Douglas Anton | 2013 | Journal of Integrative Medicine2013，11，6： | 4 |
| 2 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 3 | Growing Operational Use of FY-3 Data in the ECMWF System显示文摘This paper reviews the data quality and impact of observations from the FY-3 satellite series used operationally in the ECMWF system. This includes data from the passive microwave radiometers MWHS-1, MWHS-2 and MWRI, as well as observations from the radio occultation receiver GNOS. Evaluations against background equivalents show that the quality of the observations is broadly comparable to that of similar instruments on other polar-orbiting satellites, even though biases for the passive microwave observations can be somewhat larger and more complex for some channels. An observing system experiment shows that the FY-3 instruments jointly contribute significantly to the forecast skill in the ECMWF system. Positive impact of up to 2% is seen for most variables out to the day-2 forecasts over hemispheric scales, with significant benefits for total column water vapor or for temperature and wind in the stratosphere out to day 4. | Niels BORMANN David DUNCAN Stephen ENGLISH Sean HEALY Katrin LONITZ Keyi CHEN Heather LAWRENCE Qifeng LU | 2021 | Advances in Atmospheric Sciences2021，38，8： | 3 |
| 4 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 5 | Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar显示文摘School-aged children(SAC)have a considerable burden of intestinal schistosomiasis in Madagascar yet its burden in pre-school aged children(PSAC)is currently overlooked.To assess the at-risk status of PSAC,we undertook a pilot epidemiological survey in June 2019 examining children(n=89),aged 2-4-years of balanced gender,in six remote villages in Marolambo District,Madagascar.Diagnosis included use of urine-circulating cathodic antigen(CCA)dipsticks and coproscopy of stool with duplicate Kato-Katz(K-K)thick smears. | Caitlin Sheehy Heather Lawson Emmanuel H.Andriamasy Hannah J.Russell Alice Reid Gina U.Raderalazasoa Graham Dodge Robbie Kornitschky James M.StJPenney Tahiry N.Ranaivoson Antsa Andria niaina Jenny S.Emmanoela Amaya L.Bustinduy JRussell Stothard Louis Andrianjaka Stephen A.Spencer | 2021 | Infectious Diseases of Poverty2021，10，3： | 2 |
| 6 | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology显示文摘 | Rebecca Kunder Christian Kunder Heather Y. Sun Gerald Berry Anna Messner Jennifer Frankovich Stephen Roth John Mark F. J. Aspa T. A. Chiang H. Matsuoka F. Midulla H. Niwa | 2013 | Case Reports in Pulmonology2013，，： | 1 |
| 7 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet . 2012 (9859)2012，，9859： | 1 |
| 8 | The value of urban tree cover: A hedonic property price model in Ramsey and Dakota Counties, Minnesota, USA显示文摘 | Heather Sander Stephen Polasky Robert G. Haight | 2010 | Ecological Economics2010，，8： | 1 |
| 9 | Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands显示文摘 | Heather M. O’Hagan Wei Wang Subhojit Sen Christina DeStefano Shields Stella S. Lee Yang W. Zhang Eriko G. Clements Yi Cai Leander Van Neste Hariharan Easwaran Robert A. Casero Cynthia L. Sears Stephen B. Baylin | 2011 | Cancer Cell2011，，5： | 1 |
| 10 | Developing Measures of Teachers’Mathematics Knowledge for Teaching显示文摘 | Heather C Hill Stephen G Schilling Deborah Loewenberg Ball | 2013 | The Elementary School Journal2013，，1： | 1 |
| 11 | Transforming cerebrospinal fluid Aβ42 measures into calculated Pittsburgh compound B units of brain Aβ amyloid显示文摘 | Stephen D. Weigand Prashanthi Vemuri Heather J. Wiste Matthew L. Senjem Vernon S. Pankratz Paul S. Aisen Michael W. Weiner Ronald C. Petersen Leslie M. Shaw John Q. Trojanowski David S. Knopman Clifford R. Jack | 2011 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2011，，2： | 1 |
| 12 | Role of aquaporin-4 in the development of brain oedema in liver failure显示文摘 | Gavin Wright Robin Soper Heather F. Brooks Vanessa Stadlbauer Balasubramaniyan Vairappan Nathan A. Davies Fausto Andreola Stephen Hodges Raymond F. Moss D. Ceri Davies Rajiv Jalan | 2010 | Journal of Hepatology2010，，1： | 1 |
| 13 | Certification of SRM 1589a PCBs, pesticides, PBDEs, and dioxins/furans in human serum显示文摘 | Michele M. Schantz Jennifer M. Keller Stefan Leigh Donald G. Patterson Katherine E. Sharpless Andreas Sj?din Heather M. Stapleton Robert Swarthout Wayman E. Turner Stephen A. Wise | 2007 | Analytical and Bioanalytical Chemistry2007，，4： | 1 |
| 14 | CT scanning for the detection of tuberculous mediastinal and hilar lymphadenopathy in children显示文摘 | Savvas Andronikou Elaine Joseph Susan Lucas Stephen Brachmeyer George Toit Heather Zar George Swingler | 2004 | Pediatric Radiology2004，，3： | 1 |
| 15 | Kudzu [ Pueraria montana (Lour.) Merr. Variety lobata ]: A new source of carbohydrate for bioethanol production显示文摘 | Rowan F. Sage Heather A. Coiner Danielle A. Way G. Brett Runion Stephen A. Prior H. Allen Torbert Richard Sicher Lewis Ziska | 2008 | Biomass and Bioenergy2008，，1： | 1 |
| 16 | The Effect of Gasoline Taxes and Public Transit Investments on Driving Patterns显示文摘 | Elisheba Spiller Heather Stephens Christopher Timmins Allison Smith | 2014 | Environmental and Resource Economics2014，，1： | 1 |
| 17 | A comprehensive obstetric patient safety program reduces liability claims and payments显示文摘 | Christian M. Pettker Stephen F. Thung Heather S. Lipkind Jessica L. Illuzzi Catalin S. Buhimschi Cheryl A. Raab Joshua A. Copel Charles J. Lockwood Edmund F. Funai | 2014 | American Journal of Obstetrics and Gynecology2014，，： | 1 |
| 18 | Ratiometric and Fluorescence- Lifetime -Based Biosensors Incorporating Cytochrome c and the Detection of Extra - and Intracellular Macrophage Nitric Oxide 显示文摘 | Susan L R B Heather A C Stephen F S Raoul K | 1999 | Anal Chem1999，71，： | 1 |
| 19 | Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study显示文摘 | Michelle M. Mielke Rodolfo Savica Heather J. Wiste Stephen D. Weigand Prashanthi Vemuri David S. Knopman Val J. Lowe Rosebud O. Roberts Mary M. Machulda Yonas E. Geda Ronald C. Petersen Clifford R. Jack | 2014 | Neurology2014，，1： | 1 |
| 20 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 1 |
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