|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MiR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma显示文摘MicroRNAs(miRNAs) are endogenous small non-coding RNAs that repress their targets at post transcriptional level.Existing studies have shown that miRNAs are important regulatory genes in hepatocellular carcinoma(HCC),as either tumor suppressors or oncogenes.MiR-122 is normally downregulated in HCC and regarded as a tumor suppressor.Recently miR-122 has been reported to be regulated by CEBPA,which is then involved in a novel pathway to influence proliferation of tumor cells.However it is unknown whether CEBPA is regulated by miRNAs in HCC.In this study,we find that miR-182 is upregulated in HCC model rat,and represses CEBPA in both rat and human.This further improves the current CEBPA/miR-122 pathway that controls the proliferation of tumor cells.These results suggest that miR-182 is a potential oncogene in HCC and could be used as a diagnostic marker and drug target of HCC. | Chenggang Wang Ren Ren Haolin Hu Changjun Tan Miao Han Xiaolin Wang Yun Zheng | 2014 | Chinese Journal of Cancer Research2014，26，1： | 13 |
| 2 | Re-Os Dating of Molybdenite from the Yaogangxian Tungsten Deposit,South China,and Its Geological Significance显示文摘Yaogangxian 钨存款位于 Nanling polymetallic metallogenic 省的中央部分。orebodies 作为静脉发生。黑钨矿和辉钼矿是主导的矿石矿物质。二件样品为标明日期预定矿化作用以便阐明的辉钼矿 Re-Os 被选择。从石英黑钨矿静脉的辉钼矿的 Re-Os datings 并且在 153 散猠' ?獡愠 ' 詳?湡 ? 湩敶獲? 楬扭 ? 景愠瑮捩楬敮 ? 愠摮映牯敭 ? 慭獳癩? 湡 ? 敶湩漠敲 ? 的花岗石收益年龄传播了?档愠 ? 桴 ? 楊湡慹潧 ? 湡 ? 敄杮楪獡慨 ? 祴数搠灥獯瑩? | WANG Yonglei PEI Rongfu LI Jinwen QU Wenjun LI Li WANG Haolin DU Andao | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 8 |
| 3 | Analysis of users’ electricity consumption behavior based on ensemble clustering显示文摘Due to the increase in the number of smart meter devices,a power grid generates a large amount of data.Analyzing the data can help in understanding the users’electricity consumption behavior and demands;thus,enabling better service to be provided to them.Performing power load profile clustering is the basis for mining the users’electricity consumption behavior.By examining the complexity,randomness,and uncertainty of the users’electricity consumption behavior,this paper proposes an ensemble clustering method to analyze this behavior.First,principle component analysis(PCA)is used to reduce the dimensions of the data.Subsequently,the single clustering method is used,and the majority is selected for integrated clustering.As a result,the users’electricity consumption behavior is classified into different modes,and their characteristics are analyzed in detail.This paper examines the electricity power data of 19 real users in China for simulation purposes.This manuscript provides a thorough analysis along with suggestions for the users’weekly electricity consumption behavior.The results verify the effectiveness of the proposed method. | Qi Zhao Haolin Li Xinying Wang Tianjiao Pu Jiye Wang | 2019 | Global Energy Interconnection2019，2，6： | 7 |
| 4 | Soil erosion and sediment interception by check dams in a watershed for an extreme rainstorm on the Loess Plateau,China显示文摘The magnitude of soil erosion and sediment load reduction efficiency of check dams under extreme rainstorms is a long-standing concern.The current paper aims to use check dams to deduce the amount of soil erosion under extreme rainstorms in a watershed and to identify the difference in sediment interception efficiency of different types of check dams.Based on the sediment deposition at 12 check dams with 100% sediment interception efficiency and sub-catchment clustering by taking 12 damcontrolled catchments as clustering criteria,the amount of soil erosion resulting from an extreme rainstorm event on July 26,2017(named '7·26' extreme rainstorm) was estimated in the Chabagou watershed in the hill and gully region of the Loess Plateau.The differences in the sediment interception efficiency among the check dams in the watershed were analyzed according to field observations at 17 check dams.The results show that the average erosion intensity under the '7-26' extreme rainstorm was approximately 2.03×10~4 t/km^2,which was 5 times that in the second largest erosive rainfall in 2017(4.15×10~3 t/km^2) and 11-384 times that for storms in 2018(0.53×10~2 t/km^2-1.81×10~3 t/km^2).Under the '7-26' extreme rainstorm,the amount of soil erosion in the Chabagou watershed above the Caoping hydrological station was 4.20 × 106 t.The sediment interception efficiency of the check dams with drainage canals(including the destroyed check dams) and with drainage culverts was 6.48 and 39.49%,respectively.The total actual sediment amount trapped by the check dams was 1.11 × 106 t,accounting for 26.36% of the total amount of soil erosion.In contrast,3.09×106 t of sediment were input to the downstream channel,and the sediment deposition in the channel was 2.23×10~6 t,accounting for 53.15%of the total amount of soil erosion.The amount of sediment transport at the hydrological station was8.60×10~5 t.The Sediment Delivery Ratio(SDR) under the '7·26' extreme rainstorm was 0.21.The results indicated that the amount of soil erosion was huge,and the sediment interception efficiency of the check dams was greatly reduced under extreme rainstorms.It is necessary to strengthen the management and construction technology standards of check dams to improve the sediment interception efficiency and flood safety in the watershed. | Leichao Bai Nan Wang Juying Jiao Yixian Chen Bingzhe Tang Haolin Wang Yulan Chen Xiqin Yan Zhijie Wang | 2020 | International Journal of Sediment Research2020，35，4： | 7 |
| 5 | An efficient bifunctional electrocatalyst derived from layer-by-layer self-assembly of a three-dimensional porous Co-N-C@graphene显示文摘Three-dimensional (3D) porous carbon-based materials with tunable composition and microstructure are of great interest for the development of oxygen involved electrocatalytic reactions. Here, we report the synthesis of 3D porous carbon-based electrocatalyst by self-assembling Co-metal organic frameworks (MOF) building blocks on graphene via a layer-by-layer technique. Precise control of the structure and morphology is achieved by varying the MOF layer to tune the electrocatalytic properties. The as-produced electrocatalyst exhibits an excellent catalytic activity for the oxygen reduction reaction in 0.1molL^-1 KOH, showing a high onset potential of 0.963V vs. reversible hydrogen electrode (RHE) and a low tafel slope of 54mVdec^-1, compared to Pt/C (0.934V and 52mVdec^-1, respectively). Additionally, it shows a slightly lower potential vs. RHE (1.72V) than RuO2 (1.75V) at 10mAcm^-2 in an alkaline electrolyte. A rechargeable Zn-air battery based on the as-produced 3D porous catalyst demonstrates a high peak power density of 119mWcm^-2 at a cell voltage of 0.578V while retaining an excellent stability over 250 charge-discharge cycles. | Shichang Cai Rui Wang William M. Yourey Junsheng Li Haining Zhang Haolin Tang | 2019 | Science Bulletin2019，64，14： | 6 |
| 6 | Properties of Cloud and Precipitation over the Tibetan Plateau显示文摘The characteristics of seasonal precipitation over the Tibetan Plateau(TP) were investigated using TRMM(Tropical Rainfall Measuring Mission) precipitation data(3B43). Sensitive regions of summer precipitation interannual variation anomalies were investigated using EOF(empirical orthogonal function) analysis. Furthermore, the profiles of cloud water content(CWC) and precipitable water in different regions and seasons were analyzed using TRMM-3A12 data observed by the TRMM Microwave Imager. Good agreement was found between hydrometeors and precipitation over the eastern and southeastern TP, where water vapor is adequate, while the water vapor amount is not significant over the western and northern TP.Further analysis showed meridional and zonal anomalies of CWC centers in the ascending branch of the Hadley and Walker Circulation, especially over the south and east of the TP. The interannual variation of hydrometeors over the past decade showed a decrease over the southeastern and northwestern TP, along with a corresponding increase over other regions. | WANG Chenghai SHI Hongxia HU Haolin WANG Yi XI Baike | 2015 | Advances in Atmospheric Sciences2015，32，11： | 6 |
| 7 | MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells显示文摘MicroRNA-132(miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain.Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells(NSCs)and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration(MSA) model. We found that miR-132 overexpression enhanced the differentiation of NSCs in vivo and in vitro. Similarly, speci?c overexpression of miR-132 in NSCs of the adult hippocampal dentate gyrus(DG) during the acquisition stage of MSA potentiated morphine-seeking behavior. These ?ndings indicate that miR-132 is involved in opioid addiction,probably by promoting the differentiation of NSCs in the adult DG. | Meng Jia Xuewei Wang Haolin Zhang Can Ye Hui Ma Mingda Yang Yijing Li Cailian Cui | 2019 | Neuroscience Bulletin2019，35，3： | 6 |
| 8 | Rational design of hierarchically porous Fe-N-doped carbon as efficient electrocatalyst for oxygen reduction reaction and Zn-air batteries显示文摘The rational design and construction of hierarchically porous nanostructure for oxygen reduction reaction (ORR) electrocatalysts is crucial to facilitate the exposure of accessible active sites and promote the mass/electron transfer under the gas-solid-liquid triple-phase condition. Herein, an ingenious method through the pyrolysis of creative polyvinylimidazole coordination with Zn/Fe salt precursors is developed to fabricate hierarchically porous Fe-N-doped carbon framework as efficient ORR electrocatalyst. The volatilization of Zn species combined with the nanoscale Kirkendall effect of Fe dopants during the pyrolysis build the hierarchical micro-, meso-, and macroporous nanostructure with a high specific surface area (1,586 m^(2)·g^(−1)), which provide sufficient exposed active sites and multiscale mass/charge transport channels. The optimized electrocatalyst exhibits superior ORR activity and robust stability in both alkaline and acidic electrolytes. The Zn-air battery fabricated by such attractive electrocatalyst as air cathode displays a higher peak power density than that of Pt/C-based Zn-air battery, suggesting the great potential of this electrocatalyst for Zn-air batteries. | Zihan Meng Neng Chen Shichang Cai Jiawei Wu Rui Wang Tian Tian Haolin Tang | 2021 | Nano Research2021，14，12： | 4 |
| 9 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 10 | Geology, Geochemistry, and Geochronology of the Fenghuangshan Skarn-type Copper Deposit in the Tongling Ore Cluster, Anhui Province, East China显示文摘The Fenghuangshan skarn-type Cu deposit, Tongling Ore Cluster, Anhui Province, is an important component in the Middle-Lower Yangtze River ore-forming belt. To better understand magmatism and its relationship to mineralization, we investigated geochemical features, ore-forming fluids, and geochronology of the Xinwuli intrusion and the related Fenghuangshan Cu deposit. Lithogeochemical characteristics show that the Xinwuli quartz monzodiorite is formed by mixing magma derived from upper mantle alkaline basalt that has been contaminated by crust materials. C, H and O isotopes indicate that ore-forming fluids mainly come from the magma, with minor amounts of meteoric fluids involved at the late stage. S and Pb isotopic components indicate that ore-forming materials are derived from the mantle. Molybdenite Re-Os isotopic dating yields Re-Os model ages ranging from 139.1±2.4 Ma to 142.0±2.2 Ma, with an isochronal age of 141.1±1.4 Ma, which is consistent with sensitive, high-resolution ion microprobe (SHRIMP) zircon U-Pb ages of quartz monzodiorite and granodiorite in the mining area. Dating analysis yields ages from 136.0±2.0 Ma to 143.0±2.4 Ma for the quartz monzodiorite (a weighted average of 139.4±1.2 Ma) and ages from 136.7±2.0 Ma to 145.3±2.4 Ma for granodiorite (a weighted average of 141.0±1.1 Ma). | QU Hongying PEI Rongfu FEI Hongcai LI Jinwen WANG Yonglei WANG Haolin YAO Lei | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 3 |
| 11 | Improved thermal stability and infrared emissivity of high-entropy REMgAl_(11)O_(19)and LaMAl_(11)O_(19)(RE=La,Nd,Gd,Sm,Pr,Dy;M=Mg,Fe,Co,Ni,Zn)显示文摘LaMgAl_(11)O_(19)(LMA),characterized by high melting point,low density and thermal conductivity as well as good infrared emissivity,is regarded as a potential candidate for the thermal protection of hypersonic vehicles.Nevertheless,the unsatisfied phase stability at high temperature results in declining of the emissivity below 6μm,which limits the extensive applications of LaMgAl_(11)O_(19).In order to overcome this obstacle,three dense bulk high-entropy ceramics,(La_(0.2)Nd_(0.2)Gd_(0.2)Sm_(0.2)Pr_(0.2))MgAl_(11)O_(19)(HE LMA-1),(La_(0.2)Nd_(0.2)Gd_(0.2)Sm_(0.2)Dy_(0.2))Mg Al_(11)O_(19)(HE LMA-2)and La(Mg_(0.2)Fe_(0.2)Co_(0.2)Ni_(0.2)Zn_(0.2))Al_(11)O_(19)(HE LMA-3),were designed and successfully prepared through solid state reaction at 1700℃for 4 h in one step.XRD analyses show that the phase compositions of HE LMA-1,HE LMA-2 and HE LMA-3 are single-phase solid solutions with the relative density of 95.61%,95.49%and 94.31%,respectively.Heat treatment experiments demonstrate that the phase composition of HE LMA-1 remains a single phase after high-temperature heating,while second phase appears in other two samples.The stability of HE LMA-1 is attributed to small average size differenceδ(~4%)of constitute elements.Intriguingly,the average emissivity of HE LMA-1 in the range of 3-6μm reaches 0.9,which is significantly higher than that of LMA and other two HE LMA samples.The emissivity of all samples remains above 0.95 from 6 to 10μm.In the far infrared region(10-14μm),although the emissivity of these specimens decreases slightly,it still exceeds 0.85.The UV-Vis absorption spectra indicate that the formation of many discrete impurity energy levels with small intervals in HE LMA-1 promotes the f electrons to transit between adjacent impurity energy levels and conduction band,which enhances the infrared emission of HE LMA-1 below 6μm.In a word,with improved phase stability and thermal emissivity in infrared range,high-entropy REMgAl_(11)O_(19),especially(La_(0.2)Nd_(0.2)Gd_(0.2)Sm_(0.2)Pr_(0.2))MgAl_(11)O_(19)(HE LMA-1),is a promising candidate in thermal protection coatings of hypersonic vehicles. | Haolin Zhu Ling Liu Huimin Xiang Fu-Zhi Dai Xiaohui Wang Zhuang Ma Yanbo Liu Yanchun Zhou | 2022 | Journal of Materials Science & Technology2022，，9： | 3 |
| 12 | New Recognized Intellect for Prospecting Large-superlarge Mineral Deposits显示文摘Based on the data base of 1285 mineral deposits of 22 commodities in 121 countries of 6 continents of the world, the authors use the linear trend analysis for their reserves to determine the cut-off limited order of reserves to select 36 exceptional superlarge (as peak mineral), 95 superlarge and 314 large deposits as new recognized intellect for their quantitative change. We have projected above 445 large-superlarge deposits on (1:5 M) global tectonic background map and divided 4 metallogenic domains, 21 metallogenic belts. Global metallogeny of large-superlarge deposits are: unity by endogenic, exogenic metamorphic and epigenetic in origin; speciality in different metallogenic domains and belts; preferentiality to ore-forming elements of Cu, Au, Fe, Ag, Cr, Mn, Zn, Pb, Sb, Hg, to continental margins or plate convergent belts, to Intra-continental tectono-magmatic complex belts and Large ductile shear zones; abnormality by the global oxyatmversion (excess oxygen atmospheric event) in Archean, redoxyatmversion (lack oxygen atmospheric event) in Proterozoic-Paleozoic, and tectonosphere thermal erosion (great amount of tectonic magmatic event) in Mesozoic-Cenozoic. | PEI Rongfu MEI Yanxiong WANG Haolin QU Hongying | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 3 |
| 13 | Application of fast factorized back-projection algorithm for high-resolution highly squinted airborne SAR imaging显示文摘In squinted synthetic aperture radar(SAR) imaging, the range-azimuth coupling requires precise range cell migration correction(RCMC). Moreover, for high-resolution airborne SAR, motion compensation(MOCO) becomes complicated as the squint angle increases, thereby degrading the performance of Dopplerdomain imaging algorithms. On the other hand, time-domain back-projection(BP) SAR imaging approaches are considered as optimal solutions to performing precise image focusing and MOCO. Among current BP algorithms,the fast factorized back-projection(FFBP) algorithm is one of the most essential representatives that achieve high-resolution images in an efficient manner. In this paper, the principle and applications of the FFBP algorithm are investigated through the derivation of the azimuth impulse response function(AIRF) of the resulting image.The phenomenon of spectrum displacement induced by motion errors in the BP image is presented and analyzed.Based on rigorous mathematical derivations, a modified FFBP algorithm is proposed to facilitate a seamless integration with motion compensation and accurate imagery of high-resolution highly squinted airborne SAR.Real data results confirm the effectiveness of the proposed approaches. | Lei ZHANG Haolin LI Zhiwei XU Hongxian WANG | 2017 | Science China(Information Sciences)2017，60，6： | 2 |
| 14 | Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid显示文摘The development of two-dimensional(2D)transition metal dichalcogenides has been in a rapid growth phase for the utilization in surface-enhanced Raman scattering(SERS)analysis.Here,we report a promising 2D transition metal tellurides(TMTs)material,hafnium ditelluride(HfTe2),as an ultrasensitive platform for Raman identification of trace molecules,which demonstrates extraordinary SERS activity in sensitivity,uniformity,and reproducibility.The highest Raman enhancement factor of 2.32×10^(6)is attained for a rhodamine 6G molecule through the highly efficient charge transfer process at the interface between the HfTe2 layered structure and the adsorbed molecules.At the same time,we provide an effective route for large-scale preparation of SERS substrates in practical applications via a facile stripping strategy.Further application of the nanosheets for reliable,rapid,and label-free SERS fingerprint analysis of uric acid molecules,one of the biomarkers associated with gout disease,is performed,which indicates arresting SERS signals with the limits of detection as low as 0.1 mmol/L.The study based on this type of 2D SERS substrate not only reveals the feasibility of applying TMTs to SERS analysis,but also paves the way for nanodiagnostics,especially early marker detection. | YANG LI HAOLIN CHEN YANXIAN GUO KANGKANG WANG YUE ZHANG PEILIN LAN JINHAO GUO WEN ZHANG HUIQING ZHONG ZHOUYI GUO ZHENGFEI ZHUANG ZHIMING LIU | 2021 | Photonics Research2021，9，6： | 2 |
| 15 | Polycyclic aromatic hydrocarbons (PAHs) in soils and vegetation near an e-waste recycling site in South China: Concentration, distribution, source, and risk assessment显示文摘 | Yan Wang Zhongjing Tian Haolin Zhu Zhineng Cheng Meiling Kang Chunling Luo Jun Li Gan Zhang | 2012 | Science of the Total Environment2012，，： | 1 |
| 16 | Pervasive hybridization during evolutionary radiation of Rhododendron subgenus Hymenanthes in mountains of southwest China显示文摘Radiations are especially important for generating species biodiversity in mountainous ecosystems.The contribution of hybridization to such radiations has rarely been examined.Here,we use extensive genomic data to test whether hybridization was involved in evolutionary radiation within Rhododendron subgenus Hymenanthes,whose members show strong geographic isolation in the mountains of southwest China.We sequenced genomes for 143 species of this subgenus and 93 species of four other subgenera,and found that Hymenanthes was monophyletic and radiated during the late Oligocene to middle Miocene.Widespread hybridization events were inferred within and between the identified clades and subclades.This suggests that hybridization occurred both early and late during diversification of subgenus Hymenan thes,although the extent to which hybridization,speciation through mixing-isolation-mixing or hybrid speciation,accelerated the diversification needs further exploration.Cycles of isolation and contact in such and other montane ecosystems may have together promoted species radiation through hybridization between diverging populations and species.Similar radiation processes may apply to other montane floras in this region and elsewhere. | Yazhen Ma Xingxing Mao Ji Wang Lei Zhang Yuanzhong Jiang Yuying Geng Tao Ma Liming Cai Shuangquan Huang Pete Hollingsworth Kangshan Mao Minghui Kang Yiling Li Wenlu Yang Haolin Wu Yang Chen Charles C.Davis Nawal Shrestha Richard H.Ree Zhenxiang Xi Quanjun Hu Richard I.Milne Jianquan Liu | 2022 | National Science Review2022，9，12： | 1 |
| 17 | General modeling and numerical simulation of the burning characteristics of porous chars显示文摘 | Wang Xiaohan Zeng Xiaojun Yang Haolin | | 0，，07： | 1 |
| 18 | Recent progress in synthesis of two-dimensional hexagonal boron nitride显示文摘Two-dimensional(2D) materials have recently received a great deal of attention due to their unique structures and fascinating properties,as well as their potential applications.2D hexagonal boron nitride(2D hBN),an insulator with excellent thermal stability,chemical inertness,and unique electronic and optical properties,and a band gap of 5.97 e V,is considered to be an ideal candidate for integration with other 2D materials.Nevertheless,the controllable growth of high-quality 2D h-BN is still a great challenge.A comprehensive overview of the progress that has been made in the synthesis of 2D h-BN is presented,highlighting the advantages and disadvantages of various synthesis approaches.In addition,the electronic,optical,thermal,and mechanical properties,heterostructures,and related applications of 2D h-BN are discussed. | Haolin Wang Yajuan Zhao Yong Xie Xiaohua Ma Xingwang Zhang | 2017 | Journal of Semiconductors2017，38，3： | 1 |
| 19 | Performance of direct methanol fuel cells prepared by hotpressed MEA and catalyst-coated membrane (CCM)显示文摘 | Tang Haolin Wang Shenlong Pan Mu | 2007 | Electrochimica Acta2007，52，： | 1 |
| 20 | A degradation study of Nafion proton exchange membrane of PEM fuel cells显示文摘 | Haolin Tang Shen Peikang San Ping Jiang Fang Wang Mu Pan | 2007 | Journal of Power Sources2007，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员