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| 1 | Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine显示文摘AIM:To study whether the inflammatory bowel disease(IBD)colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak.METHODS:We examined the effects of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-1-β(IL1β)and hydrogen peroxide(H_2O_2)-singly and in combinations-on barrier function of CACO-2 cell layers.Our focus was on the type(not simply the magnitude)of transepithelial leak generated by these agents as measured by transepithelial electrical resistance(TER)and transepithelial flux of ^(14)C-D-mannitol,3H-Lactulose and ^(14)C-Polyethylene glycol as radiolabeled probe molecules.The isoquinoline alkaloid,berberine,was then examined for its ability to reduce specific types of transepithelial leak.RESULTS:Exposure to TNF-α alone(200 ng/mL;48 h)induced a 50% decrease in TER,i.e.,increased leak of Na^+ and Cl--with only a marginal but statistically significant increase in transepithelial leak of ^(14)C-mannitol(Jm).Exposure to TNF-α + IFN-γ(200 ng/mL;48 h)+ IL1β(50 ng/mL;48 h)did not increase the TER change(from TNF-α alone),but there was now a 100% increase in J_m.There however was no increase in transepithelial leak of two larger probe molecules,~3H-lactulose and ^(14)C-polyethylene glycol(PEG).However,exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to2 mmol/L H_2O_2 resulted in a 500% increase in ^(14)C-PEG leak as well as leak to the luminal mitogen,epidermal growth factor.CONCLUSION:This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances. | Katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro Julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 6 |
| 2 | A bulk micromachined silicon thermopile with high sensitivity显示文摘 | Allison S C Smith R L | 2003 | Sens Actuators A2003，104，1： | 1 |
| 3 | Breath Biopsy^(®) to Identify Exhaled Volatile Organic Compounds Biomarkers for Liver Cirrhosis Detection显示文摘Background and Aims:The prevalence of chronic liver dis-ease in adults exceeds 30%in some countries and there is significant interest in developing tests and treatments to help control disease progression and reduce healthcare burden.Breath is a rich sampling matrix that offers non-invasive so-lutions suitable for early-stage detection and disease moni-toring.Having previously investigated targeted analysis of a single biomarker,here we investigated a multiparametric approach to breath testing that would provide more robust and reliable results for clinical use.Methods:To identify can-didate biomarkers we compared 46 breath samples from cir-rhosis patients and 42 from controls.Collection and analysis used Breath Biopsy OMNI™,maximizing signal and contrast to background to provide high confidence biomarker detec-tion based upon gas chromatography mass spectrometry(GC-MS).Blank samples were also analyzed to provide de-tailed information on background volatile organic compounds(VOCs)levels.Results:A set of 29 breath VOCs differed significantly between cirrhosis and controls.A classification model based on these VOCs had an area under the curve(AUC)of 0.95±0.04 in cross-validated test sets.The seven best performing VOCs were sufficient to maximize classifica-tion performance.A subset of 11 VOCs was correlated with blood metrics of liver function(bilirubin,albumin,prothrom-bin time)and separated patients by cirrhosis severity using principal component analysis.Conclusions:A set of seven VOCs consisting of previously reported and novel candidates show promise as a panel for liver disease detection and mon-itoring,showing correlation to disease severity and serum biomarkers at late stage. | Giuseppe Ferrandino Giovanna De Palo Antonio Murgia Owen Birch Ahmed Tawfike Rob Smith Irene Debiram-Beecham Olga Gandelman Graham Kibble Anne Marie Lydon Alice Groves Agnieszka Smolinska Max Allsworth Billy Boyle Marc P.van der Schee Michael Allison Rebecca C.Fitzgerald Matthew Hoare Victoria K.Snowdon | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 4 | A bulk micromachined silicon thermopile with high sensitivity 显示文摘 | Allison S C Smith R L | 2003 | Sensors and Actuators A2003，104，1： | 1 |
| 5 | Effects of cadmium on osteoclast formation and activity in vitro显示文摘 | Allison K W Elizabeth A C Smith B D | 1996 | Toxicol Appl Pharm1996，140，2： | 1 |
| 6 | The Effect of Gasoline Taxes and Public Transit Investments on Driving Patterns显示文摘 | Elisheba Spiller Heather Stephens Christopher Timmins Allison Smith | 2014 | Environmental and Resource Economics2014，，1： | 1 |
| 7 | Biosynthesis of amino acids by ruminal microgranisms显示文摘 | Allison M N Smith R H | 1967 | Animal Science1967，29，： | 1 |
| 8 | Analysis of Efficacy and Failure in Proximal Humerus Fractures Treated With Locking Plates显示文摘 | Juan Agudelo Matthias Schürmann Philip Stahel Peter Helwig Steven J Morgan Wolfgang Zechel Christian Bahrs Anand Parekh Bruce Ziran Allison Williams Wade Smith | 2007 | Journal of Orthopaedic Trauma2007，，10： | 1 |
| 9 | Efficient modal analysis for structures with soil-structure interaction显示文摘 | Wu Wen-Hwa Smith H Allison | 1995 | Earthquake Engineering and Structure Dynamic1995，24，： | 1 |
| 10 | Efficient Model Analysis for Structures with Soil-Structures Interaction显示文摘 | Wen-Hwa Wu Allison Smith H | 1995 | EESD1995，，24： | 1 |
| 11 | Overcrowding, food and phosphorus limitation effects on ephipphia production and population dynamics in the invasive species Daphnia lumholtzi显示文摘 | Allison S. Smith Kumud Acharya Jeffrey Jack | 2009 | Hydrobiologia2009，，1： | 1 |
| 12 | Biosynthesis of amino acids by ruminal microorganisms显示文摘 | Allison M N Smith R H | 1967 | J Animal Sci1967，29，： | 1 |
| 13 | Efficient Modal Analysis for Structures with Soil-Structure inter-action 显示文摘 | WU Wen-hua SMITH H ALLISON | 1995 | Earthquake Engineering and Structure Dynamic1995，24，： | 1 |
| 14 | Studies on the uterus, skin and femur of rats treated with 17-beta-oestradiol benzoate for one to twenty-one days显示文摘 | Smith Q T Allison D J | 1966 | Acta Endocrinol(Copenh)1966，53，： | 1 |
| 15 | Association between health care providers'influence on parents who have concerns about vaccine safety and vaccination coverage显示文摘 | SMITH PHILIP J KENNEDY ALLISON M WOOTEN KAREN | 2006 | Pediatrics2006，118，5： | 1 |
| 16 | Calorie restriction:what recent results suggest for the future of ageing research显示文摘 | Smith DL Jr Nagy TR Allison DB | | 0，，05： | 1 |
| 17 | Mechaical and microstructural properties of 'wet' alginate and composite films containing various carbohydrates显示文摘 | ALLISON B BARBUT S SMITH A | 2015 | Journal of Food Science2015，80，1： | 1 |
| 18 | Biosynthesis of amino acids by ruminal microorganisms显示文摘 | ALLISON M N SMITH R H | 1967 | Journal of Animal Science1967，29，： | 1 |
| 19 | Analysis of Efficacy and Failure in Proximal Humerus Fractures Treated With Locking Plates显示文摘 | Juan Agudelo Matthias Schürmann Philip Stahel Peter Helwig Steven J Morgan Wolfgang Zechel Christian Bahrs Anand Parekh Bruce Ziran Allison Williams Wade Smith | 2007 | Journal of Orthopaedic Trauma2007，，10： | 1 |
| 20 | Arandomized controlled trial of late cinverson from calcincurin inhibitor(CNl)-base to sirplimus-base immunosuppression in liver transplant recipients with impaired renal function显示文摘 | Watson CJ Gimson A E Alexander G J Allison M E Gibbs P Smith J C | | 0，，： | 1 |
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